The DOI matches its Crossref record; 63 of the 64 references it cites were found in a registry or an index.
Microglial imaging with positron emission tomography and atrophy measurements with magnetic resonance imaging in multiple sclerosis: a correlative study
Abstract
Objective The objectives of the present study were to assess brain atrophy in multiple sclerosis (MS) patients during different disease stages and to investigate by PET and [11C]PK11195, a marker of microglial activation, the relationship between inflammation, atrophy and clinically relevant measures. Methods Eight healthy subjects and 22 MS patients were included. Semiquantitative [11C]PK11195 uptake values, with normalization on cortical grey matter, were measured for magnetic resonance imaging T2- and T1-lesions and normal appearing white matter (NAWM). As atrophy index we used the ratio of the amount of white and grey matter divided by the ventricular size, using an optimized a priori based segmentation algorithm (SPM99). Results Atrophy was significantly greater in MS patients compared to age-matched controls. A significant correlation was found between brain atrophy and both disease duration and disability, as measured with the Expanded Disability Status Scale. For NAWM, [11C]PK11195 uptake increased with the amount of atrophy, while T2-lesional [11C]PK11195 uptake values decreased according to increasing brain atrophy. Conclusions The present study suggests that brain atrophy, correlating with disease duration and disability, is directly related to NAWM and T2-lesional inflammation as measured by microglial activation.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“TSPO PET signal is markedly upregulated in neurodegenerative and neuroinflammatory diseases including multiple sclerosis”
From A quantitative neuropathological assessment of translocator protein expression in multiple sclerosis (2019) · cites this paper as Versijpt et al., 2005
Citations
Cites
Voxel-Based Morphometry—The Methods
Ashburner, J., & Friston, K. J. (2000) · NeuroImage · doi:10.1006/nimg.2000.0582 · Cited by 8,676
McDonald, W. I., Compston, A., Edan, G., Goodkin, D., Hartung, H., Lublin, F. D., McFarland, H. F., Paty, D. W., Polman, C. H., Reingold, S. C., et al. (2001) · Annals of Neurology · doi:10.1002/ana.1032 · Cited by 6,969
Axonal transection in the lesions of multiple sclerosis
Trapp, B. D., Peterson, J., Ransohoff, R. M., Rudick, R., Mörk, S., & Bö, L. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801293380502 · Cited by 4,029
Comparing Functional (PET) Images: The Assessment of Significant Change
Friston, K. J., Frith, C., Liddle, P. F., & Frackowiak, R. S. J. (1991) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1991.122 · Cited by 1,626
Frackowiak, R. S. J., Lenzi, G.-L., Jones, T., & Heather, J. D. (1980) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-198012000-00001 · Cited by 1,241
Relapsing and remitting multiple sclerosis: Pathology of the newly forming lesion
Barnett, M. H., & Prineas, J. W. (2004) · Annals of Neurology · doi:10.1002/ana.20016 · Cited by 1,184
Multimodal image coregistration and partitioning--a unified framework.
Ashburner, J., & Friston, K. (1997) · NeuroImage · doi:10.1006/nimg.1997.0290 · Cited by 1,051
Turner, M. R., Cagnin, A., Turkheimer, F. E., Miller, C. C. J., Shaw, C. E., Brooks, D. J., Leigh, P. N., & Banati, R. B. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2003.12.012 · Cited by 737
Use of the brain parenchymal fraction to measure whole brain atrophy in relapsing-remitting MS
Rudick, R. A., Fisher, E., Lee, J.-C., Simon, J. H., & Jacobs, L. (1999) · Neurology · doi:10.1212/wnl.53.8.1698 · Cited by 736
Miller, D. H. (2002) · Brain · doi:10.1093/brain/awf177 · Cited by 628
Research works printed but not linked: 2
- 10.1097/00019052-200306000-00004 · DOI
- Zivadinov R , Fisher E , Grop A , Nasuelli D , Bratina A , Zorzon M et al. Normalized versus absolute brain atrophy measures in multiple sclerosis . Mult Scler 2001; 7: S47-S47 (abstract).
