The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Depression Comorbid with Anxiety: Results from the WHO Study on Psychological Disorders in Primary Health Care
Abstract
The World Health Organization collaborative study on “Psychological Problems in General Health Care” investigated the form, frequency, course and outcome of common psychological problems in primary care settings at 15 international sites. The research employed a two-stage case-finding procedure. GHQ–12 was administered to 25 916 adults who consulted health-care services. The second-stage assessment (n=5438) consisted of the Composite International Diagnostic Interview (GDI), the Social Disability Schedule, and questionnaires. Possible cases or borderline cases of mental disorder, and a sample of known cases, were followed up at three months and one year. Using standard diagnostic algorithms (ICD–10), prevalence rates were calculated for current disorder (one-month) and lifetime experience disorder. Well-defined psychological problems are frequent in all the general health-care settings examined (median 24.0%). Among the most common were depression, anxiety, alcohol misuse, somatoform disorders, and neurasthenia. Nine per cent of patients suffered from a “subthreshold condition” that did not meet diagnostic criteria but had clinically significant symptoms and functional impairment. The most common co-occurrence was depression and anxiety. Comorbidity increases the likelihood of recognition of mental disorders in general health care, and the likelihood of receiving treatment.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Research has shown that nearly half of all cases of depression and anxiety occur in the same patients at the same time [74].”
From Correlations between social media addiction and anxiety, depression, FoMO, loneliness and self-esteem among students: A systematic review and meta-analysis (2025) · cites this paper as [74]
Citations
Cites
Kessler, R. C. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950010008002 · Cited by 12,370
Research works printed but not linked: 10
- Ormel J. , Von Korff M. , Üstün T. B. , et al (1966) Psychopathology and disability are associated across the world: Results from the WHO Collaborative Study. Journal of the American Medical Association, (in press).
- Zung, 1990, The comorbidity of anxiety and depression in general medical patients: a longitudinal study, Journal of Clinical Psychiatry, 51, 77
- Sanderson, 1990, Syndrome comorbidity in patients with major depression or dysthymia: prevalence and temporal relationships, American Journal of Psychiatry, 147, 1025, 10.1176/ajp.147.8.1025 · DOI
- 10.1001/archpsyc.1993.01820220075008 · DOI
- Wittchen, 1993, Comorbidity and mixed anxiety–depressive disorders: is there epidemiologic evidence?, Journal of Clinical Psychiatry, 54, 9
- 10.2190/E3QN-9KTR-66CR-Q8TF · DOI
- Üstün, 1995, Mental Illness in General Health Care: An International Study
- Wittchen, 1991, Anxiety disorders: Similarities and differences of comorbidity in treated and untreated groups, British Journal of Psychiatry, 159, 23, 10.1192/S0007125000296219 · DOI
- Goldberg, 1988, A User Guide to the General Health Questionnaire: GHQ
- 10.1097/00005053-199206000-00006 · DOI
Cited by
Sorted by citations
Items 401–451 of 451
Evaluation of major depression in a routine clinical assessment
Mezzasalma, M. A. (2010) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-2-9 · Cited by 1
“In order to understand why depression and anxiety coexist in over 70% of the cases, if we analyze the symptoms presented there is a huge intersection[33].”
Validity of the Geriatric Depression Scale for Patients Seen at General Outpatient Clinics
Vargas, H. O., Matsuo, T., & Blay, S. L. (2007) · Clinical Gerontologist · doi:10.1300/j018v30n04_05 · Cited by 4
Psychological Particularity in Acne Vulgaris
Datuashvili, M., Chitashvili, M., & Katsitadze, A. (2002) · Dermatology and Psychosomatics \/ Dermatologie Und Psychosomatik · doi:10.1159/000064500 · Cited by 1
“We focused on the most commonly encountered clinical situation with a mixture of anxiety and depressive symptoms [Sartorius et al., 1996; Stahl, 1993].”
