Cited by 337Peroxisome Proliferator-Activated ReceptorsImmune Response and InflammationFatty Acid Research and Health

The DOI matches its Crossref record; 99 of the 100 references it cites were found in a registry or an index.

The role of PPARs in inflammation and immunity

Clark, Robert B·2002·Journal of Leukocyte Biology

Open this paper in CoChat — free account

Abstract

The family of transcription factors termed peroxisome proliferator-activated receptors (PPARs) has recently been the focus of much interest for their possible role in the regulation of inflammation and immune responses. PPARalpha and PPARgamma have been implicated in the regulation of macrophage and endothelial cell inflammatory responses. Although PPAR activation has generally been shown to have anti-inflammatory effects, opposite effects have been noted, and results often appear to depend on the ligands being used and the inflammatory parameters being measured. Recently, my laboratory and others have described a role for PPARgamma in the responses of T lymphocytes. Ligands for PPARgamma have been found to inhibit proliferation of activated T cells, and this appears to involve inhibition of IL-2 secretion and/or the induction of apoptosis. However, one problem in the interpretation of many of the studies of PPARgamma, inflammation, and immunity is that ligands thought to be specific for PPARgamma may have regulatory effects on inflammatory parameters that are PPARgamma-independent. Future studies of the role of the PPARs in inflammatory and immune responses should include further studies of T cells, T-cell subsets, and dendritic cells but will have to re-examine the issue of PPAR specificity of the ligands being used. This may require further knockout studies and technology, together with the identification of endogenous and perhaps more specific synthetic PPAR ligands.

Integrity signals

Registry

Crossref · 10.1189/jlb.71.3.388

Cites

99 of 99 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The nuclear receptor superfamily: the second decade
Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90199-x · Cited by 6,964
An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)
Lehmann, J. M., Moore, L. B., Smith-Oliver, T. A., Wilkison, W. O., Willson, T. M., & Kliewer, S. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.22.12953 · Cited by 3,645
Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor
Tontonoz, P., Hu, E., & Spiegelman, B. M. (1994) · Cell · doi:10.1016/0092-8674(94)90006-x · Cited by 3,564
The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
Ricote, M., Li, A. C., Willson, T. M., Kelly, C. J., & Glass, C. K. (1998) · Nature · doi:10.1038/34178 · Cited by 3,525
Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
Issemann, I., & Green, S. (1990) · Nature · doi:10.1038/347645a0 · Cited by 3,519
The RXR heterodimers and orphan receptors
Mangelsdorf, D. J., & Evans, R. M. (1995) · Cell · doi:10.1016/0092-8674(95)90200-7 · Cited by 3,165
PPAR-γ agonists inhibit production of monocyte inflammatory cytokines
Jiang, C., Ting, A. T., & Seed, B. (1998) · Nature · doi:10.1038/34184 · Cited by 2,899
A decade of molecular biology of retinoic acid receptors
Chambon, P. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.9.8801176 · Cited by 2,889
15-Deoxy-Δ12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ
FORMAN, B. M., Tontonoz, P., Chen, J., Brun, R. P., Spiegelman, B. M., & Evans, R. M. (1995) · Cell · doi:10.1016/0092-8674(95)90193-0 · Cited by 2,857
Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat
Braissant, O., Foufelle, F., Scotto, C., Dauça, M., & Wahli, W. (1996) · Endocrinology · doi:10.1210/endo.137.1.8536636 · Cited by 2,217

Flagged first, then by citations

Show all 100 references

1 of the 100 references couldn’t be matched to a known paper.

Research works printed but not linked: 6

Schmidt, 1992, Identification of a new member of the steroid hormone receptor superfamily that is activated by peroxisome proliferator and fatty acid, Mol. Endocrinol., 6, 1634
Peters, 1997, Alterations in lipoprotein metabolism in peroxisome proliferator-activated receptor alpha-deficient mice, J. Biol. Chem., 272, 27307, 10.1074/jbc.272.43.27307 · DOI
Chinetti, 1998, Activation of proliferator-activated receptors α and γ induces apoptosis of human monocyte-derived macrophages, J. Biol. Chem., 273, 25573, 10.1074/jbc.273.40.25573 · DOI
Huang, 1999, Interleukin-4-dependent production of PPARγ ligands in macrophages by 12/15-lipoxygenase, Nature, 400, 378, 10.1038/22572 · DOI
Nagy, 1998, Oxidized LDL regulates macrophage gene expression through ligand activation of PPARγ, Cell, 93, 229, 10.1016/S0092-8674(00)81574-3 · DOI
Bishop-Bailey, 1999, Endothelial cell apoptosis induced by the peroxisome proliferator-activated receptor (PPAR) ligand 15de-oxyΔ12–14 prostaglandin J2, J. Biol. Chem., 274, 17042, 10.1074/jbc.274.24.17042 · DOI

