Soluble adhesion molecules and marine n-3 fatty acids in patients referred for coronary angiography
Abstract
Objective To investigate the relationship between soluble cellular adhesion molecules (sCAMs) and the extent of coronary artery disease (CAD) in patients with stable angina pectoris.Methods and results Two hundred and ninety-one subjects had fasting levels of circulating intercellular adhesion molecule-1(sICAM-1), vascular cellular adhesion molecule-1 (sVCAM-1), sP-selectin and contents of n-3 polyunsaturated fatty acids (n-3 PUFA) in granulocyte membranes and adipose tissue determined before undergoing elective coronary angiography. Levels of soluble VCAM-1 (983+/-216 versus 893+/-196 ng/l, p<0.001), ICAM-1 (318+/-140 versus 290+/-75 ng/l, p<0.05) and P-selectin (90+/-27 versus 80+/-23 ng/l, p<0.01) were significantly increased in subjects with significant CAD compared to subjects with no significant stenoses. In a linear regression analysis, both sVCAM-1 and sP-selectin, but not sICAM-1, correlated to the presence and the severity of CAD. Both sICAM-1 and sP-selectin were significantly correlated to current smoking status and a history of myocardial infarction. The content of total n-3 PUFA and docosahexaenoic acid in adipose tissue was marginally, but significant positively correlated to VCAM-1.Conclusion sVCAM-1 and sP-selectin may serve as markers of CAD in patients with stable angina pectoris. Only sVCAM-1 was weakly correlated to n-3 PUFA in adipose tissue.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Elderly people have higher basal levels of inflammation independently of disease status.
“Elderly people have higher basal levels of inflammation independently of disease status, and a considerable number of studies have been carried out in this population to assess associations between physical activity and inflammatory markers (190,223 -230) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [223]
Cites
Atherosclerosis--an inflammatory disease
Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725 · see citing works
Fish Consumption, Fish Oil, Omega-3 Fatty Acids, and Cardiovascular Disease
Kris-Etherton, P. M., Harris, W. S., & Appel, L. J. (2002) · Circulation · doi:10.1161/01.cir.0000038493.65177.94 · Cited by 3,707 · see citing works
Ridker, P. M., Hennekens, C. H., Roitman-Johnson, B., Stampfer, M. J., & Allen, J. (1998) · The Lancet · doi:10.1016/s0140-6736(97)09032-6 · Cited by 1,229 · see citing works
Adhesion molecules and atherosclerosis
Blankenberg, S., Barbaux, S., & Tiret, L. (2003) · Atherosclerosis · doi:10.1016/s0021-9150(03)00097-2 · Cited by 1,075 · see citing works
Circulating Cell Adhesion Molecules and Death in Patients With Coronary Artery Disease
Blankenberg, S., Rupprecht, H. J., Bickel, C., Peetz, D., Hafner, G., Tiret, L., Meyer, J., & for the AtheroGene Investigators (2001) · Circulation · doi:10.1161/hc3701.095949 · Cited by 593 · see citing works
Soluble P-Selectin and the Risk of Future Cardiovascular Events
Ridker, P. M., Buring, J. E., & Rifai, N. (2001) · Circulation · doi:10.1161/01.cir.103.4.491 · Cited by 564 · see citing works
The adhesion molecule P-selectin and cardiovascular disease
Blann, A. D. (2003) · European Heart Journal · doi:10.1016/j.ehj.2003.08.021 · Cited by 513 · see citing works
Malik, I. S., Danesh, J., Whincup, P. H., Bhatia, V. K., Papacosta, O., Walker, M., LENNON, L. T., Thomson, A. G., & Haskard, D. O. (2001) · The Lancet · doi:10.1016/s0140-6736(01)06104-9 · Cited by 389 · see citing works
Levels of Soluble Cell Adhesion Molecules in Patients With Dyslipidemia
