The DOI matches its Crossref record; 240 of the 254 references it cites were found in a registry or an index.
Retinal very long-chain PUFAs: new insights from studies on ELOVL4 protein
Open accessAbstract
Compared with other mammalian tissues, retina is highly enriched in PUFA. Long-chain PUFA (LC-PUFA; C18-C24) are essential FAs that are enriched in the retina and are necessary for maintenance of normal retinal development and function. The retina, brain, and sperm also contain very LC-PUFA (VLC-PUFA; >C24). Although VLC-PUFA were discovered more than two decades ago, very little is known about their biosynthesis and functional roles in the retina. This is due mainly to intrinsic difficulties associated with working on these unusually long polyunsaturated hydrocarbon chains and their existence in small amounts. Recent studies on the FA elongase elongation of very long chain fatty acids-4 (ELOVL4) protein, however, suggest that VLC-PUFA probably play some uniquely important roles in the retina as well as the other tissues. Mutations in the ELOVL4 gene are found in patients with autosomal dominant Stargardt disease. Here, we review the recent literature on VLC-PUFA with special emphasis on the elongases responsible for their synthesis. We focus on a novel elongase, ELOVL4, involved in the synthesis of VLC-PUFA, and the importance of these FAs in maintaining the structural and functional integrity of retinal photoreceptors.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Citations
Cites
Allikmets, R., Singh, N., Sun, H., Shroyer, N. F., Hutchinson, A., Chidambaram, A., Gerrard, B., Baird, L., Stauffer, D., Peiffer, A., et al. (1997) · Nature Genetics · doi:10.1038/ng0397-236 · Cited by 1,435
Dietary polyunsaturated fatty acids and inflammatory mediator production
James, M. J., Gibson, R. A., & Cleland, L. G. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.1.343s · Cited by 1,129
Chemistry and metabolism of lipids in the vertebrate retina
Fliesler, A. J., & Anderson, R. E. (1983) · Progress in Lipid Research · doi:10.1016/0163-7827(83)90004-8 · Cited by 1,052
Reddy, J. K., & Hashimoto, T. (2001) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.21.1.193 · Cited by 991
Fatty acid elongases in mammals: their regulation and roles in metabolism
JAKOBSSON, A., WESTERBERG, R., & JACOBSSON, A. (2006) · Progress in Lipid Research · doi:10.1016/j.plipres.2006.01.004 · Cited by 936
Neuringer, M. D., CONNOR, W. E., Lin, D. S., Barstad, L., & Luck, S. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.11.4021 · Cited by 914
Guillou, H., Zadravec, D., Martin, P. G. P., & Jacobsson, A. (2009) · Progress in Lipid Research · doi:10.1016/j.plipres.2009.12.002 · Cited by 913
The role of omega-3 long-chain polyunsaturated fatty acids in health and disease of the retina
SanGiovanni, J. P., & Chew, E. Y. (2004) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2004.06.002 · Cited by 905
Weng, J., Mata, N. L., Azarian, S. M., Tzekov, R. T., Birch, D. G., & Travis, G. H. (1999) · Cell · doi:10.1016/s0092-8674(00)80602-9 · Cited by 881
Mutation of the Stargardt Disease Gene ( ABCR ) in Age-Related Macular Degeneration
Allikmets, R. L., Shroyer, N. F., Singh, N., Seddon, J. M., Lewis, R. A., Bernstein, P. S., Peiffer, A. P., Zabriskie, N. A., Li, Y., Hutchinson, A. A., et al. (1997) · Science · doi:10.1126/science.277.5333.1805 · Cited by 879
Mukherjee, P. K., Marcheselli, V. L., Serhan, C. N., & Bazan, N. G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402531101 · Cited by 753
Structure of Bovine Rhodopsin in a Trigonal Crystal Form
Li, J., Edwards, P. C., Burghammer, M. C., Villa, C., & Schertler, G. F. X. (2004) · Journal of Molecular Biology · doi:10.1016/j.jmb.2004.08.090 · Cited by 724
Frankel, E. N. (1980) · Progress in Lipid Research · doi:10.1016/0163-7827(80)90006-5 · Cited by 655
Dietary omega-3 fatty acid deficiency and visual loss in infant rhesus monkeys.
