The DOI matches its Crossref record; 27 of the 29 references it cites were found in a registry or an index.
Telephone-supported computerised cognitive–behavioural therapy: REEACT-2 large-scale pragmatic randomised controlled trial
Open accessAbstract
Background: Computerised cognitive–behavioural therapy (cCBT) for depression has the potential to be efficient therapy but engagement is poor in primary care trials. Aims: We tested the benefits of adding telephone support to cCBT. Method: We compared telephone-facilitated cCBT (MoodGYM) (n = 187) to minimally supported cCBT (MoodGYM) (n = 182) in a pragmatic randomised trial (trial registration: ISRCTN55310481). Outcomes were depression severity (Patient Health Questionnaire (PHQ)-9), anxiety (Generalized Anxiety Disorder Questionnaire (GAD)-7) and somatoform complaints (PHQ-15) at 4 and 12 months. Results: Use of cCBT increased by a factor of between 1.5 and 2 with telephone facilitation. At 4 months PHQ-9 scores were 1.9 points lower (95% CI 0.5–3.3) for telephone-supported cCBT. At 12 months, the results were no longer statistically significant (0.9 PHQ-9 points, 95% CI −0.5 to 2.3). There was improvement in anxiety scores and for somatic complaints. Conclusions: Telephone facilitation of cCBT improves engagement and expedites depression improvement. The effect was small to moderate and comparable with other low-intensity psychological interventions.
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“The existing digital therapeutic and telehealth interventions with didactic components, which enable health care providers to communicate with patients via digital platforms (eg, email and video call), have encountered several challenges, including relatively low adherence, unsustainability, and inflexibility [3,4].”
From Artificial Intelligence-Based Chatbots for Promoting Health Behavioral Changes: Systematic Review. (2023) · cites this paper as [4]
Experimental — accuracy not yet measuredIn the citing paper
“In the last 10 years, several large implementation studies of DMHIs have shown that the majority of patients offered these interventions do not engage at the recommended frequency or complete the full course of treatment [4-6].”
From Digital Mental Health Interventions for Depression: Scoping Review of User Engagement (2022) · cites this paper as [4]
In the citing paper
“Similarly, concerns related to sustained engagement with web-based psychiatric interventions have been reported in routine-care implementation studies [4-6,17].”
From Digital Mental Health Interventions for Depression: Scoping Review of User Engagement (2022) · cites this paper as [4]
In the citing paper
“Although some trials have shown strong patient engagement in health care settings (59), others have had high dropout rates (60, 61).”
From Banbury forum consensus statement on the path forward for digital mental health treatment (2021) · cites this paper as [60]
In the citing paper
“Patient engagement has been a challenge for some DMHTs. Although some trials have shown strong patient engagement in health care settings (59), others have had high dropout rates (60, 61).”
From Banbury forum consensus statement on the path forward for digital mental health treatment (2021) · cites this paper as [60]
In the citing paper
“Existing digital therapies have suffered from low adherence and concerns about their efficiency without continued human support [12,13].”
From Conversational agents in the treatment of mental health problems: mixed-method systematic review (2019) · cites this paper as [13]
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The PHQ-9: A New Depression Diagnostic and Severity Measure
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Kroenke, K., Spitzer, R. L., & Williams, J. B. W. (2002) · Psychosomatic Medicine · doi:10.1097/00006842-200203000-00008 · Cited by 3,415
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Self-citationInternet-based cognitive behaviour therapy for symptoms of depression and anxiety: A meta-analysis
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- 2009, Depression in Adults: The Treatment and Management of Depression in Adults (Update – NICE clinical guideline 90)
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Items 101–116 of 116
Uso de tecnologia no acompanhamento da saúde mental do trabalhador: uma revisão de escopo
Barbosa, M. D. S. A., do Nascimento, K. C., de Lima, T. N. B., Costa, W. T., Santos, A. K. T. D., Souza, M. E., Neves, A. B. S., Lira, R., Silva, K. N. F., da Silva, F. P., et al. (2023) · Contribuciones a las Ciencias Sociales · doi:10.55905/revconv.16n.10-058
Fuster‐Casanovas, A., Melero, S. M., Cabutto, D., Carrión, C., Vidal‐Alaball, J., Herrera‐Ramos, E., Barcons, C., & Duarte‐Díaz, A. (2024) · doi:10.2196/preprints.68851
Digital Therapies of Psychiatric Disorders
Biagianti, B., Nahum, M., Yitzhak, N., & Vinogradov, S. (2025) · Oxford University Press eBooks · doi:10.1093/med/9780197640654.003.0073
Self-Guided Mental Health Interventions for Premenstrual Mood Symptoms
Gordon, J. L., & Chenji, S. (2025) · Current Psychiatry Reports · doi:10.1007/s11920-025-01645-1
“In one trial [40], a telephone-facilitated version of iCBT was found to have greater program engagement, such as more frequent access to the program modules, relative to a non-facilitated version; however, this did not translate into significant differences in any psychological outcome.”
