Retinal very long-chain PUFAs: new insights from studies on ELOVL4 protein

Elovl4 haploinsufficiency does not induce early onset retinal degeneration in mice

Li, W., Chen, Y., Cameron, D. J., Wang, C., Karan, G., Yang, Z., Zhao, Y., Pearson, E., Chen, H., Deng, C., et al. (2007) · Vision Research · doi:10.1016/j.visres.2006.10.023 · Cited by 34

Essentiality of ?3 Fatty Acids: Evidence from the Primate Model and Implications for Human Nutrition1

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The metabolism of 4,7,10,13,16-[5-14c]docosapentaenoic acid in the testis of the rat

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Lipid metabolism in Zellweger's syndrome

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Biosynthesis of long‐chain polyenoic acids from arachidonic acid in cultures of enriched spermatocytes and spermatids from mouse testis

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Cryptosporidium parvum Long-Chain Fatty Acid Elongase

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Very Long-Chain Fatty Acids in Peroxisomal Disease

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Alteration of Disc Formation in Photoreceptors of Rat Retina

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Effect of prolonged cryptorchidism on germ cell apoptosis and testicular sperm count.

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Metabolism of saturated and polyunsaturated fatty acids by normal and Zellweger syndrome skin fibroblasts

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Degenerative Changes in Spermatogonia Are Associated with Loss of Glucose Transporter (Glut 3) in Abdominal Testis of Surgically Induced Unilateral Cryptorchidism in Rats

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Labeling of lipids of retina subcellular fractions by [1-14C]eicosatetraenoate (20:4(n − 6)) docosapentaenoate (22:5(n − 3)) and docosahexaenoate (22:6(n − 3))

Rotstein, N. P., & Aveldaño, M. I. (1987) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(87)90022-1 · Cited by 28

Identification of very-long-chain polyunsaturated fatty acids from Amphidinium carterae by atmospheric pressure chemical ionization liquid chromatography–mass spectroscopy

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Chain elongation of polyunsaturated fatty acids by vascular endothelial cells: Studies with arachidonate analogues

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Changes in the lipid and fatty acid composition of developing rabbit brain

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Targeted Disruption of the Peroxisomal Fatty Acyl‐CoA Oxidase Gene: Generation of a Mouse Model of Pseudoneonatal Adrenoleukodystrophya

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Double‐bond patterns of fatty acids and alcohols in steer and human meibomian gland lipids

Nicolaides, N. C., Santos, E. C. D. S., & Papadakis, K. (1984) · Lipids · doi:10.1007/bf02534454 · Cited by 24

Fatty acid synthesis in isolated spermatocytes and spermatids of mouse testis

Grogan, W. M., & Lam, J. W. (1982) · Lipids · doi:10.1007/bf02535366 · Cited by 24

Monoenoic fatty acids in human brain lipids: Isomer identification and distribution

Johnson, D. W., Beckman, K., Fellenberg, A. J., Robinson, B. S., & Poulos, A. (1992) · Lipids · doi:10.1007/bf02536174 · Cited by 23

A novel mutation in the ABCR gene in four patients with autosomal recessive Stargardt disease

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Labeling of phosphatidylcholines of retina subcellular fractions by [1-14C)eicosatetraenoate (20:4(n − 6)), docosapentaenoate (22:5(n − 3)) and docosahexaenoate (22:6(n − 3))

Rotstein, N. P., & Aveldaño, M. I. (1987) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(87)90023-3 · Cited by 22

The occurrence of long chain α,ω‐diols in the lipids of steer and human meibomian glands

Nicolaides, N. C., Santos, E. C. D. S., Papadakis, K., Ruth, E. C., & Müller, L. (1984) · Lipids · doi:10.1007/bf02534741 · Cited by 22

Metabolism of saturated and polyunsaturated very-long-chain fatty acids in fibroblasts from patients with defects in peroxisomal β-oxidation

Street, J., Singh, H., & Poulos, A. (1990) · Biochemical Journal · doi:10.1042/bj2690671 · Cited by 21

Simultaneous determination of methyl esters of α-hydroxy and nonhydroxy fatty acids from brain cerebroside by fused-silica capillary gas chromatography

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Identification of very-long-chain fatty acids in rat and mouse Harderian gland lipids by capillary gas chromatography—mass spectrometry

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Autosomal dominant Star ardt-hke macular dystrophy segregating in a large Canadian family

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Molecular Cloning of ELOVL4 Gene from Cynomolgus Monkey (Macaca fascicularis).

Umeda, S., Ayyagari, R., Suzuki, M., Fumiko, O. N. O., Iwata, F., Fujiki, K., Kanai, A., TAKADA, Y., YOSHIKAWA, Y., TANAKA, Y., et al. (2003) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.52.129 · Cited by 18

Metabolism of hexacosatetraenoic acid (C26:4,n-6) in immature rat brain

Robinson, B. S., Johnson, D. W., & Poulos, A. (1990) · Biochemical Journal · doi:10.1042/bj2670561 · Cited by 15

Dominant inheritance of Stargardt's disease.

