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Hepatic lipase mediates an increase in selective uptake of HDL-associated cholesteryl esters by cells in culture independent from SR-BI

Brundert, May, Heeren, Joerg, Greten, Heiner, Rinninger, Franz·2003·Journal of Lipid Research
DOI 10.1194/jlr.m300058-jlr200
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Abstract

Scavenger receptor class B type I (SR-BI) mediates the selective uptake of HDL cholesteryl esters (CEs) by the liver. Hepatic lipase (HL) promotes this lipid uptake independent from lipolysis. The role of SR-BI in this HL-mediated increase in selective CE uptake was explored. Baby hamster kidney (BHK) cells were transfected with the SR-BI cDNA yielding cells with SR-BI expression, whereas no SR-BI was detected in control cells. These cells were incubated in medium containing 125I [3H]cholesteryl oleyl ether-labeled HDL3 (d = 1.125-1.21 g/ml) and HL was absent or present. Tetrahydrolipstatin (THL) blocked lipolysis. In control BHK cells and in BHK cells with SR-BI, HDL3 selective CE uptake (3H-125I) was detectable and SR-BI promoted this uptake. In both cell types, HL mediated an increase in selective CE uptake from HDL3. Quantitatively, this HL effect was similar in control BHK cells and in BHK cells with SR-BI. These results suggest that HL promotes selective uptake independent from SR-BI. To investigate the role of cell surface proteoglycans on the HL-mediated HDL3 uptake, proteoglycan deficiency was induced by heparinase digestion. Proteoglycan deficiency decreased the HL-mediated promotion of selective CE uptake. In summary, the stimulating HL effect on HDL selective CE uptake is independent from SR-BI and lipolysis. Proteoglycans are a requisite for the HL action on selective uptake. Results suggest that (a) pathway(s) distinct from SR-BI mediate(s) selective CE uptake f…

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Research works printed but not linked: 48