Sorted by citations

Inflammation and cancer: how hot is the link?
Aggarwal, B. B., Shishodia, S., Sandur, S. K., Pandey, M. K., & Sethi, G. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.06.029 · Cited by 1,312
Emerging roles of PPARS in inflammation and immunity
Daynes, R. A., & Jones, D. C. (2002) · Nature reviews. Immunology · doi:10.1038/nri912 · Cited by 926
Anti-inflammatory lipid mediators and insights into the resolution of inflammation
Lawrence, T., Willoughby, D. A., & Gilroy, D. W. (2002) · Nature reviews. Immunology · doi:10.1038/nri915 · Cited by 879
Diabetes, oxidative stress and therapeutic strategies
Rochette, L., Zeller, M., Cottin, Y., & Vergely, C. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2014.05.017 · Cited by 543
Immunotoxicity of Perfluorinated Compounds: Recent Developments
DeWitt, J. C., Peden-Adams, M. M., Keller, J. M., & Germolec, D. R. (2012) · Toxicologic Pathology · doi:10.1177/0192623311428473 · Cited by 457
Anti-inflammatory effects of omega-3 fatty acids in the brain: physiological mechanisms and relevance to pharmacology
Layé, S., Nadjar, A., Joffre, C., & Bazinet, R. P. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.014092 · Cited by 420
15d-PGJ2: The anti-inflammatory prostaglandin?
Scher, J. U., & Pillinger, M. H. (2004) · Clinical Immunology · doi:10.1016/j.clim.2004.09.008 · Cited by 353
Fatty Acids as Modulators of the Immune Response
Fritsche, K. L. (2006) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.25.050304.092610 · Cited by 316
Peroxisome Proliferator–activated Receptors α and γ Down-regulate Allergic Inflammation and Eosinophil Activation
Woerly, G., Honda, K., Loyens, M., Papin, J.-P., Auwerx, J. H., Staels, B., Capron, M., & Dombrowicz, D. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021384 · Cited by 245
Dietary (n-3) Polyunsaturated Fatty Acids Remodel Mouse T-Cell Lipid Rafts
Fan, Y., McMurray, D. N., Ly, L. H., & Chapkin, R. S. (2003) · Journal of Nutrition · doi:10.1093/jn/133.6.1913 · Cited by 238
Healing fats of the skin: the structural and immunologic roles of the ω-6 and ω-3 fatty acids
McCusker, M. M., & Grant-Kels, J. M. (2010) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2010.03.020 · Cited by 233
iNOS as a metabolic enzyme under stress conditions
Anavi, S., & Tirosh, O. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.10.411 · Cited by 229
The Potential Contributions of Chronic Inflammation to Lung Carcinogenesis
Ballaz, S., & Mulshine, J. L. (2003) · Clinical Lung Cancer · doi:10.3816/clc.2003.n.021 · Cited by 212
METRNL attenuates lipid-induced inflammation and insulin resistance via AMPK or PPARδ-dependent pathways in skeletal muscle of mice
Jung, T. W., Lee, S. H., Kim, H.-C., Bang, J. S., Abd El-Aty, A. M., Hacımüftüoğlu, A., Shin, Y. K., & Jeong, J. H. (2018) · Experimental & Molecular Medicine · doi:10.1038/s12276-018-0147-5 · Cited by 203
Role of peroxisome proliferator-activated receptor γ and retinoid X receptor heterodimer in hepatogastroenterological diseases
Dubuquoy, L., Dharancy, S., Nutten, S., Pettersson, S., Auwerx, J. H., & Desreumaux, P. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11395-x · Cited by 201
Hemozoin (Malarial Pigment) Inhibits Differentiation and Maturation of Human Monocyte-Derived Dendritic Cells: A Peroxisome Proliferator-Activated Receptor-γ-Mediated Effect
Skorokhod, O. A., Alessio, M., Mordmüller, B. G., Arese, P., & Schwarzer, E. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.6.4066 · Cited by 188
Probiotic bacteria prevent hepatic damage and maintain colonic barrier function in a mouse model of sepsis
Ewaschuk, J. B., Endersby, R. V. W., Thiel, D., Díaz, H., Backer, J., Ma, M. M., Churchill, T. A., & Madsen, K. L. (2007) · Hepatology · doi:10.1002/hep.21750 · Cited by 186
Peroxisome Proliferator-Activated Receptors: Experimental Targeting for the Treatment of Inflammatory Bowel Diseases
Decara, J. M., Rivera, P., López-Gambero, A. J., Serrano, A., Pavón, F. J., Baixerás, E., de Fonseca, F. R., & Suárez, J. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00730 · Cited by 186
