The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Cellular uptake of lipoprotein[a] by mouse embryonic fibroblasts via the LDL receptor and the LDL receptor-related protein
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Other studies have found no influence of LDLR on cellular Lp(a) binding or uptake in vitro.
“However, other studies have found no influence of LDLR on cellular Lp(a) binding or uptake in vitro31-34.”
From Functional interrogation of cellular Lp(a) uptake by genome-scale CRISPR screening (2025) · cites this paper as [31]
Multiple studies of LDLR in cells, animal models, and humans have provided inconsistent or conflicting results.
“Multiple studies of the LDL receptor (LDLR) in cells27-34, animal models25,32,35,36, and humans10,28,37-48 have provided inconsistent or conflicting results.”
From Functional interrogation of cellular Lp(a) uptake by genome-scale CRISPR screening (2025) · cites this paper as [31]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
cDNA sequence of human apolipoprotein(a) is homologous to plasminogen
McLean, J. W., Tomlinson, J. E., Kuang, W.-J., Eaton, D. L., Chen, E. Y., Fless, G. M., Scanu, A. M., & Lawn, R. M. (1987) · Nature · doi:10.1038/330132a0 · Cited by 1,886 · cited 1×
“Several studies have demonstrated that Lp[a], due to the homolog7.., of’ apo[a] with plasminogen (34), binds to plasminogen receptors on monocytoid cells, endothelial cells, human fibroblasts, and HepG2 cells (32, 35, 36).”
Flagged first, then by citations
Research works printed but not linked: 53
- Krempler, 1980, Turnover of lipoprotein [a] in man, J. Clin. Invest., 80, 1483, 10.1172/JCI109813 · DOI
- Kraft, 1989, Changes of genetic apolipoprotein phenotypes caused by liver transplantation. Implications for apolipoprotein synthesis, J. Clin. Invest., 83, 137, 10.1172/JCI113849 · DOI
- Edelstein, 1994, Oleate stimulates the formation of triglyceride-rich particles containing apoB-100-apo[a] in long-term primary cultures of human hepatocytes, Chem. Phys. Lpids., 67/68, 135, 10.1016/0009-3084(94)90132-5 · DOI
- Rader, 1993, Variation in lipoprotein [a] concentrations among individuals with the same apolipoprotein [a] isoform is determined by the rate of lipoprotein [a] production, J. Clin. Invest., 91, 443, 10.1172/JCI116221 · DOI
- Rader, 1994, The inverse association of plasma lipoprotein [a] concentrations with apolipoprotein [a] isoform size is not due to differences in Lp[a] catabolism but to differences in production rate, J. Clin. Invest., 93, 2758, 10.1172/JCI117292 · DOI
- Azrolan, 1991, Plasma lipoprotein[aj concentration is controlled by apolipopro-tein[a] (apo[a]) protein size and the abundance of hepatic apo[a] rnRNA in a cynomolgus monkey model, J. Biol. Chem., 266, 13866, 10.1016/S0021-9258(18)92782-1 · DOI
- White, 1993, Intracellular maturation of apolipoprotein [a] and assembly of lipoprotein [a] in primary baboon hepatocytes, J. Lipid Res., 34, 509, 10.1016/S0022-2275(20)40742-4 · DOI
- White, 1994, Cell surface assembly of lipoprotein [a] in primary cultures of baboon hepatocytes, J. Biol. Chem., 269, 28716, 10.1016/S0021-9258(19)61964-2 · DOI
- Wilkinson, 1994, Apolipoprotein [a] is not associated with apolipoprotein B in human liver, J. Lipid Res., 35, 1896, 10.1016/S0022-2275(20)39785-6 · DOI
- Havekes, 1981, Binding of Lp[a] to the low density lipoprotein receptor of human fibroblasts, FEBS lett., 132, 169, 10.1016/0014-5793(81)81153-2 · DOI
- Krempler, 1983, Studies on the role of specific cell surface receptors in the removal of lipoprotein [a] in man, J. Clin. Invest., 71, 1431, 10.1172/JCI110896 · DOI · Paper page
- Armstrong, 1990, Heterogeneity of human lipoprotein Lp[a]: cytochemical and biochemical studies on the interaction of two Lp[a] species with the LDL receptor, J. Lipid Res., 31, 429, 10.1016/S0022-2275(20)43165-7 · DOI
- Haberland, 1992, Malondialdehyde modification of lipoprotein [a] produces avid uptake by human monocyte-macrophages, J. Biol. Chem., 267, 4143, 10.1016/S0021-9258(19)50640-8 · DOI
- Floren, 1981, Uptake ofLp[a] lipoprotein by cultured fibroblasts, Biochem. Biophys. Res. Commun., 102, 636, 10.1016/S0006-291X(81)80179-9 · DOI · Paper page
