Acute effects of treatment for prodromal symptoms for people putatively in a late initial prodromal state of psychosis
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Background: People in a putatively late prodromal state not only have an enhanced risk for psychosis but already suffer from mental and functional disturbances Aims: To evaluate the acute effects of a combined supportive and antipsychotic treatment on prodromal symptoms Method: Putatively prodromal individuals were randomly assigned to a needs-focused intervention without (n=59) or with amisulpride (n=65). Outcome measures at 12-weeks effects were prodromal symptoms, global functioning and extrapyramidal side-effects Results: Amisulpride plus the needs-focused intervention produced superior effects on attenuated and full-blown psychotic symptoms, basic, depressive and negative symptoms, and global functioning. Main side-effects were prolactin associated Conclusions: Coadministration of amisulpride yielded a marked symptomatic benefit. Effects require confirmation by a placebo-controlled study
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The Stafford et al meta-analysis analyzed 11 studies, but one was open-label and another did not use standard clinical high risk for psychosis criteria, leaving nine studies with 1,043 patients in common with the current study.
“For example, the metaanalysis by Stafford et al 15 -on which current clinical guidelines are based -analyzed 11 studies, but one of them included an open-label trial (N5124) 94 and another did not assess participants against standard CHR-P criteria (N579) 20 , leaving nine studies (N51,043) that are in common with the current”
From Lack of evidence to favor specific preventive interventions in psychosis: a network meta‐analysis (2018) · cites this paper as [94]
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- Authors
- Ruhrmann, S., Bechdolf, A., Kühn, K.-U., Wagner, M., Schultze-Lutter, F., Janssen, B., Maurer, K., Häfner, H., Gaebel, W., Möller, H.-J., Maier, W., & Klosterkötter, J.
- Affiliations
- University of Cologne (DE)
- University of Bonn (DE)
- Heinrich Heine University Düsseldorf (DE)
- Ludwig-Maximilians-Universität München (DE)
- Corresponding author
- Ruhrmann, Stephan
- ORCID
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 2007-12
- Volume
- 191
- Issue
- S51
- Pages
- s88-s95
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- OpenAlex
- W2020819504
- Cited by
- 150
- References
- 33
- Citations by year
- 2026: 2 · 2025: 2 · 2023: 1 · 2022: 3 · 2021: 5 · 2020: 7 · 2019: 7 · 2018: 4 · 2017: 2 · 2016: 13 · 2015: 13 · 2014: 12 · 2013: 12 · 2012: 12
- FWCI
- 7.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The British Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Sanofi
- Bundesministerium für Bildung und Forschung
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Keywords
- prodromal psychosis, amisulpride, antipsychotic drugs, support measures, attenuated psychotic symptoms, negative symptoms, depressive symptoms, global functioning, extrapyramidal symptoms, prolactin
- MeSH terms
- Amisulpride, Adolescent, Adult, Combined Modality Therapy, Drug Administration Schedule, Female, Humans, Male, Psychiatric Status Rating Scales, Psychotic Disorders, Schizophrenia, Schizotypal Personality Disorder, Sulpiride, Antipsychotic Agents, Treatment Outcome, Needs Assessment, Early Diagnosis
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