Neuringer, M., CONNOR, W. E., Petten, C. V., & Barstad, L. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111202 · Cited by 645
The animal fatty acid synthase: one gene, one polypeptide, seven enzymes
Smith, S. (1994) · The FASEB Journal · doi:10.1096/fasebj.8.15.8001737 · Cited by 601
Elongation of long-chain fatty acids
Leonard, A. E., Pereira, S. L., Sprecher, H. W., & Huang, Y. S. (2003) · Progress in Lipid Research · doi:10.1016/s0163-7827(03)00040-7 · Cited by 584
Fat-1 mice convert n-6 to n-3 fatty acids
Kang, J. X., Wang, J., Wu, L., & Kang, Z. B. (2004) · Nature · doi:10.1038/427504a · Cited by 545
Oh, C.-S., Toke, D. A., MANDALA, S. M., & Martin, C. E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.28.17376 · Cited by 487
Salem, N., Wegher, B., Mena, P. R., & Uauy, R. D. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.1.49 · Cited by 483
Chemistry of free radical and singlet oxidation of lipids
Frankel, E. N. (1984) · Progress in Lipid Research · doi:10.1016/0163-7827(84)90011-0 · Cited by 465
Mata, N. L., Weng, J., & Travis, G. H. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.130110497 · Cited by 456
Zhang, K., Kniazeva, M., Han, M., Li, W., Yu, Z., Yang, Z., Li, Y., Metzker, M. L., Allikmets, R. L., Zack, D. J., et al. (2001) · Nature Genetics · doi:10.1038/83817 · Cited by 453
Qualitative alteration in substrate specificity of mitochondrial monoamine oxidase in brain
Moskvitina, T. A., Kamyshanskaya, N. S., Kaverina, L. P., & Gorkin, V. Z. (1976) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1976.tb04462.x · Cited by 440
Biophysical properties of lipids and dynamic membranes
Janmey, P. A., & Kinnunen, P. K. J. (2006) · Trends in Cell Biology · doi:10.1016/j.tcb.2006.08.009 · Cited by 431
Dietary essential fatty acid supply and visual acuity development.
Birch, E. E., Birch, D. G., Hoffman, D. R., & Uauy, R. D. (1992) · PubMed · Cited by 423
Modulation of rhodopsin function by properties of the membrane bilayer
Brown, M. F. (1994) · Chemistry and Physics of Lipids · doi:10.1016/0009-3084(94)90180-5 · Cited by 422
Genetic dissection of polyunsaturated fatty acid synthesis in Caenorhabditis elegans
Watts, J. L., & Browse, J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.092064799 · Cited by 403
Polyunsaturated fatty acids activate the Drosophila light-sensitive channels TRP and TRPL
Chyb, S., Raghu, P., & Hardie, R. (1999) · Nature · doi:10.1038/16703 · Cited by 397
Bazan, N. G. (2006) · Brain Pathology · doi:10.1111/j.1750-3639.2005.tb00513.x · Cited by 380
DSPP mutation in dentinogenesis imperfecta Shields type II
Zhang, X., Zhao, J. L., Li, C., Gao, S., Qiu, C., Liu, P., Wu, G., Qiang, B., Lo, W. H. Y., & Shen, Y. (2001) · Nature Genetics · doi:10.1038/84765 · Cited by 370
Moon, Y.-A., Shah, N. A., Mohapatra, S., Warrington, J. A., & Horton, J. D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m108413200 · Cited by 353
Singh, I., Moser, A. E., Goldfischer, S. L., & Moser, H. W. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.13.4203 · Cited by 348
Biochemistry of essential fatty acids
Sprecher, H. W. (1981) · Progress in Lipid Research · doi:10.1016/0163-7827(81)90009-6 · Cited by 335
Mutations in the ABCA4 (ABCR) Gene Are the Major Cause of Autosomal Recessive Cone-Rod Dystrophy