Fibrotic disorders in the eye: Targets of gene therapy
Saika, S., Yamanaka, O., Sumioka, T., Miyamoto, T., Miyazaki, K.-I., Okada, Y., Kitano, A., Shirai, K., Tanaka, S., & Ikeda, K. (2007) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2007.12.002 · Cited by 174
Immunomodulatory Effects of (n-3) Fatty Acids: Putative Link to Inflammation and Colon Cancer ,
Chapkin, R. S., Davidson, L. A., Ly, L. H., Weeks, B. R., Lupton, J. R., & McMurray, D. N. (2007) · Journal of Nutrition · doi:10.1093/jn/137.1.200s · Cited by 163
PPARγ in immunity and inflammation: cell types and diseases
Széles, L., Törőcsik, D., & Nagy, L. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2007.02.005 · Cited by 166
Pioglitazone attenuates mitochondrial dysfunction, cognitive impairment, cortical tissue loss, and inflammation following traumatic brain injury
Sauerbeck, A. D., Gao, J., Readnower, R. D., Liu, M., Pauly, J. R., Bing, G., & Sullivan, P. G. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2010.10.003 · Cited by 157
Molecular basis of age-associated cytokine dysregulation in LPS-stimulated macrophages
Chelvarajan, R. L., Liu, Y., Popa, D., Getchell, M. L., Getchell, T. V., Stromberg, A. J., & Bondada, S. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0106024 · Cited by 151
PPAR‐α and ‐γ but not ‐δ agonists inhibit airway inflammation in a murine model of asthma: in vitro evidence for an NF‐κB‐independent effect
Trifilieff, A., Bench, A., Hanley, M., Bayley, D., Campbell, E. M., & Whittaker, P. A. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705232 · Cited by 150
Noradrenergic depletion increases inflammatory responses in brain: effects on IκB and HSP70 expression
Heneka, M. T., Gavrilyuk, V., Landreth, G. E., O’Banion, M. K., Weinberg, G. L., & Feinstein, D. L. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01694.x · Cited by 144
Multiple facets of macrophages in renal injury
Kluth, D., Erwig, L., & Rees, A. J. (2004) · Kidney International · doi:10.1111/j.1523-1755.2004.00773.x · Cited by 139
Peroxisome Proliferator-Activated Receptor γ (PPARγ) and Immunoregulation: Enhancement of Regulatory T Cells through PPARγ-Dependent and -Independent Mechanisms
Wohlfert, E., Nichols, F., Nevius, E., & Clark, R. (2007) · Journal of Immunology · doi:10.4049/jimmunol.178.7.4129 · Cited by 128
Self-citation
Peroxisome proliferator?activated receptor $gamma; is expressed in airways and inhibits features of airway remodeling in a mouse asthma model*1
Honda, K., Marquillies, P., Capron, M., & Dombrowicz, D. (2004) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2004.02.036 · Cited by 143
Peroxisome Proliferator-Activated Receptors (PPARs) and the Human Skin
Sertznig, P., Seifert, M., Tilgen, W., & Reichrath, J. (2008) · American Journal of Clinical Dermatology · doi:10.2165/00128071-200809010-00002 · Cited by 135
Modulation of Non‐Alcoholic Steatohepatitis by Pattern Recognition Receptors in Mice: The Role of Toll‐Like Receptors 2 and 4
Szabó, G., Velayudham, A., Romics, L., & Mandrekar, P. (2005) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000189287.83544.33 · Cited by 138
A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC-derived microglia
Piers, T. M., Cosker, K., Mallach, A., Johnson, G. T., Guerreiro, R., Hardy, J., & Pocock, J. M. (2020) · The FASEB Journal · doi:10.1096/fj.201902447r · Cited by 135
Peroxisome Proliferator-Activated Receptor-γ Is Deficient in Alveolar Macrophages from Patients with Alveolar Proteinosis
Bonfield, T. L., Farver, C. F., Barna, B. P., Malur, A., Abraham, S., Raychaudhuri, B., Kavuru, M. S., & Thomassen, M. J. (2003) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2003-0148oc · Cited by 133
Fetal origin of endocrine dysfunction in the adult: The phthalate model
Martinez-Arguelles, D. B., Campioli, E., Culty, M., Zirkin, B. R., & Papadopoulos, V. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.01.007 · Cited by 132
Peroxisome proliferator-activated receptors: a critical review on endogenous pathways for ligand generation
Bishop‐Bailey, D., & Wray, J. A. (2003) · Prostaglandins & Other Lipid Mediators · doi:10.1016/s0090-6980(03)00003-0 · Cited by 131