Hackman, A. M., Abe, Y., Insull, W., Pownall, H. J., Smith, L. C., Dunn, K., Gotto, A. M., & Ballantyne, C. M. (1996) · Circulation · doi:10.1161/01.cir.93.7.1334 · Cited by 310 · see citing works
Johansen, O., Seljeflot, I., Høstmark, A. T., & Arnesen, H. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.7.1681 · Cited by 169 · see citing works
Plasma concentration of soluble vascular cell adhesion molecule-1 and subsequent cardiovascular risk
de Lemos, J. A., Hennekens, C. H., & Ridker, P. M. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)00742-7 · Cited by 163 · see citing works
Christensen, J. H., Skou, H. A., Fog, L., Hansen, V. E., Vesterlund, T., Dyerberg, J., Toft, E. S., & Schmidt, E. B. (2001) · Circulation · doi:10.1161/01.cir.103.5.651 · Cited by 158 · see citing works
Clausen, P., Jacobsen, P. K., Rossing, K., Jensen, J. S., Parving, H. ‐., & Feldt‐Rasmussen, B. (2000) · Diabetic Medicine · doi:10.1046/j.1464-5491.2000.00347.x · Cited by 150 · see citing works
Dietary intake of long-chain n−3 polyunsaturated fatty acids and the risk of primary cardiac arrest
Siscovick, D. S., Raghunathan, T., King, I. B., Weinmann, S. A., Bovbjerg, V. E., Kushi, L. H., Cobb, L. A., Copass, M. K., Psaty, B. M., Lemaître, R. N., et al. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.1.208s · Cited by 135 · see citing works
Collie-Duguid, E. S. R., & Wahle, K. W. J. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.0516 · Cited by 130 · see citing works
Mulvihill, N. T., Foley, J. B., Murphy, R. T., Curtin, R., Crean, P., & Walsh, M. (2001) · Heart · doi:10.1136/heart.85.6.623 · Cited by 126 · see citing works
Parissis, J., Korovesis, S., Giazitzoglou, E., Kalivas, P., & Katritsis, D. G. (2002) · International Journal of Cardiology · doi:10.1016/s0167-5273(02)00021-9 · Cited by 101 · see citing works
Evidence of prolonged inflammation in unstable angina and non–Q wave myocardial infarction
Mulvihill, N. T., Foley, J. B., Murphy, R. T., Crean, P., & Walsh, M. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)00824-x · Cited by 88 · see citing works
Mazzone, A., Cusa, C., Mazzucchelli, I., Vezzoli, M., Ottini, E., Ghio, S., Tossini, G., Pacifici, R., & Zuccaro, P. (2001) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2001.136 · Cited by 86 · see citing works
n-3 fatty acids from fish and coronary artery disease: implications for public health
Schmidt, E. B., Skou, H. A., Christensen, J. H., & Dyerberg, J. (2000) · Public Health Nutrition · doi:10.1017/s1368980000000112 · Cited by 86 · see citing works
Biomarkers of habitual fish intake in adipose tissue
Marckmann, P., Lassen, A. D., Haraldsdóttir, J., & Sandström, B. (1995) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/62.5.956 · Cited by 66 · see citing works
Porsch-Oezçueruemez, M., Kunz, D., Kloer, H.-U., & Luley, C. H. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00473-8 · Cited by 65 · see citing works
Semaan, H. B., Gurbel, P. A., Anderson, J. L., Muhlestein, J. B., Carlquist, J. F., Horne, B. D., & Serebruany, V. L. (2000) · Cardiology · doi:10.1159/000006995 · Cited by 65 · see citing works
Strączkowski, M., Lewczuk, P., Dzienis-Straczkowska, S., Kowalska, I., Stecedilpienacute, A., & Kinalska, I. (2002) · Metabolism · doi:10.1053/meta.2002.28095 · Cited by 60 · see citing works
Duplàa, C., Couffinhal, T., Labat, L., Moreau, C., Petitjean, M. E., Doutre, M. ‐., Lamazière, J. D., & Bonnet, J. L. (1996) · Atherosclerosis · doi:10.1016/0021-9150(95)05729-3 · Cited by 55 · see citing works
