The DOI matches its Crossref record; 97 of the 97 references it cites were found in a registry or an index.
Extracellular vesicles: lipids as key components of their biogenesis and functions
Open accessAbstract
Intercellular communication has been known for decades to involve either direct contact between cells or to operate via circulating molecules, such as cytokines, growth factors, or lipid mediators. During the last decade, we have begun to appreciate the increasing importance of intercellular communication mediated by extracellular vesicles released by viable cells either from plasma membrane shedding (microvesicles, also named microparticles) or from an intracellular compartment (exosomes). Exosomes and microvesicles circulate in all biological fluids and can trigger biological responses at a distance. Their effects include a large variety of biological processes, such as immune surveillance, modification of tumor microenvironment, or regulation of inflammation. Extracellular vesicles can carry a large array of active molecules, including lipid mediators, such as eicosanoids, proteins, and nucleic acids, able to modify the phenotype of receiving cells. This review will highlight the role of the various lipidic pathways involved in the biogenesis and functions of microvesicles and exosomes.
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“This specific lipid enrichment, their membrane high protein/lipid ratio and asymmetric distribution are associated with a higher membrane rigidity in ELVs in comparison with parent cells (Record et al., 2018).”
From Skeletal Muscle-Released Extracellular Vesicles: State of the Art (2019) · cites this paper as Record et al., 2018
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Lipids and cancer: Emerging roles in pathogenesis, diagnosis and therapeutic intervention
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Metadata
- Authors
- Record, M., Silvente-Poirot, S., Poirot, M., & Wakelam, M. O.
- Affiliations
- Université Toulouse III - Paul Sabatier (FR)
- Corresponding author
- Record, Michel
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2018-08
- Volume
- 59
- Issue
- 8
- Pages
- 1316-1324
- ISSN
- 0022-2275 (ISSN-L)
- PMC
- PMC6071772
- OpenAlex
- W2804173945
- Cited by
- 328
- References
- 97
- Citations by year
- 2026: 31 · 2025: 33 · 2024: 35 · 2023: 36 · 2022: 56 · 2021: 50 · 2020: 55 · 2019: 27 · 2018: 5
- FWCI
- 3.34
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Lipid Research (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Cancer Research UK (18720)
- Biotechnology and Biological Sciences Research Council (BBS/E/B/000C0411, BBS/E/B/000C0433, BBS/E/B/000C0431, BBS/E/B/0000S227)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
- Keywords
- extracellular vesicles, exosomes, microvesicles, lipid mediators, eicosanoids, vesicle biogenesis, intercellular communication, tumor microenvironment, inflammation, immune surveillance
- MeSH terms
- Extracellular Vesicles, Humans, Signal Transduction, Lipid Metabolism, Cell-Derived Microparticles, Exosomes
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