Maugeri, A., Klevering, B. J., Rohrschneider, K., Blankenagel, A., Brunner, H. G., Deutman, A. F., Hoyng, C. B., & Cremers, F. P. M. (2000) · The American Journal of Human Genetics · doi:10.1086/303079 · Cited by 329
Abbadi, A., Domergue, F., Bauer, J., Napier, J. A., Welti, R., Zähringer, U., Cirpus, P., & Heinz, E. (2004) · The Plant Cell · doi:10.1105/tpc.104.026070 · Cited by 322
Membrane Fatty Acids Associated with the Electrical Response in Visual Excitation
Benolken, R. M., Anderson, R. E., & Wheeler, T. G. (1973) · Science · doi:10.1126/science.182.4118.1253 · Cited by 321
Spector, A. A. (1999) · Lipids · doi:10.1007/bf02562220 · Cited by 310
The enzymic chain elongation of fatty acids by rat-liver microsomes
Nugteren, D. H. (1965) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(65)90036-6 · Cited by 293
A role for phospholipid polyunsaturation in modulating membrane protein function
Litman, B. J., & Mitchell, D. C. (1996) · Lipids · doi:10.1007/bf02637075 · Cited by 281
A Molecular Caliper Mechanism for Determining Very Long-Chain Fatty Acid Length
Denic, V., & Weissman, J. S. (2007) · Cell · doi:10.1016/j.cell.2007.06.031 · Cited by 279
Meibomian gland studies: comparison of steer and human lipids.
Nicolaides, N. C., Kaitaranta, J. K., Rawdah, T. N., Macy, J. I., Boswell, F. M., & Smith, R. E. (1981) · PubMed · Cited by 277
Agbaga, M., Brush, R. S., Mandal, M. N. A., Henry, K. R., Elliott, M. H., & Anderson, R. E. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802607105 · Cited by 276
Standardized Full-Field Electroretinography
Birch, D. G. (1992) · Archives of Ophthalmology · doi:10.1001/archopht.1992.01080230071024 · Cited by 276
The Cerebrohepatorenal (Zellweger) Syndrome
Moser, A. E., Singh, I., Brown, F. R., Solish, G. I., Kelley, R. I., Benke, P. J., & Moser, H. W. (1984) · New England Journal of Medicine · doi:10.1056/nejm198405033101802 · Cited by 271
Fan, C.-Y., Pan, J., Chu, R., Lee, D., Kluckman, K. D., Usuda, N., Singh, I., Yeldandi, A. V., Rao, M. S., Maeda, N., et al. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.40.24698 · Cited by 268
n-3 Fatty Acids in the Brain and Retina: Evidence for Their Essentiality
Neuringer, M. D., & Connor, W. E. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1986.tb07660.x · Cited by 267
Bach, L., Michaelson, L. V., Haslam, R. P., Bellec, Y., Gissot, L., Marion, J., Costa, M. D., Boutin, J., Miquel, M., Tellier, F., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805089105 · Cited by 263
Bazan, N. G. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r800068-jlr200 · Cited by 256
Anderson, R. E. (1970) · Experimental Eye Research · doi:10.1016/s0014-4835(70)80046-x · Cited by 248
Vasireddy, V., Uchida, Y., Salem, N., Kim, S. Y., Mandal, M. N. A., Reddy, G. B., Bodepudi, R., Alderson, N. L., Brown, J. C., Hama, H., et al. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddl480 · Cited by 247
Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice
Moon, Y.-A., Hammer, R. E., & Horton, J. D. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m800383-jlr200 · Cited by 243
The fatty acid chain elongation system of mammalian endoplasmic reticulum
Cinti, D. L., Cook, L. S., Nagi, M. N., & Suneja, S. K. (1992) · Progress in Lipid Research · doi:10.1016/0163-7827(92)90014-a · Cited by 241
Essential Fatty Acids: The Importance of n-3 Fatty Acids in the Retina and Brain
