Cited by 337Peroxisome Proliferator-Activated ReceptorsImmune Response and InflammationFatty Acid Research and Health

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The role of PPARs in inflammation and immunity

Clark, Robert B·2002·Journal of Leukocyte Biology

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Abstract

The family of transcription factors termed peroxisome proliferator-activated receptors (PPARs) has recently been the focus of much interest for their possible role in the regulation of inflammation and immune responses. PPARalpha and PPARgamma have been implicated in the regulation of macrophage and endothelial cell inflammatory responses. Although PPAR activation has generally been shown to have anti-inflammatory effects, opposite effects have been noted, and results often appear to depend on the ligands being used and the inflammatory parameters being measured. Recently, my laboratory and others have described a role for PPARgamma in the responses of T lymphocytes. Ligands for PPARgamma have been found to inhibit proliferation of activated T cells, and this appears to involve inhibition of IL-2 secretion and/or the induction of apoptosis. However, one problem in the interpretation of many of the studies of PPARgamma, inflammation, and immunity is that ligands thought to be specific for PPARgamma may have regulatory effects on inflammatory parameters that are PPARgamma-independent. Future studies of the role of the PPARs in inflammatory and immune responses should include further studies of T cells, T-cell subsets, and dendritic cells but will have to re-examine the issue of PPAR specificity of the ligands being used. This may require further knockout studies and technology, together with the identification of endogenous and perhaps more specific synthetic PPAR ligands.

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Authors: Clark, R. B.
Affiliations: UConn Health (US)
Corresponding author: Clark, Robert B
ORCID: Clark, Robert B
Venue: Journal of Leukocyte Biology
Publisher: Oxford University Press (OUP)
Published: 2002-03-01
Volume: 71
Issue: 3
Pages: 388-400
ISSN: 0741-5400 (ISSN-L)
1938-3673
DOI: 10.1189/jlb.71.3.388
OpenAlex: W2167908723
Cited by: 337
References: 100
Citations by year: 2026: 1 · 2025: 6 · 2024: 5 · 2023: 7 · 2022: 7 · 2021: 5 · 2020: 14 · 2019: 15 · 2018: 10 · 2017: 15 · 2016: 15 · 2015: 21 · 2014: 23 · 2013: 11 · 2012: 10
FWCI: 7.76
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: Journal of Leukocyte Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Keywords: peroxisome proliferator-activated receptors, PPARγ, PPARα, inflammation, immune response, T cells, T cell proliferation, IL-2 secretion, apoptosis, macrophages, endothelial cells, PPAR ligands, ligand specificity, dendritic cells
MeSH terms: Animals, Humans, Immunity, Inflammation, Nuclear Proteins, Transcription Factors, Receptors, Cytoplasmic and Nuclear

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The role of PPARs in inflammation and immunity

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