Cited by 150Schizophrenia research and treatmentBipolar Disorder and TreatmentMaternal Mental Health During Pregnancy and Postpartum

Acute effects of treatment for prodromal symptoms for people putatively in a late initial prodromal state of psychosis

Open access
Ruhrmann, Stephan, Bechdolf, Andreas, Kühn, Kai-Uwe, Wagner, Michael, Schultze-Lutter, Frauke, Janssen, Birgit, Maurer, Kurt, Häfner, Heinz +4 more·2007·British Journal of Psychiatry

Abstract

Background: People in a putatively late prodromal state not only have an enhanced risk for psychosis but already suffer from mental and functional disturbances Aims: To evaluate the acute effects of a combined supportive and antipsychotic treatment on prodromal symptoms Method: Putatively prodromal individuals were randomly assigned to a needs-focused intervention without (n=59) or with amisulpride (n=65). Outcome measures at 12-weeks effects were prodromal symptoms, global functioning and extrapyramidal side-effects Results: Amisulpride plus the needs-focused intervention produced superior effects on attenuated and full-blown psychotic symptoms, basic, depressive and negative symptoms, and global functioning. Main side-effects were prolactin associated Conclusions: Coadministration of amisulpride yielded a marked symptomatic benefit. Effects require confirmation by a placebo-controlled study

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1192/bjp.191.51.s88

Cites

33 of 33 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The Stafford et al meta-analysis analyzed 11 studies, but one was open-label and another did not use standard clinical high risk for psychosis criteria, leaving nine studies with 1,043 patients in common with the current study.

    “For example, the metaanalysis by Stafford et al 15 -on which current clinical guidelines are based -analyzed 11 studies, but one of them included an open-label trial (N5124) 94 and another did not assess participants against standard CHR-P criteria (N579) 20 , leaving nine studies (N51,043) that are in common with the current”

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Ruhrmann, S., Bechdolf, A., Kühn, K.-U., Wagner, M., Schultze-Lutter, F., Janssen, B., Maurer, K., Häfner, H., Gaebel, W., Möller, H.-J., Maier, W., & Klosterkötter, J.
Affiliations
  • University of Cologne (DE)
  • University of Bonn (DE)
  • Heinrich Heine University Düsseldorf (DE)
  • Ludwig-Maximilians-Universität München (DE)
Corresponding author
Ruhrmann, Stephan
Venue
British Journal of Psychiatry
Published
2007-12
Volume
191
Issue
S51
Pages
s88-s95
ISSN
  • 0007-1250 (ISSN-L)
  • 1472-1465
OpenAlex
W2020819504
Cited by
150
References
33
Citations by year
2026: 2 · 2025: 2 · 2023: 1 · 2022: 3 · 2021: 5 · 2020: 7 · 2019: 7 · 2018: 4 · 2017: 2 · 2016: 13 · 2015: 13 · 2014: 12 · 2013: 12 · 2012: 12
FWCI
7.67
Type
journal article
Language
en
Open access
Locations
  • The British Journal of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Sanofi
  • Bundesministerium für Bildung und Forschung
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Keywords
prodromal psychosis, amisulpride, antipsychotic drugs, support measures, attenuated psychotic symptoms, negative symptoms, depressive symptoms, global functioning, extrapyramidal symptoms, prolactin
MeSH terms
Amisulpride, Adolescent, Adult, Combined Modality Therapy, Drug Administration Schedule, Female, Humans, Male, Psychiatric Status Rating Scales, Psychotic Disorders, Schizophrenia, Schizotypal Personality Disorder, Sulpiride, Antipsychotic Agents, Treatment Outcome, Needs Assessment, Early Diagnosis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review