BackgroundKim, Y. S., Lee, K., Kim, B. S., Shin, H., Sung, E., Lee, S. Y., Sung, S.-W., Moon, Y., Song, S.-W., & Kim, C. (2002) · doi:10.12793/jkscpt.2002.10.1.51 · Cited by 1
Brain-Machine Interfaces for Closed-Loop Electrical Brain Stimulation in Neuropsychiatric Disorders
Sani, O. G., Yang, Y., & Shanechi, M. M. (2021) · Handbook of Neuroengineering · doi:10.1007/978-981-15-2848-4_107-1
The Effect of Anxiety Therapy and Self-Confidence Therapy on the Shot Accuracy in Football Game
Irfan, & Abbas, I. (2020) · Proceedings of the 3rd International Conference on Education, Science, and Technology (ICEST 2019) · doi:10.2991/assehr.k.201027.065 · Cited by 1
Comorbid Psychiatric Illnesses
Thorsteinsson, E., & Brown, R. F. (2019) · Springer eBooks · doi:10.1007/978-3-030-32545-9_6 · Cited by 1
Mirdamadi, M. (2019) · doi:10.17635/lancaster/thesis/653 · Cited by 1
Chapter 32 – How Does One Assess for Psychiatric Illness in Patients With Advanced Disease?
Klipstein, K., & Marin, D. (2013) · Elsevier eBooks · doi:10.1016/b978-1-4377-3796-7.00032-x · Cited by 1
Komorbiditat von Depression und Angststorungen
Boerner, R. (2002) · Springer eBooks · doi:10.1007/978-3-642-59394-9_9 · Cited by 1
Die Macht der Ökonomie in der Psychotherapie
Geyer, M. (2000) · Lindauer Texte · doi:10.1007/978-3-642-59782-4_3 · Cited by 1
Byllesby, B. M., Charak, R., Durham, T. A., Wang, X., & Elhai, J. D. (2016) · Journal of Psychopathology and Behavioral Assessment · doi:10.1007/s10862-016-9555-9 · Cited by 60
Peker, M., Booth, R. W., & Güney, O. (2018) · Current Psychology · doi:10.1007/s12144-018-0034-1 · Cited by 4
Senta, J., Collins, A. G. E., Dayan, P., & Bishop, S. J. (2026) · Translational Psychiatry · doi:10.1038/s41398-026-04194-0
“Further, despite the high comorbidity between anxiety and depression [26 – 28], there has been little human research investigating the relationship of anxiety with individual differences in effortful reward pursuit.”
Effects of Arvcf on anxiety- and depression-like behaviors in mice of different ages and sexes.
Li, H.-Q., Zhao, Y.-C., Zhang, M., Zhao, P., Zhang, B., Li, B.-G., Yang, Z.-L., & Li, M. D. (2026) · Journal of Affective Disorders · doi:10.1016/j.jad.2026.121790
Numata, N., Sutoh, C., Bai, Y.-J., Okada, S., Muramatsu, K., & Shimizu, E. (2026) · Behavioural and Cognitive Psychotherapy · doi:10.1017/s1352465826101301
“Depression and anxiety are prevalent mental disorders frequently encountered in both the general population and in primary care settings (Hirschfeld, 2001; Sartorius et al ., 1996).”
Li, D., & Li, K. (2025) · Iranian Journal of Public Health · doi:10.18502/ijph.v54i7.19153
“Due to their strong curiosity and limited self-regulation, adolescents are particularly vulnerable to becoming engrossed in novel smartphone content, which may lead to excessive immersion and behavioral addiction (16).”
Adolescent Anxiety and TikTok. An exploratory study
Zheluk, A., Anderson, J., & Dineen-Griffin, S. (2022) · medRxiv · doi:10.1101/2022.09.27.22280435
“Studies have suggested that between 20 and 50% of anxiety cases are formally diagnosed [10].”
