Cited by 298Schizophrenia research and treatmentGenetic Associations and EpidemiologyGenomic variations and chromosomal abnormalities

The DOI matches its Crossref record; 85 of the 85 references it cites were found in a registry or an index.

Schizophrenia: a common disease caused by multiple rare alleles

Open access

McClellan, Jon M., Susser, Ezra, King, Mary-Claire·2007·British Journal of Psychiatry

DOI 10.1192/bjp.bp.106.025585

Open this paper in CoChat — free account Open PDF

Abstract

Summary: Schizophrenia is widely held to stem from the combined effects of multiple common polymorphisms, each with a small impact on disease risk. We suggest an alternative view: that schizophrenia is highly heterogeneous genetically and that many predisposing mutations are highly penetrant and individually rare, even specific to single cases or families. This ‘common disease – rare alleles' hypothesis is supported by recent findings in human genomics and by allelic and locus heterogeneity for other complex traits. We review the implications of this model for gene discovery research in schizophrenia.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1192/bjp.bp.106.025585

Cites

85 of 85 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Initial sequencing and analysis of the human genome
International Human Genome Sequencing Consortium, Whitehead Institute for Biomedical Research, C. F. G. R., Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., et al. (2001) · Nature · doi:10.1038/35057062 · Cited by 24,216
Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
Jaenisch, R., & Bird, A. (2003) · Nature Genetics · doi:10.1038/ng1089 · Cited by 6,325
Finishing the euchromatic sequence of the human genome
International Human Genome Sequencing Consortium (2004) · Nature · doi:10.1038/nature03001 · Cited by 4,971
Cancer genes and the pathways they control
Vogelstein, B., & Kinzler, K. W. (2004) · Nature Medicine · doi:10.1038/nm1087 · Cited by 4,346
Epigenetic differences arise during the lifetime of monozygotic twins
Fraga, M. F., Ballestar, E., Paz, M. F., Ropero, S., Setien, F., Ballestar, M. L., Heine-Suñer, D., Cigudosa, J. C., Urioste, M., Benitez, J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500398102 · Cited by 3,602
The History and Geography of Human Genes
Cavalli-Sforza, L. L., Menozzi, P., & Piazza, A. (2018) · Princeton University Press eBooks · doi:10.2307/j.ctv301gjp · Cited by 3,175
Large-scale copy number polymorphism in the human genome
Sebat, J., Lakshmi, B., Troge, J., Alexander, J., Young, J., Lundin, P., Månér, S., Massa, H., Walker, M., Chi, M., et al. (2004) · Science · doi:10.1126/science.1098918 · Cited by 2,557
Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence
Harrison, P. J., & Weinberger, D. R. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001558 · Cited by 2,020
The UCSC Genome Browser Database: update 2006
Hinrichs, A. S. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkj144 · Cited by 1,646
History and Geography of Human Genes
Piazza, A. (1994) · Advances in forensic haemogenetics · doi:10.1007/978-3-642-78782-9_1 · Cited by 1,639
Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease
Botstein, D., & Risch, N. (2003) · Nature Genetics · doi:10.1038/ng1090 · Cited by 1,503
The history and geography of human genes
Cann, R. L. (1995) · Choice Reviews Online · doi:10.5860/choice.33-0316 · Cited by 1,328
Linkage strategies for genetically complex traits. I. Multilocus models.
RISCH, N. J. (1990) · PubMed · Cited by 1,315
Disruption of two novel genes by a translocation co-segregating with schizophrenia
Millar, J. K. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.9.1415 · Cited by 1,254
Schizophrenia: The epigenetic puzzle
Haier, R. J. (1982) · Psychiatry Research · doi:10.1016/0165-1781(92)90099-o · Cited by 1,171
Multiple Rare Alleles Contribute to Low Plasma Levels of HDL Cholesterol
Cohen, J. C., Kiss, R. S., Pertsemlidis, A., Marcel, Y. L., McPherson, R., & Hobbs, H. H. (2004) · Science · doi:10.1126/science.1099870 · Cited by 1,108
Segmental Duplications and Copy-Number Variation in the Human Genome