Glass, J. E., Dorsey, C. N., Beatty, T. C., Bobb, J. F., Wong, E. S., Palazzo, L. G., King, D., Mogk, J. M., Stefanik-Guizlo, K., Idu, A., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22610842
Glass, J. E., Dorsey, C. N., Beatty, T. C., Bobb, J. F., Wong, E. S., Palazzo, L. G., King, D., Mogk, J. M., Stefanik-Guizlo, K., Idu, A., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22610845
Glass, J. E., Dorsey, C. N., Beatty, T. C., Bobb, J. F., Wong, E. S., Palazzo, L. G., King, D., Mogk, J. M., Stefanik-Guizlo, K., Idu, A., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22610833
Glass, J. E., Dorsey, C. N., Beatty, T. C., Bobb, J. F., Wong, E. S., Palazzo, L. G., King, D., Mogk, J. M., Stefanik-Guizlo, K., Idu, A., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22610836
Glass, J. E., Dorsey, C. N., Beatty, T. C., Bobb, J. F., Wong, E. S., Palazzo, L. G., King, D., Mogk, J. M., Stefanik-Guizlo, K., Idu, A., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22610839
Glass, J. E., Dorsey, C. N., Beatty, T. C., Bobb, J. F., Wong, E. S., Palazzo, L. G., King, D., Mogk, J. M., Stefanik-Guizlo, K., Idu, A., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22610830
Glass, J. E., Dorsey, C. N., Beatty, T. C., Bobb, J. F., Wong, E. S., Palazzo, L. G., King, D., Mogk, J. M., Stefanik-Guizlo, K., Idu, A., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22610848
Wong, E. S., Dorsey, C. N., Beatty, T. C., Bobb, J. F., Stefanik-Guizlo, K., Key, D. L., Ramaprasan, A., Idu, A., Fortney, J. C., Mogk, J. M., et al. (2026) · PLOS Digital Health · doi:10.1371/journal.pdig.0001145
Wang, X., Yu, K., Zhao, J., & Shi, Y. (2026) · International Urology and Nephrology · doi:10.1007/s11255-026-05129-w
“…therapeutic and telehealth interventions with didactic components, which enable health care providers to communicate with patients via digital platforms (e.g. email and video call), have encountered several challenges, including relatively low adherence, unsustainability, and inflex-ibility [7, 8].”
Huang, W., Wu, Y., Shen, Y., Song, H., Chen, Y., Lin, R., Wang, Y., & Yang, X. H. (2026) · Healthcare · doi:10.3390/healthcare14101325
“However, internet-based interventions still encounter challenges, such as relatively low adherence rates, issues with sustainability, and limitations in flexibility [23,24].”
Kandasamy, G., Orayj, K. M., Asiri, R., Alshahrani, A. M., Alharbi, G., Abutaily, S. A., Suhaym, A. Y. A., & Alyahya, A. A. (2026) · Frontiers in Public Health · doi:10.3389/fpubh.2026.1862006
“Their conversational adaptability allows individuals, particularly those who may experience stigma or discomfort when seeking medical care, to communicate privately and safely from any location at any time (4, 5).”
Susanti, H., Asha, N. N., Bee, P., Windarwati, H. D., Keliat, B. A., Rahayu, A. P., Blakemore, A., Handayani, A., Sodikin, M. A., & Brooks, H. L. (2026) · PLoS ONE · doi:10.1371/journal.pone.0358869
“Effective psychological interventions exist for depression and anxiety, and are under-pinned by a robust evidence base [7,8].”
Metadata
- Authors
- Gilbody, S., Brabyn, S., Lovell, K., Kessler, D., Devlin, T., Smith, L., Araya, R., Barkham, M., Bower, P., Cooper, C., Knowles, S., Littlewood, E., Richards, D. A., Tallon, D., White, D., Worthy, G., & collaborative, O. B. O. T. R.
- Affiliations
- University of Manchester (GB)
- University of Exeter (GB)
- ORCID
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 2017-05
- Volume
- 210
- Issue
- 5
- Pages
- 362-367
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- OpenAlex
- W2591924907
- Cited by
- 116
- References
- 29
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 4 · 2023: 18 · 2022: 8 · 2021: 15 · 2020: 13 · 2019: 7 · 2018: 29 · 2017: 4
- FWCI
- 16.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The British Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion, other-oa)
- Explore Bristol Research (publishedVersion, other-oa)
- White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
- Open Research Exeter (University of Exeter) (acceptedVersion)
- LSHTM Research Online (London School of Hygiene and Tropical Medicine) (acceptedVersion)
- Research Portal (King's College London) (submittedVersion, cc-by-nc-nd)
- University of Derby Online Research Archive. (University of Derby) (submittedVersion)
- Figshare (submittedVersion)
- Bristol Research (University of Bristol) (submittedVersion, other-oa)
- Funders
- London School of Hygiene and Tropical Medicine
- National Institute for Health and Care Research (NF-SI-0514-10037, NF-SI-0611-10203, 06/43/504, HTA/06/43/504)
- University of Exeter
- University of Bristol
- Health Technology Assessment Programme (06/43/504)
- NIHR School for Primary Care Research
- Topics
- Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Telemedicine and Telehealth Implementation
- Keywords
- computerized cognitive behavioral therapy, telephone support, depression, MoodGYM, treatment engagement, primary care, anxiety, somatic symptoms, low-intensity psychological interventions
- MeSH terms
- Adult, Anxiety Disorders, Depressive Disorder, Female, Humans, Male, Telephone, Therapy, Computer-Assisted, Cognitive Behavioral Therapy, Treatment Outcome, Remote Consultation, Medication Adherence
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