The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Neurodevelopmental hypothesis of schizophrenia
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Summary: The neurodevelopmental hypothesis of schizophrenia provided a valuable framework that allowed a condition that usually presents with frank disorder in adolescence or early adulthood to be understood at least in part as a consequence of events occurring early in development. However, the implications of the neurodevelopmental hypothesis for nosological conceptions of the disorder can only now be fully appreciated. Recent research indicates genetic overlap between schizophrenia and syndromes in which psychopathology is manifest in childhood and that are often grouped together as ‘neurodevelopmental disorders' such as autism-spectrum disorders, intellectual disability and attention-deficit hyperactivity disorder. These findings challenge the aetiological basis of current diagnostic categories and, together with evidence for frequent comorbidity, suggest that we should view the functional psychoses as members of a group of related and overlapping syndromes that result in part from a combination of genetic and environmental effects on brain development and that are associated with specific and general impairments of cognitive function. This has important implications for future research and for the configuration of psychiatric services.
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“The overlapping genetic predisposition by 16p11.2 CNVs to both SZ and more typical NDDs like ASD and ID appears to support a neurodevelopmental origin of SZ [46].”
From 16p11.2 Copy Number Variations and Neurodevelopmental Disorders (2020) · cites this paper as [46]
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Simonoff, E., Pickles, A., Charman, T., Chandler, S., Loucas, T., & Baird, G. (2008) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e318179964f · Cited by 3,399
Lichtenstein, P., Yip, B. H., Björk, C., Pawitan, Y., Cannon, T. D., Sullivan, P. F., & Hultman, C. M. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60072-6 · Cited by 2,125
van Os, J., & Kapur, S. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60995-8 · Cited by 1,971
The neuropathology of schizophrenia
Harrison, P. J. (1999) · Brain · doi:10.1093/brain/122.4.593 · Cited by 1,677
Genome-wide association studies: theoretical and practical concerns
Wang, W. Y. S., Barratt, B. J., Clayton, D. G., & Todd, J. A. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1522 · Cited by 1,183
Is schizophrenia a neurodevelopmental disorder?
Murray, R. M., & Lewis, S. W. (1988) · BMJ · doi:10.1136/bmj.296.6614.63 · Cited by 911
Is schizophrenia a neurodevelopmental disorder?
Murray, R. M., & Lewis, S. W. (1987) · BMJ · doi:10.1136/bmj.295.6600.681 · Cited by 889
Continuities and discontinuities in psychopathology between childhood and adult life
Rutter, M., Kim‐Cohen, J., & Maughan, B. (2006) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2006.01614.x · Cited by 824
Cannon, M., Caspi, A., Moffitt, T. E., Harrington, H., Taylor, A., Murray, R. M., & Poulton, R. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.5.449 · Cited by 783
Risk Factors for Autism: Perinatal Factors, Parental Psychiatric History, and Socioeconomic Status
Larsson, H. J., Eaton, W. W., Madsen, K. M., Vestergaard, M., Olesen, A. V., Agerbo, E., Schendel, D., Thorsen, P., & Mortensen, P. B. (2005) · American Journal of Epidemiology · doi:10.1093/aje/kwi123 · Cited by 727
The Kraepelinian dichotomy – going, going … but still not gone
Craddock, N., & Owen, M. J. (2010) · British Journal of Psychiatry · doi:10.1192/bjp.bp.109.073429 · Cited by 587
Self-citationWilliams, N. M., Zaharieva, I., Martin, A., Langley, K., Mantripragada, K., Fossdal, R., Stefansson, H., Stefansson, K., Magnusson, P., Gudmundsson, O. O., et al. (2010) · The Lancet · doi:10.1016/s0140-6736(10)61109-9 · Cited by 572
Self-citationShared heritability of attention-deficit/hyperactivity disorder and autism spectrum disorder
Rommelse, N. N. J., Franke, B., Geurts, H. M., Hartman, C. A., & Buitelaar, J. K. (2010) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-010-0092-x · Cited by 564 · cited 1×
“20,22 Autism-spectrum disorder and ADHD also frequently co-occur 23,24 and rates of both are increased in those with intellectual disability.”
A Meta-Analysis of Cognitive Deficits in Adults with a Diagnosis of Schizophrenia
Fioravanti, M., Carlone, O., Vitale, B., Cinti, M. E., & Clare, L. (2005) · Neuropsychology Review · doi:10.1007/s11065-005-6254-9 · Cited by 472
Rapoport, J. L., Chavez, A. M., GREENSTEIN, D. K., Addington, A. M., & Gogtay, N. (2008) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e31818b1c63 · Cited by 409
The beginning of the end for the Kraepelinian dichotomy
Craddock, N. J., & Owen, M. J. (2005) · The British Journal of Psychiatry · doi:10.1192/bjp.186.5.364 · Cited by 403
Self-citationMorgan, V. A., Leonard, H., Bourke, J., & Jablensky, A. V. (2008) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.107.044461 · Cited by 328
Parental psychiatric disorders associated with autism spectrum disorders in the offspring
Daniels, J. L., Forssen, U., Hultman, C. M., Cnattingius, S., Savitz, D. A., Feychting, M., & Sparen, P. (2008) · Pediatrics · doi:10.1542/peds.2007-2296 · Cited by 288
Stahlberg, O., Soderstrom, H., Rastam, M., & Gillberg, C. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-004-0115-1 · Cited by 273
The Genetic Deconstruction of Psychosis
Owen, M. J., Craddock, N., & Jablensky, A. (2007) · Schizophrenia Bulletin · doi:10.1093/schbul/sbm053 · Cited by 262
Self-citationSebat, J., Levy, D. L., & McCarthy, S. E. (2009) · Trends in Genetics · doi:10.1016/j.tig.2009.10.004 · Cited by 260
The neurology of schizophrenia
Trimble, M. (1987) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a072203 · Cited by 254
Zanelli, J., Reichenberg, A., Morgan, K. D., Fearon, P., Kravariti, E., Dazzan, P., Morgan, C., Zanelli, C., Demjaha, A., Jones, P. B., et al. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.09010118 · Cited by 208
Cognitive heterogeneity in schizophrenia
Joyce, E. M., & Roiser, J. P. (2007) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e3280ba4975 · Cited by 198
Grozeva, D. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.25 · Cited by 192 · cited 1×
“30 Under the assumption that large copy number variants are likely to have adverse consequences on brain development, these findings are consistent with the view that schizophrenia has a stronger neurodevelopmental component than bipolar disorder.”