Sharp, A. J., Locke, D. P., McGrath, S. D., Cheng, Z., Bailey, J. A., Vallente, R. U., Pertz, L. M., Clark, R. A., Schwartz, S., Segraves, R., et al. (2005) · The American Journal of Human Genetics · doi:10.1086/431652 · Cited by 983
The origins, patterns and implications of human spontaneous mutation
Crow, J. F. (2000) · Nature Reviews Genetics · doi:10.1038/35049558 · Cited by 928
A physical map of the human genome
McPherson, J. D., Marra, M. A., Hillier, L., Waterston, R., Chinwalla, A., Wallis, J. W., Sekhon, M., Wylie, K. M., Mardis, E. R., Wilson, R. K., et al. (2001) · Nature · doi:10.1038/35057157 · Cited by 925
Genetic Variation in the 6p22.3 Gene DTNBP1, the Human Ortholog of the Mouse Dysbindin Gene, Is Associated with Schizophrenia
Straub, R. E., Jiang, Y., MacLean, C. J., Ma, Y., Webb, B. T., Myakishev, M. V., Harris‐Kerr, C., Wormley, B., Sadek, H., Kadambi, B., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/341750 · Cited by 867
Rates of Adult Schizophrenia Following Prenatal Exposure to the Chinese Famine of 1959-1961
Clair, D. S. (2005) · JAMA · doi:10.1001/jama.294.5.557 · Cited by 817
Schizophrenia After Prenatal Famine
Susser, E. (1996) · Archives of General Psychiatry · doi:10.1001/archpsyc.1996.01830010027005 · Cited by 741
Self-citation
Association within a family of a balanced autosomal translocation with major mental illness
St Clair, D., Blackwood, D., Muir, W., Walker, M., St Clair, D., Muir, W., Carothers, A., Spowart, G., Gosden, C., & Evans, H. J. (1990) · The Lancet · doi:10.1016/0140-6736(90)91520-k · Cited by 727
Spectrum of Mutations in BRCA1, BRCA2, CHEK2, and TP53 in Families at High Risk of Breast Cancer
Walsh, T., Casadei, S., Coats, K. H., Swisher, E. M., Stray, S. M., Higgins, J., Roach, K. C., Mandell, J. B., Lee, M. K., Čierniková, S., et al. (2006) · JAMA · doi:10.1001/jama.295.12.1379 · Cited by 673
Self-citation
DISC1 and PDE4B Are Interacting Genetic Factors in Schizophrenia That Regulate cAMP Signaling
Millar, J. K., Pickard, B. S., Mackie, S., James, R., Christie, S., Buchanan, S. R., Malloy, M. P., Chubb, J. E., Huston, E., Baillie, G. S., et al. (2005) · Science · doi:10.1126/science.1112915 · Cited by 648
Population genetics—making sense out of sequence
Chakravarti, A. (1999) · Nature Genetics · doi:10.1038/4482 · Cited by 631
Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21
Blouin, J., Dombroski, B. A., Nath, S. K., Lasseter, V. K., Wolyniec, P. S., Nestadt, G., Thornquist, M. H., Ullrich, G., McGrath, J. A., Kasch, L. M., et al. (1998) · Nature Genetics · doi:10.1038/1734 · Cited by 531
Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia
Callicott, J. H., Straub, R. E., Pezawas, L., Egan, M. F., Mattay, V. S., Hariri, A. R., Verchinski, B. A., Meyer‐Lindenberg, A., Balkissoon, R., Kolachana, B. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500515102 · Cited by 519
Location of a Major Susceptibility Locus for Familial Schizophrenia on Chromosome 1q21-q22
Brzustowicz, L. M., Hodgkinson, K. A., Chow, E. W. C., Honer, W. G., & Bassett, A. S. (2000) · Science · doi:10.1126/science.288.5466.678 · Cited by 516
A potential vulnerability locus for schizophrenia on chromosome 6p24–22: evidence for genetic heterogeneity
Straub, R. E., MacLean, C. J., O’Neill, F. A., Burke, J. G., Murphy, B. M., Duke, F., Shinkwin, R., Webb, B. T., Zhang, J., Walsh, D., et al. (1995) · Nature Genetics · doi:10.1038/ng1195-287 · Cited by 452
Disrupted in Schizophrenia 1 (DISC1): Association with Schizophrenia, Schizoaffective Disorder, and Bipolar Disorder
Hodgkinson, C. A., Goldman, D. A., Jaeger, J., Persaud, S. D., Kane, J. M., Lipsky, R. H., & Malhotra, A. K. (2004) · The American Journal of Human Genetics · doi:10.1086/425586 · Cited by 442
Phenotypic differences in genetically identical organisms: the epigenetic perspective.
Wong, A., Gottesman, I., & Petronis, A. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi116 · Cited by 438
High genomic deleterious mutation rates in hominids
Eyre‐Walker, A., & Keightley, P. D. (1999) · Nature · doi:10.1038/16915 · Cited by 404
Multiple rare variants in NPC1L1 associated with reduced sterol absorption and plasma low-density lipoprotein levels
Cohen, J. C., Pertsemlidis, A., Fahmi, S., Esmail, S., Vega, G. L., Grundy, S. M., & Hobbs, H. H. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508483103 · Cited by 380
Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophrenia.
Numakawa, T., Yagasaki, Y., Ishimoto, T., Okada, T., Suzuki, T., Iwata, N., Ozaki, N., Taguchi, T., Tatsumi, M., Kamijima, K., et al. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh280 · Cited by 373
Support for Association of Schizophrenia with Genetic Variation in the 6p22.3 Gene, Dysbindin, in Sib-Pair Families with Linkage and in an Additional Sample of Triad Families
Schwab, S. G., Knapp, M., Mondabon, S., Hallmayer, J. F., Borrmann-Hassenbach, M., Albus, M., Lerer, B., Rietschel, M., Trixler, M., Maier, W., et al. (2003) · The American Journal of Human Genetics · doi:10.1086/345463 · Cited by 353
Human Dysbindin (DTNBP1) Gene Expression inNormal Brain and in Schizophrenic Prefrontal Cortex and Midbrain
Weickert, C. S., Straub, R. E., McClintock, B., Matsumoto, M., Hashimoto, R., Hyde, T. M., Herman, M. M., Weinberger, D. R., & Kleinman, J. E. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.6.544 · Cited by 352
Association of DISC1/TRAX Haplotypes With Schizophrenia, Reduced Prefrontal Gray Matter, and Impaired Short- and Long-term Memory
Cannon, T. D., Hennah, W., van Erp, T. G. M., Thompson, P. M., Lonnqvist, J., Huttunen, M., Gasperoni, T., Tuulio-Henriksson, A., Pirkola, T., Toga, A. W., et al. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.11.1205 · Cited by 337
The molecular genetics of schizophrenia: new findings promise new insights
Owen, M. J., Williams, N. M., & O’Donovan, M. C. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001444 · Cited by 328
Haplotype transmission analysis provides evidence of association for DISC1 to schizophrenia and suggests sex-dependent effects
Hennah, W. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg341 · Cited by 325
Molecular Genetics of Hearing Loss
Petit, C., Levilliers, J., & Hardelin, J. (2001) · Annual Review of Genetics · doi:10.1146/annurev.genet.35.102401.091224 · Cited by 325
Chromosome 1 loci in Finnish schizophrenia families
Ekelund, J. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.15.1611 · Cited by 311
Paternal age and schizophrenia: a population based cohort study
Sipos, A., Rasmussen, F. E., Harrison, G. L., Tynelius, P., Lewis, G., Leon, D. A., & Gunnell, D. (2004) · BMJ · doi:10.1136/bmj.38243.672396.55 · Cited by 292
Disc1 is mutated in the 129S6/SvEv strain and modulates working memory in mice
Koike, H., Arguello, P. A., Kvajo, M., Karayiorgou, M., & Gogos, J. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511189103 · Cited by 277
The Epidemiology of Schizophrenia
Abstract, E. F. T. (2002) · Cambridge University Press eBooks · doi:10.1017/cbo9780511544118 · Cited by 275
Schizophrenia After Prenatal Famine
van Os, J. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830180095015 · Cited by 264
Human Nonsyndromic Sensorineural Deafness
Friedman, T. B., & Griffith, A. J. (2003) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.4.070802.110347 · Cited by 234
A frameshift mutation in Disrupted in Schizophrenia 1 in an American family with schizophrenia and schizoaffective disorder
Sachs, N. A., Sawa, A., Holmes, S. E., Ross, C. A., DeLisi, L. E., & Margolis, R. L. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001667 · Cited by 221
Paternal Age and Risk of Schizophrenia in Adult Offspring
Brown, A. S., Schaefer, C. A., Wyatt, R. J., Begg, M. D., Goetz, R. R., Bresnahan, M. A., Harkavy‐Friedman, J., Gorman, J. M., Malaspina, D., & Susser, E. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.9.1528 · Cited by 203
Self-citation
Parental Age and Risk of Schizophrenia
Byrne, M., Agerbo, E., Ewald, H., Eaton, W. W., & Mortensen, P. B. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.7.673 · Cited by 195
Identification in 2 Independent Samples of a Novel Schizophrenia RiskHaplotype of the Dystrobrevin Binding Protein Gene (DTNBP1)
Williams, N. M., Preece, A. C., Morris, D. W., Spurlock, G., Bray, N. J., Stephens, M., Norton, N., Williams, H. J., Clement, M., Dwyer, S., et al. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.4.336 · Cited by 187
Genomewide Linkage Scan in Schizoaffective Disorder