n‐3 fatty acids: Antiatherosclerotic effects
Caterina, R. D., & Zampolli, A. (2001) · Lipids · doi:10.1007/s11745-001-0685-9 · Cited by 54 · see citing works
Winkelmann, B. R., Boehm, B. O., Nauck, M., Kleist, P., März, W., Verho, N. K., Ranjith, N., & KNEISSL, G. D. (2001) · Current Medical Research and Opinion · doi:10.1185/030079901317010801 · Cited by 45 · see citing works
Winkelmann, B. R., Boehm, B. O., Nauck, M., et al. (2001) · Current Medical Research and Opinion · doi:10.1185/0300799039117049 · Cited by 35 · see citing works
Ikata, J., Wakatsuki, T., Oishi, Y., Oki, T., & Ito, S. (2000) · Coronary Artery Disease · doi:10.1097/00019501-200009000-00001 · Cited by 34 · see citing works
Saku, K., Zhang, B., Ohta, T., Shirai, K., Tsuchiya, Y., & Arakawa, K. (1999) · Japanese Circulation Journal-english Edition · doi:10.1253/jcj.63.19 · Cited by 28 · see citing works
Omega-3 Fatty Acids Alter Soluble Coronary Heart Disease Patients Markers of Endothelial Function in
Meydani, M. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.2000.tb07812.x · Cited by 28 · see citing works
Hajilooi, M., Sanati, A., Ahmadieh, A., Ghofraniha, A., & Massoud, A. M. (2003) · Immunological Investigations · doi:10.1081/imm-120025104 · Cited by 21 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098 · see citing works
The paradox of the neutrophilˈs role in tissue injury
Segel, G. B., Halterman, M. W., & Lichtman, M. A. (2010) · Journal of Leukocyte Biology · doi:10.1189/jlb.0910538 · Cited by 308 · see citing works
Circulating markers of endothelial function in cardiovascular disease
Constans, J., & Conri, C. (2006) · Clinica Chimica Acta · doi:10.1016/j.cca.2005.12.030 · Cited by 277 · see citing works
Dewell, A., Marvasti, F. F., Harris, W. S., Tsao, P., & Gardner, C. D. (2011) · The Journal of Nutrition · doi:10.3945/jn.111.142240 · Cited by 98 · see citing works
Association Between Arsenic Exposure From Drinking Water and Plasma Levels of Cardiovascular Markers
Wu, F., Jasmine, F., Kibriya, M. G., Liu, M., Wójcik, O. P., Parvez, F., Rahaman, R. O., Roy, S., Paul-Brutus, R., Segers, S., et al. (2012) · American Journal of Epidemiology · doi:10.1093/aje/kwr464 · Cited by 71 · see citing works
Gamma-glutamyltransferase to Determine Cardiovascular Risk: Shifting the Paradigm Forward
Turgut, O. O., & Tandoğan, İ. (2011) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.6189 · Cited by 69 · see citing works
Manolakis, A. C., Kapsoritakis, A. N., & Potamianos, S. P. (2007) · Helicobacter · doi:10.1111/j.1523-5378.2007.00511.x · Cited by 63 · see citing works
Tretjakovs, P., Jurka, A., Bormane, I., Miķelsone, I., Elksne, K., Krieviņa, G., Reihmane, D., Verbovenko, J., & Bahs, G. (2011) · Clinica Chimica Acta · doi:10.1016/j.cca.2011.10.009 · Cited by 43 · see citing works
Paulo, M. C., Andrade, A. M., Andrade, M. L., Morais, M. G., Kiely, M. E., Parra, D., Martínez, J. A., Þórsdóttir, I., & Bandarra, N. M. (2008) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2007.11.007 · Cited by 26 · see citing works
Rostampour, N. (2017) · JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH · doi:10.7860/jcdr/2017/26623.10541 · Cited by 25 · see citing works
Eschen, O., Christensen, J. H., Rovere, M. T. L., Romano, P., Sala, P., & Schmidt, E. B. (2010) · PubMed · Cited by 24 · see citing works
Mirmiran, P., Davari, M., Hashemi, R., Hedayati, M., Sahranavard, S., Bahreini, S., Tavakoly, R., & Talaei, B. (2019) · European Journal of Clinical Nutrition · doi:10.1038/s41430-019-0523-9 · Cited by 16 · see citing works