Cited by
Sorted by citations
Rupprecht, R., Papadopoulos, V., Rammes, G., Baghai, T. C., Fan, J., Akula, N., Groyer, G., Adams, D., & Schumacher, M. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3295 · Cited by 930
Translocator protein 18 kDa (TSPO): Molecular sensor of brain injury and repair
Chen, M.-K., & Guilarte, T. R. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.12.004 · Cited by 506
Venneti, S., Lopresti, B. J., & Wiley, C. A. (2006) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.10.002 · Cited by 373
Noninvasive Molecular Imaging of Neuroinflammation
Jacobs, A. H., Tavitian, B., & the INMiND consortium (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.53 · Cited by 245
Pathogenesis of multiple sclerosis: insights from molecular and metabolic imaging
Ciccarelli, O., Barkhof, F., Bodini, B., Stefano, N. D., Golay, X., Nicolay, K., Pelletier, D., Pouwels, P. J. W., Smith, S. A., Wheeler‐Kingshott, C. A. M. G., et al. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70101-2 · Cited by 253
Dupont, A.-C., Largeau, B., Santiago Ribeiro, M., Guilloteau, D., Tronel, C., & Arlicot, N. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040785 · Cited by 182
Increased PK11195 PET binding in the cortex of patients with MS correlates with disability
Politis, M., Giannetti, P., Su, P., Turkheimer, F., Keihaninejad, S., Wu, K., Waldman, A., Malik, O., Matthews, P. M., Reynolds, R., et al. (2012) · Neurology · doi:10.1212/wnl.0b013e3182635645 · Cited by 176
Rissanen, E., Tuisku, J., Rokka, J., Paavilainen, T., Parkkola, R., Rinne, J. O., & Airas, L. (2014) · Journal of Nuclear Medicine · doi:10.2967/jnumed.113.131698 · Cited by 171
Imaging Microglial Activation During Neuroinflammation and Alzheimer’s Disease
Venneti, S., Wiley, C. A., & Kofler, J. (2008) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-008-9142-2 · Cited by 172
Mechanisms of Neurodegeneration and Axonal Dysfunction in Progressive Multiple Sclerosis
Correale, J., Marrodan, M., & Ysrraelit, M. C. (2019) · Biomedicines · doi:10.3390/biomedicines7010014 · Cited by 167
Clinical aspects of inflammation in Alzheimer's disease
Rosenberg, P. B. (2005) · International Review of Psychiatry · doi:10.1080/02646830500382037 · Cited by 158
A TSPO ligand is protective in a mouse model of multiple sclerosis
Daugherty, D. J., Selvaraj, V., Chechneva, O. V., Liu, X., Pleasure, D., & Deng, W. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201202124 · Cited by 158
In vivo imaging of neuroinflammation in schizophrenia
Pasternak, O., Kubicki, M. R., & Shenton, M. E. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2015.05.034 · Cited by 156
Neuroimaging Biomarkers of Neurodegenerative Diseases and Dementia
Risacher, S. L., & Saykin, A. J. (2013) · Seminars in Neurology · doi:10.1055/s-0033-1359312 · Cited by 155
Kamma, E., Lasisi, W. O., Libner, C. D., Ng, H. S., & Plemel, J. R. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02408-y · Cited by 157
A quantitative neuropathological assessment of translocator protein expression in multiple sclerosis
Nutma, E., Stephenson, J. A., Gorter, R. P., de Bruin, J., Boucherie, D. M., Donat, C. K., Breur, M., van der Valk, P., Matthews, P. M., Owen, D. R., et al. (2019) · Brain · doi:10.1093/brain/awz287 · Cited by 138
“TSPO PET signal is markedly upregulated in neurodegenerative and neuroinflammatory diseases including multiple sclerosis (Vowinckel et al., 1997; Versijpt et al., 2005; Oh et al., 2011; Rissanen et al., 2014; Datta et al., 2017b), Alzheimer’s disease (Edison et al.”
