Rethinking placebo in psychiatry: how and why placebo effects occur
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Summary: This article outlines proximate (physical and mental) and ultimate mechanisms of placebo effects. Interpersonal processes contributing to placebo effects are reviewed and illustrated through research into the process of psychotherapy. Evolutionary theories of how and why the capacity for placebo effects might have evolved are described. The components of treatment and placebo effects are defined. It is concluded that maximising therapeutic placebo effects is effective and a valid clinical goal.
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It seems clearly adaptive for expectations to modulate sensory perception to some extent.
“It seems clearly adaptive for expectations to modulate sensory perception to some extent13,14.”
From Boundary effects of expectation in human pain perception (2019) · cites this paper as [14]
The ‘Meaning responses’ and expectations section (page unavailable) describes expectancy-related changes in perceived symptoms, including a placebo-phototherapy example in which only patients’ perceptions appeared to change. The ‘function (adaptation)’ section (page unavailable) suggests that adapting internal processes to environmental appraisals might have advantages, but does not establish that modulation of sensory perception by expectations is itself clearly adaptive. (LLM, conf=0.83)
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Cites
(1969) · Cited by 18,340 · see citing works
Attachment and Loss. Vol. 1. Attachment
Rever, G. W. (1972) · Psychosomatic Medicine · doi:10.1097/00006842-197211000-00011 · Cited by 8,446 · cited 3× · see citing works
“(Bowlby 1969: p. 47) https://doi.org/10.1192/apt.bp.112.010405 Published online by Cambridge University Press Advances in psychiatric treatment (2013), vol. 19, 171–180 doi: 10.1192/apt.bp.112.010405178 in failure to thrive, susceptibility to infection and ultimately death.”
BackgroundInfluentialOn aims and methods of ethology
Tinbergen, N. (1963) · Zeitschrift für Tierpsychologie · doi:10.1111/j.1439-0310.1963.tb01161.x · Cited by 4,551 · see citing works
Attachment and Loss. Vol. I. Attachment.
Jones, N. B., & Bowlby, J. (1970) · Man · doi:10.2307/2798963 · Cited by 4,201 · see citing works
Affect Regulation, Mentalization, and the Development of the Self
Fonagy, P., Gergely, G., Jurist, E. L., & Target, M. (2018) · doi:10.4324/9780429471643 · Cited by 3,886 · see citing works
Bion, W. R., & Hinshelwood, R. (2023) · Routledge eBooks · doi:10.4324/9781003411840 · Cited by 3,051 · see citing works
The Interpersonal World of the Infant: A View from Psychoanalysis and Developmental Psychology
Zeanah, C. H. (1986) · Journal of the American Academy of Child Psychiatry · doi:10.1016/s0002-7138(10)60025-8 · Cited by 2,810 · see citing works
The Interpersonal World of the Infant: A View from Psychoanalysis and Developmental Psychology
Stern, D. N. (2019) · Cited by 2,490 · see citing works
Affect regulation, mentalization, and the development of the self
Koh, E. (2004) · Australian & New Zealand Journal of Psychiatry · doi:10.1111/j.1440-1614.2004.01308.x · Cited by 1,709 · see citing works
Hospitalism; an inquiry into the genesis of psychiatric conditions in early childhood.
Spitz, R. A. (1945) · PubMed · Cited by 1,563 · see citing works
vernersson, I. (2000) · Cited by 1,481 · see citing works
Hospitalism: An Inquiry into the Genesis of Psychiatric Conditions in Early Childhood
Spitz, R. A. (1945) · The Psychoanalytic Study of the Child · doi:10.1080/00797308.1945.11823126 · Cited by 1,476 · see citing works
Components of placebo effect: randomised controlled trial in patients with irritable bowel syndrome
Kaptchuk, T. J., Kelley, J. M., Conboy, L. A., Davis, R. B., Kerr, C. E., Jacobson, E. E., Kirsch, I., Schyner, R. N., Nam, B. H., Nguyen, L. T., et al. (2008) · BMJ · doi:10.1136/bmj.39524.439618.25 · Cited by 1,196 · see citing works
Psychotherapy for depression in adults: A meta-analysis of comparative outcome studies.
