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Cited by 126Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration MechanismsAdvanced MRI Techniques and Applications

The DOI matches its Crossref record; 63 of the 64 references it cites were found in a registry or an index.

Microglial imaging with positron emission tomography and atrophy measurements with magnetic resonance imaging in multiple sclerosis: a correlative study

Versijpt, J, Debruyne, J C, Van Laere, K J, De Vos, F, Keppens, J, Strijckmans, K, Achten, E, Slegers, G, Dierckx, R A, Korf, J, De Reuck, J L·2005·Multiple Sclerosis Journal
DOI 10.1191/1352458505ms1140oa
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Abstract

Objective The objectives of the present study were to assess brain atrophy in multiple sclerosis (MS) patients during different disease stages and to investigate by PET and [11C]PK11195, a marker of microglial activation, the relationship between inflammation, atrophy and clinically relevant measures. Methods Eight healthy subjects and 22 MS patients were included. Semiquantitative [11C]PK11195 uptake values, with normalization on cortical grey matter, were measured for magnetic resonance imaging T2- and T1-lesions and normal appearing white matter (NAWM). As atrophy index we used the ratio of the amount of white and grey matter divided by the ventricular size, using an optimized a priori based segmentation algorithm (SPM99). Results Atrophy was significantly greater in MS patients compared to age-matched controls. A significant correlation was found between brain atrophy and both disease duration and disability, as measured with the Expanded Disability Status Scale. For NAWM, [11C]PK11195 uptake increased with the amount of atrophy, while T2-lesional [11C]PK11195 uptake values decreased according to increasing brain atrophy. Conclusions The present study suggests that brain atrophy, correlating with disease duration and disability, is directly related to NAWM and T2-lesional inflammation as measured by microglial activation.

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  1. 10.1097/00019052-200306000-00004 · DOI
  2. Zivadinov R , Fisher E , Grop A , Nasuelli D , Bratina A , Zorzon M et al. Normalized versus absolute brain atrophy measures in multiple sclerosis . Mult Scler 2001; 7: S47-S47 (abstract).

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Metadata

Authors
Versijpt, J., Debruyne, J. C., Van Laere, K. J., De Vos, F., Keppens, J., Strijckmans, K., Achten, E., Slegers, G., Dierckx, R. A., Korf, J., & De Reuck, J. L.
Affiliations
  • University Medical Center Groningen (NL)
  • Ghent University Hospital (BE)
  • Division of Nuclear Medicine, Ghent University Hospital, Ghent, the Netherlands
  • Laboratory of Radiopharmacy, Ghent University, Ghent, the Netherlands
  • Ghent University (BE)
  • Department of Neurology, Ghent University Hospital, Ghent, the Netherlands
Corresponding author
Debruyne, J C
ORCID
Venue
Multiple Sclerosis Journal
Publisher
SAGE Publications
Published
2005-04
Volume
11
Issue
2
Pages
127-134
ISSN
  • 1352-4585 (ISSN-L)
  • 1477-0970
DOI
10.1191/1352458505ms1140oa
OpenAlex
W1993466811
Cited by
126
References
64
Citations by year
2026: 3 · 2025: 1 · 2024: 6 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 9 · 2018: 5 · 2017: 12 · 2016: 11 · 2015: 7 · 2014: 14 · 2013: 4 · 2012: 8
FWCI
4.01
Type
journal article
Language
en
Open access
closed
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • Multiple Sclerosis Journal (publishedVersion)
  • PubMed (publishedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Keywords
multiple sclerosis, brain atrophy, microglial activation, [11C]PK11195, positron emission tomography, normal-appearing white matter, T2 lesions, disease duration, disability, neuroinflammation
MeSH terms
Adult, Aged, Antineoplastic Agents, Atrophy, Brain, Carbon Radioisotopes, Female, Humans, Isoquinolines, Magnetic Resonance Imaging, Male, Middle Aged, Multiple Sclerosis, Microglia, Positron-Emission Tomography

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