Doorduin, J., Klein, H. C., Dierckx, R., James, M. L., Kassiou, M., & de Vries, E. F. J. (2009) · Molecular Imaging and Biology · doi:10.1007/s11307-009-0211-6 · Cited by 131
Self-citationChing, A. S. C., Kühnast, B., Damont, A., Roeda, D., Tavitian, B., & Dollé, F. (2011) · Insights into Imaging · doi:10.1007/s13244-011-0128-x · Cited by 139
Venneti, S., Wang, G., Nguyen, J., & Wiley, C. A. (2008) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e318188b204 · Cited by 122
Translocator Protein PET Imaging for Glial Activation in Multiple Sclerosis
Oh, U., Fujita, M., Ikonomidou, V. N., Evangelou, I. E., Matsuura, E., Harberts, E. M., Ohayon, J. M., Pike, V. W., Zhang, Y., Zoghbi, S. S., et al. (2010) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-010-9243-6 · Cited by 118
Translocator Protein 18 kDa Negatively Regulates Inflammation in Microglia
Bae, K.-R., Shim, H.-J., Balu, D., Kim, S. R., & Yu, S. (2014) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-014-9540-6 · Cited by 124
Imaging of microglia in patients with neurodegenerative disorders
Politis, M. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00096 · Cited by 111
Rosano, C., Marsland, A. L., & Gianaros, P. J. (2012) · Europe PMC (PubMed Central) · Cited by 111
Doorduin, J., de Vries, E. F. J., Dierckx, R. A. J. O., & Klein, H. (2008) · Current Pharmaceutical Design · doi:10.2174/138161208786549443 · Cited by 107
Self-citationIncreased PK11195-PET binding in normal-appearing white matter in clinically isolated syndrome
Giannetti, P., Politis, M., Su, P., Turkheimer, F., Malik, O., Shiva Keihaninejad, A., Wu, K., Waldman, A. D., Reynolds, R., Nicholas, R. S., et al. (2014) · Brain · doi:10.1093/brain/awu331 · Cited by 106
Datta, G., Colasanti, A., Rabiner, E. A., Gunn, R. N., Malik, O., Ciccarelli, O., Nicholas, R. S., Vlierberghe, E. V., Hecke, W. V., Searle, G. E., et al. (2017) · Brain · doi:10.1093/brain/awx228 · Cited by 99
In Vivo Assessment of Brain White Matter Inflammation in Multiple Sclerosis with18F-PBR111 PET
Colasanti, A., Guo, Q., Muhlert, N., Giannetti, P., Onega, M., Newbould, R. D., Ciccarelli, O., Rison, S., Thomas, C., Nicholas, R., et al. (2014) · Journal of Nuclear Medicine · doi:10.2967/jnumed.113.135129 · Cited by 100
Positron emission tomography imaging in neurological disorders
Politis, M., & Piccini, P. P. (2012) · Journal of Neurology · doi:10.1007/s00415-012-6428-3 · Cited by 102
Evaluation of Reference Tissue Models for the Analysis of [ 11 C]( R )-PK11195 Studies
Kropholler, M. A., Boellaard, R., Schuitemaker, A., Folkersma, H., van Berckel, B. N. M., & Lammertsma, A. A. (2006) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600289 · Cited by 94
Thompson, K. K., & Tsirka, S. E. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030504 · Cited by 100
Decreased microglial activation in MS patients treated with glatiramer acetate
Ratchford, J. N., Endres, C. J., Hammoud, D. A., Pomper, M. G., Shiee, N., McGready, J., Pham, D. L., & Calabresi, P. A. (2011) · Journal of Neurology · doi:10.1007/s00415-011-6337-x · Cited by 91
Owen, D. R., & Matthews, P. M. (2011) · International review of neurobiology · doi:10.1016/b978-0-12-387718-5.00002-x · Cited by 88
Radu, C. G., Shu, C. J., Shelly, S. M., Phelps, M. E., & Witte, O. N. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610544104 · Cited by 87
Venneti, S., Lopresti, B. J., Wang, G., Slagel, S., Mason, N. S., Mathis, C. A., Fischer, M. L., Larsen, N. J., Mortimer, A. D., Hastings, T. G., et al. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04690.x · Cited by 85
Wesselingh, R., Butzkueven, H., Buzzard, K., Tarlinton, D., O'Brien, T. J., & Monif, M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02066 · Cited by 83
Mirzaei, N., Tang, S. P., Ashworth, S., Coello, C., Plisson, C., Passchier, J., Selvaraj, V., Tyacke, R. J., Nutt, D. J., & Sastre, M. (2016) · Glia · doi:10.1002/glia.22978 · Cited by 82
Natalizumab treatment reduces microglial activation in the white matter of the MS brain
Sucksdorff, M., Tuisku, J., Matilainen, M., Vuorimaa, A., Smith, S., Keitilä, J., Rokka, J., Parkkola, R., Nylund, M., Rinne, J., et al. (2019) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000574 · Cited by 71
Airas, L. M., Nylund, M., & Rissanen, E. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00181 · Cited by 78
Imaging neuroinflammation in multiple sclerosis using TSPO-PET
Airas, L. M., Rissanen, E., & Rinne, J. O. (2015) · Clinical and Translational Imaging · doi:10.1007/s40336-015-0147-6 · Cited by 78
PET tracers for the peripheral benzodiazepine receptor and uses thereof
Schweitzer, P. J., Fallon, B. A., Mann, J. J., & Kumar, J. S. D. (2010) · Drug Discovery Today · doi:10.1016/j.drudis.2010.08.012 · Cited by 70
Radioisotopic Imaging of Neuroinflammation: FIGURE 1.
