Impaired In Vivo Immune Responses in Patients with Melancholia

Hickie, Ian; Hickie, Catherine; Lloyd, Andrew; Silove, Derrick; Wakefield, Denis

doi:10.1192/bjp.162.5.651

Cited by 75Tryptophan and brain disordersStress Responses and CortisolTreatment of Major Depression

Impaired In Vivo Immune Responses in Patients with Melancholia

Hickie, Ian, Hickie, Catherine, Lloyd, Andrew, Silove, Derrick, Wakefield, Denis·1993·British Journal of Psychiatry

DOI 10.1192/bjp.162.5.651

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Abstract

Previous attempts to establish a relationship between impaired cell-mediated immunity (CMI) and major mood disorders have been limited by a failure to explore the relevance of depressive subcategories or to assess CMI by in vivo methods. In this case-control study CMI was assessed in 57 patients with major depression (31 with melancholic, 26 with non-melancholic disorders), and in age- and sex-matched controls by both in vitro and in vivo immunological techniques. Compared with control subjects and patients with non-melancholic depression, patients with melancholia demonstrated reduced in vivo CMI as assessed by delayed-type hypersensitivity (DTH) skin responses. Although increasing age, severity of depression, hospital admission for treatment, and reported weight loss are correlates of melancholia, none of these factors alone, or in combination, accounted for the differences in DTH responses observed between the two depressive subtypes. These data suggest that impaired CMI in vivo may be limited to those with melancholic disorders. At this stage the factors which account for this effect are unclear.

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Immune Dysfunction In Depressive Disorders
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Authors: Hickie, I., Hickie, C., Lloyd, A., Silove, D., & Wakefield, D.
Affiliations: UNSW Sydney (AU)
Liverpool Hospital (AU)
Corresponding author: Hickie, Ian
ORCID: Hickie, Ian
Hickie, Catherine
Silove, Derrick
Wakefield, Denis
Venue: British Journal of Psychiatry
Publisher: Royal College of Psychiatrists
Published: 1993-05
Volume: 162
Issue: 5
Pages: 651-657
ISSN: 0007-1250 (ISSN-L)
1472-1465
DOI: 10.1192/bjp.162.5.651
OpenAlex: W2041533847
Cited by: 75
References: 23
Citations by year: 2024: 1 · 2020: 1 · 2019: 1 · 2018: 3 · 2015: 2 · 2014: 2 · 2013: 1 · 2012: 3
FWCI: 2.28
Type: journal article
Language: en
Open access: closed
Licence: www.cambridge.org/core/terms (unspecified, 9012 d)
Locations: The British Journal of Psychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords: melancholia, major depressive disorder, cell-mediated immunity, delayed-type hypersensitivity, in vivo immune response, depression subtypes, weight loss, depression severity, age
MeSH terms: Age Factors, Aged, Depressive Disorder, Female, Humans, Immunity, Cellular, Lymphocyte Activation, Lymphocytes, Male, Middle Aged, Phytohemagglutinins, Psychiatric Status Rating Scales, Severity of Illness Index, Skin Tests, Weight Loss

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Impaired In Vivo Immune Responses in Patients with Melancholia

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