Cited by 448Anxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesMental Health Treatment and AccessChild and Adolescent Psychosocial and Emotional Development

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Lifetime panic–depression comorbidity in the National Comorbidity Survey: Association with symptoms, impairment, course and help-seeking

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Roy-Byrne, Peter P., Stang, Paul, Wittchen, Hans-Ulrich, Ustun, Bedirhan, Walters, Ellen E., Kessler, Ronald C.·2000·British Journal of Psychiatry

DOI 10.1192/bjp.176.3.229

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Abstract

Background: Most prior studies of panic-depression comorbidity have been limited methodologically by use of small clinical samples and incomplete analyses. Aims: General population data were used to study the association of lifetime and recent (12 months) panic–depression comorbidity with symptom severity, impairment, course and help-seeking in the National Comorbidity Survey (NCS). Method: The NCS is a nationally representative survey of the prevalences and correlates of major DSM–III–R disorders in the US household population. Results: Strong lifetime and current comorbidity were found between panic and depression. Comorbidity was associated with greater symptom severity, persistence, role impairment, suicidality and help-seeking, with many findings persisting after controlling for additional comorbid diagnoses. Findings did not differ according to which disorder was chronologically primary. Conclusions: Both lifetime and current panic–depression comorbidity are markers for more severe, persistent and disabling illness. Neither additional comorbid diagnoses nor the primary–secondary distinction were important moderators of these associations.

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Authors: Roy-Byrne, P. P., Stang, P., Wittchen, H.-U., Ustun, B., Walters, E. E., & Kessler, R. C.
Affiliations: University of North Carolina at Chapel Hill (US)
Harvard University (US)
ORCID: Stang, Paul
Walters, Ellen E.
Kessler, Ronald C.
Venue: British Journal of Psychiatry
Publisher: Royal College of Psychiatrists
Published: 2000-03
Volume: 176
Issue: 3
Pages: 229-235
ISSN: 0007-1250 (ISSN-L)
1472-1465
DOI: 10.1192/bjp.176.3.229
OpenAlex: W2004030076
Cited by: 446
References: 29
Citations by year: 2026: 4 · 2025: 6 · 2024: 3 · 2023: 6 · 2022: 27 · 2021: 14 · 2020: 13 · 2019: 15 · 2018: 14 · 2017: 16 · 2016: 15 · 2015: 19 · 2014: 25 · 2013: 22 · 2012: 26
FWCI: 28.57
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.cambridge.org/core/terms (unspecified, 6516 d)
Locations: The British Journal of Psychiatry (publishedVersion)
PubMed (publishedVersion)
Max Planck Institute for Plasma Physics (submittedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion)
Funders: National Institutes of Health (5r01mh052861-04)
National Institute of Mental Health (MH52861, R01 MH52861, K05 MH 00507, R01MH046376, MH 00507, MH-49098, R01 MH46376, MH 46376, 90135190, R01-MH49098, R01MH049098)
Topics: Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Keywords: panic disorder, depression, comorbidities, symptom severity, role impairment, suicidality, help-seeking, clinical course, National Comorbidity Survey
MeSH terms: Adolescent, Adult, Depression, Female, Health Surveys, Humans, Male, Middle Aged, Patient Acceptance of Health Care, Severity of Illness Index, United States, Comorbidity, Prevalence, Panic Disorder, Age of Onset

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Lifetime panic–depression comorbidity in the National Comorbidity Survey: Association with symptoms, impairment, course and help-seeking

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