Synthesis of Lipoxin A4by 5-Lipoxygenase Mediates PPARγ-Dependent, Neuroprotective Effects of Rosiglitazone in Experimental Stroke
Sobrado, M., Pereira, M. P., Ballesteros, I., Hurtado, O., Fernández‐López, D., Pradillo, J. M., Caso, J. R., Vivancos, J., Nombela, F., Serena, J. L., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5529-08.2009 · Cited by 127
Airway inflammation and adjuvant effect after repeated airborne exposures to di-(2-ethylhexyl)phthalate and ovalbumin in BALB/c mice
Larsen, S. T., Hansen, J. S., Hansen, E. W., Clausen, P. A., & Nielsen, G. D. (2007) · Toxicology · doi:10.1016/j.tox.2007.03.010 · Cited by 127
Anti-inflammatory effect of fibrate protects from cisplatin-induced ARF.
Li, S.-Y., Gokden, N., Okusa, M., Bhatt, R., & Portilla, D. (2005) · AJP - Renal Physiology · doi:10.1152/ajprenal.00038.2005 · Cited by 134
PPAR and Immune System-What Do We Know?
Zhang, X., & Young, H. A. (2002) · International Immunopharmacology · doi:10.1016/s1567-5769(02)00057-7 · Cited by 123
Peroxisome Proliferator-Activated Receptor γ Control of Dendritic Cell Function Contributes to Development of CD4+ T Cell Anergy
Klotz, L., Dani, I., Edenhofer, F., Nolden, L., Evert, B. O., Paul, B., Kolanus, W., Klockgether, T., Knolle, P. A., & Diehl, L. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.4.2122 · Cited by 123
Present concepts and future outlook: Function of peroxisome proliferator‐activated receptors (PPARs) for pathogenesis, progression, and therapy of cancer
Sertznig, P., Seifert, M., Tilgen, W., & Reichrath, J. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.20998 · Cited by 119
Hesperidin protects against cyclophosphamide-induced hepatotoxicity by upregulation of PPARγ and abrogation of oxidative stress and inflammation
Mahmoud, A. M. (2014) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2014-0204 · Cited by 118
Cytochrome P450-derived eicosanoids and heart function
Jamieson, K. L., Endo, T. H., Darwesh, A. M., Samokhvalov, V., & Seubert, J. M. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.05.005 · Cited by 122
Lauric Acid Is an Inhibitor of Clostridium difficile Growth in Vitro and Reduces Inflammation in a Mouse Infection Model
Yang, H.-T., Chen, J.-W., Rathod, J., Jiang, Y.-Z., Tsai, P.-J., Hung, Y.-P., Ko, W.-C., Paredes-Sabja, D., & Huang, I.-H. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.02635 · Cited by 117
Proteomic Analysis of S-Nitrosylated Proteins in Mesangial Cells
Kuncewicz, T., Sheta, E. A., Goldknopf, I. L., & Kone, B. C. (2003) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m300003-mcp200 · Cited by 113
ORIGINAL ARTICLE: Duration of Intralipid’s Suppressive Effect on NK Cell’s Functional Activity
Roussev, R., Acacio, B., Ng, S. C., & Coulam, C. (2008) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.2008.00621.x · Cited by 116
15-Deoxy-∆-12,14-Prostaglandin J2 (15d-PGJ2), an Endogenous Ligand of PPAR- γ : Function and Mechanism
Li, J., Guo, C., & Wu, J. (2019) · PPAR Research · doi:10.1155/2019/7242030 · Cited by 107
Infectobesity: Obesity of Infectious Origin
Dhurandhar, N. V. (2001) · Journal of Nutrition · doi:10.1093/jn/131.10.2794s · Cited by 104
The Ubiquitination of NF-κB Subunits in the Control of Transcription
Collins, P. E., Mitxitorena, I., & Carmody, R. J. (2016) · Cells · doi:10.3390/cells5020023 · Cited by 107
Role of Peroxisome Proliferator‐Activated Receptors in Inflammation Control
Youssef, J., & Badr, M. Z. (2004) · BioMed Research International · doi:10.1155/s1110724304308065 · Cited by 105
The role of the peroxisome proliferator-activated receptor-α (PPAR-α) in the regulation of acute inflammation
Cuzzocrea, S., Mazzon, E., Paola, R. D., Peli, A., Bonato, A., Britti, D., Genovese, T., Muià, C., Crisafulli, C., & Caputi, A. P. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0605341 · Cited by 101
Expression of Concern: Rosiglitazone and 15‐deoxy‐Δ12,14‐prostaglandin J2, ligands of the peroxisome proliferator‐activated receptor‐γ (PPAR‐γ), reduce ischaemia/reperfusion injury of the gut