Cuijpers, P., van Straten, A., Andersson, G., & van Oppen, P. (2008) · Journal of Consulting and Clinical Psychology · doi:10.1037/a0013075 · Cited by 1,050 · see citing works
Behaviorally Conditioned Immunosuppression
Ader, R., & Cohen, N. (1975) · Psychosomatic Medicine · doi:10.1097/00006842-197507000-00007 · Cited by 1,023 · see citing works
Nesse, R. M. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.1.14 · Cited by 891 · see citing works
Neurobiological Mechanisms of the Placebo Effect
Benedetti, F., Mayberg, H., Wager, T., Stohler, C., & Zubieta, J. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3458-05.2005 · Cited by 771 · see citing works
Deconstructing the Placebo Effect and Finding the Meaning Response
Moerman, D. E., & Jonas, W. B. (2002) · Annals of Internal Medicine · doi:10.7326/0003-4819-136-6-200203190-00011 · Cited by 745 · see citing works
Adult Ependymal Cells Are Postmitotic and Are Derived from Radial Glial Cells during Embryogenesis
Spassky, N., Merkle, F. T., Flames, N., Tramontin, A. D., García-Verdugo, J. M., & Alvarez-Buylla, A. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1108-04.2005 · Cited by 717 · see citing works
The Placebo Effect: Dissolving the Expectancy Versus Conditioning Debate.
Stewart‐Williams, S., & Podd, J. (2004) · Psychological Bulletin · doi:10.1037/0033-2909.130.2.324 · Cited by 664 · see citing works
The Patient-Provider Relationship: Attachment Theory and Adherence to Treatment in Diabetes
Ciechanowski, P. S., Katon, W. J., Russo, J. E., & Walker, E. A. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.1.29 · Cited by 604 · see citing works
The researcher's own therapy allegiances: A "wild card" in comparisons of treatment efficacy.
Luborsky, L., Diguer, L., Seligman, D. A., Rosenthal, R., Krause, E. D., Johnson, S., Halperin, G., Bishop, M., Berman, J. S., & Schweizer, E. (1999) · Clinical Psychology: Science and Practice · doi:10.1093/clipsy.6.1.95 · Cited by 572 · see citing works
NIMH Treatment of Depression Collaborative Research Program
Elkin, I. (1985) · Archives of General Psychiatry · doi:10.1001/archpsyc.1985.01790260103013 · Cited by 520 · see citing works
Psychodynamic psychiatry in clinical practice
Gabbard, G. O. (1990) · Cited by 429 · see citing works
General practice consultations: is there any point in being positive?
Thomas, K. (1987) · BMJ · doi:10.1136/bmj.294.6581.1200 · Cited by 420 · see citing works
Concept of true and perceived placebo effects
Ernst, E., & Resch, K. (1995) · BMJ · doi:10.1136/bmj.311.7004.551 · Cited by 407 · see citing works
Through Paediatrics to Psychoanalysis: Collected Papers
Winnicott, D. W. (1975) · Cited by 403 · see citing works
(2007) · W W Norton & Co eBooks · Cited by 369 · see citing works
Adherence to Treatment and Health Outcomes
Horwitz, R. I. (1993) · Archives of Internal Medicine · doi:10.1001/archinte.1993.00410160017001 · Cited by 367 · see citing works
Active placebos versus antidepressants for depression
Moncrieff, J., Wessely, S., & Hardy, R. (2004) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003012.pub2 · Cited by 342 · see citing works