Winkeler, A., Boisgard, R., Martín, A., & Tavitian, B. (2009) · Journal of Nuclear Medicine · doi:10.2967/jnumed.109.065680 · Cited by 70
Vicidomini, C., Panico, M., Greco, A., Gargiulo, S., Coda, A. R. D., Zannetti, A., Gramanzini, M., Roviello, G. N., Quarantelli, M., Alfano, B., et al. (2014) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2014.11.009 · Cited by 70
Clinical correlates of grey matter pathology in multiple sclerosis
Horáková, D., Kalinčík, T., Dušánková, J. B., & Doležal, O. (2012) · BMC Neurology · doi:10.1186/1471-2377-12-10 · Cited by 68
Ma, L., Zhang, H., Liu, N., Wang, P., Guo, W.-Z., Fu, Q., Jiao, L.-B., Ma, Y., & Mi, W. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.02.001 · Cited by 66
Venneti, S., Wagner, A. K., Wang, G. K., Slagel, S., Chen, X., Lopresti, B. J., Mathis, C. A., & Wiley, C. A. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.06.003 · Cited by 62
Scott, L. L., & Downing, T. G. (2017) · Toxins · doi:10.3390/toxins10010022 · Cited by 59
Vellinga, M. M., Vrenken, H., Hulst, H. E., Polman, C. H., Uitdehaag, B. M. J., Pouwels, P. J. W., Barkhof, F., & Geurts, J. J. G. (2009) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.21678 · Cited by 51
Neuroimaging Techniques to Assess Inflammation in Multiple Sclerosis
Tommasin, S., Giannì, C., Giglio, L. D., & Pantano, P. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.07.055 · Cited by 51
Vignal, N., Cisternino, S., Rizzo-Padoin, N., San, C., Hontonnou, F., Gelé, T., Declèves, X., Sarda‐Mantel, L., & Hosten, B. (2018) · Molecules · doi:10.3390/molecules23061375 · Cited by 55
Development of a PET radioligand for potassium channels to image CNS demyelination
Brugarolas, P., Sánchez‐Rodríguez, J. E., Tsai, H., Basuli, F., Cheng, S., Zhang, X., Caprariello, A. V., Lacroix, J. J., Freifelder, R. H., Murali, D., et al. (2018) · Scientific Reports · doi:10.1038/s41598-017-18747-3 · Cited by 50
Mendell, A. L., & MacLusky, N. J. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00359 · Cited by 46
Schependom, J. V., Guldolf, K., D'hooghe, M. B., Nagels, G., & D’haeseleer, M. (2019) · Translational Neurodegeneration · doi:10.1186/s40035-019-0178-4 · Cited by 44
Imaging Neuroinflammation – from Bench to Bedside
Pulli, B. (2014) · Journal of Clinical & Cellular Immunology · doi:10.4172/2155-9899.1000226 · Cited by 41
Faria, D. D. P., de Vries, E. F. J., Sijbesma, J. W. A., Buchpiguel, C. A., Dierckx, R., & Copray, S. C. V. M. (2014) · Multiple Sclerosis Journal · doi:10.1177/1352458514526941 · Cited by 41
Self-citationLeva, G., Klein, C., Benyounes, J., Hallé, F., Bihel, F. J. ‐., Collongues, N., Seze, J. D., Mensah‐Nyagan, A. G., & Patte‐Mensah, C. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.09.007 · Cited by 42
Azrad, M., Zeineh, N., Weizman, A., Veenman, L., & Gavish, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030594 · Cited by 37
PET imaging in multiple sclerosis
Faria, D. D. P., Copray, S. C. V. M., Buchpiguel, C. A., Dierckx, R., & de Vries, E. F. J. (2014) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-014-9544-2 · Cited by 40
Self-citationDatta, G., Violante, I., Scott, G., Zimmerman, G., Santos-Ribeiro, A., Rabiner, E., Gunn, R., Malik, O., Ciccarelli, O., Nicholas, R., et al. (2016) · Multiple Sclerosis · doi:10.1177/1352458516681504 · Cited by 35