- Widhalm, 1988, Increased lipoprotein [a] levels in children with familial hypercholesterolae-mia [letter], Lancet., 2, 1262, 10.1016/S0140-6736(88)90864-1 · DOI
- Utermann, 1989, Defects in the low density lipoprotein receptor gene affect lipoprotein [a] levels: multiplicative interaction of two gene loci associated with premature atherosclerosis, Proc. Natl. Acad. Sci. USA., 86, 4171, 10.1073/pnas.86.11.4171 · DOI
- Guo, 1991, Lipoprotein Lp[a] in homozygous familial hypercholesterolemia: density profile, particle heterogeneity and apolipoprotein [a] phenotype, Atherosclerosis., 86, 69, 10.1016/0021-9150(91)90100-H · DOI
- Mbewu, 1991, Serum lipoprotein [a] in patients heterozygous for familial hypercholesterolemia their relatives, and unrelated control populations, Arterioscler. Thromb., 11, 940, 10.1161/01.ATV.11.4.940 · DOI
- Hofmann, 1990, Overexpression of human low density lipoprotein receptors leads to accelerated catabolism of Lp[a] lipoprotein in transgenic mice, J. Clin. Invest., 85, 1542, 10.1172/JCI114602 · DOI · Paper page
- Maartmann, Moe, 1981, Lp[a] lipoprotein enters cultured fibroblasts independently of the plasma membrane low density receptor, Clin. Genet., 20, 352, 10.1111/j.1399-0004.1981.tb01047.x · DOI
- Neven, 1990, Rhesus monkey model of familial hypercholesterolemia: relation between plasma Lp[a] levels, apo[a] isoforms, and LDL-receptor function, J. Lipid Res., 31, 633, 10.1016/S0022-2275(20)42831-7 · DOI
- Snyder, 1992, Comparative binding and degradation of lipoprotein [a] and low density lipoprotein by human monocyte-derived macrophages, J. Biol. Chem., 267, 339, 10.1016/S0021-9258(18)48499-2 · DOI
- Rader, 1995, The low density lipoprotein receptor is not required for normal catabolism of Lp[a] in humans, J. Clin. Invest., 95, 1403, 10.1172/JCI117794 · DOI · Paper page
- Soutar, 1991, Relationship between apolipoprotein [a] phenotype, lipoprotein [a] concentration in plasma, and low density lipoprotein receptor function in a large kindred with familial hypercholesterolemia due to the pro664-leu mutation in the LDL receptor gene, J. Clin Invest., 88, 483, 10.1172/JCI115329 · DOI
- Vessby, 1982, Diverging effects of cholestyramine on apolipoprotein B and lipoprotein Lp[a], Atherosclerosis, 44, 61, 10.1016/0021-9150(82)90053-3 · DOI
- Thiery, 1988, Serum lipoprotein Lp[a] concentrations are not influenced by an HMG-CoA reductase inhibitor, Klin. Wochenschr., 66, 462, 10.1007/BF01745519 · DOI
- Fieseler, 1991, Serum Lp[a] concentrations are unaffected by treatment with the HMG-CoA reductase inhibitor pravastatin: results of a 2-year investigation, Clin. Chim. Acta., 204, 291, 10.1016/0009-8981(91)90239-9 · DOI
- Armstrong, 1985, Isolation, characterization, and uptake in human fibroblasts of an apo[a]-free lipoprotein obtained on reduction of lipoprotein [a], J. Lipid Res., 26, 1314, 10.1016/S0022-2275(20)34257-7 · DOI
- Gries, 1988, Interaction of LDL, Lp[a], and reduced Lp[a] with monoclonal antibodies against apoB, J. Lipid Res., 29, 1, 10.1016/S0022-2275(20)38555-2 · DOI
- Marz, 1993, Heterogeneous lipoprotein [a] size isoforms differ by their interaction with the low density lipoprotein receptor and the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor, FEBS Lett., 325, 271, 10.1016/0014-5793(93)81087-G · DOI · Paper page
- Kostner, 1993, Interaction of Lp[a] and of apo[a] with liver cells, Arterioscler. Thromb., 13, 1101, 10.1161/01.ATV.13.7.1101 · DOI · Paper page
- Tam, 1996, Interaction of a recombinant form of apolipoprotein [a] with human fibroblasts and with the human hepatoma cell line HepG2, J. Lipid Res., 37, 518, 10.1016/S0022-2275(20)37595-7 · DOI · Paper page
- Williams, 1992, Mechanisms by which lipoprotein lipase alters cellular metabolism of lipoprotein [a] low density lipoprotein, and nascent lipoproteins, Roles for low density lipoprotein receptors and heparan sulfate proteoglycans J. Biol. Chem., 267, 13284
- Miles, 1995, Interaction of Lp[aJ with plasminogen binding sites on cells, Thromb. Haemost., 73, 458, 10.1055/s-0038-1653797 · DOI