CLINICIANS' EXPECTATIONS INFLUENCE PLACEBO ANALGESIA
Gracely, R. H., Dubner, R. A., Deeter, W. R., & Wolskee, P. J. (1985) · The Lancet · doi:10.1016/s0140-6736(85)90984-5 · Cited by 311 · see citing works
Primitive Emotional Development
Winnicott, D. W. (2016) · Oxford University Press eBooks · doi:10.1093/med:psych/9780190271343.003.0058 · Cited by 311 · see citing works
The Placebo Effect: Illness and Interpersonal Healing
Miller, F. G., Colloca, L., & Kaptchuk, T. J. (2009) · Perspectives in biology and medicine · doi:10.1353/pbm.0.0115 · Cited by 254 · see citing works
Nesse, R. M. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb03472.x · Cited by 254 · see citing works
Influence of Patient Attachment Style on Self-care and Outcomes in Diabetes
Ciechanowski, P., Russo, J., Katon, W., Korff, M. V., Ludman, E., Lin, E., Simon, G., & Bush, T. (2004) · Psychosomatic Medicine · doi:10.1097/01.psy.0000138125.59122.23 · Cited by 253 · see citing works
Let's Face Facts: Common Factors Are More Potent Than Specific Therapy Ingredients
Messer, S. B. (2002) · Clinical Psychology Science and Practice · doi:10.1093/clipsy/9.1.21 · Cited by 242 · see citing works
Benedetti, F., Maggi, G., Lopiano, L., Lanotte, M., Rainero, I., Vighetti, S., & Pollo, A. (2003) · Prevention & Treatment · doi:10.1037/1522-3736.6.1.61a · Cited by 221 · see citing works
Stiles, W. B., Barkham, M., Twigg, E., Mellor‐Clark, J., & Cooper, M. (2006) · Psychological Medicine · doi:10.1017/s0033291706007136 · Cited by 179 · see citing works
Psychiatrist effects in the psychopharmacological treatment of depression
McKay, K. M., Imel, Z. E., & Wampold, B. E. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.01.020 · Cited by 169 · see citing works
Placebo psychotherapy: Synonym or oxymoron?
Kirsch, I. (2005) · Journal of Clinical Psychology · doi:10.1002/jclp.20126 · Cited by 164 · see citing works
Reconsidering the Placebo Response from a Broad Anthropological Perspective
Thompson, J. J., Ritenbaugh, C., & Nichter, M. (2009) · Culture, Medicine, and Psychiatry · doi:10.1007/s11013-008-9122-2 · Cited by 159 · see citing works
Another look at the nonspecific hypothesis of therapeutic effectiveness.
Jones, E. E., Cumming, J. D., & Horowitz, M. J. (1988) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.56.1.48 · Cited by 153 · see citing works
Walach, H. (2001) · The Journal of Alternative and Complementary Medicine · doi:10.1089/107555301300328070 · Cited by 147 · see citing works
Psychodynamic Psychiatry in Clinical Practice
Kim, E. J. (1990) · Jefferson Journal of Psychiatry · doi:10.29046/jjp.008.2.013 · Cited by 145 · see citing works
BAKWIN, H. T. (1942) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.1942.02010010031003 · Cited by 136 · see citing works
The Placebo Puzzle: Putting Together the Pieces.
Stewart‐Williams, S. (2004) · Health Psychology · doi:10.1037/0278-6133.23.2.198 · Cited by 119 · see citing works
Another look at the nonspecific hypothesis of therapeutic effectiveness.
