The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Mast cells, macrophages, and crown-like structures distinguish subcutaneous from visceral fat in mice
Open accessAbstract
Obesity is accompanied by adipocyte death and accumulation of macrophages and mast cells in expanding adipose tissues. Considering the differences in biological behavior of fat found in different anatomical locations, we explored the distribution of mast cells, solitary macrophages, and crown-like structures (CLS), the surrogates for dead adipocytes, in subcutaneous and abdominal visceral fat of lean and diet-induced obese C57BL/6 mice. In fat depots of lean mice, mast cells were far less prevalent than solitary macrophages. Subcutaneous fat contained more mast cells, but fewer solitary macrophages and CLS, than visceral fat. Whereas no significant change in mast cell density of subcutaneous fat was observed, obesity was accompanied by a substantial increase in mast cells in visceral fat. CLS became prevalent in visceral fat of obese mice, and the distribution paralleled mast cells. Adipose tissue mast cells contained and released preformed TNF-α, the cytokine implicated in the pathogenesis of obesity-linked insulin resistance. In summary, subcutaneous fat differed from visceral fat by immune cell composition and a lower prevalence of CLS both in lean and obese mice. The increase in mast cells in visceral fat of obese mice suggests their role in the pathogenesis of obesity and insulin resistance.
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“Consistent with previous reports, our data confirm a more pronounced accumulation of large Cd68-eGFP+ clusters in the visceral fat compared with in the subcutaneous fat38.”
From A deep-learning framework reveals whole-body perturbations at cell level (2026) · cites this paper as [38]
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Metadata
- Authors
- Altintas, M. M., Azad, A., Nayer, B., Contreras, G., Zaias, J., Faul, C., Reiser, J., & Nayer, A.
- Affiliations
- University of Miami (US)
- Corresponding author
- Nayer, Ali
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 52
- Issue
- 3
- Pages
- 480-488
- ISSN
- 0022-2275 (ISSN-L)
- PMC
- PMC3035684
- OpenAlex
- W2089000416
- Cited by
- 198
- References
- 48
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 14 · 2023: 6 · 2022: 14 · 2021: 10 · 2020: 17 · 2019: 12 · 2018: 14 · 2017: 19 · 2016: 12 · 2015: 19 · 2014: 13 · 2013: 21 · 2012: 9
- FWCI
- 7.91
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Lipid Research (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- mast cells, macrophages, crown-like structures, subcutaneous adipose tissue, visceral fat, obesity, adipocyte death, TNF-α, insulin resistance, adipose tissue inflammation, diet-induced obesity, C57BL/6 mice
- MeSH terms
- Animals, Diet, Epididymis, Macrophages, Male, Mast Cells, Mice, Inbred C57BL, Obesity, Thinness, Subcutaneous Fat, Intra-Abdominal Fat, Mice
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