Connor, W. E., Neuringer, M., & Reisbick, S. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1992.tb01286.x · Cited by 240
Niu, S., Mitchell, D. C., Lim, S., Wen, Z., Kim, H., Salem, N., & Litman, B. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404376200 · Cited by 235
Singh, I., Moser, A. E., Moser, H. W., & Kishimoto, Y. (1984) · Pediatric Research · doi:10.1203/00006450-198403000-00016 · Cited by 234
Δ6‐Desaturase (FADS2) deficiency unveils the role of ω3‐ and ω6‐polyunsaturated fatty acids
Stoffel, W., Holz, B., Jenke, B., Binczek, E., Günter, R. H., Kiss, C., Karakesisoglou, I., Thevis, M., Weber, A., Arnhold, S., et al. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.156 · Cited by 229
Leonard, A. E., BOBIK, E. G., DORADO, J., Kroeger, P. E., Chuang, L., Thurmond, J. M., PARKER-BARNES, J. M., Das, T., Huang, Y. S., & Mukerji, P. (2000) · Biochemical Journal · doi:10.1042/bj3500765 · Cited by 222
Tvrdík, P., Westerberg, R., Silve, S., Asadi, A., Jakobsson, A., Cannon, B., Loison, G., & Jacobsson, A. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.149.3.707 · Cited by 221
Odd-numbered very-long-chain fatty acids from the microbial, animal and plant kingdoms
Řezanka, T., & Sigler, K. (2009) · Progress in Lipid Research · doi:10.1016/j.plipres.2009.03.003 · Cited by 218
Meibomian Gland Lipids, Evaporation, and Tear Film Stability
Mathers, W. D., & Lane, J. A. (1998) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-5359-5_50 · Cited by 217
The effect of age on human cone and rod ganzfeld electroretinograms.
Weleber, R. G. (1981) · PubMed · Cited by 216
Role of essential fatty acids in the function of the developing nervous system
Uauy, R. D., Peirano, P. D., Hoffman, D. R., Mena, P., Birch, D. G., & Birch, E. E. (1996) · Lipids · doi:10.1007/bf02637071 · Cited by 216
Litman, B. J., Niu, S., Polozova, A., & Mitchell, D. C. (2001) · Journal of Molecular Neuroscience · doi:10.1385/jmn:16:2-3:237 · Cited by 214
Isolation and Characterization of a Gene Affecting Fatty Acid Elongation in Saccharomyces cerevisiae
Toke, D. A., & Martin, C. E. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.31.18413 · Cited by 214
Identification and expression of mammalian long‐chain PUFA elongation enzymes
Leonard, A. E., Kelder, B., Bobik, E. G., Chuang, L., Lewis, C. J., Kopchick, J. J., Mukerji, P., & Huang, Y. (2002) · Lipids · doi:10.1007/s11745-002-0955-6 · Cited by 209
Frankel, E. N., Satué-Gracia, T., Meyer, A. S., & German, J. B. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0111458 · Cited by 208
The genetics of inherited macular dystrophies
Michaelides, M., Hunt, D. M., & Moore, A. T. (2003) · Journal of Medical Genetics · doi:10.1136/jmg.40.9.641 · Cited by 207
Tamura, K., Makino, A., Hullin‐Matsuda, F., Kobayashi, T., Furihata, M., Chung, S., Ashida, S., Miki, T., Fujioka, T., Shuin, T., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-0775 · Cited by 206
Aveldaño, M. I., VanRollins, M., & Horrocks, L. A. (1983) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38027-5 · Cited by 201
Immunomodulation by Polyunsaturated Fatty Acids: Mechanisms and Effects
Stulnig, T. M. (2003) · International Archives of Allergy and Immunology · doi:10.1159/000074898 · Cited by 198
