Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp.

Bergman, R N; Prager, R; Volund, A; Olefsky, J M

doi:10.1172/jci112886

Cited by 772Diabetes, Cardiovascular Risks, and LipoproteinsPancreatic function and diabetesDiabetes Management and Research

Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp.

Open access

Bergman, R N, Prager, R, Volund, A, Olefsky, J M·1987·Journal of Clinical Investigation

DOI 10.1172/jci112886PMC PMC424201

Open this paper in CoChat — free account Open PDF

Abstract

Studies were done to determine whether the minimal model approach and the glucose clamp measure equivalent indices of insulin action. Euglycemic glucose clamps (glucose, G: 85 mg/dl) were performed at two rates of insulin (I) infusion (15 and 40 mU/min per m2) in 10 subjects (body mass index, BMI, from 21 to 41 kg/m2). Insulin sensitivity index (SI) from clamps varied from 0.15 to 3.15 (mean: 1.87 +/- 0.36 X 10(-2) dl/[min per m2] per microU/ml), and declined linearly with increasing adiposity (versus BMI: r = -0.97; P less than 0.001). SI from modeling the modified frequently sampled intravenous tolerance test varied from 0.66 to 7.34 X 10(-4) min-1 per microU/ml, and was strongly correlated with SIP(clamp) (r = 0.89; P less than 0.001). SI and SIP(clamp) were similar (0.046 +/- 0.008 vs. 0.037 +/- 0.007 dl/min per microU/ml, P greater than 0.35); the relation had a slope not different from unity (1.05 P greater than 0.70) and passed through the origin (P greater than 0.40). However, on a period basis, SI exceeded SIP(clamp) slightly, due to inhibition of hepatic glucose output during the FSIGT, not included in SIP(clamp). These methods are equivalent for assessment of overall insulin sensitivity in normal and insulin-resistant nondiabetic subjects.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1172/jci112886

