Cited by 1,058Chemokine receptors and signalingNF-κB Signaling PathwaysCytokine Signaling Pathways and Interactions

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Multiple control of interleukin-8 gene expression

Hoffmann, Elke, Dittrich-Breiholz, Oliver, Holtmann, Helmut, Kracht, Michael·2002·Journal of Leukocyte Biology

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Abstract

Interleukin (IL)-8, a prototypic human chemokine, was detected more than a decade ago as the founding member of the chemokine superfamily. One of the most remarkable properties of IL-8 is the variation of its expression levels. In healthy tissues, IL-8 is barely detectable, but it is rapidly induced by ten- to 100-fold in response to proinflammatory cytokines such as tumor necrosis factor or IL-1, bacterial or viral products, and cellular stress. Recently, significant advances in the understanding of signaling pathways, which coordinately regulate IL-8 transcription as well as mRNA stabilization in response to external stimuli, have been made. Maximal IL-8 amounts are generated by a combination of three different mechanisms: first, derepression of the gene promoter; second, transcriptional activation of the gene by nuclear factor-κB and JUN-N-terminal protein kinase pathways; and third, stabilization of the mRNA by the p38 mitogen-activated protein kinase pathway. In that way, cells are able to rapidly increase and at the same time, to fine-tune the amount of IL-8 secreted and thereby control the extent of leukocytes attracted to sites of tissue injury.

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Signal transduction by the JNK group of MAP kinases
Davis, R. J. (2000) · Cell · doi:10.1016/s0092-8674(00)00116-1 · Cited by 4,237
Chemokines
Zlotnik, A., & Yoshie, O. (2000) · Immunity · doi:10.1016/s1074-7613(00)80165-x · Cited by 3,923
NF-κB: Ten Years After
Baeuerle, P. A., & Baltimore, D. (1996) · Cell · doi:10.1016/s0092-8674(00)81318-5 · Cited by 3,002
The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases
Ogryzko, V. V., Schiltz, R. L., Russanova, V., Howard, B. H., & Nakatani, Y. (1996) · Cell · doi:10.1016/s0092-8674(00)82001-2 · Cited by 2,952
AP-1 function and regulation
Karin, M., Liu, Z.-G., & Zandi, E. (1997) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(97)80068-3 · Cited by 2,904
SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase
Bennett, B. L., Sasaki, D. T., Murray, B. W., O'Leary, E. C., Sakata, S. T., Xu, W., Leisten, J. C., Motiwala, A., Pierce, S., Satoh, Y., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.251194298 · Cited by 2,558
Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways
Whitmarsh, A. J., & Davis, R. J. (1996) · Journal of Molecular Medicine · doi:10.1007/s001090050063 · Cited by 1,543
Signal transduction by the c-Jun N-terminal kinase (JNK) — from inflammation to development
Ip, Y. T., & Davis, R. J. (1998) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(98)80143-9 · Cited by 1,538
MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1
Malinin, N. L., Boldin, M., Kovalenko, A. V., & Wallach, D. (1997) · Nature · doi:10.1038/385540a0 · Cited by 1,279
The kinase TAK1 can activate the NIK-IκB as well as the MAP kinase cascade in the IL-1 signalling pathway
Ninomiya‐Tsuji, J., Kishimoto, K., Hiyama, A., Inoue, J., Cao, Z., & Matsumoto, K. (1999) · Nature · doi:10.1038/18465 · Cited by 1,187

Flagged first, then by citations

Show all 87 references

Research works printed but not linked: 29

Kasahara, 1991, Immunology, 74, 60
Aihara, 1997, Inf, Immun., 65, 3218
Lee, 1997, Mol, Cell. Biol., 17, 5097
Holtmann, 1999, Mol, Cell. Biol., 19, 6742
Albanyan, 2000, Infect, Immun., 68, 2053
Marie, 1999, Infect, Immun., 67, 688
Feoktistov, 1999, Mol, Pharmacol., 55, 726
Shono, 1996, Mol, Cell. Biol., 16, 4231
Yoshida, 1997, Mol, Cell. Biol., 17, 4015
Kunsch, 1993, Mol, Cell. Biol., 13, 6137
Huang, 2000, Cytokines Cell, Mol. Ther., 6, 9
Yu, 2001, Inflamm, Res., 50, 220
Bocker, 2000, J, Biol. Chem., 275, 12207
Li, 1999, Infect, Immun., 67, 3893
Schmitz, 2001, Trends Biochem, Sci., 26, 186
Matsukaka, 1993, Proc, Natl. Acad. Sci. USA, 90, 10193
Ashburner, 2001, Mol, Cell. Biol., 21, 7065
Stein, 1993, Mol, Cell. Biol., 13, 7191
Vanden Berghe, 1999, J, Biol. Chem., 274, 32091
Zandi, 1999, Mol, Cell. Biol., 19, 4547
Nebreda, 2000, Trends Biochem, Sci., 25, 257
Schmidt-Supprian, 2000, Mol, Cell, 5, 981
Kracht, 2000, Eur, Cytokine Netw., 11, 497
Wathelet, 1998, Mol, Cell, 1, 507
Falvo, 2000, Mol, Cell. Biol., 20, 4814
Zhong, 1998, Mol, Cell, 1, 661
Merika, 1998, Mol, Cell, 1, 277
Davies, 2000, Biochem, J., 351, 95
Widmann, 1999, Physiol, Rev., 79, 143

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Authors: Hoffmann, E., Dittrich-Breiholz, O., Holtmann, H., & Kracht, M.
Affiliations: Medizinische Hochschule Hannover (DE)
Institute of Pharmacology, Medical School Hannover , Germany
Corresponding author: Kracht, Michael
ORCID: Hoffmann, Elke
Kracht, Michael
Venue: Journal of Leukocyte Biology
Publisher: Oxford University Press (OUP)
Published: 2002-11-01
Volume: 72
Issue: 5
Pages: 847-855
ISSN: 0741-5400 (ISSN-L)
1938-3673
DOI: 10.1189/jlb.72.5.847
OpenAlex: W2149122802
Cited by: 1,058
References: 87
Citations by year: 2026: 15 · 2025: 20 · 2024: 17 · 2023: 35 · 2022: 37 · 2021: 35 · 2020: 31 · 2019: 35 · 2018: 37 · 2017: 39 · 2016: 49 · 2015: 79 · 2014: 64 · 2013: 54 · 2012: 39
FWCI: 17.59
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: Journal of Leukocyte Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Keywords: interleukin-8, chemokines, gene expression regulation, transcriptional activation, NF-κB, JNK signaling, p38 MAPK, mRNA stabilization, inflammatory cytokines, chemokine induction, leukocyte recruitment
MeSH terms: Animals, Base Sequence, DNA-Binding Proteins, Gene Expression Regulation, Humans, Molecular Sequence Data, Repressor Proteins, Transcription Factors, Transcription, Genetic, Signal Transduction, Transcriptional Activation, Interleukin-8, NF-kappa B, RNA Stability, Mitogen-Activated Protein Kinases, MAP Kinase Kinase Kinases, Mice

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Multiple control of interleukin-8 gene expression

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