Cytokine production in major depressed patients before and after clomipramine treatment

Weizman, Ronit; Laor, Nathaniel; Podliszewski, Eduardo; Notti, Ida; Djaldetti, Meir; Bessler, Hanna

doi:10.1016/0006-3223(94)91166-5

Cited by 126Tryptophan and brain disordersStress Responses and CortisolTreatment of Major Depression

Cytokine production in major depressed patients before and after clomipramine treatment

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Weizman, Ronit, Laor, Nathaniel, Podliszewski, Eduardo, Notti, Ida, Djaldetti, Meir, Bessler, Hanna·1994·Biological Psychiatry

DOI 10.1016/0006-3223(94)91166-5

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Abstract

Cytokine production by peripheral blood mononuclear cells (PBMC) was assessed in 10 major depressed patients (5 men and 5 women) before and after 4 weeks of clomipramine treatment and in age- and gender-matched healthy controls. A significant reduction in interleukin-1B (IL-1B), interleukin-2 (IL-2) and interleukin-3-like activity (IL-3-LA) was observed in untreated depressed patients when compared to controls. IL-1B and IL-3-LA synthesis was significantly increased after drug treatment. The suppression of cytokine production by PBMC in depressed patients may be attributed to the depression per se, or it may be related to depression-associated hyperactivity of the hypothalamic-pituitary-adrenal axis. The mode of interaction between depression and cellular immune function and the mediators responsible for the reduced cytokine production need to be studied further.

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Authors: Weizman, R., Laor, N., Podliszewski, E., Notti, I., Djaldetti, M., & Bessler, H.
Affiliations: Tel Aviv University (IL)
Corresponding author: Weizman, Ronit
ORCID: Bessler, Hanna
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 1994-01
Volume: 35
Issue: 1
Pages: 42-47
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/0006-3223(94)91166-5
OpenAlex: W1998153328
Cited by: 126
References: 48
Citations by year: 2025: 4 · 2024: 2 · 2021: 2 · 2020: 3 · 2019: 5 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 1 · 2013: 1 · 2012: 2
FWCI: 1.86
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor, 3362 d)
Locations: Biological Psychiatry (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords: major depressive disorder, clomipramine, cytokine production, peripheral blood mononuclear cells, IL-1β, interleukin-2, cellular immune function, hypothalamic-pituitary-adrenal axis, antidepressant treatment
MeSH terms: Adult, Aged, Clomipramine, Depressive Disorder, Female, Humans, Interleukin-1, Interleukin-2, Interleukin-3, Interleukins, Male, Middle Aged, Monocytes

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Cytokine production in major depressed patients before and after clomipramine treatment

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