BackgroundJahromi, L. R., Mazidi, S. S., Khoshroo, M., & Javid, M. (2022) · Journal of Pharmaceutical Negative Results · doi:10.47750/pnr.2022.13.s01.35
“(44) showed that the risk of depression in patients with a history of other psychiatric or medical problems is 9 times higher than that of people with no other medical conditions, it seems that physical problems can make people vulnerable to psychiatric disorders.”
BackgroundPencer, A., Patterson, V., Rossi, M., & Wozney, L. (2021) · doi:10.2196/preprints.33374
Bronk, J. (2021) · Whitehall Papers · doi:10.1080/02681307.2021.2005905
Khademi, M., Zohrabi, S., Mohtashamalsharieh, A., & Zahiroddin, A. (2020) · Iranian Journal of Psychiatry and Behavioral Sciences · doi:10.5812/ijpbs.66117
Ranjan, P., & Das, J. (2020) · doi:10.18203/2349-3933.ijam20202115
“Indeed, according to findings from the World Mental Health Survey, diabetes is roughly equally associated with depression and anxiety around the world.(11,12) Yet, with very few exceptions, the potential impact of anxiety disorders on diabetes has received much less attention than diabetes-depression comorbidity.”
BackgroundDelahunty, F., Johansson, R., & Arčan, M. (2019) · doi:10.2196/preprints.16918
Passive Diagnosis of Mental Health Disorders Incorporating an Empathic Dialogue SystemPreprint
Delahunty, F., Arčan, M., & Johansson, R. (2019) · Thesis Commons (OSF Preprints) · doi:10.31237/osf.io/98c3q · Cited by 1
“of two weeks, making depression the largest cause of disability worldwide [5].”
BackgroundSchlarb, A. A., Lutchen, U., Brenner, T., & Faber, J. (2017) · Somnologie - Schlafforschung und Schlafmedizin · doi:10.1007/s11818-017-0135-3
Depression in young adults with chronic somatic illness – An analysis of 1970 British Cohort Study
Mihăilescu, A., Matei, V., Diaconescu, L., Al-Bataineh, R., & Purnichi, T. (2016) · Romanian Journal of Psychiatry and Psychotherapy · doi:10.37897/rjpp.2016.2.5
“In patients with two or more chronic medical conditions the risk of depression is six times higher comparing with healthy persons (17).”
BackgroundPlasma Homocysteine Concentraton according to the Depression and Degree of Stress
Lim, C., Moon, J., Kim, H., & Kong, M. H. (2015) · doi:10.17547/kjsr.2015.23.4.179
La asociación psiquiátrica de América Latina
Rojas, R. N. C. (2014) · Revista Colombiana de Psiquiatría · doi:10.1016/j.rcp.2014.06.001
Сексуальные нарушения у женщин с синдромом поликистозных яичников
Гродницкая, Е. Э., Ильина, Н. А., Довженко, Т. В., Латышкевич, О. А., Курцер, М. А., Мельниченко, Г. А., Grodnitskaya, E. E., Ilina, N., Довженко, Т. В., Latyshkevich, O., et al. (2013) · Russian Journal of Human Reproduction · doi:10.17116/repro201622337-44
Donker, T., Warmerdam, L., van Straten, A., & Cuijpers, P. J. (2011) · GZ - Psychologie · doi:10.1007/s41480-011-0083-7
Is the DHEAS/cortisol ratio a potential filter for non-operable constipated cases?
El-Tawil, A. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i6.659 · Cited by 2
Depression among Patients Attending Physiotherapy Clinics in Erbil City
Ali, S., Zangana, J., & Tahir, D. H. (2009) · Zanco Journal of Medical Sciences · doi:10.15218/zjms.2009.015
Ansseaua, M., Fischler, B., Dierick, M., Mignond, A., & Leymand, S. (2005) · European psychiatry (Ed Española) · doi:10.1017/s1134066500008936
Anxiety disorders: does one treatment fit all?