Arbo, B. D., Benetti, F., García‐Segura, L. M., & Ribeiro, M. F. M. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.07.007 · Cited by 40
Airas, L., Rissanen, E., & Rinne, J. (2017) · Multiple Sclerosis · doi:10.1177/1352458516674568 · Cited by 32
Marro, M., Taubes, A. L., Abernathy, A. M., Balint, S., Moreno, B., Sánchez-Dalmau, B. F., Martínez‐Lapiscina, E. H., Amat‐Roldan, I., Petrov, D. V., & Villoslada, P. (2013) · Journal of Biophotonics · doi:10.1002/jbio.201300101 · Cited by 34
Quantification of (R)-[11C]PK11195 binding in rheumatoid arthritis
Kropholler, M. A., Boellaard, R., Elzinga, E. H., van der Laken, C. J., Maruyama, K., Kloet, R. W., Voskuyl, A. E., Dijkmans, B. A. C., & Lammertsma, A. A. (2008) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-008-0987-7 · Cited by 34
PET Evaluation of Microglial Activation in Non-neurodegenerative Brain Diseases
Ghadery, C., Best, L. A., Pavese, N., Tai, Y., & Strafella, A. P. (2019) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-019-0951-x · Cited by 34
Iversen, P., Aagaard, D., Bender, D., Rodell, A. B., Munk, O. L., Cumming, P. D., & Keiding, S. (2006) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-005-0052-8 · Cited by 32
The Role of Advanced Magnetic Resonance Imaging Techniques in Multiple Sclerosis Clinical Trials
Mahajan, K. R., & Ontaneda, D. (2017) · Neurotherapeutics · doi:10.1007/s13311-017-0561-8 · Cited by 34
Poutiainen, P., Jaronen, M., Quintana, F. J., & Brownell, A. (2016) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2016.00085 · Cited by 33
Neuroinflammatory Imaging Biomarkers: Relevance to Multiple Sclerosis and its Therapy
Tourdias, T., & Dousset, V. (2012) · Neurotherapeutics · doi:10.1007/s13311-012-0155-4 · Cited by 32
Novel MRI and PET markers of neuroinflammation in multiple sclerosis
Hagens, M. H. J., van Berckel, B. N. M., & Barkhof, F. (2016) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000326 · Cited by 29
Converse, A. K., Larsen, E. C., Engle, J. W., Barnhart, T. E., Nickles, R. J., & Duncan, I. D. (2011) · Journal of Nuclear Medicine · doi:10.2967/jnumed.110.082743 · Cited by 29
Niccolini, F., Su, P., & Politis, M. (2015) · Clinical Nuclear Medicine · doi:10.1097/rlu.0000000000000359 · Cited by 23
The translocator protein (18 kDa) and its role in neuropsychiatric disorders
Barichello, T., Simões, L. R., Collodel, A., Giridharan, V. V., Dal‐Pizzol, F., Macêdo, D. S., & Quevedo, J. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.10.010 · Cited by 30
Pedersen, M. D., Minuzzi, L., Wirenfeldt, M., Meldgaard, M., Slidsborg, C., Cumming, P. D., & Finsen, B. R. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04975.x · Cited by 26
Folkersma, H., Boellaard, R., Vandertop, W. P., Kloet, R. W., Lubberink, M., Lammertsma, A. A., & van Berckel, B. N. M. (2009) · Journal of Nuclear Medicine · doi:10.2967/jnumed.109.067512 · Cited by 25
Zwergal, A., Gunther, L. M., Brendel, M., Beck, R., Lindner, S., Xiong, G., Eilles, E., Unterrainer, M., Albert, N. L., Becker‐Bense, S., et al. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00665 · Cited by 22
Exploring the role of microglia in mood disorders associated with experimental multiple sclerosis
Gentile, A., Vito, F. D., Fresegna, D., Musella, A., Buttari, F., Bullitta, S., Mandolesi, G., & Centonze, D. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00243 · Cited by 22