Chen, C., Lee, C., Hsu, H., Yang, C.-Y., Chow, L., & Lee, Y. (2007) · Life Sciences · doi:10.1016/j.lfs.2007.04.007 · Cited by 14 · see citing works
Cao, J., Lü, L., Zhu, Z. B., Zhang, R., Zhang, Q., Du, R., Ding, F. H., Chen, Q., & Shen, W. F. (2010) · Coronary Artery Disease · doi:10.1097/mca.0b013e32833b20f1 · Cited by 13 · see citing works
Yeboah, J., Klein, K., Brosnihan, B., Reboussin, D. M., & Herrington, D. M. (2008) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e31816d8171 · Cited by 12 · see citing works
Adhesion Molecules as Prognostic Biomarkers in Coronary Artery Disease
Sagris, Μ., Theofilis, P., Antonopoulos, A. S., Oikonomou, E. K., Simantiris, S., Papaioannou, S., Tsioufis, C., & Tousoulis, D. (2023) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026623666230104125104 · Cited by 9 · see citing works
Adhesion molecules and C-reactive protein are associated to adverse events in angina pectoris
Eschen, O., Christensen, J. H., Johnsen, S. P., Dethlefsen, C., & Schmidt, E. B. (2010) · Scandinavian Cardiovascular Journal · doi:10.3109/14017431003615634 · Cited by 8 · see citing works
Djindjić, B., Ranković, G. Ž., Živić, M., Savić, T., Spasić, M., & Bubanj, M. (2009) · Vojnosanitetski pregled · doi:10.2298/vsp0912966d · Cited by 7 · see citing works
Platelet reactivity and the identification of acute coronary syndromes in the emergency department
Darling, C. E., Michelson, A. D., Volturo, G., & Przyklenk, K. (2008) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-008-0242-x · Cited by 5 · see citing works
Hejazi, S. M., Abrishami, L. H., Khani, J. M., & Boghrabadi, V. (2013) · Advanced Studies in Biology · doi:10.12988/asb.2013.3210 · Cited by 4 · see citing works
Tretjakovs, P., Jurka, A., Bormane, I., Miķelsone, I., Reihmane, D., Krieviņa, G., Marksa, I., Elksne, K., Verbovenko, J., & Bahs, G. (2011) · Proceedings of the Latvian Academy of Sciences Section B Natural Exact and Applied Sciences · doi:10.2478/v10046-011-0023-3
Hogue, J. (2008) · Corpus Université Laval (Université Laval)
Eschen, O., Christensen, J. H., & Schmidt, E. B. (2010) · Science Publishers eBooks · doi:10.1201/b10167-30
Ahmadi, S. H., & Daneshjoo, A. (2021) · Journal of Sports Physiology and Athletic Conditioning · doi:10.61186/jspac.19946.1.1.54
- Authors
- Eschen, O., Christensen, J. H., Toft, E., & Schmidt, E. B.
- Affiliations
- Aalborg University Hospital (DK)
- Corresponding author
- Eschen, Ole
- Venue
- Atherosclerosis
- Publisher
- Elsevier BV
- Published
- 2005-06
- Volume
- 180
- Issue
- 2
- Pages
- 327-331
- ISSN
- 0021-9150 (ISSN-L)
- OpenAlex
- W1983213880
- Cited by
- 25
- References
- 31
- Citations by year
- 2023: 1 · 2021: 1 · 2019: 1 · 2017: 1 · 2016: 1 · 2013: 1 · 2012: 1
- FWCI
- 2.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Atherosclerosis (publishedVersion)
- PubMed (publishedVersion)
- VBN Forskningsportal (Aalborg Universitet) (submittedVersion)
- Funders
- Hjerteforeningen
- Fondation pour la Recherche Médicale
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- soluble adhesion molecules, soluble VCAM-1, soluble ICAM-1, P-selectin, omega-3 fatty acids, docosahexaenoic acid, coronary artery disease, stable angina, coronary stenosis severity, biomarkers, smoking, myocardial infarction
- MeSH terms
- Adipose Tissue, Angina Pectoris, Coronary Artery Disease, Fatty Acids, Female, Fish Oils, Granulocytes, Humans, Male, Middle Aged, Severity of Illness Index, Cohort Studies, Biomarkers, Coronary Angiography, P-Selectin, Vascular Cell Adhesion Molecule-1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