Hamshere, M. L., Bennett, P. R., Williams, N. M., Segurado, R., Cardno, A. G., Norton, N., Lambert, D., Williams, H. J., Kirov, G., Corvin, A. P., et al. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.10.1081 · Cited by 187
Haplotypes at the dystrobrevin binding protein 1 (DTNBP1) gene locus mediate risk for schizophrenia through reduced DTNBP1 expression
Bray, N. J., Preece, A. C., Williams, N. M., Moskvina, V., Buckland, P. R., Owen, M. J., & O’Donovan, M. C. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi199 · Cited by 186
Genetic heterogeneity, modifier genes, and quantitative phenotypes in psychiatric illness: searching for a framework
Fanous, A. H., & Kendler, K. S. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001571 · Cited by 175
Will the Genomics Revolution Revolutionize Psychiatry?
Merikangas, K. R., & RISCH, N. J. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.4.625 · Cited by 171
Association of the DTNBP1 Locus with Schizophrenia in a U.S. Population
Funke, B., Finn, C. T., Plocik, A. M., Lake, S. L., DeRosse, P., Kane, J. M., Kucherlapati, R., & Malhotra, A. K. (2004) · The American Journal of Human Genetics · doi:10.1086/425279 · Cited by 160
Strong evidence for association between the dystrobrevin binding protein 1 gene (DTNBP1) and schizophrenia in 488 parent-offspring trios from Bulgaria
Kirov, G., Ivanov, D. K., Williams, N. M., Preece, A. C., Nikolov, I., Milev, R., Koleva, S., Dimitrova, A., Toncheva, D. I., O’Donovan, M. C., et al. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.01.025 · Cited by 156
Paternal age and sporadic schizophrenia: Evidence for de novo mutations
Malaspina, D., Corcoran, C. M., Fahim, C., Berman, A., Harkavy‐Friedman, J., Yale, S. A., Goetz, D. M., Goetz, R. R., Harlap, S., & Gorman, J. M. (2002) · American Journal of Medical Genetics · doi:10.1002/ajmg.1701 · Cited by 140
Identification of Epilepsy Genes in Human and Mouse
Meisler, M. H., Kearney, J. A., Ottman, R., & Escayg, A. (2001) · Annual Review of Genetics · doi:10.1146/annurev.genet.35.102401.091142 · Cited by 138
H UMAN M IGRATIONS AND P OPULATION S TRUCTURE : What We Know and Why it Matters
Goldstein, D. B., & Chikhi, L. (2002) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.3.022502.103200 · Cited by 138
Paternal Age and Schizophrenia: Further Support for an Association
Dalman, C., & Allebeck, P. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.9.1591 · Cited by 136
Fertility of Patients With Schizophrenia, Their Siblings, and the General Population: A Cohort Study From 1950 to 1959 in Finland
Haukka, J., Suvisaari, J., & Lönnqvist, J. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.3.460 · Cited by 126
Identification of polymorphisms within Disrupted in Schizophrenia 1 and Disrupted in Schizophrenia 2, and an investigation of their association with schizophrenia and bipolar affective disorder
Devon, R. S., Anderson, S., Teague, P. W., Burgess, P., Kipari, T. M. J., Semple, C. A. M., Millar, J. K., Muir, W. J., Murray, V., Pelosi, A. J., et al. (2001) · Psychiatric Genetics · doi:10.1097/00041444-200106000-00003 · Cited by 124
Genetic Factors in Alzheimer's Disease
Bird, T. D. (2005) · New England Journal of Medicine · doi:10.1056/nejmp058027 · Cited by 122
Paternal and maternal age as risk factors for psychosis: findings from Denmark, Sweden and Australia
El-Saadi, O., Pedersen, C. B., McNeil, T. F., Saha, S., Welham, J., O’Callaghan, E., Cantor‐Graae, E., Chant, D. C., Mortensen, P. B., & McGrath, J. J. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(03)00100-2 · Cited by 107
DISC1 and neurocognitive function in schizophrenia
Burdick, K. E., Hodgkinson, C. A., Szeszko, P. R., Lencz, T., Ekholm, J. M., Kane, J. M., Goldman, D. A., & Malhotra, A. K. (2005) · Neuroreport · doi:10.1097/01.wnr.0000175248.25535.f6 · Cited by 105
A meta‐analysis of the MTHFR C677T polymorphism and schizophrenia risk
Lewis, S. J., Zammit, S., Gunnell, D., & Smith, G. D. (2005) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30170 · Cited by 100
Dysbindin (DTNBP1, 6p22.3) is Associated with Childhood-Onset Psychosis and Endophenotypes Measured by the Premorbid Adjustment Scale (PAS)