Faria, D. D. P., Vlaming, M. L. H., Copray, S. C. V. M., Tielen, F. J., Anthonijsz, H. J. A., Sijbesma, J. W. A., Buchpiguel, C. A., Dierckx, R., van der Hoorn, J. W. A., & de Vries, E. F. J. (2014) · Journal of Nuclear Medicine · doi:10.2967/jnumed.114.137216 · Cited by 21
Self-citationSpinal Fluid Myeloid Microvesicles Predict Disease Course in Multiple Sclerosis
Gelibter, S., Pisa, M., Croese, T., Finardi, A., Mandelli, A., Sangalli, F., Colombo, B., Martinelli, V., Comı, G., Filippi, M., et al. (2021) · Annals of Neurology · doi:10.1002/ana.26154 · Cited by 19
Nuclear Imaging of Inflammation in Neurologic and Psychiatric Disorders
de Vries, E. F. J., Dierckx, R., & Klein, H. C. (2006) · Current Clinical Pharmacology · doi:10.2174/157488406778249334 · Cited by 20
Self-citationZhang, H., Ma, L., Yin, Y., Dong, L.-Q., Cheng, G., Ma, Y., Li, Y., & Xu, B. (2016) · Brain Research · doi:10.1016/j.brainres.2016.06.001 · Cited by 19
TSPO-PET Imaging to Assess Cerebral Microglial Activation in Multiple Sclerosis
Weiner, H. L., Bakshi, R., & Singhal, T. (2017) · Seminars in Neurology · doi:10.1055/s-0037-1608715 · Cited by 18
Cumming, P. D., Pedersen, M. D., Minuzzi, L., Mezzomo, K. M., Danielsen, E. H., Iversen, P., Aagaard, D., Keiding, S., Munk, O. L., & Finsen, B. R. (2006) · Synapse · doi:10.1002/syn.20257 · Cited by 19
Guanabenz modulates microglia and macrophages during demyelination
Thompson, K. K., & Tsirka, S. E. (2020) · Scientific Reports · doi:10.1038/s41598-020-76383-w · Cited by 17
Lopresti, B. J., Royse, S. K., Mathis, C. A., Tollefson, S., & Narendran, R. (2022) · Journal of Neurochemistry · doi:10.1111/jnc.15615 · Cited by 16
Magnetic resonance imaging of glutamate in neuroinflammation
Chen, Y., Dai, Z., Shen, Z., Lin, G., Zhuang, C., Li, H. J., & Wu, R. (2016) · Radiology of Infectious Diseases · doi:10.1016/j.jrid.2016.03.006 · Cited by 16
Linking Cognitive Impairment to Neuroinflammation in Multiple Sclerosis using neuroimaging tools
Barros, C., & Fernandes, A. M. A. (2020) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2020.102622 · Cited by 15
Kikinis, Z., Castañeyra-Perdomo, A., González–Mora, J. L., Rushmore, J., Toppa, P. H., Haggerty, K., Papadimitriou, G., Yogesh Rathi, A., Kubicki, M. R., Kikinis, R., et al. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1337888 · Cited by 13
Herholz, K. (2006) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2005.09.012 · Cited by 13
Microglia and Multiple Sclerosis
Hammond, B. P., Panda, S. P., Kaushik, D. K., & Plemel, J. R. (2024) · Advances in neurobiology · doi:10.1007/978-3-031-55529-9_25 · Cited by 11
Chang, C.-W., Chiu, C.-H., Lin, M.-H., Wu, H., Yu, T.-H., Wang, P.-Y., Kuo, Y.-Y., Huang, Y.-Y., Shiue, C., Huang, W.-S., et al. (2021) · EJNMMI Research · doi:10.1186/s13550-021-00768-9 · Cited by 11
Towards molecular imaging of multiple sclerosis
Owen, D. R., Piccini, P. P., & Matthews, P. M. (2011) · Multiple Sclerosis Journal · doi:10.1177/1352458510390070 · Cited by 11
Arnold, D. L., Li, D., Hohol, M. J., Chakraborty, S., Chankowsky, J., Alikhani, K., Duquette, P., Bhan, V., Montanera, W. J., Rabinovitch, H., et al. (2015) · Multiple Sclerosis Journal - Experimental Translational and Clinical · doi:10.1177/2055217315589775 · Cited by 10
Zhang, Y., Yu, S., Li, X., Yang, B., & Wu, C. Y. (2016) · Clinical Science · doi:10.1042/cs20160547 · Cited by 8
