The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
The lipogenic enzymes DGAT1, FAS, and LPL in adipose tissue: effects of obesity, insulin resistance, and TZD treatment
Open accessAbstract
Acyl-coenzyme A:diacylglycerol transferase (DGAT), fatty acid synthetase (FAS), and LPL are three enzymes important in adipose tissue triglyceride accumulation. To study the relationship of DGAT1, FAS, and LPL with insulin, we examined adipose mRNA expression of these genes in subjects with a wide range of insulin sensitivity (SI). DGAT1 and FAS (but not LPL) expression were strongly correlated with SI. In addition, the expression of DGAT1 and FAS (but not LPL) were higher in normal glucose-tolerant subjects compared with subjects with impaired glucose tolerance (IGT) (P < 0.005). To study the effects of insulin sensitizers, subjects with IGT were treated with pioglitazone or metformin for 10 weeks, and lipogenic enzymes were measured in adipose tissue. After pioglitazone treatment, DGAT1 expression was increased by 33 +/- 10% (P < 0.05) and FAS expression increased by 63 +/- 8% (P < 0.05); however, LPL expression was not altered. DGAT1, FAS, and LPL mRNA expression were not significantly changed after metformin treatment. The treatment of mice with rosiglitazone also resulted in an increase in adipose expression of DGAT1 by 2- to 3-fold, as did the treatment of 3T3 F442A adipocytes in vitro with thiazolidinediones. These data support a more global concept suggesting that adipose lipid storage functions to prevent peripheral lipotoxicity.
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Cites
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“SI was calculated from the insulin and glucose data using the MINMOD program (25, 26).”
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Cloning of DGAT2, a Second Mammalian Diacylglycerol Acyltransferase, and Related Family Members
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Cited by
Thematic review series: Glycerolipids. DGAT enzymes and triacylglycerol biosynthesis
Yen, C.-L. E., Stone, S. J., Koliwad, S., Harris, C., & Farese, R. V. (2008) · Journal of Lipid Research · doi:10.1194/jlr.r800018-jlr200 · Cited by 1,105
Glycerolipid Metabolism and Signaling in Health and Disease
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Harford, K. A., Reynolds, C. M., McGillicuddy, F. C., & Roche, H. M. (2011) · Proceedings of the Nutrition Society · doi:10.1017/s0029665111000565 · Cited by 299
Nutritional Interventions to Alleviate the Negative Consequences of Heat Stress
Rhoads, R. P., Baumgard, L. H., Suagee, J. K., & Sanders, S. R. (2013) · Advances in Nutrition · doi:10.3945/an.112.003376 · Cited by 256
Metformin in polycystic ovary syndrome
Diamanti‐Kandarakis, E., Economou, F., Palimeri, S., & Christakou, C. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05679.x · Cited by 109
Metadata
- Authors
- Ranganathan, G., Unal, R., Pokrovskaya, I., Yao-Borengasser, A., Phanavanh, B., Lecka-Czernik, B., Rasouli, N., & Kern, P. A.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2006-11
- Volume
- 47
- Issue
- 11
- Pages
- 2444-2450
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W2124241212
- Cited by
- 178
- References
- 9
- FWCI
- 3.86
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: The lipogenic enzymes DGAT1, FAS, and LPL in adipose tissue: effects of obesity, insulin resistance, and TZD treatment. https://app.cochat.ai/papers/10.1194/jlr.m600248-jlr200
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- Ranganathan, G., Unal, R., Pokrovskaya, I., Yao-Borengasser, A., Phanavanh, B., Lecka-Czernik, B., Rasouli, N., & Kern, P. A. (2006). The lipogenic enzymes DGAT1, FAS, and LPL in adipose tissue: effects of obesity, insulin resistance, and TZD treatment. Journal of Lipid Research. https://doi.org/10.1194/jlr.m600248-jlr200
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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