Cuzzocrea, S., Pisano, B., Dugo, L., Ianaro, A., Patel, N. S. A., Paola, R. D., Genovese, T., Chatterjee, P. K., Rosa, M. D., Caputi, A. P., et al. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705419 · Cited by 97
Inonotus obliquus – from folk medicine to clinical use
Szychowski, K. A., Skóra, B., Pomianek, T., & Gmiński, J. (2020) · Journal of Traditional and Complementary Medicine · doi:10.1016/j.jtcme.2020.08.003 · Cited by 98
Neuroimmune Pathways in Alcohol Consumption: Evidence from Behavioral and Genetic Studies in Rodents and Humans
Robinson, G., Most, D., Ferguson, L. B., Mayfield, J., Harris, R. A., & Blednov, Y. A. (2014) · International review of neurobiology · doi:10.1016/b978-0-12-801284-0.00002-6 · Cited by 98
Anti-inflammatory and antiproliferative actions of PPAR-γ agonists on T lymphocytes derived from MS patients
Schmidt, S., Moric, E., Schmidt, M., Sastre, M., Feinstein, D. L., & Heneka, M. T. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0803402 · Cited by 96
Magnolol ameliorates lipopolysaccharide-induced acute lung injury in rats through PPAR-γ-dependent inhibition of NF-kB activation
Lin, M.-H., Chen, M.-C., Chen, T.-H., Chang, H., & Chou, T.-C. (2015) · International Immunopharmacology · doi:10.1016/j.intimp.2015.05.051 · Cited by 96
Pharmacological Potential of Betulin as a Multitarget Compound
Adepoju, F. O., Duru, K. C., Li, E., Kovaleva, E. G., & Tsurkan, M. V. (2023) · Biomolecules · doi:10.3390/biom13071105 · Cited by 102
Peroxisome Proliferator-activated Receptor β (δ)-dependent Regulation of Ubiquitin C Expression Contributes to Attenuation of Skin Carcinogenesis
Kim, D. J., Akiyama, T. E., Harman, F. S., Burns, A., Shan, W., Ward, J. M., Kennett, M. J., Gonzalez, F. J., & Peters, J. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312063200 · Cited by 92
Wogonin prevents lipopolysaccharide‐induced acute lung injury and inflammation in mice via peroxisome proliferator‐activated receptor gamma‐mediated attenuation of the nuclear factor‐kappaB pathway
Yao, J., Pan, D., Zhao, Y., Zhao, L., Sun, J. L., Wang, Y., You, Q., Xi, T., Guo, Q., & Lu, N. (2014) · Immunology · doi:10.1111/imm.12305 · Cited by 90
Peroxisome Proliferator-Activated Receptor γ Inhibits the Migration of Dendritic Cells: Consequences for the Immune Response
Angéli, V., Hammad, H., Staels, B., Capron, M., Lambrecht, B. N., & Trottein, F. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.10.5295 · Cited by 92
Infectobesity: Obesity of Infectious Origin
Pasarica, M., & Dhurandhar, N. V. (2007) · Advances in food and nutrition research · doi:10.1016/s1043-4526(06)52002-9 · Cited by 88
Diverse regulation of NF-κB and peroxisome proliferator-activated receptors in murine nonalcoholic fatty liver
Romics, L., Kodys, K., Dolganiuc, A., Graham, L. S., Velayudham, A., Mandrekar, P., & Szabó, G. (2004) · Hepatology · doi:10.1002/hep.20304 · Cited by 87
Transcriptomic Profiling of the Development of the Inflammatory Response in Human Monocytes In Vitro
Italiani, P., Mazza, E. M. C., Lucchesi, D., Cifola, I., Gemelli, C., Grande, A., Battaglia, C., Bicciato, S., & Boraschi, D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087680 · Cited by 89
A Cyclooxygenase Metabolite of Anandamide Causes Inhibition of Interleukin-2 Secretion in Murine Splenocytes
Rockwell, C. E., & Kaminski, N. E. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.065524 · Cited by 86
Sex-specific regulation of immune responses by PPARs
Park, H.-J., & Choi, J. (2017) · Experimental & Molecular Medicine · doi:10.1038/emm.2017.102 · Cited by 88
Peroxisome Proliferator-activated Receptor-β/δ Inhibits Epidermal Cell Proliferation by Down-regulation of Kinase Activity
Kim, D. J., Murray, I. A., Burns, A., Gonzalez, F. J., Perdew, G. H., & Peters, J. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413808200 · Cited by 86
Effect of pioglitazone treatment in a patient with secondary multiple sclerosis.
Pershadsingh, H. A., Heneka, M. T., Saini, R., Amin, N. M., Broeske, D. J., & Feinstein, D. L. (2004) · Journal of Neuroinflammation · doi:10.1186/1742-2094-1-3 · Cited by 84