Jones, E. E., Cumming, J. D., & Horowitz, M. J. (1988) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.56.1.48 · Cited by 100 · see citing works
Side Effects and Placebo Amplification
Thomson, R. J. (1982) · The British Journal of Psychiatry · doi:10.1192/bjp.140.1.64 · Cited by 94 · see citing works
Bone Marrow as a Source of Endothelial Cells for Natural and Iatrogenic Vascular Repair
Isner, J. M., Kalka, C., Kawamoto, A., & Asahara, T. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb02075.x · Cited by 92 · see citing works
Situational factors contributing to the placebo effect
Gryll, S. L., & Katahn, M. (1978) · Psychopharmacology · doi:10.1007/bf00426747 · Cited by 91 · see citing works
Bowers, T. G., & Clum, G. A. (1988) · Psychological Bulletin · doi:10.1037/0033-2909.103.3.315 · Cited by 89 · see citing works
Frank, A. W., & Fox, N. J. (1993) · The Canadian Journal of Sociology · doi:10.2307/3340907 · Cited by 86 · see citing works
SYMPOSIUM ON THE CONTRIBUTION OF CURRENT THEORIES TO AN UNDERSTANDING OF CHILD DEVELOPMENT
Bowlby, J. (1957) · British Journal of Medical Psychology · doi:10.1111/j.2044-8341.1957.tb01202.x · Cited by 72 · see citing works
Evidence for Increased Effectiveness of Placebos With Increased Stress
Beecher, H. K. (1956) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1956.187.1.163 · Cited by 72 · see citing works
Ma, K. (2006) · Advances in Psychiatric Treatment · doi:10.1192/apt.12.6.440 · Cited by 64 · see citing works
Side effects and the "blindability" of clinical drug trials
White, K., Kando, J. C., Park, T., WATERNAUX, C. M., & Brown, W. A. (1992) · American Journal of Psychiatry · doi:10.1176/ajp.149.12.1730 · Cited by 52 · see citing works
Cox, K. (1993) · Australian and New Zealand Journal of Surgery · doi:10.1111/j.1445-2197.1993.tb00070.x · Cited by 48 · see citing works
Great expectations: The evolutionary psychology of faith healing and the placebo effect
Humphrey, N. K. (2002) · Psychology Press eBooks · doi:10.4324/9780203989432-35 · Cited by 42 · see citing works
Evolution: medicine's most basic science
Nesse, R. M. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61877-2 · Cited by 36 · see citing works
Tutter, A. (2006) · Journal of the American Psychoanalytic Association · doi:10.1177/00030651060540031401 · Cited by 34 · see citing works
The effects of a single acupuncture treatment in horses with severe recurrent airway obstruction
Wilson, D. V., Lankenau, C., BERNEY, C., Peroni, D., Mullineaux, D. R., & ROBINSON, N. E. (2004) · Equine Veterinary Journal · doi:10.2746/0425164044877323 · Cited by 25 · see citing works
Attachment theory in adult psychiatry. Part 2: Importance to the therapeutic relationship
Ma, K. (2006) · Advances in Psychiatric Treatment · doi:10.1192/apt.bp.105.001867 · Cited by 21 · see citing works
Dr, D., Vn, V., & Mp, B. (1978) · PubMed · Cited by 11 · see citing works
AN ETHOLOGICAL APPROACH TO RESEARCH IN CHILD DEVELOPMENT
Bowlby, J. (2012) · doi:10.4324/9780203441008-7 · Cited by 10 · see citing works
Mirror, mirror on the wall: placebo effects that exist only in the eye of the beholder
Kelley, J. M., Boulos, P. R., Rubin, P. A. D., & Kaptchuk, T. J. (2009) · Journal of Evaluation in Clinical Practice · doi:10.1111/j.1365-2753.2008.00999.x · Cited by 8 · see citing works
Placebo Effects: Biological, Clinical and Ethical Advances
Finniss, D., Kaptchuk, T., Miller, F. G., & Benedetti, F. (2010) · The Lancet · doi:10.1016/s0140-6736(09)61706-2 · Cited by 5 · see citing works
A psychoanalytic understanding of antipsychotic drug treatment: an attempt at applied psychoanalysis
Titelman, D. (1999) · The Scandinavian Psychoanalytic Review · doi:10.1080/01062301.1999.10592692 · Cited by 1 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Steiner J, Jackson M (2001) Henri Rey (1912-2000). International Journal of Psycho-Analysis 82: 397-9.