Baldwin, D. (2004) · International journal of psychiatry in clinical practice · doi:10.1080/13651500410005531
“1%, for anxiety and depression, respectively) (Figure 1).(2) Furthermore, the prevalence for the two disorders existing”
BackgroundWomen's Health in Mid-Life: Depression and anxiety
Walling, A. (2004) · Cambridge University Press eBooks · doi:10.1017/cbo9780511545672.007
ALPRAZOLAM: profilo farmacoeconomico nei disturbi d’ansia e da attacchi di panico
Eandi, M. (2002) · Farmeconomia Health economics and therapeutic pathways · doi:10.7175/fe.v3i1.742
Screening for primary care in community and primary care populations
Murthy, R. S. (1997) · Current Opinion in Psychiatry · doi:10.1097/00001504-199703000-00008
Belongs to Tomorrow—Outcomes and Interventions for Academic Procrastination
董, 锐. (2023) · Advances in Social Sciences · doi:10.12677/ass.2023.12121025
Brown, R., & Thorsteinsson, E. (2019) · Springer eBooks · doi:10.1007/978-3-030-32545-9_2
Issues in Counseling South Asian Americans
Ibrahim, F. A., & Heuer, J. R. (2018) · Cross-cultural research in health, illness and well-being · doi:10.1007/978-3-319-91120-5_10
Идрисов, К. А., & Krasnov, V. (2015) · Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova · doi:10.17116/jnevro20151154165-69
Modeling Depression in the Rat: The Development and Usefulness of a Female-centric Approach
Baker, S. (2011) · uO Research (University of Ottawa) · doi:10.20381/ruor-4807
Agoraphobie und Panikstörung (episodisch paroxysmale Angst)
Marx, R. (2006) · Springer eBooks · doi:10.1007/3-211-36649-0_10
Nuevas tendencias en la investigación en salud mental
ten Horn, G. H. T. (2004) · Revista de la Asociación Española de Neuropsiquiatría · doi:10.4321/s0211-57352004000200011
Co-morbidity of Psychiatric Disorders
Creed, F. (2001) · Springer eBooks · doi:10.1007/978-3-642-59519-6_140
Marx, R. (2000) · Springer eBooks · doi:10.1007/978-3-7091-3768-0_10
Komorbidität psychiatrischer Störungen
Creed, F. (2000) · Springer eBooks · doi:10.1007/978-3-642-59627-8_24
The Influence of Depression and Anxiety on the Course of Somatization in Primary Case
Gureje, O. (1999) · Springer eBooks · doi:10.1007/978-4-431-68500-5_14
Metadata
- Authors
- Sartorius, N., Üstün, T. B., Lecrubier, Y., & Wittchen, H.-U.
- Affiliations
- University of Geneva (CH)
- World Health Organization (CH)
- Inserm (FR)
- Corresponding author
- Üstün, T. Bedirhan
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 1996-06
- Volume
- 168
- Issue
- S30
- Pages
- 38-43
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- OpenAlex
- W2765030473
- Cited by
- 541
- References
- 0
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 6 · 2023: 23 · 2022: 13 · 2021: 19 · 2020: 28 · 2019: 26 · 2018: 21 · 2017: 17 · 2016: 17 · 2015: 21 · 2014: 18 · 2013: 17 · 2012: 24
- FWCI
- 18.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The British Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Keywords
- depression, anxiety, comorbidities, primary care, mental illness, prevalence, mental disorder recognition, treatment seeking, alcohol abuse, somatoform disorders, neurasthenia
- MeSH terms
- Adolescent, Adult, Aged, Antidepressive Agents, Anxiety Disorders, Chronic Disease, Depressive Disorder, Female, Humans, Male, Middle Aged, Primary Health Care, Professional Impairment, Psychotropic Drugs, Sampling Studies, World Health Organization, Comorbidity, Prevalence, Odds Ratio
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review