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Cited by 362Cardiac Health and Mental HealthCardiovascular Health and Risk FactorsAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

The DOI matches its Crossref record; 114 of the 116 references it cites were found in a registry or an index.

Anxiety and new onset of cardiovascular disease: critical review and meta-analysis

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Batelaan, Neeltje M., Seldenrijk, Adrie, Bot, Mariska, van Balkom, Anton J. L. M., Penninx, Brenda W. J. H.·2016·British Journal of Psychiatry
DOI 10.1192/bjp.bp.114.156554
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Abstract

BACKGROUND: Anxiety has been associated with new-onset cardiovascular disease (CVD), but the quality of this relationship is unclear. Only if anxiety is a causal, independent cardiovascular risk factor might it be a target for CVD prevention. AIMS: To determine and examine the independent association and causality between anxiety and incident CVD. METHOD: PubMed, EMBASE and PsycINFO databases were searched up to October 2013. A review of Hill's criteria for causality and random effects meta-analysis were conducted of prospective, population-based studies examining anxiety and incident CVD in people free from CVD at baseline. RESULTS: The meta-analysis comprised 37 papers (n = 1 565 699). The follow-up ranged from 1 to 24 years. Anxiety was associated with a 52% increased incidence of CVD (hazard ratio = 1.52, 95% CI 1.36-1.71). The risk seemed independent of traditional risk factors and depression. The evaluation of Hill's criteria largely argued in favour of causality. CONCLUSIONS: Anxiety may be of interest for CVD prevention. Future research should examine biological and behavioural underpinnings of the association in order to identify targets for intervention.

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  1. 2011, Generalised Anxiety Disorder and Panic Disorder (With or Without Agoraphobia) in Adults: Management in Primary, Secondary and Community Care. Clinical Guideline 113

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Metadata

Authors
Batelaan, N. M., Seldenrijk, A., Bot, M., van Balkom, A. J. L. M., & Penninx, B. W. J. H.
Affiliations
Amsterdam Public Health (NL)
Corresponding author
Batelaan, Neeltje M.
ORCID
Venue
British Journal of Psychiatry
Publisher
Royal College of Psychiatrists
Published
2016-03
Volume
208
Issue
3
Pages
223-231
ISSN
  • 0007-1250 (ISSN-L)
  • 1472-1465
DOI
10.1192/bjp.bp.114.156554
OpenAlex
W2294500753
Cited by
362
References
116
Citations by year
2026: 25 · 2025: 27 · 2024: 29 · 2023: 76 · 2022: 55 · 2021: 42 · 2020: 43 · 2019: 17 · 2018: 23 · 2017: 15 · 2016: 10
FWCI
3.83
Type
journal article
Language
en
Open access
Licence
www.cambridge.org/core/terms (unspecified, 672 d)
Locations
  • The British Journal of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
  • Pure Amsterdam UMC (submittedVersion, other-oa)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Funders
  • Vrije Universiteit Amsterdam
  • Nederlandse Organisatie voor Wetenschappelijk Onderzoek (91811602)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
anxiety, cardiovascular disease, incident cardiovascular disease, cardiovascular risk factors, causality, Hill's criteria, depression, cardiovascular disease prevention, psychological risk factors
MeSH terms
Anxiety Disorders, Cardiovascular Diseases, Depressive Disorder, Humans, Risk Factors, Incidence

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