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Alfonsson, S., Olsson, E., & Hursti, T. (2016) · Journal of Medical Internet Research · doi:10.2196/jmir.5352 · Cited by 118 · see citing works
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Hird, E. J., Charalambous, C., El-Deredy, W., Jones, A. K. P., & Talmi, D. (2019) · Scientific Reports · doi:10.1038/s41598-019-45811-x · Cited by 68 · see citing works
Placebo effects in allergen immunotherapy—An EAACI Task Force Position Paper
Pfaar, O., Agache, I. O., Bergmann, K., Bindslev‐Jensen, C., Bousquet, J. J., Creticos, P. S., Devillier, P., Durham, S. R., Hellings, P. W., Kaul, S., et al. (2020) · Allergy · doi:10.1111/all.14331 · Cited by 57 · see citing works
Ryder, A. G., & Chentsova-Dutton, Y. E. (2015) · Cambridge University Press eBooks · doi:10.1017/cbo9781139424745.019 · Cited by 46 · see citing works
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Pronovost-Morgan, C., Hartogsohn, I., & Ramaekers, J. G. (2023) · Journal of Psychopharmacology · doi:10.1177/02698811231182602 · Cited by 36 · see citing works
Orsolini, L., St John-Smith, P., McQueen, D., Papanti, D., Corkery, J., & Schifano, F. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666161111114838 · Cited by 28 · see citing works
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Self-citationRodríguez, S. C. (2022) · Anales de la Real Academia Nacional de Farmacia · doi:10.53519/analesranf.2022.88.01.02 · Cited by 15 · see citing works
The Biopsychosocial Model Advanced by Evolutionary Theory
Hunt, A., John‐Smith, P. S., & Abed, R. (2022) · Cambridge University Press eBooks · doi:10.1017/9781009030564.004 · Cited by 14 · see citing works
Richards, K. C., Fry, L., Lozano, A. J., Ji, W., Morrison, J. D., Britt, K. C., Bliwise, D. L., Gooneratne, N. S., & Hanlon, A. L. (2025) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2025.105485 · Cited by 6 · see citing works
Evolutionary Psychology and Psychiatry
Abed, R., & John‐Smith, P. S. (2020) · SAGE Publications Ltd eBooks · doi:10.4135/9781529739428.n2 · Cited by 6 · see citing works
Jakovljević, M. (2015) · PubMed · Cited by 5 · see citing works
Body, Meaning, and Time: Healing Response as a Transtemporal and Multimodal Meaning-Making Process
Goli, F. (2022) · Cognitive systems monographs · doi:10.1007/978-3-031-17678-4_6 · Cited by 8 · see citing works
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Salmoiraghi, A., & Zarotti, N. (2024) · BJPsych Bulletin · doi:10.1192/bjb.2024.94 · Cited by 4 · see citing works
Doğan, R. N. G., & Ali, A. (2025) · Transcultural Psychiatry · doi:10.1177/13634615251357470 · Cited by 3 · see citing works
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What is evidence? bridging the gap between trials and treatment implementation
Wykes, T. (2023) · Journal of Mental Health · doi:10.1080/09638237.2023.2210672 · Cited by 1 · see citing works
de Manincor, & Michael, J. (2017)
Discourse, materiality and power: Dietary supplements and their users
Bidwell, S. (2020) · Otago University Research Archive (University of Otago)
- Authors
- McQueen, D., Cohen, S., St John-Smith, P., & Rampes, H.
- Affiliations
- Centre for Addiction and Mental Health (CA)
- ORCID
- McQueen, Daniel
- Venue
- Advances in Psychiatric Treatment
- Publisher
- Cambridge University Press (CUP)
- Published
- 2013-05
- Volume
- 19
- Issue
- 3
- Pages
- 171-180
- ISSN
- 1355-5146 (ISSN-L)
- 1472-1481
- OpenAlex
- W2072543676
- Cited by
- 23
- References
- 66
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 3 · 2022: 5 · 2020: 4 · 2019: 1 · 2017: 1 · 2016: 2 · 2015: 3 · 2013: 1
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Advances in Psychiatric Treatment (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
- Keywords
- placebo effect, placebo mechanisms, interpersonal processes, psychotherapy, psychiatric treatment
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