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Scavenger receptor-BI is a receptor for lipoprotein(a)

Yang, Xiao-Ping, Amar, Marcelo J., Vaisman, Boris, Bocharov, Alexander V., Vishnyakova, Tatyana G., Freeman, Lita A., Kurlander, Roger J., Patterson, Amy P., Becker, Lewis C., Remaley, Alan T.·2013·Journal of Lipid Research
DOI 10.1194/jlr.m038877
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Abstract

Scavenger receptor class B type I (SR-BI) is a multi-ligand receptor that binds a variety of lipoproteins, including high density lipoprotein (HDL) and low density lipoprotein (LDL), but lipoprotein(a) [Lp(a)] has not been investigated as a possible ligand. Stable cell lines (HEK293 and HeLa) expressing human SR-BI were incubated with protein- or lipid-labeled Lp(a) to investigate SR-BI-dependent Lp(a) cell association. SR-BI expression enhanced the association of both (125)I- and Alexa Fluor-labeled protein from Lp(a). By confocal microscopy, SR-BI was also found to promote the internalization of fluorescent lipids (BODIPY-cholesteryl ester (CE)- and DiI-labeled) from Lp(a), and by immunocytochemistry the cellular internalization of apolipoprotein(a) and apolipoprotein B. When dual-labeled ((3)H-cholesteryl ether,(125)I-protein) Lp(a) was added to cells expressing SR-BI, there was a greater relative increase in lipid uptake over protein, indicating that SR-BI mediates selective lipid uptake from Lp(a). Compared with C57BL/6 control mice, transgenic mice overexpressing human SR-BI in liver were found to have increased plasma clearance of (3)H-CE-Lp(a), whereas mouse scavenger receptor class B type I knockout (Sr-b1-KO) mice had decreased plasma clearance (fractional catabolic rate: 0.63 ± 0.08/day, 1.64 ± 0.62/day, and 4.64 ± 0.40/day for Sr-b1-KO, C57BL/6, and human scavenger receptor class B type I transgenic mice, respectively). We conclude that Lp(a) is a novel ligand for…

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  • Several other candidate Lp(a) receptors have been proposed, including other lipoprotein receptors, toll-like receptors, scavenger receptors, lectins, and plasminogen receptors.

    “Over time, several other candidate Lp(a) receptors have been proposed, including other lipoprotein receptors49,50, toll-like receptors51, scavenger receptors52,53, lectins26,54, and plasminogen receptors29,33.”

    From Functional interrogation of cellular Lp(a) uptake by genome-scale CRISPR screening (2025) · cites this paper as [52]

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Research works printed but not linked: 32

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Metadata

Authors
Yang, X.-P., Amar, M. J., Vaisman, B., Bocharov, A. V., Vishnyakova, T. G., Freeman, L. A., Kurlander, R. J., Patterson, A. P., Becker, L. C., & Remaley, A. T.
Venue
Journal of Lipid Research
Publisher
Elsevier BV
Published
2013-09
Volume
54
Issue
9
Pages
2450-2457
ISSN
0022-2275
DOI
10.1194/jlr.m038877
Cited by
113
References
1
Language
en
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