Preterm neonates display altered plasmacytoid dendritic cell function and morphology
Abstract
Functionality and morphology of pDCs of preterm newborns, with emphasis on TLR9 triggered IFN-α production. Bacterial and viral infections cause high rates of morbidity and mortality in premature newborns. In the setting of viral infection, pDCs play a key role as strong producers of IFN-α upon TLR9 activation. We analyzed pDC frequency, phenotype, morphology, and function in CB of preterm and term newborns in comparison with adults. Whereas all age groups show similar pDC numbers, BDCA-2, CD123, and TLR9 levels, the expression of BDCA-4 and capacity to produce IFN-α upon TLR9 challenge were decreased significantly in preterm neonates. Furthermore, we show by means of electron microscopy that pDCs from preterm newborns exhibit a distinct, “immature” morphology. Taken together, these findings suggest decreased functionality of pDCs in the premature newborn. The reduced capacity to produce IFN-α is likely to render such infants more susceptible to viral infections.
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Newborn pDC are severely limited in secreting interferon α/β upon exposure to different viruses, despite expressing TLR7 and TLR9 levels similar to adults.
“However, newborn pDC are severely limited in secreting interferon α/β upon exposure to different viruses, despite expressing levels of TLR7 and TLR9 that are similar to adults [13].”
From Evolution of the immune system in humans from infancy to old age (2015) · cites this paper as [13]
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- Authors
- Schüller, S. S., Sadeghi, K., Wisgrill, L., Dangl, A., Diesner, S. C., Prusa, A. R., Klebermasz-Schrehof, K., Greber-Platzer, S., Neumüller, J., Helmer, H., Husslein, P., Pollak, A., Spittler, A., & Förster-Waldl, E.
- Affiliations
- Medical University of Vienna (AT)
- Department of Pediatrics and Adolescent Medicine, Division of Neonatology, Pediatric Intensive Care and Neuropediatrics, Medical University of Vienna , Vienna, Austria
- University of Vienna (AT)
- Corresponding author
- Sadeghi, K
- Venue
- Journal of Leukocyte Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-05-01
- Volume
- 93
- Issue
- 5
- Pages
- 781-788
- ISSN
- 0741-5400 (ISSN-L)
- 1938-3673
- OpenAlex
- W2161545758
- Cited by
- 50
- References
- 36
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 2 · 2022: 3 · 2021: 7 · 2020: 6 · 2019: 5 · 2018: 4 · 2017: 2 · 2016: 7 · 2015: 3 · 2014: 3
- FWCI
- 2.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Leukocyte Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Austrian National Bank “Jubiläumsfond” (13071)
- Hochschuljubiläumsstiftung (H-2541/2009)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- plasmacytoid dendritic cells, preterm infants, umbilical cord blood, interferon-alpha production, TLR9, CD123, BDCA-2, dendritic cell morphology, viral susceptibility, neonatal immunity
- MeSH terms
- Adult, Age Factors, Antigens, Surface, Cell Count, Cells, Cultured, Dendritic Cells, Humans, Infant, Newborn, Infant, Premature, Interferon-alpha, Thrombomodulin, Toll-Like Receptor 9, Interleukin-3 Receptor alpha Subunit
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