Cites

33 of 33 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Minimal model analysis of a frequently sampled iv glucose tolerance test is a well accepted alternative for estimating insulin sensitivity.
“A well accepted alternative for estimating insulin sensitivity involves minimal model analysis of a frequently sampled iv glucose tolerance test (FSIVGTT) (9 -11).”
From Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans (2000) · cites this paper as [9]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Quantitative estimation of insulin sensitivity.
Bergman, R. N., Ider, Y. Z., Bowden, C. R., & Cobelli, C. (1979) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1979.236.6.e667 · Cited by 1,874 · cited 2× · see citing works
“The equations of the minimal model are as follows (7): dG(t)/dt = -[pi + X(t)]G(t) + pGb, dX(t)/dt”
MethodSelf-citation
INFLUENCES OF GLUCOSE LOADING AND OF INJECTED INSULIN ON HEPATIC GLUCOSE OUTPUT*
Steele, R. D. (1959) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1959.tb44923.x · Cited by 1,680 · see citing works
Physiologic evaluation of factors controlling glucose tolerance in man: measurement of insulin sensitivity and beta-cell glucose sensitivity from the response to intravenous glucose
Bergman, R. N., Phillips, L. S., & Cobelli, C. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110398 · Cited by 1,640 · cited 3× · see citing works
“23, Table and the range of SI values is consistent with previous reports in ,ed a large secnormal and obese subjects in whomthe previously used protocol grated, 22-180 (glucose alone) was employed (8, 12).”
BackgroundMethodSelf-citation
Use of Polyethylene Glycol to Separate Free and Antibody-Bound Peptide Hormones in Radioimmunoassays†
Desbuquois, B., & Aurbach, G. D. (1971) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-33-5-732 · Cited by 1,301 · see citing works
Assessment of insulin sensitivity in vivo.
Bergman, R., Finegood, D., & Ader, M. (1985) · Endocrine reviews · doi:10.1210/edrv-6-1-45 · Cited by 1,215 · see citing works
Self-citation
Measurement of Size and Turnover Rate of Body Glucose Pool by the Isotope Dilution Method
Steele, R., Wall, J. S., de Bodo, R. C., & Altszuler, N. (1956) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1956.187.1.15 · Cited by 816 · see citing works
MINMOD: a computer program to calculate insulin sensitivity and pancreatic responsivity from the frequently sampled intravenous glucose tolerance test
Pacini, G., & Bergman, R. N. (1986) · Computer Methods and Programs in Biomedicine · doi:10.1016/0169-2607(86)90106-9 · Cited by 695 · see citing works
Self-citation
Mechanisms of insulin resistance in human obesity: evidence for receptor and postreceptor defects.
Kolterman, O. G., Insel, J., Saekow, M., & Olefsky, J. M. (1980) · Journal of Clinical Investigation · doi:10.1172/jci109790 · Cited by 664 · see citing works
Self-citation
Glucose Intolerance and Aging: Evidence for Tissue Insensitivity to Insulin
DeFronzo, R. A. (1979) · Diabetes · doi:10.2337/diab.28.12.1095 · Cited by 595 · see citing works
Comparison of impedance to insulin-mediated glucose uptake in normal subjects and in subjects with latent diabetes
Shen, S.-W., Reaven, G. M., & Farquhar, J. W. (1970) · Journal of Clinical Investigation · doi:10.1172/jci106433 · Cited by 494 · see citing works
A model of the kinetics of insulin in man
Sherwin, R. S., Kramer, K. J., Tobin, J. D., Insel, P. A., Liljenquist, J. E., Berman, M., & Andres, R. (1974) · Journal of Clinical Investigation · doi:10.1172/jci107697 · Cited by 460 · cited 1× · see citing works
“One of the primary simplifications implemented in the model is that during the FSIGT, glucose distribution can be described by a single compartment representation, despite evidence for three-compartment distribution of labeled glucose moieties when sufficient time is allotted (30, 31).”
Glucose intolerance and aging
DeFronzo, R. A. (1981) · Diabetes Care · doi:10.2337/diacare.4.4.493 · Cited by 389 · see citing works
The Insulin Sensitivity Index in Nondiabetic Man: Correlation Between Clamp-derived and IVGTT-derived Values
Beard, J. C., Bergman, R. N., Ward, W., & Porte, D. (1986) · Diabetes · doi:10.2337/diab.35.3.362 · Cited by 287 · see citing works
Self-citation
Experimental validation of measurements of glucose turnover in nonsteady state.
Radziuk, J., Norwich, K. H., & Vranic, M. (1978) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1978.234.1.e84 · Cited by 277 · see citing works
Demonstration of insulin resistance in untreated adult onset diabetic subjects with fasting hyperglycemia.
