NICE CG178 Psychosis and Schizophrenia in Adults: Treatment and Management – an evidence-based guideline?
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Summary: National Institute for Health and Care Excellence (NICE) clinical guideline (CG)178 was published in 2014. NICE guidelines occupy an important international position. We argue that CG178 overemphasises the use of cognitive–behavioural therapy for schizophrenia and those ‘at risk’ of psychosis, with recommendations that do not always reflect the evidence base. The CG178 recommendations on medications are limited.
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The evidence supporting current guidelines for preventive interventions in clinical high risk for psychosis is relatively unclear.
“The evidence supporting these partially conflicting recommendations is relatively unclear 11 , despite several pairwise meta-analyses having been published to date 10,[12][13][14][15][16][17][18] .”
From Lack of evidence to favor specific preventive interventions in psychosis: a network meta‐analysis (2018) · cites this paper as [11]
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Lack of evidence to favor specific preventive interventions in psychosis: a network meta‐analysis
Davies, C., Cipriani, A., Ioannidis, J. P. A., Radua, J., Stahl, D., Provenzani, U., McGuire, P., & Fusar‐Poli, P. (2018) · World Psychiatry · doi:10.1002/wps.20526 · Cited by 229 · see citing works
Treatment of depression in schizophrenia: Systematic review and meta-analysis
Gregory, A., Mallikarjun, P., & Upthegrove, R. (2017) · British Journal of Psychiatry · doi:10.1192/bjp.bp.116.190520 · Cited by 109 · see citing works
Hurtado, M. M., Villena-Jimena, A., Quemada, C., & Morales-Asencio, J. M. (2021) · European Journal of Psychotraumatology · doi:10.1080/20008198.2021.1940759 · Cited by 3 · see citing works
- Authors
- Taylor, M., & Perera, U.
- Affiliations
- The University of Queensland (AU)
- Corresponding author
- Taylor, Mark
- ORCID
- Taylor, Mark
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 2015-05
- Volume
- 206
- Issue
- 5
- Pages
- 357-359
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- OpenAlex
- W2125613153
- Cited by
- 102
- References
- 12
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 8 · 2023: 7 · 2022: 2 · 2021: 34 · 2020: 10 · 2019: 9 · 2018: 10 · 2017: 3 · 2016: 5 · 2015: 7 · 2014: 1
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The British Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Social Sciences › Psychology › Clinical Psychology › Psychiatric care and mental health services
- Keywords
- psychosis, schizophrenia, cognitive behavioral therapy, antipsychotic drugs, treatment guidelines, evidence base
- MeSH terms
- Adult, Humans, Psychotic Disorders, Schizophrenia, Antipsychotic Agents, Cognitive Behavioral Therapy, Practice Guidelines as Topic, Evidence-Based Medicine, Disease Management
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