Cited by 601Schizophrenia research and treatmentMental Health Treatment and AccessSuicide and Self-Harm Studies

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Twenty-five year mortality of a community cohort with schizophrenia

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Brown, Steve, Kim, Miranda, Mitchell, Clemence, Inskip, Hazel·2010·British Journal of Psychiatry

DOI 10.1192/bjp.bp.109.067512PMC PMC4560167

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Abstract

Background: People with schizophrenia have significantly raised mortality but we do not know how these mortality patterns in the UK have changed since the 1990s. Aims: To measure the 25-year mortality of people with schizophrenia with particular focus on changes over time. Method: Prospective record linkage study of the mortality of a community cohort of 370 people with schizophrenia. Results: The cohort had an all-cause standardised mortality ratio of 289 (95% CI 247–337). Most deaths were from the common causes seen in the general population. Unnatural deaths were concentrated in the first 5 years of follow-up. There was an indication that cardiovascular mortality may have increased relative to the general population ( P = 0.053) over the course of the study. Conclusions: People with schizophrenia have a mortality risk that is two to three times that of the general population. Most of the extra deaths are from natural causes. The apparent increase in cardiovascular mortality relative to the general population should be of concern to anyone with an interest in mental health.

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Authors: Brown, S., Kim, M., Mitchell, C., & Inskip, H.
Affiliations: Southern Health NHS Foundation Trust (GB)
University of Southampton (GB)
Corresponding author: Brown, Steve
ORCID: Kim, Miranda
Inskip, Hazel
Venue: British Journal of Psychiatry
Publisher: Royal College of Psychiatrists
Published: 2010-02
Volume: 196
Issue: 2
Pages: 116-121
ISSN: 0007-1250 (ISSN-L)
1472-1465
DOI: 10.1192/bjp.bp.109.067512
PMC: PMC4560167
OpenAlex: W2117811890
Cited by: 601
References: 30
Citations by year: 2026: 7 · 2025: 20 · 2024: 39 · 2023: 29 · 2022: 24 · 2021: 37 · 2020: 36 · 2019: 43 · 2018: 45 · 2017: 39 · 2016: 46 · 2015: 50 · 2014: 42 · 2013: 62 · 2012: 42
FWCI: 30.97
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.cambridge.org/core/terms (unspecified, 2892 d)
Locations: The British Journal of Psychiatry (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
ePrints Soton (University of Southampton) (submittedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
Keywords: schizophrenia, mortality, all-cause mortality, cardiovascular mortality, unnatural death, natural death, mortality trends, community-based cohort, data linkage
MeSH terms: Adolescent, Adult, Aged, Cardiovascular Diseases, England, Epidemiologic Methods, Female, Humans, Male, Middle Aged, Mortality, Schizophrenia, Sex Factors, Smoking, Young Adult

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Twenty-five year mortality of a community cohort with schizophrenia

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