The DOI matches its Crossref record; 149 of the 149 references it cites were found in a registry or an index.
Current trends in inflammatory and immunomodulatory mediators in sepsis
Open accessAbstract
Review on sepsis mediators, and roles in innate and adaptive immune systems, as well as implications for therapeutics. Sepsis refers to severe systemic inflammation in response to invading pathogens. An overwhelming immune response, as mediated by the release of various inflammatory mediators, can lead to shock, multiple organ damage, and even death. Cytokines, proteases, lipid mediators, gaseous substances, vasoactive peptides, and cell stress markers play key roles in sepsis pathophysiology. Various adhesion molecules and chemokines sequester and activate neutrophils into the target organs, further augmenting inflammation and tissue damage. Although the anti-inflammatory substances counterbalance proinflammatory mediators, prolonged immune modulation may cause host susceptibility to concurrent infections, thus reflecting enormous challenge toward developing effective clinical therapy against sepsis. To understand the complex interplay between pro- and anti-inflammatory phenomenon in sepsis, there is still an unmet need to study newly characterized mediators. In addition, revealing the current trends of novel mediators will upgrade our understanding on their signal transduction, cross-talk, and synergistic and immunomodulating roles during sepsis. This review highlights the latest discoveries of the mediators in sepsis linking to innate and adaptive immune systems, which may lead to resolution of many unexplored queries.
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1 retracted
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Cited by
Akt Signaling Pathway in Macrophage Activation and M1/M2 Polarization
Vergadi, E., Ieronymaki, E., Lyroni, K., Vaporidi, K., & Tsatsanis, C. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601515 · Cited by 1,148
Immunotherapeutic Implications of Il-6 Blockade for Cytokine Storm
Tanaka, T., Narazaki, M., & Kishimoto, T. (2016) · Immunotherapy · doi:10.2217/imt-2016-0020 · Cited by 708
Denning, N.-L., Aziz, M., Gurien, S. D., & Wang, P. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02536 · Cited by 623
Self-citationInflammasome Activation Triggers Blood Clotting and Host Death through Pyroptosis
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Dobrev, D., Heijman, J., Hiram, R., Li, N., & Nattel, S. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00759-w · Cited by 268
Metadata
- Authors
- Aziz, M., Jacob, A., Yang, W.-L., Matsuda, A., & Wang, P.
- Venue
- Journal of Leukocyte Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-11-07
- Volume
- 93
- Issue
- 3
- Pages
- 329-342
- ISSN
- 0741-5400 (ISSN-L)
- 1938-3673
- OpenAlex
- W2160167304
- Cited by
- 309
- References
- 149
- FWCI
- 14.22
- Type
- journal article
- Language
- en
- Open access
- green
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- Aziz, M., Jacob, A., Yang, W.-L., Matsuda, A., & Wang, P. (2012). Current trends in inflammatory and immunomodulatory mediators in sepsis. Journal of Leukocyte Biology. https://doi.org/10.1189/jlb.0912437
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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