Ginsberg, H., Kimmerling, G., Olefsky, J. M., & Reaven, G. M. (1975) · Journal of Clinical Investigation · doi:10.1172/jci107951 · Cited by 225 · see citing works
Self-citation
INTERPRETATION OF THE RAPID INTRAVENOUS GLUCOSE TOLERANCE TEST IN NORMAL INDIVIDUALS AND IN MILD DIABETES MELLITUS 1
Amatuzio, D. S., Stutzman, F. L., Vanderbilt, M. J., et al. (1953) · Journal of Clinical Investigation · doi:10.1172/jci102755 · Cited by 213 · see citing works
ON THE INTRAVENOUS GLUCOSE TOLERANCE TEST
Ikkos, D., & Luft, R. (1957) · European Journal of Endocrinology · doi:10.1530/acta.0.0250312 · Cited by 195 · see citing works
Extreme Insulin Resistance in Ataxia Telangiectasia
Bar, R. S., Levis, W. R., Rechler, M. M., Harrison, L. C., Siebert, C., Podskalny, J. M., Roth, J., & Muggeo, M. (1978) · New England Journal of Medicine · doi:10.1056/nejm197805252982103 · Cited by 180 · see citing works
Importance of Glucose Per Se to Intravenous Glucose Tolerance: Comparison of the Minimal-Model Prediction with Direct Measurements
Ader, M., Pacini, G., Yang, Y. J., & Bergman, R. N. (1985) · Diabetes · doi:10.2337/diab.34.11.1092 · Cited by 169 · see citing works
Self-citation
THE INTRAVENOUS GLUCOSE TOLERANCE TEST
Duncan, L. J. P. (1956) · Quarterly Journal of Experimental Physiology and Cognate Medical Sciences · doi:10.1113/expphysiol.1956.sp001165 · Cited by 162 · see citing works
Use of Glucose Uptake and Glucose Clearance for the Evaluation of Insulin Action In Vivo
Gottesman, I. S., Mandarino, L. J., & Gerich, J. E. (1984) · Diabetes · doi:10.2337/diab.33.2.184 · Cited by 91 · see citing works
Relationship between in Vivo Insulin Resistance and Decreased Insulin Receptors in Obese Man*
KOLTERMAN, O. G., REAVEN, G. M., & OLEFSKY, J. M. (1979) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-48-3-487 · Cited by 85 · see citing works
Self-citation
Optimal segments: a method for smoothing tracer data to calculate metabolic fluxes
Finegood, D. T., & Bergman, R. N. (1983) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1983.244.5.e472 · Cited by 84 · see citing works
Self-citation
Presentation of a new method for specific measurement of in vivo insulin-stimulated glucose disposal in humans: comparison of this approach with the insulin clamp and minimal model techniques.
Donner, C., Fraze, E., Chen, Y.-D.-I., Hollenbeck, C., Folley, J. E., & Reaven, G. (1985) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jcem-60-4-723 · Cited by 55 · see citing works
Quantification of Insulin Secretion and In Vivo Insulin Action in Nonobese and Moderately Obese Individuals with Normal Glucose Tolerance
Reaven, G. M., Moore, J., & Greenfield, M. S. (1983) · Diabetes · doi:10.2337/diab.32.7.600 · Cited by 55 · see citing works
Importance of glucose per se to intravenous glucose tolerance. Comparison of the minimal-model prediction with direct measurements
Ader, M., Pacini, G., Yang, Y. J., et al. (1985) · Diabetes · doi:10.2337/diabetes.34.11.1092 · Cited by 52 · see citing works
In Vivo Deactivation of Peripheral, Hepatic, and Pancreatic Insulin Action in Man
Gray, R. S., Scarlett, J. A., Griffin, J., Olefsky, J. M., & Kolterman, O. (1982) · Diabetes · doi:10.2337/diab.31.10.929 · Cited by 45 · see citing works
Self-citation
Estimates of In Vivo Insulin Action in Humans: Comparison of the Insulin Clamp and the Minimal Model Techniques
Foley, J. E., Chen, Y. I., Lardinois, C. K., Hollenbeck, C. B., Liu, G. C., & Reaven, G. M. (1985) · Hormone and Metabolic Research · doi:10.1055/s-2007-1013559 · Cited by 34 · see citing works
Tracer Probes in Steady State Systems
Steele, R., Thomas, C. C., & Manning, G. S. (1972) · Soil Science · doi:10.1097/00010694-197212000-00021 · Cited by 25 · see citing works
In vivo deactivation of peripheral, hepatic, and pancreatic insulin action in man
Gray, R. S., Scarlett, J. A., Griffin, J., et al. (1982) · Diabetes · doi:10.2337/diabetes.31.10.929 · Cited by 21 · see citing works
Evaluation of Insulin Resistance in Patients with Primary Hyperparathyroidism
Ginsberg, H. N., Olefsky, J. M., & Reaven, G. M. (1975) · Experimental Biology and Medicine · doi:10.3181/00379727-148-38665 · Cited by 18 · see citing works
Self-citation
Quantification of insulin secretion and in vivo insulin action in nonobese and moderately obese individuals with normal glucose tolerance
Reaven, G. M., Moore, J., & Greenfield, M. (1983) · Diabetes · doi:10.2337/diabetes.32.7.600 · Cited by 16 · see citing works
Glucose storage deficiency as a cause of insulin resistance in obese-hyperinsulinaemic diabetes.
Felber, J.-P., & Jéquier, E. (1982) · PubMed · Cited by 10 · see citing works

