Cited by 117Maternal Mental Health During Pregnancy and PostpartumPregnancy and Medication ImpactAutism Spectrum Disorder Research

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Prenatal exposure to selective serotonin reuptake inhibitors and social responsiveness symptoms of autism: population-based study of young children

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Marroun, Hanan El, White, Tonya J. H., van der Knaap, Noortje J. F., Homberg, Judith R., Fernández, Guillén, Schoemaker, Nikita K., Jaddoe, Vincent W. V., Hofman, Albert, Verhulst, Frank C., Hudziak, James J., Stricker, Bruno H. C., Tiemeier, Henning·2014·British Journal of Psychiatry

DOI 10.1192/bjp.bp.113.127746

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Abstract

Background: Selective serotonin reuptake inhibitors (SSRIs) are considered safe and are frequently used during pregnancy. However, two case–control studies suggested an association between prenatal SSRI exposure with childhood autism. Aims: To prospectively determine whether intra-uterine SSSRI exposure is associated with childhood autistic symptoms in a population-based study. Method: A total of 376 children prenatally exposed to maternal depressive symptoms (no SSRI exposure), 69 children prenatally exposed to SSRIs and 5531 unexposed children were included. Child pervasive developmental and affective problems were assessed by parental report with the Child Behavior Checklist at ages 1.5, 3 and 6. At age 6, we assessed autistic traits using the Social Responsiveness Scale (n= 4264). Results: Prenatal exposure to maternal depressive symptoms without SSRIs was related to both pervasive developmental (odds ratio (OR) = 1.44, 95% CI 1.07–1.93) and affective problems (OR = 1.44, 95% CI 1.15–1.81). Compared with unexposed children, those prenatally exposed to SSRIs also were at higher risk for developing pervasive developmental problems (OR = 1.91, 95% CI 1.13–3.47), but not for affective problems. Children prenatally exposed to SSRIs also had more autistic traits (B= 0.15, 95% CI 0.08–0.22) compared with those exposed to depressive symptoms only. Conclusions: Our results suggest an association between prenatal SSRI exposure and autistic traits in children. Prenatal depressive symptoms without SSRI use were also associated with autistic traits, albeit this was weaker and less specific. Long-term drug safety trials are needed before evidence-based recommendations are possible.

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Authors: Marroun, H. E., White, T. J. H., van der Knaap, N. J. F., Homberg, J. R., Fernández, G., Schoemaker, N. K., Jaddoe, V. W. V., Hofman, A., Verhulst, F. C., Hudziak, J. J., Stricker, B. H. C., & Tiemeier, H.
Affiliations: Erasmus MC (NL)
University of Vermont (US)
Corresponding author: Tiemeier, Henning
ORCID: Marroun, Hanan El
White, Tonya J. H.
Homberg, Judith R.
Fernández, Guillén
Schoemaker, Nikita K.
Jaddoe, Vincent W. V.
Verhulst, Frank C.
Hudziak, James J.
Stricker, Bruno H. C.
Tiemeier, Henning
Venue: British Journal of Psychiatry
Publisher: Royal College of Psychiatrists
Published: 2014-08
Volume: 205
Issue: 2
Pages: 95-102
ISSN: 0007-1250 (ISSN-L)
1472-1465
DOI: 10.1192/bjp.bp.113.127746
OpenAlex: W1981456496
Cited by: 117
References: 54
Citations by year: 2026: 3 · 2025: 6 · 2024: 1 · 2023: 9 · 2022: 3 · 2021: 7 · 2020: 13 · 2019: 11 · 2018: 16 · 2017: 15 · 2016: 18 · 2015: 11 · 2014: 3
FWCI: 15.52
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.cambridge.org/core/terms (unspecified, 1250 d)
Locations: The British Journal of Psychiatry (publishedVersion)
PubMed (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
Radboud Repository (Radboud University) (submittedVersion)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Keywords: prenatal SSRI exposure, selective serotonin reuptake inhibitors, autism spectrum disorder, autistic traits, social responsiveness, maternal depression, emotional problems, child behavior, drug safety in pregnancy
MeSH terms: Autistic Disorder, Depressive Disorder, Female, Humans, Pregnancy, Prenatal Exposure Delayed Effects, Selective Serotonin Reuptake Inhibitors

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Prenatal exposure to selective serotonin reuptake inhibitors and social responsiveness symptoms of autism: population-based study of young children

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