Peroxisome proliferator-activated receptor-?: therapeutic target for diseases beyond diabetes: quo vadis?
Pershadsingh, H. A. (2004) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.13.3.215 · Cited by 83
Phospholipase A2 isozymes in pregnancy and parturition
Lappas, M., & Rice, G. E. (2003) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2003.04.001 · Cited by 81
Insulin resistance and impaired functional vasodilation in obese Zucker rats
Xiang, L., Dearman, J., Abram, S. R., Carter, C. B., & Hester, R. L. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01206.2007 · Cited by 81
Peroxisome proliferator‐activated receptor‐γ agonists as potential anti‐inflammatory agents in asthma and chronic obstructive pulmonary disease
Spears, M., McSharry, C. P., & Thomson, N. C. (2006) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2006.02604.x · Cited by 80
PPARG in Human Adipogenesis: Differential Contribution of Canonical Transcripts and Dominant Negative Isoforms
Aprile, M., Ambrosio, M. R., D’Esposito, V., Bèguinot, F., Formisano, P., Costa, V., & Ciccodicola, A. (2014) · PPAR Research · doi:10.1155/2014/537865 · Cited by 83
Effect of overexpression of pparγ on the healing process of corneal alkali burn in mice
Saika, S., Yamanaka, O., Okada, Y., Miyamoto, T. K., Kitano, A., Flanders, K. C., Ohnishi, Y., Nakajima, Y., Kao, W. W. ‐., & Ikeda, K. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00332.2006 · Cited by 76
Peroxisome proliferator-activated receptors (PPARs) and PPAR agonists: the ‘future’ in dermatology therapeutics?
Gupta, M., Mahajan, V. K., Mehta, K. S., Chauhan, P. S., & Rawat, R. (2015) · Archives of Dermatological Research · doi:10.1007/s00403-015-1571-1 · Cited by 76
A Novel Antipyretic Action of 15-Deoxy-Δ12,14-Prostaglandin J2in the Rat Brain
Mouihate, A., Lomax, L. B., & Pittman, Q. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3145-03.2004 · Cited by 76
Inhibition of MMP-9 expression by PPAR activators in human bronchial epithelial cells
Hetzel, M. (2003) · Thorax · doi:10.1136/thorax.58.9.778 · Cited by 75
THE ROLE OF ENDOGENOUS AND EXOGENOUS LIGANDS FOR THE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPAR-α) IN THE REGULATION OF INFLAMMATION IN MACROPHAGES
Crisafulli, C., & Cuzzocrea, S. (2009) · Shock · doi:10.1097/shk.0b013e31818bbad6 · Cited by 75
Protective properties afforded by pioglitazone against intrastriatal LPS in Sprague–Dawley rats
Hunter, R. L., Choi, D., Ross, S. A., & Bing, G. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.12.019 · Cited by 75
Peroxisome proliferator activated
Alexander, S. P. H., Mathie, A. A., & Peters, J. A. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706481 · Cited by 74
Activation of Peroxisome Proliferator–Activated Receptor Gamma and Retinoid X Receptor Results in Net Depletion of Cellular Cholesteryl Esters in Macrophages Exposed to Oxidized Lipoproteins
Argmann, C., Sawyez, C. G., McNeil, C. J., Hegele, R. A., & Huff, M. W. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000058860.62870.6e · Cited by 74
Antidiabetic effect of Achillea millefollium through multitarget interactions: α-glucosidases inhibition, insulin sensitization and insulin secretagogue activities
Chávez-Silva, F., Cerón‐Romero, L., Arias-Durán, L., Navarrete‐Vázquez, G., Almanza-Pérez, J. C., Román‐Ramos, R., Ramírez-Ávila, G., Perea-Arango, I., Villalobos‐Molina, R., & Estrada-Soto, S. E. (2017) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2017.10.005 · Cited by 77
Adiposity induced by adenovirus 5 inoculation
So, P., Herlihy, A. H., & Bell, J. D. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0802917 · Cited by 72
Modulating Tumor-Associated Macrophage Polarization by Synthetic and Natural PPARγ Ligands as a Potential Target in Breast Cancer
Gionfriddo, G., Plastina, P., Augimeri, G., Catalano, S., Giordano, C., Barone, I., Morelli, C., Giordano, F., Gelsomino, L., Sisci, D., et al. (2020) · Cells · doi:10.3390/cells9010174 · Cited by 71
Bergenin Exerts Hepatoprotective Effects by Inhibiting the Release of Inflammatory Factors, Apoptosis and Autophagy via the PPAR-γ Pathway