Crawford, M. A., Costeloe, K., Ghebremeskel, K., Phylactos, A., Skirvin, L., & Stacey, F. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/66.4.1032s · Cited by 198
Role for ELOVL3 and Fatty Acid Chain Length in Development of Hair and Skin Function
Westerberg, R., Tvrdík, P., Undén, A.-B., Månsson, J.-E., Norlen, L. P. O., Jakobsson, A., Holleran, W. H., Elias, P. M., Asadi, A., Flodby, P., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310529200 · Cited by 198
Very long chain fatty acids in higher animals: a review
Poulos, A. (1995) · Lipids · doi:10.1007/bf02537036 · Cited by 192
Polyunsaturated fatty acids, membrane organization, T cells, and antigen presentation
Shaikh, S. R., & Edidin, M. A. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.6.1277 · Cited by 192
Novel fatty acid elongases and their use for the reconstitution of docosahexaenoic acid biosynthesis
Meyer, A., Kirsch, H., Domergue, F., Abbadi, A., Sperling, P., Bauer, J., Cirpus, P., Zank, T. K., Moreau, H., Roscoe, T. J., et al. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m400181-jlr200 · Cited by 185
Omega-O-acylceramide, a lipid essential for mammalian survival
Uchida, Y., & Holleran, W. M. (2008) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2008.01.002 · Cited by 184
Ramstedt, B., & Slotte, J. P. (1999) · Biophysical Journal · doi:10.1016/s0006-3495(99)77254-1 · Cited by 184
Karan, G., Lillo, C., Yang, Z., Cameron, D. J., Locke, K. G., Zhao, Y., Thirumalaichary, S., Li, C., Birch, D. G., Vollmer-Snarr, H. R., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407698102 · Cited by 182
Fat-1 transgenic mice: A new model for omega-3 research
Kang, J. X. (2007) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2007.10.010 · Cited by 179
Butovich, I. A., Wojtowicz, J. C., & Molai, M. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m900252-jlr200 · Cited by 179
On the Lipid Composition of Human Meibum and Tears: Comparative Analysis of Nonpolar Lipids
Butovich, I. A. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-1889 · Cited by 179
Bernert, J. T., & Sprecher, H. W. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)39911-8 · Cited by 175
Beharry, S., Zhong, M., & Molday, R. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405216200 · Cited by 174
Genome-wide profiling at methylated promoters in pancreatic adenocarcinoma
Omura, N., Li, C., Li, A., Hong, S., Walter, K., Jimeno, A., Hidalgo, M. M., & Goggins, M. (2008) · Cancer Biology & Therapy · doi:10.4161/cbt.7.7.6208 · Cited by 174
The role of ELOVL1 in very long-chain fatty acid homeostasis and X-linked adrenoleukodystrophy
Ofman, R., Dijkstra, I. M. E., van Roermund, C. W. T., Burger, N., Turkenburg, M., van Cruchten, A., van Engen, C. E., Wanders, R. J. A., & Kemp, S. (2010) · EMBO Molecular Medicine · doi:10.1002/emmm.201000061 · Cited by 170
Stone, E. M. (1994) · Archives of Ophthalmology · doi:10.1001/archopht.1994.01090180063036 · Cited by 167
Li, W., Sandhoff, R., Kono, M., Zerfas, P. M., Hoffmann, V., Ding, B. C.-H., Proia, R. L., & Deng, C. (2007) · International Journal of Biological Sciences · doi:10.7150/ijbs.3.120 · Cited by 162
The Lipid Secretion of the Meibomian Glands
Tiffany, J. M. (1987) · Advances in lipid research · doi:10.1016/b978-0-12-024922-0.50005-9 · Cited by 159
Diverse macular dystrophy phenotype caused by a novel complex mutation in the ELOVL4 gene.