  1. Pittman, 1987, A nonendocytotic mechanism for the selective uptake of high density lipoprotein-associated cholesterol esters, J. Biol. Chem., 262, 2443, 10.1016/S0021-9258(18)61524-8 · DOI
  2. Acton, 1996, Identification of scavenger receptor SR-BI as a high density lipoprotein receptor, Science., 271, 518, 10.1126/science.271.5248.518 · DOI · Paper page
  3. Rigotti, 1997, A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolism, Proc. Natl. Acad. Sci. USA., 94, 12610, 10.1073/pnas.94.23.12610 · DOI
  4. Varban, 1998, Targeted mutation reveals a central role for SR-BI in hepatic selective uptake of high density lipoprotein cholesterol, Proc. Natl. Acad. Sci. USA., 95, 4619, 10.1073/pnas.95.8.4619 · DOI
  5. Goldberg, 1996, Lipoprotein lipase and lipolysis: central roles in lipoprotein metabolism and atherogenesis, J. Lipid Res., 37, 693, 10.1016/S0022-2275(20)37569-6 · DOI
  6. Jansen, 1979, Secretion of triacylglycerol hydrolase activity by isolated parenchymal rat liver cells, FEBS Lett., 98, 299, 10.1016/0014-5793(79)80204-5 · DOI
  7. Kuusi, 1979, Localization of the heparin-releasable lipase in situ in the rat liver, Biochem. J., 181, 245, 10.1042/bj1810245 · DOI
  8. Sanan, 1997, Hepatic lipase is abundant on both hepatocyte and endothelial cell surfaces in the liver, J. Lipid Res., 38, 1002, 10.1016/S0022-2275(20)37224-2 · DOI · Paper page
  9. Bengtsson, 1980, The hepatic heparin releasable lipase binds to high density lipoproteins, FEBS Lett., 119, 290, 10.1016/0014-5793(80)80274-2 · DOI
  10. Beisiegel, 1991, Lipoprotein lipase enhances the binding of chylomicrons to low density lipoprotein receptor-related protein, Proc. Natl. Acad. Sci. USA., 88, 8342, 10.1073/pnas.88.19.8342 · DOI · Paper page
  11. Eisenberg, 1992, Lipoprotein lipase enhances binding of lipoproteins to heparan sulfate on cell surfaces and extracellular matrix, J. Clin. Invest., 90, 2013, 10.1172/JCI116081 · DOI
  12. Rumsey, 1992, Lipoprotein lipase-mediated uptake and degradation of low density lipoproteins by fibroblasts and macrophages, J. Clin. Invest., 90, 1504, 10.1172/JCI116018 · DOI
  13. Ji, 1997, Heparan sulfate proteoglycans participate in hepatic lipase- and apolipoprotein E-mediated binding and uptake of plasma lipoproteins, including high density lipoproteins, J. Biol. Chem., 272, 31285, 10.1074/jbc.272.50.31285 · DOI · Paper page
  14. Chappell, 1992, The low density lipoprotein receptor-related protein/alpha2-macroglobulin receptor binds and mediates catabolism of bovine milk lipoprotein lipase, J. Biol. Chem., 267, 25764, 10.1016/S0021-9258(18)35675-8 · DOI · Paper page
  15. Kounnas, 1995, The cellular internalization and degradation of hepatic lipase is mediated by low density lipoprotein receptor-related protein and requires cell surface proteoglycans, J. Biol. Chem., 270, 9307, 10.1074/jbc.270.16.9307 · DOI
  16. Krapp, 1996, Hepatic lipase mediates the uptake of chylomicrons and beta-VLDL into cells via the LDL receptor-related protein (LRP), J. Lipid Res., 37, 926, 10.1016/S0022-2275(20)42004-8 · DOI
  17. Kadowaki, 1992, Metabolism of high density lipoprotein lipids by the rat liver: evidence for participation of hepatic lipase in the uptake of cholesteryl ester, J. Lipid Res., 33, 1689, 10.1016/S0022-2275(20)41391-4 · DOI
  18. Marques-Vidal, 1994, Hepatic lipase promotes the uptake of HDL esterified cholesterol by the perfused rat liver: a study using reconstituted HDL particles of defined phospholipid composition, J. Lipid Res., 35, 373, 10.1016/S0022-2275(20)41190-3 · DOI
  19. Bamberger, 1983, Hepatic lipase stimulates the uptake of high density lipoprotein cholesterol by hepatoma cells, J. Lipid Res., 24, 869, 10.1016/S0022-2275(20)37932-3 · DOI
  20. Panzenboeck, 1997, Implications of endogenous and exogenous lipoprotein lipase for the selective uptake of HDL3-associated cholesteryl esters by mouse peritoneal macrophages, J. Lipid Res., 38, 239, 10.1016/S0022-2275(20)37437-X · DOI
  21. Rinninger, 1998, Hepatic lipase mediates an increase in selective uptake of high-density lipoprotein-associated cholesteryl esters by human Hep 3B hepatoma cells in culture, Atherosclerosis., 141, 273, 10.1016/S0021-9150(98)00181-6 · DOI
  22. Rinninger, 1998, Lipoprotein lipase mediates an increase in the selective uptake of high density lipoprotein-associated cholesteryl esters by hepatic cells in culture, J. Lipid Res., 39, 1335, 10.1016/S0022-2275(20)32514-1 · DOI
  23. Seo, 2000, Lipoprotein lipase-mediated selective uptake from low density lipoprotein requires cell surface proteoglycans and is independent of scavenger receptor class B type 1, J. Biol. Chem., 275, 30355, 10.1074/jbc.M910327199 · DOI
  24. Rinninger, 2001, Lipoprotein lipase mediates an increase in selective uptake of HDL-associated cholesteryl esters by cells in culture independent of scavenger receptor BI, J. Lipid Res., 42, 1740, 10.1016/S0022-2275(20)31500-5 · DOI
  25. Lambert, 1999, Hepatic lipase promotes the selective uptake of high density lipoprotein-cholesteryl esters via the scavenger receptor B1, J. Lipid Res., 40, 1294, 10.1016/S0022-2275(20)33491-X · DOI
  26. Pittman, 1986, Methods for assessment of tissue sites of lipoprotein degradation, Methods Enzymol., 129, 612, 10.1016/0076-6879(86)29094-1 · DOI
  27. Rinninger, 1994, Selective uptake of high-density lipoprotein-associated cholesteryl esters by human hepatocytes in primary culture, Hepatology., 19, 1100, 10.1002/hep.1840190507 · DOI
  28. Zaidan, 1985, Lipid clearing in premature infants during continous heparin infusion: role of circulating lipases, Pediatr. Res., 19, 23, 10.1203/00006450-198501000-00007 · DOI
  29. Heeren, 1999, Intracellular processing of endocytosed triglyceride-rich lipoproteins comprises both recycling and degradation, J. Cell Sci., 112, 349, 10.1242/jcs.112.3.349 · DOI · Paper page
  30. Heeren, 2001, Recycling of apolipoprotein E and lipoprotein lipase through endosomal compartments in vivo, J. Biol. Chem., 276, 42333, 10.1074/jbc.M107461200 · DOI · Paper page
  31. Nakabayashi, 1982, Growth of human hepatoma cell lines with differentiated functions in chemically defined medium, Cancer Res., 42, 3858
  32. Jansen, 1997, Common C-to-T substitution at position –480 of the hepatic lipase promoter is associated with a lowered lipase activity in coronary artery disease patients, Arterioscler. Thromb. Vasc. Biol., 17, 2837, 10.1161/01.ATV.17.11.2837 · DOI
  33. Hadvary, 1991, The lipase inhibitor tetrahydrolipstatin binds covalently to the putative active site serine of pancreatic lipase, J. Biol. Chem., 266, 2021, 10.1016/S0021-9258(18)52203-1 · DOI
  34. Lookene, 1994, Interactions of lipoprotein lipase with the active-site inhibitor tetrahydrolipstatin (Orlistat(R)), Eur. J. Biochem., 222, 395, 10.1111/j.1432-1033.1994.tb18878.x · DOI
  35. Rinninger, 1993, A pool of reversibly cell-associated cholesteryl esters involved in the selective uptake of cholesteryl esters from high-density lipoproteins by Hep G2 hepatoma cells, Biochim. Biophys. Acta., 1166, 275, 10.1016/0005-2760(93)90108-L · DOI
  36. Webb, 1998, SR-BII, an isoform of the scavenger receptor BI containing an alternate cytoplasmic tail, mediated lipid transfer between high density lipoprotein and cells, J. Biol. Chem., 273, 15241, 10.1074/jbc.273.24.15241 · DOI
  37. Rigotti, 1996, Regulation by adrenocorticotropic hormone of the in vivo expression of scavenger receptor class B type I (SR-BI), a high density lipoprotein receptor, in steroidogenic cells of the murine adrenal gland, J. Biol. Chem., 271, 33545, 10.1074/jbc.271.52.33545 · DOI
  38. Obunike, 1994, Cellular differences in lipoprotein lipase-mediated uptake of low density lipoproteins, J. Biol. Chem., 269, 13129, 10.1016/S0021-9258(17)36808-4 · DOI
  39. Rodriguza, 1999, Mechanism of scavenger receptor class B type I-mediated selective uptake of cholesteryl esters from high density lipoprotein to adrenal cells, J. Biol. Chem., 274, 20344, 10.1074/jbc.274.29.20344 · DOI
  40. Connelly, 1999, Comparison of class B scavenger receptors, CD36 and scavenger receptor BI (SR-BI), shows that both receptors mediate high density lipoprotein-cholesteryl ester selective uptake but SR-BI exhibits a unique enhancement of cholesteryl ester uptake, J. Biol. Chem., 274, 41, 10.1074/jbc.274.1.41 · DOI
  41. Morrison, 1994, Cholesteryl ester transfer between high density lipoprotein and phospholipid bilayers, J. Biol. Chem., 269, 13911, 10.1016/S0021-9258(17)36734-0 · DOI
  42. Dichek, 1998, Overexpression of hepatic lipase in transgenic mice decreaes apolipoprotein B-containing and high density lipoproteins, J. Biol. Chem., 273, 1896, 10.1074/jbc.273.4.1896 · DOI · Paper page
  43. Homanics, 1995, Mild dyslipidemia in mice following targeted inactivation of the hepatic lipase gene, J. Biol. Chem., 270, 2974, 10.1074/jbc.270.7.2974 · DOI
  44. Fan, 1994, Overexpression of hepatic lipase in transgenic rabbits leads to a marked reduction of plasma high density lipoproteins and intermediate density lipoproteins, Proc. Natl. Acad. Sci. USA., 91, 8724, 10.1073/pnas.91.18.8724 · DOI
  45. Busch, 1994, Human hepatic triglyceride lipase expression reduces high density lipoprotein and aortic cholesterol in cholesterol-fed transgenic mice, J. Biol. Chem., 269, 16376, 10.1016/S0021-9258(17)34018-8 · DOI
  46. Wang, 1998, Liver-specific overexpression of scavenger receptor BI decreases levels of very low density lipoprotein apoB, low density lipoprotein apoB, and high density lipoprotein in transgenic mice, J. Biol. Chem., 273, 32920, 10.1074/jbc.273.49.32920 · DOI
  47. Wang, 1996, Scavenger receptor BI (SR-BI) is up-regulated in adrenal gland in apolipoprotein A-I and hepatic lipase knock-out mice as a response to depletion of cholesterol stores, J. Biol. Chem., 271, 21001, 10.1074/jbc.271.35.21001 · DOI · Paper page
  48. Thuren, 2000, Hepatic lipase and HDL metabolism, Curr. Opin. Lipidol., 11, 277, 10.1097/00041433-200006000-00008 · DOI

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Metadata

Authors
Brundert, M., Heeren, J., Greten, H., & Rinninger, F.
Venue
Journal of Lipid Research
Publisher
Elsevier BV
Published
2003-05
Volume
44
Issue
5
Pages
1020-1032
ISSN
0022-2275
DOI
10.1194/jlr.m300058-jlr200
Cited by
17
References
0
Language
en
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