Gornick, M. C., Addington, A. M., Sporn, A. L., Gogtay, N., GREENSTEIN, D. K., Lenane, M., Gochman, P., Ordóñez, A. E., Balkissoon, R., Vakkalanka, R., et al. (2005) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-005-0028-3 · Cited by 85
Advanced paternal age associated with an elevated risk for schizophrenia in offspring in a Japanese population
Tsuchiya, K. J., Takagai, S., Kawai, M., Matsumoto, H., Nakamura, K., Minabe, Y., Mori, N., & Takei, N. (2005) · Schizophrenia Research · doi:10.1016/j.schres.2005.03.004 · Cited by 83
There's Something Curious About Paternal-Age Effects
Crow, J. F. (2003) · Science · doi:10.1126/science.1088552 · Cited by 74
Association study of polymorphisms in the 5′ upstream region of human DISC1 gene with schizophrenia
Kockelkorn, T. T. J. P., Arai, M., Matsumoto, H., Fukuda, N., Yamada, K., Minabe, Y., Toyota, T., Ujike, H., Sora, I., Mori, N., et al. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.06.048 · Cited by 70
Maternal Famine, De Novo Mutations, and Schizophrenia
McClellan, J. M., Susser, E., & King, M. (2006) · JAMA · doi:10.1001/jama.296.5.582 · Cited by 69
Self-citation
Resampling‐based multiple hypothesis testing procedures for genetic case‐control association studies
Chen, B. E., Sakoda, L. C., Hsing, A. W., & Rosenberg, P. S. (2006) · Genetic Epidemiology · doi:10.1002/gepi.20162 · Cited by 65
Do Maternal Folate and Homocysteine Levels Play a Role in Neurodevelopmental Processes That Increase Risk for Schizophrenia?
Picker, J. D., & Coyle, J. T. (2005) · Harvard Review of Psychiatry · doi:10.1080/10673220500243372 · Cited by 65
Association study of the locus with schizophrenia in a Japanese population
Zhang, X., Tochigi, M., Ohashi, J., Maeda, K., Kato, T., OKAZAKI, Y., Kato, N., TOKUNAGA, K., Sawa, A., & Sasaki, T. (2005) · Schizophrenia Research · doi:10.1016/j.schres.2005.05.023 · Cited by 55
Linkage disequlibrium in the DTNBP1 (dysbindin) gene region and on chromosome 1p36 among psychotic patients from a genetic isolate in Israel: Findings from identity by descent haplotype sharing analysis
Kohn, Y., Danilovich, E., Filon, D., Oppenheim, A., Karni, O., Kanyas, K., Turetsky, N., Korner, M., & Lerer, B. (2004) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30044 · Cited by 48
22q11 DS: genomic mechanisms and gene function in DiGeorge/velocardiofacial syndrome
Maynard, T. M., Haskell, G., Lieberman, J. A., & LaMantia, A. (2002) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(02)00050-3 · Cited by 47
Serum dopamine-beta-hydroxylase activity: Clinical applications in child psychiatry
Young, J. G., Kyprie, R. M., Ross, N. T., & Cohen, D. J. (1980) · Journal of Autism and Developmental Disorders · doi:10.1007/bf02408428 · Cited by 37
Prenatal and perinatal risk factors for schizophrenia
Cannon, M. D., Kendell, R. E., Susser, E., & Jones, P. B. (2002) · Cambridge University Press eBooks · doi:10.1017/cbo9780511544118.009 · Cited by 36
Self-citation
Reduced fertility in schizophrenia: here to stay?
Nimgaonkar, V. L. (1998) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1998.tb10097.x · Cited by 34
Evidence that a DISC1 frame-shift deletion associated with psychosis in a single family may not be a pathogenic mutation
Green, E., Norton, N., Peirce, T., Grozeva, D., Kirov, G., Owen, M. J., O’Donovan, M. C., & Craddock, N. J. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001853 · Cited by 27
Medicare Part D: early findings on enrollment and choices for rural beneficiaries.
McBride, T. D., Terry, T. L., & Mueller, K. J. (2006) · PubMed · Cited by 23
Mutation analysis of the human dystrobrevin-binding protein 1 gene in schizophrenic patients
Liao, H. (2004) · Schizophrenia Research · doi:10.1016/j.schres.2003.11.002 · Cited by 18
A long-range restriction map across 3 Mb of the chromosome 11 breakpoint region of a translotion linked to schizophrenia
Millar, J. K., Brown, J. L., Maule, J. C., Shibasaki, Y., CHRISTIE, S., Lawson, D., Anderson, S. M., Wilson-Annan, J. C., Devon, R. S., Clair, D. M. S., et al. (1998) · Psychiatric Genetics · doi:10.1097/00041444-199800830-00007 · Cited by 15
The Genetics of Common Diseases: 10 Million Times as HardPreprint
Goldstein, D. B., Cavalleri, G. L., & Ahmadi, K. R. (2003) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2003.68.395 · Cited by 10