Bernstein, P. S., Tammur, J., Singh, N., Hutchinson, A. A., Dixon, M., Pappas, C. M., Zabriskie, N. A., Zhang, K., Petrukhin, K. E., Leppert, M., et al. (2001) · PubMed · Cited by 156
Roqueta‐Rivera, M., Stroud, C. K., Haschek, W. M., Akare, S., Segre, M., Brush, R. S., Agbaga, M., Anderson, R. E., Hess, R. A., & Nakamura, M. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m001180 · Cited by 154
Paul, S., Gable, K. S., Beaudoin, F., Cahoon, E. B., Jaworski, J. G., Napier, J. A., & Dunn, T. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m507723200 · Cited by 153
The Meibomian Puzzle: Combining pieces together
Butovich, I. A. (2009) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2009.07.002 · Cited by 151
Individual variations in human meibomian lipid composition
Tiffany, J. M. (1978) · Experimental Eye Research · doi:10.1016/0014-4835(78)90164-1 · Cited by 151
Polyunsaturated fatty acids of photoreceptor membranes
Anderson, R. E., Benolken, R. M., Dudley, P. A., Landis, D. J., & Wheeler, T. G. (1974) · Experimental Eye Research · doi:10.1016/0014-4835(74)90149-3 · Cited by 151
Aveldano, M. I. (1988) · Biochemistry · doi:10.1021/bi00404a024 · Cited by 149
ELOVL3 Is an Important Component for Early Onset of Lipid Recruitment in Brown Adipose Tissue
Westerberg, R., Månsson, J.-E., Golozoubova, V., Shabalina, I. G., Backlund, E. C., Tvrdík, P., Retterstøl, K., Capecchi, M. R., & Jacobsson, A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m511588200 · Cited by 149
Enhancement of G protein‐coupled signaling by DHA phospholipids
Mitchell, D. C., Niu, S., & Litman, B. J. (2003) · Lipids · doi:10.1007/s11745-003-1081-1 · Cited by 147
Lipids of human meibum: mass-spectrometric analysis and structural elucidation
Butovich, I. A., Uchiyama, E., & McCulley, J. P. (2007) · Journal of Lipid Research · doi:10.1194/jlr.m700237-jlr200 · Cited by 147
Anderson, R. E., & Maude, M. B. (1972) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(72)90497-3 · Cited by 145
Aveldaño, M. I., & Sprecher, H. W. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)75768-8 · Cited by 145
Aveldaño, M. I. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)75767-6 · Cited by 142
Cameron, D. J., Tong, Z., Yang, Z., Kaminoh, J., Kamiyah, S., Chen, H., Zeng, J., Chen, Y., Luo, L., & Zhang, K. (2007) · International Journal of Biological Sciences · doi:10.7150/ijbs.3.111 · Cited by 142
Internal Hydration Increases during Activation of the G-Protein-Coupled Receptor Rhodopsin
Grossfield, A. M., Pitman, M. C., Feller, S. E., Soubias, O., & Gawrisch, K. (2008) · Journal of Molecular Biology · doi:10.1016/j.jmb.2008.05.036 · Cited by 141
Remodeling of Retinal Fatty Acids in an Animal Model of Diabetes
Tikhonenko, M., Lydic, T. A., Wang, Y., Chen, W., Opreanu, M., Sochacki, A. L., McSorley, K. M., Renis, R. L., Kern, T. S., Jump, D. Β., et al. (2009) · Diabetes · doi:10.2337/db09-0728 · Cited by 134
Cholesteryl esters as a depot for very long chain fatty acids in human meibum
Butovich, I. A. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m800426-jlr200 · Cited by 130
Mazelova, J., Ransom, N. L., Astuto-Gribble, L. M., Wilson, M. C., & Deretic, D. (2009) · Journal of Cell Science · doi:10.1242/jcs.039982 · Cited by 130