Flagged first, then by citations

Research works printed but not linked: 4

[9]9. Bergman, R. N., J. Beard, and M. Chen. 1986. The minimal mod- eling method. Assessment of insulin sensitivity and B-cell function in vivo. In Methods in Clinical Diabetes Research. J. Larner and S. Pohl, editors. Wiley International, New York. pp. 13-20.
[23]23. Ginsberg, H., J. M. Olefsky, andG. M. Reaven. 1975. Evaluation ofinsulin resistance in patients with primary hyperparathyroidism. Proc. Soc. Exp. Bio. Med. 148:942-945.
[28]28. Finegood, D. T., R. Watanabe, and R. N. Bergman. 1984. Val- idation of estimation by optimal segments of the end of extracellular mixing of injected glucose. Fed. Proc. 43:41 1A. (Abstr.)
[29]29. Ganong, W. F. 1981. Review ofMedical Physiology. Lange Med- ical Publications, Los Altos, CA. 221.

Sorted by citations

Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans
Katz, A., Nambi, S. S., Mather, K., Baron, A. D., Follmann, D. A., Sullivan, G., & Quon, M. J. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.7.6661 · Cited by 3,831 · see citing works
Pathophysiology of Sleep Apnea
Dempsey, J. A., Veasey, S. C., Morgan, B. J., & O'Donnell, C. P. (2010) · Physiological Reviews · doi:10.1152/physrev.00043.2008 · Cited by 2,243 · see citing works
Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance
Kern, P. A., Ranganathan, S., Li, C., Wood, L., & Ranganathan, G. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.5.e745 · Cited by 1,883 · see citing works
Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study
Martin, B. C., Warram, J. H., Krolewski, A. S., Soeldner, J. S., Kahn, C. R., Martin, B. C., & Bergman, R. N. (1992) · The Lancet · doi:10.1016/0140-6736(92)92814-v · Cited by 1,158 · see citing works
Self-citation
Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity
Pajvani, U. B., Hawkins, M., Combs, T. P., Rajala, M. W., Doebber, T., Berger, J. P., Wagner, J. A., Wu, M., Knopps, A., Xiang, A. H., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311113200 · Cited by 1,163 · see citing works
Self-citation
Adiponectin Expression From Human Adipose Tissue
Kern, P. A., Di Gregorio, G. B., Lu, T., Rassouli, N., & Ranganathan, G. (2003) · Diabetes · doi:10.2337/diabetes.52.7.1779 · Cited by 875 · see citing works
Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance
Moreno-Navarrete, J. M., Ortega, F., Serrano, M., Guerra, E., Pardo, G., Tinahones, F., Ricart, W., & Fernández-Real, J. M. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2749 · Cited by 788 · see citing works
Contributions of β-Cell Dysfunction and Insulin Resistance to the Pathogenesis of Impaired Glucose Tolerance and Impaired Fasting Glucose
Abdul-Ghani, M. A., Tripathy, D., & DeFronzo, R. A. (2006) · Diabetes Care · doi:10.2337/dc05-2179 · Cited by 744 · see citing works
Surrogate markers of insulin resistance: A review
Singh, B. (2010) · World Journal of Diabetes · doi:10.4239/wjd.v1.i2.36 · Cited by 622 · see citing works
Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults
Martens, C. R., Denman, B. A., Mazzo, M. R., Armstrong, M. L., Reisdorph, N., McQueen, M. B., Chonchol, M., & Seals, D. R. (2018) · Nature Communications · doi:10.1038/s41467-018-03421-7 · Cited by 588 · see citing works
CPAP, Weight Loss, or Both for Obstructive Sleep Apnea
Chirinos, J. A., Gurubhagavatula, I., Teff, K., Rader, D. J., Wadden, T. A., Townsend, R., Foster, G. D., Maislin, G., Saif, H., Broderick, P., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1306187 · Cited by 523 · see citing works
C-Peptide Is the Appropriate Outcome Measure for Type 1 Diabetes Clinical Trials to Preserve β-Cell Function
Palmer, J. P., Fleming, G. A., Greenbaum, C. J., Herold, K. C., Jansa, L. D., Kolb, H., Lachin, J. M., Polonsky, K. S., Pozzilli, P., Skyler, J. S., et al. (2004) · Diabetes · doi:10.2337/diabetes.53.1.250 · Cited by 491 · see citing works