García, D. V., Doorduin, J., Faria, D. D. P., Dierckx, R., & de Vries, E. D. (2017) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-017-9741-x · Cited by 6
Self-citationMeasuring Pathology in Patients with Multiple Sclerosis Using Positron Emission Tomography
Brier, M. R., & Taha, F. (2023) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-023-01285-z · Cited by 7
Advances in the molecular imaging of multiple sclerosis
Matthews, P. M., & Comley, R. A. (2009) · Expert Review of Clinical Immunology · doi:10.1586/eci.09.66 · Cited by 7
Cell–cell communication by Endocannabinoids during Immune Surveillance of the Central Nervous System
Ullrich, O., Schneider‐Stock, R., & Zipp, F. (2006) · Springer eBooks · doi:10.1007/400_015 · Cited by 7
Sjöros, T., Saraste, M., Matilainen, M., Nylund, M., Koivumäki, M., Kühle, J., Leppert, D., & Airas, L. M. (2025) · Therapeutic Advances in Neurological Disorders · doi:10.1177/17562864251352998 · Cited by 5
Ro5-4864, a translocator protein ligand, regulates T cell-mediated inflammatory responses in skin
Sendai, Y., Takeda, K., Ohta, K., Nakae, S., Koshika, K., Kitamura, K., Higuchi, M., Ichinohe, T., Azuma, T., Okumura, K., et al. (2024) · International Immunology · doi:10.1093/intimm/dxae065 · Cited by 4
PET Imaging of Translocator Protein Expression in Neurological Disorders
Brooks, D. J. (2020) · Springer eBooks · doi:10.1007/978-3-030-53176-8_30 · Cited by 4
Assessment of 18F-PBR-111 in the Cuprizone Mouse Model of Multiple Sclerosis
Jewells, V. L., Yuan, H., Merrill, J. R., Frank, J. E., Patel, A., Cohen, S. M., Giglio, B. C., Feinberg, N. N., Matsushima, G. K., & Li, Z. (2021) · Diagnostics · doi:10.3390/diagnostics11050786 · Cited by 4
Metadata
- Authors
- Versijpt, J., Debruyne, J. C., Van Laere, K. J., De Vos, F., Keppens, J., Strijckmans, K., Achten, E., Slegers, G., Dierckx, R. A., Korf, J., & De Reuck, J. L.
- Affiliations
- University Medical Center Groningen (NL)
- Ghent University Hospital (BE)
- Division of Nuclear Medicine, Ghent University Hospital, Ghent, the Netherlands
- Laboratory of Radiopharmacy, Ghent University, Ghent, the Netherlands
- Ghent University (BE)
- Department of Neurology, Ghent University Hospital, Ghent, the Netherlands
- Corresponding author
- Debruyne, J C
- Venue
- Multiple Sclerosis Journal
- Publisher
- SAGE Publications
- Published
- 2005-04
- Volume
- 11
- Issue
- 2
- Pages
- 127-134
- ISSN
- 1352-4585 (ISSN-L)
- 1477-0970
- OpenAlex
- W1993466811
- Cited by
- 126
- References
- 64
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 6 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 9 · 2018: 5 · 2017: 12 · 2016: 11 · 2015: 7 · 2014: 14 · 2013: 4 · 2012: 8
- FWCI
- 4.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Multiple Sclerosis Journal (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- multiple sclerosis, brain atrophy, microglial activation, [11C]PK11195, positron emission tomography, normal-appearing white matter, T2 lesions, disease duration, disability, neuroinflammation
- MeSH terms
- Adult, Aged, Antineoplastic Agents, Atrophy, Brain, Carbon Radioisotopes, Female, Humans, Isoquinolines, Magnetic Resonance Imaging, Male, Middle Aged, Multiple Sclerosis, Microglia, Positron-Emission Tomography
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