Involvement of Long Chain Fatty Acid Elongation in the Trafficking of Secretory Vesicles in Yeast
David, D., Sundarababu, S., & Gerst, J. E. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.5.1167 · Cited by 128
Changes in lipid composition of the maturing rat testis
Davis, J., Bridges, R., & Coniglio, J. G. (1966) · Biochemical Journal · doi:10.1042/bj0980342 · Cited by 128
Xiao, Y., Ke, Q., Wang, S., Auktor, K., Yang, Y., Wang, G. K., Morgan, J. P., & Leaf, A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.061003798 · Cited by 125
Optimization of Receptor-G Protein Coupling by Bilayer Lipid Composition I
Mitchell, D. C., Niu, S., & Litman, B. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105772200 · Cited by 123
Bazan, N. G. (2007) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-0918 · Cited by 119
The fatty acid composition of the lipids from bovine and porcine reproductive tissues
Holman, R. T., & Hofstetter, H. H. (1965) · Journal of the American Oil Chemists Society · doi:10.1007/bf02540098 · Cited by 114
Neuringer, M., Reisbick, S., & Janowsky, J. S. (1994) · The Journal of Pediatrics · doi:10.1016/s0022-3476(06)80735-3 · Cited by 112
Plasmalogens participate in very-long-chain fatty acid-induced pathology
Brites, P., Mooyer, P. A. W., el Mrabet, L., Waterham, H. R., & Wanders, R. J. A. (2008) · Brain · doi:10.1093/brain/awn295 · Cited by 112
Contreras, F. ‐., Basáñez, G., Alonso, A., Herrmann, A., & Goñi, F. M. (2004) · Biophysical Journal · doi:10.1529/biophysj.104.050690 · Cited by 110
Very-long-chain fatty acids from the animal and plant kingdoms
Řezanka, T. (1989) · Progress in Lipid Research · doi:10.1016/0163-7827(89)90011-8 · Cited by 110
Optimization of Receptor-G Protein Coupling by Bilayer Lipid Composition II
Niu, S., Mitchell, D. C., & Litman, B. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105778200 · Cited by 109
Szafer‐Glusman, E., Giansanti, M. G., Nishihama, R., Bolival, B., Pringle, J. R., Gatti, M., & Fuller, M. T. (2008) · Current Biology · doi:10.1016/j.cub.2008.08.061 · Cited by 108
McMahon, A., Butovich, I. A., Mata, N. L., Klein, M., Ritter, R., Richardson, J. A., Birch, D. G., Edwards, A. O., & Kędzierski, W. (2007) · PubMed Central · Cited by 107
Tvrdík, P., Asadi, A., Kozak, L. P., Nedergaard, J., Cannon, B., & Jacobsson, A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.50.31738 · Cited by 106
Kang, Z. B., Ge, Y., Chen, Z., Cluette‐Brown, J. E., Laposata, M., Leaf, A., & Kang, J. X. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.061040198 · Cited by 104
Edwards, A. O., Donoso, L. A., & Ritter, R. (2001) · PubMed · Cited by 100
A New Locus for Autosomal Dominant Stargardt-Like Disease Maps to Chromosome 4
Kniazeva, M., Chiang, M. F., Morgan, B., Anduze, A. L., Zack, D. J., Han, M., & Zhang, K. (1999) · The American Journal of Human Genetics · doi:10.1086/302377 · Cited by 100
SCHNEITER, R., BRÜGGER, B., AMANN, C. M., PRESTWICH, G. D., EPAND, R. F., ZELLNIG, G., WIELAND, F. T., & EPAND, R. M. (2004) · Biochemical Journal · doi:10.1042/bj20040320 · Cited by 98
Beaudoin, F., Gable, K., Sayanova, O. V., Dunn, T. M., & Napier, J. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111441200 · Cited by 98