Validation of surrogate estimates of insulin sensitivity and insulin secretion in children and adolescents
Gungor, N., Saad, R., Janosky, J., & Arslanian, S. (2004) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2003.09.045 · Cited by 457 · see citing works
Acute exercise increases triglyceride synthesis in skeletal muscle and prevents fatty acid–induced insulin resistance
Schenk, S., & Horowitz, J. F. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30566 · Cited by 407 · see citing works
Expression of CD68 and Macrophage Chemoattractant Protein-1 Genes in Human Adipose and Muscle Tissues
Di Gregorio, G. B., Yao-Borengasser, A., Rasouli, N., Varma, V., Lu, T., Miles, L. M., Ranganathan, G., Peterson, C. A., McGehee, R. E., & Kern, P. A. (2005) · Diabetes · doi:10.2337/diabetes.54.8.2305 · Cited by 362 · see citing works
Pharmacokinetic/Pharmacodynamic Modeling in Drug Development
Sheiner, L. B., & Steimer, J.-L. (2000) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.40.1.67 · Cited by 351 · see citing works
Molecular evidence supporting the portal theory: a causative link between visceral adiposity and hepatic insulin resistance
Kabir, M., Catalano, K. J., Ananthnarayan, S., Kim, S. P., Van Citters, G. W., Dea, M. K., & Bergman, R. N. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00203.2004 · Cited by 327 · see citing works
Self-citation
Insulin sensitivity index, acute insulin response, and glucose effectiveness in a population-based sample of 380 young healthy Caucasians. Analysis of the impact of gender, body fat, physical fitness, and life-style factors.
Clausen, J. O., Borch-Johnsen, K., Ibsen, H., Bergman, R. N., Hougaard, P., Winther, K., & Pedersen, O. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118903 · Cited by 259 · see citing works
Self-citation
Measuring and estimating insulin resistance in clinical and research settings
Gastaldelli, A. (2022) · Obesity · doi:10.1002/oby.23503 · Cited by 244 · see citing works
Fasting triglyceride and the triglyceride-HDL cholesterol ratio are not markers of insulin resistance in African Americans.
Sumner, A. E., Finley, K. B., Genovese, D. J., Criqui, M. H., & Boston, R. C. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.12.1395 · Cited by 230 · see citing works
Circulating lipopolysaccharide-binding protein (LBP) as a marker of obesity-related insulin resistance
Moreno-Navarrete, J. M., Ortega, F., Serino, M., Luche, E., Waget, A., Pardo, G., Salvador, J., Ricart, W., Frühbeck, G., Burcelin, R., et al. (2012) · International Journal of Obesity · doi:10.1038/ijo.2011.256 · Cited by 223 · see citing works
Liraglutide, a once-daily human GLP-1 analogue, improves pancreatic B-cell function and arginine-stimulated insulin secretion during hyperglycaemia in patients with type 2 diabetes mellitus
Vilsbøll, T., Brock, B., Perrild, H., Levin, K., Lervang, H. ‐., Kølendorf, K., Krarup, T., Schmitz, O., Zdravkovic, M., Le‐Thi, T., et al. (2008) · Diabetic Medicine · doi:10.1111/j.1464-5491.2007.02333.x · Cited by 213 · see citing works
Obesity and insulin resistance: Lessons learned from the Pima indians
Lillioja, S., & Bogardus, C. (1988) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610040508 · Cited by 203 · see citing works
Effect of canagliflozin treatment on hepatic triglyceride content and glucose metabolism in patients with type 2 diabetes
Cusi, K., Bril, F., Barb, D., Polidori, D., Sha, S., Ghosh, A., Farrell, K., Sunny, N. E., Kalavalapalli, S., Pettus, J., et al. (2019) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.13584 · Cited by 204 · see citing works
Insulin Sensitivity from Meal Tolerance Tests in Normal Subjects: A Minimal Model Index
Caumo, A., Bergman, R. N., & Cobelli, C. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.11.6982 · Cited by 206 · see citing works
Self-citation