- Kanalas, 1991, Identification of the rat Heymann Nephritis Autoantigen (gp330) as a receptor site for plasminogen, J. Biol. Chem., 266, 10825, 10.1016/S0021-9258(18)99093-9 · DOI
- Zioncheck, 1991, Interaction of recombinant apolipoprotein [a] and lipoprotein [a] with macrophages, J. Clin. Invest., 87, 767, 10.1172/JCI115079 · DOI
- Snyder, 1994, Binding and degradation of lipoprotein [a] and LDL by primary cultures of human hepa-tocytes, Comparison with cultured human monocyte-macrophages and fibroblasts, Arteiioscler. Thromb., 14, 770
- Ishibashi, 1993, Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery, J. Clin. Invest., 92, 883, 10.1172/JCI116663 · DOI · Paper page
- Herz, 1992, LDI, receptor-related protein internalizes and degrades uPA-PAI-1 complexes and is essential for embryo implantation [published erratum appears in, Cell., 71, 411, 10.1016/0092-8674(92)90511-A · DOI · Paper page
- Willnow, 1994, Genetic deficiency in low density lipoprotein receptor-related protein confers cellular resistance to Pseudomonas exotoxin A. Evidence that this protein is required for uptake and degradation of multiple ligands, J. Cell Sci., 107, 719, 10.1242/jcs.107.3.719 · DOI
- Friedewald, 1972, Estimation of plasma low density lipoprotein cholesterol concentration without use of the preparative ultracentrifuge, Clin. Chem., 18, 499, 10.1093/clinchem/18.6.499 · DOI · Paper page
- Lowry, 1951, Protein measurement with the Folin phenol reagent, J. Biol. Chem., 193, 265, 10.1016/S0021-9258(19)52451-6 · DOI
- Utermann, 1995, Genetic architecture of the atherogenic lipoprotein [a], Ann. NY Acad. Sci., 748, 301, 10.1111/j.1749-6632.1994.tb17328.x · DOI
- McFarlane, 1958, Efficient trace labeling of proteins with iodine, Nature., 182, 53, 10.1038/182053a0 · DOI
- Beisiegel, 1991, Lipoprotein lipase enhances the binding of chylomicrons to low density lipoprotein receptor-related protein, Proc. Natl. Acad. Sci. USA., 88, 8342, 10.1073/pnas.88.19.8342 · DOI · Paper page
- Goldstein, 1983, Receptor-mediated endocytosis of low-density lipoprotein in cultured cells, Methods Enzymol., 98, 241, 10.1016/0076-6879(83)98152-1 · DOI
- Reblin, 1992, Correlation of apolipoprotein [a] isoproteins with Lp[a] density and distribution in fasting plasma, Atherosclerosis., 94, 223, 10.1016/0021-9150(92)90247-E · DOI
- Neville, 1971, Molecular weight determination of protein dodecyl sulfate complexes by gel electrophoresis in a discontinuous buffer system, J. Biol. Chem., 246, 6328, 10.1016/S0021-9258(18)61792-2 · DOI
- Beisiegel, 1986, Proteinblotting, Electrojihoresis., 7, 1, 10.1002/elps.1150070102 · DOI
- Rath, 1989, Detection and quantification of lipoprotein [a] in the arterial wall of 107 coronary bypass patients [published erratum appears in Arteriosclerosis. 1990. 10:1147], Arteriosclerosis., 9, 579, 10.1161/01.ATV.9.5.579 · DOI
- Bard, 1992, Isolation and characterization of two sub-species of Lp[a], one containing apoE and one free of apoE, Biochim. Biophys. Acta., 1127, 124, 10.1016/0005-2760(92)90267-Y · DOI
- Krempler, 1984, The interaction of human apoB-con-taining lipoproteins with mouse peritoneal macrophages-a comparison of Lp[a] with LDL, J. Lipid Res., 25, 283, 10.1016/S0022-2275(20)37824-X · DOI
- Tabas, 1993, J. Biol. Chem., 268, 20419, 10.1016/S0021-9258(20)80745-5 · DOI
Cited by
Sorted by citations
Fryer, J. D., DeMattos, R. B., McCormick, L. M., O'Dell, M. A., Spinner, M. L., Bales, K. R., Paul, S. M., Sullivan, P. M., Parsadanian, M., Bu, G., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502143200 · Cited by 139
Functional interrogation of cellular Lp(a) uptake by genome-scale CRISPR screening
Khan, T. G., Bragazzi Cunha, J., Raut, C., Burroughs, M., Vyas, H. S., Leix, K., Goonewardena, S. N., Smrcka, A. V., Speliotes, E. K., & Emmer, B. T. (2025) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2025.119174 · Cited by 6
Metadata
- Authors
- Reblin, T., Niemeier, A., Meyer, N., Willnow, T. E., Kronenberg, F., Dieplinger, H., Greten, H., & Beisiegel, U.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 1997-10
- Volume
- 38
- Issue
- 10
- Pages
- 2103-2110
- ISSN
- 0022-2275
- Cited by
- 57
- References
- 1
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review