The DOI matches its Crossref record; 63 of the 64 references it cites were found in a registry or an index.
Microglial imaging with positron emission tomography and atrophy measurements with magnetic resonance imaging in multiple sclerosis: a correlative study
Abstract
Objective The objectives of the present study were to assess brain atrophy in multiple sclerosis (MS) patients during different disease stages and to investigate by PET and [11C]PK11195, a marker of microglial activation, the relationship between inflammation, atrophy and clinically relevant measures. Methods Eight healthy subjects and 22 MS patients were included. Semiquantitative [11C]PK11195 uptake values, with normalization on cortical grey matter, were measured for magnetic resonance imaging T2- and T1-lesions and normal appearing white matter (NAWM). As atrophy index we used the ratio of the amount of white and grey matter divided by the ventricular size, using an optimized a priori based segmentation algorithm (SPM99). Results Atrophy was significantly greater in MS patients compared to age-matched controls. A significant correlation was found between brain atrophy and both disease duration and disability, as measured with the Expanded Disability Status Scale. For NAWM, [11C]PK11195 uptake increased with the amount of atrophy, while T2-lesional [11C]PK11195 uptake values decreased according to increasing brain atrophy. Conclusions The present study suggests that brain atrophy, correlating with disease duration and disability, is directly related to NAWM and T2-lesional inflammation as measured by microglial activation.
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“TSPO PET signal is markedly upregulated in neurodegenerative and neuroinflammatory diseases including multiple sclerosis”
From A quantitative neuropathological assessment of translocator protein expression in multiple sclerosis (2019) · cites this paper as Versijpt et al., 2005
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Rupprecht, R., Papadopoulos, V., Rammes, G., Baghai, T. C., Fan, J., Akula, N., Groyer, G., Adams, D., & Schumacher, M. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3295 · Cited by 930
Translocator protein 18 kDa (TSPO): Molecular sensor of brain injury and repair
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Metadata
- Authors
- Versijpt, J., Debruyne, J. C., Van Laere, K. J., De Vos, F., Keppens, J., Strijckmans, K., Achten, E., Slegers, G., Dierckx, R. A., Korf, J., & De Reuck, J. L.
- Affiliations
- University Medical Center Groningen (NL)
- Ghent University Hospital (BE)
- Division of Nuclear Medicine, Ghent University Hospital, Ghent, the Netherlands
- Laboratory of Radiopharmacy, Ghent University, Ghent, the Netherlands
- Ghent University (BE)
- Department of Neurology, Ghent University Hospital, Ghent, the Netherlands
- Corresponding author
- Debruyne, J C
- Venue
- Multiple Sclerosis Journal
- Publisher
- SAGE Publications
- Published
- 2005-04
- Volume
- 11
- Issue
- 2
- Pages
- 127-134
- ISSN
- 1352-4585 (ISSN-L)
- 1477-0970
- OpenAlex
- W1993466811
- Cited by
- 126
- References
- 64
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 6 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 9 · 2018: 5 · 2017: 12 · 2016: 11 · 2015: 7 · 2014: 14 · 2013: 4 · 2012: 8
- FWCI
- 4.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Multiple Sclerosis Journal (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- multiple sclerosis, brain atrophy, microglial activation, [11C]PK11195, positron emission tomography, normal-appearing white matter, T2 lesions, disease duration, disability, neuroinflammation
- MeSH terms
- Adult, Aged, Antineoplastic Agents, Atrophy, Brain, Carbon Radioisotopes, Female, Humans, Isoquinolines, Magnetic Resonance Imaging, Male, Middle Aged, Multiple Sclerosis, Microglia, Positron-Emission Tomography
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