Flagged first, then by citations

Sorted by citations

Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
The International Schizophrenia Consortium (2009) · Nature · doi:10.1038/nature08185 · Cited by 4,821
Five Years of GWAS Discovery
Visscher, P. M., Brown, M. A., McCarthy, M. I., & Yang, J. (2012) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.11.029 · Cited by 2,425
Rare Structural Variants Disrupt Multiple Genes in Neurodevelopmental Pathways in Schizophrenia
Walsh, T., McClellan, J. M., McCarthy, S. E., Addington, A. M., Pierce, S. B., Cooper, G. M., Nord, A. S., Kusenda, M., Malhotra, D., Bhandari, A., et al. (2008) · Science · doi:10.1126/science.1155174 · Cited by 1,800
Self-citation
De novo mutations in schizophrenia implicate synaptic networks
Fromer, M., Pocklington, A. J., Kavanagh, D. H., Williams, H. J., Dwyer, S., Gormley, P., Georgieva, L., Rees, E., Palta, P., Ruderfer, D. M., et al. (2014) · Nature · doi:10.1038/nature12929 · Cited by 1,617
Rare and common variants: twenty arguments
Gibson, G. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3118 · Cited by 1,278

See all 298

Authors: McClellan, J. M., Susser, E., & King, M.-C.
Affiliations: University of Washington (US)
New York State Psychiatric Institute (US)
Corresponding author: McClellan, Jon M.
ORCID: McClellan, Jon M.
Susser, Ezra
King, Mary-Claire
Venue: British Journal of Psychiatry
Publisher: Royal College of Psychiatrists
Published: 2007-03
Volume: 190
Issue: 3
Pages: 194-199
ISSN: 0007-1250 (ISSN-L)
1472-1465
DOI: 10.1192/bjp.bp.106.025585
OpenAlex: W2114381854
Cited by: 296
References: 85
Citations by year: 2026: 1 · 2025: 1 · 2024: 5 · 2023: 2 · 2022: 6 · 2021: 7 · 2020: 10 · 2019: 7 · 2018: 1 · 2017: 7 · 2016: 13 · 2015: 14 · 2014: 16 · 2013: 24 · 2012: 23
FWCI: 5.58
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.cambridge.org/core/terms (unspecified, 3960 d)
Locations: The British Journal of Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5k20mh001120-05)
National Institute of Mental Health (MH 01120)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
Keywords: schizophrenia, genetic heterogeneity, locus heterogeneity, allelic heterogeneity, rare mutations, penetrance, genetic susceptibility, gene discovery, complex traits
MeSH terms: Alleles, Humans, Genetic Linkage, Mutation, Nerve Tissue Proteins, Polymorphism, Genetic, RNA, Messenger, Schizophrenia, Genome, Human, Genetic Predisposition to Disease, Biomedical Research, RNA, Long Noncoding

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Schizophrenia: a common disease caused by multiple rare alleles

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks