Genome-wide association studies in psychiatry: what have we learned?
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Summary: Genome-wide association studies (GWAS) have been the focus of considerable effort in psychiatry. These efforts have markedly increased knowledge of the genetic basis of psychiatric disorders, and yielded empirical data on genetic architecture critical to addressing long-standing debates in the field. There is a now a clear path to increased knowledge of the ‘parts lists’ for these disorders.
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GWAS have revealed candidate genes whose mutations have been associated with these disorders.
“Genome wide association studies (GWAS) have revealed candidate genes whose mutations have been associated with these disorders41.”
From Cell type-specific transcriptional programs in mouse prefrontal cortex during adolescence and addiction (2019) · cites this paper as [41]
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- Authors
- Collins, A. L., & Sullivan, P. F.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Sullivan, Patrick F.
- ORCID
- Sullivan, Patrick F.
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 2013-01
- Volume
- 202
- Issue
- 1
- Pages
- 1-4
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- PMC
- PMC4188920
- OpenAlex
- W2084310124
- Cited by
- 73
- References
- 8
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 6 · 2022: 3 · 2021: 1 · 2020: 6 · 2019: 7 · 2018: 5 · 2017: 5 · 2016: 12 · 2015: 8 · 2014: 10 · 2013: 2
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The British Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Wellcome Trust
- National Institute of Mental Health (MH094421, U01MH085520, U01MH094421, MH085520)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Keywords
- genome-wide association study, mental illness, genetic architecture, genetic basis of mental illness, psychiatric genetics, candidate genes
- MeSH terms
- Mental Disorders, Humans, Psychiatry, Genome-Wide Association Study
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