The DOI matches its Crossref record; 29 of the 30 references it cites were found in a registry or an index.
Fluoxetine therapy in depersonalisation disorder: Randomised controlled trial
Open accessAbstract
Background: Despite anecdotal reports that serotonin reuptake inhibitors may improve depersonalisation, there is no proven efficacious treatment for depersonalisation disorder. Aims: To investigate the efficacy of fluoxetine in the treatment of depersonalisation disorder. Method: Fifty-four people who met DSM-IV criteria for depersonalisation disorder were recruited through newspaper advertisements, and 50 were randomised to a 10-week, double-blind trial of fluoxetine 10–60 mg/day or placebo. Primary outcome measures were the Dissociative Experiences Scale-epersonalisation Factor, the Depersonalization Severity Scale and the Clinical Global Impression-Improvement (CGI-1) scale. Results: Intention-to-treat analysis revealed that fluoxetine (mean dosage 48 mg/day) was not superior to placebo except for a clinically minimal but statistically significantly greater improvement in CGI-I score in the fluoxetine group prior to covarying for anxiety and depression (2.9 v. 3.6). Depersonalisation was significantly more likely to improve if comorbid anxiety disorder improved. Conclusions: Fluoxetine was not efficacious in treating depersonalisation disorder, despite the commonly reported clinical use of serotonin reuptake inhibitors for this condition.
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Metadata
- Authors
- Simeon, D., Guralnik, O., Schmeidler, J., & Knutelska, M.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Simeon, Daphne
- ORCID
- Schmeidler, James
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 2004-07
- Volume
- 185
- Issue
- 1
- Pages
- 31-36
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- OpenAlex
- W2165981166
- Cited by
- 78
- References
- 30
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 8 · 2023: 4 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 1 · 2017: 4 · 2016: 2 · 2015: 2 · 2014: 4 · 2013: 6 · 2012: 6
- FWCI
- 2.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The British Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eli Lilly and Company
- National Institute of Mental Health (R29MH055582, MH055582)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
- Keywords
- fluoxetine, serotonin reuptake inhibitors, dissociative disorders, treatment efficacy, comorbid anxiety disorders, Dissociative Experiences Scale, CGI-I
- MeSH terms
- Adult, Depersonalization, Double-Blind Method, Female, Fluoxetine, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Treatment Outcome, Selective Serotonin Reuptake Inhibitors
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