Bither, P. P., & Berns, L. A. (1988) · PubMed · Cited by 15

A simple and sensitive liquid chromatographic method for the analysis of free docosanoic, tetracosanoic and hexacosanoic acids in human plasma as fluorescent derivatives

Chung, T., Kou, H., Chao, M., Ou, Y.-J., & Wu, H. (2008) · Analytica Chimica Acta · doi:10.1016/j.aca.2008.01.062 · Cited by 13

Plasma phospholipid fatty acids in X-linked adrenoleukodystrophy

Aveldaño, M. I., & Donnari, D. (1996) · Clinical Chemistry · doi:10.1093/clinchem/42.3.454 · Cited by 12

Essential fatty acid deficiency and photoreceptor membrane renewal--a reappraisal.

Anderson, R. E. (1978) · PubMed · Cited by 9

Tetratriacontanonaenoic acid, first natural acid with nine double bonds isolated from a crustacean Bathynella natans

Řezanka, T., & Dembitsky, V. M. (2004) · Tetrahedron · doi:10.1016/j.tet.2004.03.032 · Cited by 9

[105] Renewal of lipids in rod outer segments

Anderson, R. E. (1982) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(82)81107-5 · Cited by 6

Composition of the lipophilic extract from the sponge Axinella carteri collected from the Bay of Bengal of the Orissa coast

Mishra, P. M., & Sree, A. (2008) · Chemistry of Natural Compounds · doi:10.1007/s10600-008-9043-x · Cited by 6

Focus on Molecules: ELOVL4

Bedell, M., Harkewicz, R., Wang, X., & Zhang, K. (2009) · Experimental Eye Research · doi:10.1016/j.exer.2009.10.010 · Cited by 6

Analysis of Fatty Acids by APCI-MS

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Distribution of positional isomers of monoenoic fatty acids in pig‐brain white matter sphingolipids

Pullarkat, R. K., & Reha, H. (1976) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1976.tb01590.x · Cited by 5

Abnormal Retinal Morphology and Function in Homozygous Stargardt-3 Mice Which Completely Lack Polyunsaturated C28-C36 Fatty Acids in the Mature Retina

Kędzierski, W., Liu, X., Klein, M., Jackson, S. N., Butovich, I. A., Birch, D. G., Woods, A. S., & McMahon, A. (2010) · Investigative Ophthalmology & Visual Science · Cited by 1

Generation of Homozygous Stargardt-3 Mice Which Completely Lack Retinal Polyunsaturated C28-C36 Fatty Acids

McMahon, A., Butovich, I. A., Jackson, S. N., Liu, X., Klein, M., Birch, D. G., Woods, A. S., & Kędzierski, W. (2010) · Investigative Ophthalmology & Visual Science · Cited by 1

Polyunsaturated fatty acids and fatty acid-derived lipid mediators: Recent advances in the understanding of their biosynthesis, structures, and functions

Dyall, S. C., Balas, L., Bazan, N. G., Brenna, J. T., Chiang, N., Souza, F. D. C., Dalli, J., Durand, T., Galano, J., Lein, P. J., et al. (2022) · Progress in Lipid Research · doi:10.1016/j.plipres.2022.101165 · Cited by 707

Metabolism and functional effects of plant-derived omega-3 fatty acids in humans

Baker, E. J., Miles, E. A., Burdge, G. C., Yaqoob, P., & Calder, P. C. (2016) · Progress in Lipid Research · doi:10.1016/j.plipres.2016.07.002 · Cited by 500

Long-chain polyunsaturated fatty acid biosynthesis in chordates: Insights into the evolution of Fads and Elovl gene repertoire

Castro, L. F. C., Tocher, D. R., & Monroig, Ó. (2016) · Progress in Lipid Research · doi:10.1016/j.plipres.2016.01.001 · Cited by 461

Very long-chain fatty acids: elongation, physiology and related disorders

Kihara, A. (2012) · The Journal of Biochemistry · doi:10.1093/jb/mvs105 · Cited by 453

Metabolism of Very Long-Chain Fatty Acids: Genes and Pathophysiology

Sassa, T., & Kihara, A. (2014) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2014.017 · Cited by 302

Essential Role of ELOVL4 Protein in Very Long Chain Fatty Acid Synthesis and Retinal Function

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Current Progress in Deciphering Importance of VLC-PUFA in the Retina

Bennett, L. D., & Anderson, R. E. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-17121-0_20 · Cited by 11

ELOVL4 protein preferentially elongates 20:5n3 to very long chain PUFAs over 20:4n6 and 22:6n3

Yu, M., Benham, A., Logan, S., Brush, R. S., Mandal, M. N. A., Anderson, R. E., & Agbaga, M. (2011) · Journal of Lipid Research · doi:10.1194/jlr.m021386 · Cited by 58

Very long-chain fatty acids support synaptic structure and function in the mammalian retina

Hopiavuori, B. R., Bennett, L. D., Brush, R. S., Hook, M. J. V., Thoreson, W. B., & Anderson, R. E. (2015) · OCL · doi:10.1051/ocl/2015056 · Cited by 9

Very-long-chain polyunsaturated fatty acids in the retina: analysis and clinical relevance in physiological and pathological conditions

Berdeaux, O., & Acar, N. (2011) · Oléagineux Corps gras Lipides · doi:10.1051/ocl.2011.0406 · Cited by 5