Failure of mathematical indices to accurately assess insulin resistance in lean, overweight, or obese women with polycystic ovary syndrome
Diamanti-Kandarakis, E., Kouli, C., Alexandraki, K., & Spina, G. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031205 · Cited by 150 · see citing works
Insulin insensitivity in adrenal hyperplasia due to nonclassical steroid 21-hydroxylase deficiency.
Speiser, P. W., Serrat, J., New, M. I., & Gertner, J. M. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.75.6.1464643 · Cited by 143 · see citing works
Study of glucose tolerance in consecutive patients harbouring incidental adrenal tumours
Fernández‐Real, J. M., Ricart Engel, W., Simó, R., Salinas, I., Webb, S. M., & and the Study Group of Incidental Adrenal Adenoma (1998) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1998.00437.x · Cited by 109 · see citing works
Mitochondrial Respiratory Capacity and Content Are Normal in Young Insulin-Resistant Obese Humans
Fisher-Wellman, K. H., Weber, T. M., Cathey, B. L., Brophy, P. M., Gilliam, L. A. A., Kane, C. L., Maples, J. M., Gavin, T. P., Houmard, J. A., & Neufer, P. D. (2014) · Diabetes · doi:10.2337/db13-0940 · Cited by 82 · see citing works
Importance of Obtaining Independent Measures of Insulin Secretion and Insulin Sensitivity During the Same Test
Tripathy, D., Wessman, Y., Gullström, M., Tuomi, T., & Groop, L. (2003) · Diabetes Care · doi:10.2337/diacare.26.5.1395 · Cited by 74 · see citing works
Effect of short‐term starvation <i>versus</i> high‐fat diet on intramyocellular triglyceride accumulation and insulin resistance in physically fit men
Johnson, N. A., Stannard, S. R., Rowlands, D. S., Chapman, P. G., Thompson, C. H., O'Connor, H., Sachinwalla, T., & Thompson, M. W. (2006) · Experimental Physiology · doi:10.1113/expphysiol.2006.033399 · Cited by 69 · see citing works
Effect of long-term orlistat treatment on serum levels of advanced glycation end-products in women with polycystic ovary syndrome
Diamanti‐Kandarakis, E., Katsikis, I., Piperi, C., Alexandraki, K., & Panidis, D. (2007) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2006.02693.x · Cited by 69 · see citing works
Improvements in Glucose Metabolism and Insulin Sensitivity with a Low-Carbohydrate Diet in Obese Patients with Type 2 Diabetes
Krebs, J. D., Bell, D., Hall, R., Parry-Strong, A., Docherty, P. D., Clarke, K., & Chase, J. G. (2013) · Journal of the American College of Nutrition · doi:10.1080/07315724.2013.767630 · Cited by 65 · see citing works
Continuous positive airway pressure and diabetes risk in sleep apnea patients: A systemic review and meta-analysis
Chen, L., Kuang, J., Pei, J.-H., Chen, H.-M., Chen, Z., Li, Z.-W., Yang, H.-Z., Fu, X.-Y., Wang, L., Chen, Z.-J., et al. (2017) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2016.11.010 · Cited by 57 · see citing works
Shorter Sleep Duration is Associated with Decreased Insulin Sensitivity in Healthy White Men
Wong, P. M., Manuck, S. B., DiNardo, M. M., Korytkowski, M., & Muldoon, M. F. (2015) · Sleep · doi:10.5665/sleep.4402 · Cited by 49 · see citing works
Diagnosis of insulin resistance and associated syndromes: the spectrum from the metabolic syndrome to type 2 diabetes mellitus
Simonson, G. D., & Kendall, D. M. (2005) · Coronary Artery Disease · doi:10.1097/00019501-200512000-00002 · Cited by 38 · see citing works
β-cell activity and hepatic insulin extraction following dexamethasone administration in healthy subjects
Kautzky-Willer, A., Thomaseth, K., Clodi, M., Ludvik, B., Waldhäusl, W., Prager, R., & Pacini, G. (1996) · Metabolism · doi:10.1016/s0026-0495(96)90224-3 · Cited by 35 · see citing works
Self-citation
Comparison of glucose tolerance tests to detect the insulin sensitizing effects of a bout of continuous exercise
Ortega, J. F., Hamouti, N., Fernández-Elías, V. E., & Mora-Rodriguez, R. (2014) · Applied Physiology Nutrition and Metabolism · doi:10.1139/apnm-2013-0507 · Cited by 14 · see citing works

Assessment of Insulin Sensitivity in Older Adults Using the Hyperglycemic Clamp Technique
Meneilly, G. S., & Elliott, T. G. (1998) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1998.tb01019.x · Cited by 21 · see citing works
Comparison of Insulin Sensitivity, Clearance, and Secretion Estimates Using Euglycemic and Hyperglycemic Clamps in Children
Uwaifo, G. I., Parikh, S. J., Keil, M. F., Elberg, J., Chin, J., & Yanovski, J. A. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.6.8578 · Cited by 46 · see citing works
Possible novel index determined by the glucose clamp test for selection of a suitable therapy for each type 2 diabetic patient
Gorogawa, S.-I., Kaneto, H., Matsuhisa, M., Ohtoshi, K., Kawamori, D., Hazama, Y., Yoshiuchi, K., & Yamasaki, Y. (2004) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2004.10.006 · Cited by 7 · see citing works
Hyperglycemic Clamp: A Single Experiment to Simultaneously Assess Insulin Secretion and Insulin Sensitivity in Children † 420
Suprasongsin, C., Danadian, K., & Arslanian, S. A. (1997) · Pediatric Research · doi:10.1203/00006450-199704001-00440 · Cited by 8 · see citing works
Estimates ofIn VivoInsulin Action in Man: Comparison of Insulin Tolerance Tests with Euglycemic and Hyperglycemic Glucose Clamp Studies*
Bonora, E., Moghetti, P., Zancanaro, C., CIGOLINI, M., Querena, M., Cacciatori, V., Corgnati, A., & Muggeo, M. (1989) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-68-2-374 · Cited by 525 · see citing works

Authors: Bergman, R. N., Prager, R., Volund, A., & Olefsky, J. M.
Affiliations: University of Southern California (US)
ORCID: Bergman, R N
Olefsky, J M
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1987-03-01
Volume: 79
Issue: 3
Pages: 790-800
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci112886
PMC: PMC424201
OpenAlex: W2127283734
Cited by: 772
References: 33
Citations by year: 2026: 7 · 2025: 10 · 2024: 10 · 2023: 11 · 2022: 19 · 2021: 14 · 2020: 17 · 2019: 9 · 2018: 13 · 2017: 19 · 2016: 17 · 2015: 16 · 2014: 24 · 2013: 31 · 2012: 20
FWCI: 6.60
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01am033649-03, 2r01am029867-04)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK029867)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords: insulin sensitivity index, insulin sensitivity, hyperinsulinemic-euglycemic clamp, frequently sampled intravenous glucose tolerance test, insulin resistance, adiposity, hepatic glucose production, method equivalence
MeSH terms: Adult, Blood Glucose, Female, Glucose, Glucose Tolerance Test, Humans, Insulin, Insulin Resistance, Kinetics, Male, Middle Aged, Obesity

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp.

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks