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Twenty-five year mortality of a community cohort with schizophrenia
Open accessAbstract
Background: People with schizophrenia have significantly raised mortality but we do not know how these mortality patterns in the UK have changed since the 1990s. Aims: To measure the 25-year mortality of people with schizophrenia with particular focus on changes over time. Method: Prospective record linkage study of the mortality of a community cohort of 370 people with schizophrenia. Results: The cohort had an all-cause standardised mortality ratio of 289 (95% CI 247–337). Most deaths were from the common causes seen in the general population. Unnatural deaths were concentrated in the first 5 years of follow-up. There was an indication that cardiovascular mortality may have increased relative to the general population ( P = 0.053) over the course of the study. Conclusions: People with schizophrenia have a mortality risk that is two to three times that of the general population. Most of the extra deaths are from natural causes. The apparent increase in cardiovascular mortality relative to the general population should be of concern to anyone with an interest in mental health.
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“Death rates are increased in people with severe mental illness (SMI) relative to the general population, and this is reflected in the 10- to 20-year reduced life expectancy observed.1–3”
From Mortality gap for people with bipolar disorder and schizophrenia: UK-based cohort study 2000–2014 (2017) · cites this paper as [1]
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“The same widening of the mortality gap was found in another Danish study (Nielsen et al. 2013b) and in a study from the United Kingdom (Brown et al. 2010).”
From Excess early mortality in schizophrenia. (2014) · cites this paper as Brown et al. 2010
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“In the British study, an MRR of 2 to 3 was found.”
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Metadata
- Authors
- Brown, S., Kim, M., Mitchell, C., & Inskip, H.
- Affiliations
- Southern Health NHS Foundation Trust (GB)
- University of Southampton (GB)
- Corresponding author
- Brown, Steve
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 2010-02
- Volume
- 196
- Issue
- 2
- Pages
- 116-121
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- PMC
- PMC4560167
- OpenAlex
- W2117811890
- Cited by
- 601
- References
- 30
- Citations by year
- 2026: 7 · 2025: 20 · 2024: 39 · 2023: 29 · 2022: 24 · 2021: 37 · 2020: 36 · 2019: 43 · 2018: 45 · 2017: 39 · 2016: 46 · 2015: 50 · 2014: 42 · 2013: 62 · 2012: 42
- FWCI
- 30.97
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The British Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Keywords
- schizophrenia, mortality, all-cause mortality, cardiovascular mortality, unnatural death, natural death, mortality trends, community-based cohort, data linkage
- MeSH terms
- Adolescent, Adult, Aged, Cardiovascular Diseases, England, Epidemiologic Methods, Female, Humans, Male, Middle Aged, Mortality, Schizophrenia, Sex Factors, Smoking, Young Adult
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