Xiang, S., Chen, K., Xu, L., Wang, T., & Guo, C. (2020) · Drug Design Development and Therapy · doi:10.2147/dddt.s229063 · Cited by 70
Cis-stilbene glucoside in Polygonum multiflorum induces immunological idiosyncratic hepatotoxicity in LPS-treated rats by suppressing PPAR-γ
Meng, Y.-K., Li, C., Li, R., He, L.-Z., Cui, H., Yin, P., Zhang, C.-E., Li, P.-Y., Sang, X., Wang, Y., et al. (2017) · Acta Pharmacologica Sinica · doi:10.1038/aps.2017.32 · Cited by 70
Pioglitazone ameliorates neuronal damage after traumatic brain injury via the PPARγ/NF-κB/IL-6 signaling pathway
Deng, Y., Jiang, X., Deng, X., Chen, H., Xu, J., Zhang, Z., Liu, G., Zhu, Y., Yuan, C., Sun, X., et al. (2019) · Genes & Diseases · doi:10.1016/j.gendis.2019.05.002 · Cited by 70
PPARs: Key Regulators of Airway Inflammation and Potential Therapeutic Targets in Asthma
Banno, A., Reddy, A. T., Lakshmi, S. P., & Reddy, R. C. (2018) · Nuclear Receptor Research · doi:10.11131/2018/101306 · Cited by 68
Teratogenic phthalate esters and metabolites activate the nuclear receptors PPARs and induce differentiation of F9 cells
Lampen, A., Zimnik, S., & Nau, H. (2003) · Toxicology and Applied Pharmacology · doi:10.1016/s0041-008x(03)00014-0 · Cited by 69
A pilot test of pioglitazone as an add-on in patients with relapsing remitting multiple sclerosis.
Kaiser, C., Shukla, D., Stebbins, G., Skias, D., Jeffery, D., Stefoski, D., Katsamakis, G., & Feinstein, D. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.04.011 · Cited by 67
Pioglitazone Attenuates Neuroinflammation and Promotes Dopaminergic Neuronal Survival in the Nigrostriatal System of Rats after Diffuse Brain Injury
Liu, M., Bachstetter, A., Cass, W., Lifshitz, J., & Bing, G. (2017) · Journal of Neurotrauma · doi:10.1089/neu.2015.4361 · Cited by 60
Peroxisome proliferator-activated receptor-α regulates postischemic liver injury
Okaya, T., & Lentsch, A. B. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00191.2003 · Cited by 65
Minireview: Nuclear Receptor Coregulators of the p160 Family: Insights into Inflammation and Metabolism
Rollins, D. A., Coppo, M., & Rogatsky, I. (2015) · Molecular Endocrinology · doi:10.1210/me.2015-1005 · Cited by 66
The Cyclopentenone Prostaglandin 15d-PGJ2 Inhibits the NLRP1 and NLRP3 Inflammasomes
Maier, N. K., Leppla, S. H., & Moayeri, M. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1401611 · Cited by 62
Adjuvant effects of inhaled mono-2-ethylhexyl phthalate in BALB/cJ mice
Hansen, J. S., Larsen, S. T., Poulsen, L. K., & Nielsen, G. D. (2006) · Toxicology · doi:10.1016/j.tox.2006.12.011 · Cited by 61
Hesperidin protects against stress induced gastric ulcer through regulation of peroxisome proliferator activator receptor gamma in diabetic rats
Elshazly, S. M., Motteleb, D. M. A. E., & Ibrahim, I. A. A. E.-H. (2018) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2018.06.027 · Cited by 64
Agonism of Peroxisome Proliferator Receptor-Gamma may have Therapeutic Potential for Neuroinflammation and Parkinsons Disease
Hunter, R. L., & Bing, G. (2007) · Current Neuropharmacology · doi:10.2174/157015907780077123 · Cited by 61
Expression profiling of lymph nodes in tuberculosis patients reveal inflammatory milieu at site of infection
Maji, A., Misra, R., Mondal, A. K., Kumar, D., Bajaj, D., Singhal, A., Arora, G., Bhaduri, A., Sajid, A., Bhatia, S., et al. (2015) · Scientific Reports · doi:10.1038/srep15214 · Cited by 59
Nuclear Hormone Receptors
Alexander, S. P. H. (2007) · xPharm: The Comprehensive Pharmacology Reference · doi:10.1016/b978-008055232-3.60362-9 · Cited by 60
Role of Nuclear Receptors in Central Nervous System Development and Associated Diseases
Maria, A. A., Moreno-Ramos, O. A., & Haider, N. B. (2015) · Journal of Experimental Neuroscience · doi:10.4137/jen.s25480 · Cited by 63
PPAR Agonists for the Prevention and Treatment of Lung Cancer
Lakshmi, S. P., Reddy, A. T., Banno, A., & Reddy, R. C. (2017) · PPAR Research · doi:10.1155/2017/8252796 · Cited by 61
Citral inhibits lipopolysaccharide-induced acute lung injury by activating PPAR-γ
Shen, Y., Sun, Z., & Guo, X. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.09.040 · Cited by 56

Authors: Clark, R. B.
Affiliations: UConn Health (US)
Corresponding author: Clark, Robert B
ORCID: Clark, Robert B
Venue: Journal of Leukocyte Biology
Publisher: Oxford University Press (OUP)
Published: 2002-03-01
Volume: 71
Issue: 3
Pages: 388-400
ISSN: 0741-5400 (ISSN-L)
1938-3673
DOI: 10.1189/jlb.71.3.388
OpenAlex: W2167908723
Cited by: 337
References: 100
Citations by year: 2026: 1 · 2025: 6 · 2024: 5 · 2023: 7 · 2022: 7 · 2021: 5 · 2020: 14 · 2019: 15 · 2018: 10 · 2017: 15 · 2016: 15 · 2015: 21 · 2014: 23 · 2013: 11 · 2012: 10
FWCI: 7.76
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: Journal of Leukocyte Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Keywords: peroxisome proliferator-activated receptors, PPARγ, PPARα, inflammation, immune response, T cells, T cell proliferation, IL-2 secretion, apoptosis, macrophages, endothelial cells, PPAR ligands, ligand specificity, dendritic cells
MeSH terms: Animals, Humans, Immunity, Inflammation, Nuclear Proteins, Transcription Factors, Receptors, Cytoplasmic and Nuclear

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The role of PPARs in inflammation and immunity

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks