Cited by 500Schizophrenia research and treatmentAutism Spectrum Disorder ResearchMental Health and Psychiatry

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Neurodevelopmental hypothesis of schizophrenia

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Owen, Michael J., O'Donovan, Michael C., Thapar, Anita, Craddock, Nicholas·2011·British Journal of Psychiatry

DOI 10.1192/bjp.bp.110.084384PMC PMC3764497

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Abstract

Summary: The neurodevelopmental hypothesis of schizophrenia provided a valuable framework that allowed a condition that usually presents with frank disorder in adolescence or early adulthood to be understood at least in part as a consequence of events occurring early in development. However, the implications of the neurodevelopmental hypothesis for nosological conceptions of the disorder can only now be fully appreciated. Recent research indicates genetic overlap between schizophrenia and syndromes in which psychopathology is manifest in childhood and that are often grouped together as ‘neurodevelopmental disorders' such as autism-spectrum disorders, intellectual disability and attention-deficit hyperactivity disorder. These findings challenge the aetiological basis of current diagnostic categories and, together with evidence for frequent comorbidity, suggest that we should view the functional psychoses as members of a group of related and overlapping syndromes that result in part from a combination of genetic and environmental effects on brain development and that are associated with specific and general impairments of cognitive function. This has important implications for future research and for the configuration of psychiatric services.

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Simonoff, E., Pickles, A., Charman, T., Chandler, S., Loucas, T., & Baird, G. (2008) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e318179964f · Cited by 3,399
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van Os, J., & Kapur, S. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60995-8 · Cited by 1,971
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Harrison, P. J. (1999) · Brain · doi:10.1093/brain/122.4.593 · Cited by 1,677
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Is schizophrenia a neurodevelopmental disorder?
Murray, R. M., & Lewis, S. W. (1988) · BMJ · doi:10.1136/bmj.296.6614.63 · Cited by 911
Is schizophrenia a neurodevelopmental disorder?
Murray, R. M., & Lewis, S. W. (1987) · BMJ · doi:10.1136/bmj.295.6600.681 · Cited by 889
Continuities and discontinuities in psychopathology between childhood and adult life
Rutter, M., Kim‐Cohen, J., & Maughan, B. (2006) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2006.01614.x · Cited by 824
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Cannon, M., Caspi, A., Moffitt, T. E., Harrington, H., Taylor, A., Murray, R. M., & Poulton, R. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.5.449 · Cited by 783
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Authors: Owen, M. J., O'Donovan, M. C., Thapar, A., & Craddock, N.
Affiliations: Cardiff University (GB)
Corresponding author: Owen, Michael J.
ORCID: Owen, Michael J.
Thapar, Anita
Venue: British Journal of Psychiatry
Publisher: Royal College of Psychiatrists
Published: 2011-03
Volume: 198
Issue: 3
Pages: 173-175
ISSN: 0007-1250 (ISSN-L)
1472-1465
DOI: 10.1192/bjp.bp.110.084384
PMC: PMC3764497
OpenAlex: W2046645276
Cited by: 500
References: 33
Citations by year: 2026: 18 · 2025: 28 · 2024: 26 · 2023: 25 · 2022: 42 · 2021: 49 · 2020: 38 · 2019: 49 · 2018: 25 · 2017: 36 · 2016: 17 · 2015: 33 · 2014: 32 · 2013: 35 · 2012: 36
FWCI: 24.88
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.cambridge.org/core/terms (unspecified, 2499 d)
Locations: The British Journal of Psychiatry (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion, other-oa)
PubMed Central (publishedVersion, other-oa)
PubMed (publishedVersion)
Funders: Wellcome Trust (076113)
Cardiff University
Medical Research Council
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Keywords: schizophrenia, neurodevelopmental disorders, autism spectrum disorder, intellectual disability, attention deficit hyperactivity disorder, genetic overlap, comorbidities, functional psychoses, brain development, cognitive impairment, disease classification, etiology, mental health services
MeSH terms: Adolescent, Adult, Brain, Humans, Male, Intellectual Disability, Schizophrenia, Syndrome, Comorbidity, Genetic Predisposition to Disease, Young Adult

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