The Neurology of schizophrenia
Nasrallah, H. A., & Weinberger, D. R. (1986) · Elsevier eBooks · Cited by 152
Suggestion of Roles for Both Common and Rare Risk Variants in Genome-wide Studies of Schizophrenia
Owen, M. J., Craddock, N. J., & O’Donovan, M. C. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.69 · Cited by 127
Self-citationADHD symptoms in children with mild intellectual disability.
Simonoff, E., Pickles, A., Wood, N., Gringras, P., & Chadwick, O. (2007) · Journal of the American Academy of Child and Adolescent Psychiatry · doi:10.1097/chi.0b013e3180323330 · Cited by 119
Psychopathology among offspring of parents with schizophrenia: Relationship to premorbid impairments
Keshavan, M. S., Montrose, D. M., Rajarethinam, R., Diwadkar, V. A., Prasad, K. M. R., & Sweeney, J. A. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.03.006 · Cited by 115
Phenotypic and genetic complexity of psychosis
Craddock, N. J., O’Donovan, M. C., & Owen, M. J. (2007) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.106.033761 · Cited by 103
Self-citationShould our major classifications of mental disorders be revised?
Goldberg, D. P. (2010) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.109.072405 · Cited by 34
Elevated rates of schizophrenia in a familial sample with mental illness and intellectual disability
Greenwood, C. M. T., Husted, J., Bomba, M. D., Hodgkinson, K. A., & Bassett, A. S. (2004) · Journal of Intellectual Disability Research · doi:10.1111/j.1365-2788.2004.00621.x · Cited by 23
de la Serna, E., Baeza, I., Toro, J., Andrés, S., Puig, O., Sánchez‐Gistau, V., Romero, S., Bernardo, M., & Castro‐Fornieles, J. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2009.09.001 · Cited by 23
Cited by
Sorted by citations
De novo mutations in schizophrenia implicate synaptic networks
Fromer, M., Pocklington, A. J., Kavanagh, D. H., Williams, H. J., Dwyer, S., Gormley, P., Georgieva, L., Rees, E., Palta, P., Ruderfer, D. M., et al. (2014) · Nature · doi:10.1038/nature12929 · Cited by 1,617
Self-citationSchizophrenia: an integrated sociodevelopmental-cognitive model
Howes, O. D., & Murray, R. M. (2014) · The Lancet · doi:10.1016/s0140-6736(13)62036-x · Cited by 864
Research Domain Criteria: cognitive systems, neural circuits, and dimensions of behavior
Morris, S. E., & Cuthbert, B. N. (2012) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2012.14.1/smorris · Cited by 638
Craddock, N. J., & Sklar, P. B. (2013) · The Lancet · doi:10.1016/s0140-6736(13)60855-7 · Cited by 684
Self-citationTalkowski, M. E., Rosenfeld, J. A., Blumenthal, I., Pillalamarri, V., Chiang, C., Heilbut, A., Ernst, C., Hanscom, C., Rossin, E., Lindgren, A. M., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.028 · Cited by 577
Metadata
- Authors
- Owen, M. J., O'Donovan, M. C., Thapar, A., & Craddock, N.
- Affiliations
- Cardiff University (GB)
- Corresponding author
- Owen, Michael J.
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 2011-03
- Volume
- 198
- Issue
- 3
- Pages
- 173-175
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- PMC
- PMC3764497
- OpenAlex
- W2046645276
- Cited by
- 500
- References
- 33
- Citations by year
- 2026: 18 · 2025: 28 · 2024: 26 · 2023: 25 · 2022: 42 · 2021: 49 · 2020: 38 · 2019: 49 · 2018: 25 · 2017: 36 · 2016: 17 · 2015: 33 · 2014: 32 · 2013: 35 · 2012: 36
- FWCI
- 24.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The British Journal of Psychiatry (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, other-oa)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust (076113)
- Cardiff University
- Medical Research Council
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- schizophrenia, neurodevelopmental disorders, autism spectrum disorder, intellectual disability, attention deficit hyperactivity disorder, genetic overlap, comorbidities, functional psychoses, brain development, cognitive impairment, disease classification, etiology, mental health services
- MeSH terms
- Adolescent, Adult, Brain, Humans, Male, Intellectual Disability, Schizophrenia, Syndrome, Comorbidity, Genetic Predisposition to Disease, Young Adult
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