Robinson, B. S., Johnson, D. W., & Poulos, A. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)46009-7 · Cited by 97
Mandal, M. N. A., Ambasudhan, R., WONG, P. W. K., Gage, P. J., Sieving, P. A., & Ayyagari, R. (2003) · Genomics · doi:10.1016/j.ygeno.2003.09.020 · Cited by 97
The occurrence of polyenoic fatty acids with greater than 22 carbon atoms in mammalian spermatozoa
Poulos, A., Sharp, P. C., Johnson, D., White, I., & Fellenberg, A. J. (1986) · Biochemical Journal · doi:10.1042/bj2400891 · Cited by 92
A Novel Mutation in the ELOVL4 Gene Causes Autosomal Dominant Stargardt-like Macular Dystrophy
Maugeri, A., Meire, F. M., Hoyng, C. B., Vink, C., Regemorter, N. V., Karan, G., Yang, Z., Cremers, F. P. M., & Zhang, K. (2004) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.04-0078 · Cited by 90
Furland, N. E., Oresti, G. M., Antollini, S. S., Venturino, A., Maldonado, E. N., & Aveldaño, M. I. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700709200 · Cited by 88
Wang, Y., Torres‐Gonzalez, M., Tripathy, S., Botolin, D., Christian, B., & Jump, D. Β. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m800123-jlr200 · Cited by 87
Inagaki, K., Aki, T., FUKUDA, Y., Kawamoto, S., Shigeta, S., Ono, K., & Suzuki, O. (2002) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.66.613 · Cited by 86
Age-Related Changes in the Mouse Outer Retina
Li, C., Cheng, M., Yang, H., Peachey, N. S., & NAASH, A. M. I. (2001) · Optometry and Vision Science · doi:10.1097/00006324-200106000-00015 · Cited by 86
Schneiter, R., Tatzer, V. C., Gogg‐Fassolter, G., Leitner, E., & Kohlwein, S. D. (2000) · Journal of Bacteriology · doi:10.1128/jb.182.13.3655-3660.2000 · Cited by 85
Grayson, C., & Molday, R. S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503411200 · Cited by 84
Kawamura, N., Moser, A. B., Moser, H. W., Ogino, T., Suzuki, K., Schaumburg, H. H., Milunsky, A., Murphy, J. V., & Kishimoto, Y. (1978) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(78)90584-3 · Cited by 82
Barnathan, G., Korpnrobst, J., Doumenq, P., & Mirallès, J. (1996) · Lipids · doi:10.1007/bf02522620 · Cited by 81
Furland, N. E., Zanetti, S. R., Oresti, G. M., Maldonado, E. N., & Aveldaño, M. I. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700708200 · Cited by 79
The biosynthesis of mycolic acids by Mycobacteria: current and alternative hypotheses
Asselineau, C., Asselineau, J., Lanéelle, G., & Lanéelle, M. (2002) · Progress in Lipid Research · doi:10.1016/s0163-7827(02)00008-5 · Cited by 79
Singh, J., Khan, M., & Singh, I. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m800321-jlr200 · Cited by 77
Bourre, J. M., Paturneau-Jouas, M., Daudu, O., & Baumann, N. (1977) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1977.tb11222.x · Cited by 76
A Dominant Stargardt's Macular Dystrophy Locus Maps to Chromosome 13q34
Zhang, K. (1994) · Archives of Ophthalmology · doi:10.1001/archopht.1994.01090180057035 · Cited by 75
Rosenthal, M. D., Garcia, M. C., Jones, M. R., & Sprecher, H. W. (1991) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(91)90121-w · Cited by 75
Poulos, A., Johnson, D. W., Beckman, K., White, I. G., & Easton, C. J. (1987) · Biochemical Journal · doi:10.1042/bj2480961 · Cited by 74
Fatty acid elongation in yeast
Dittrich-Domergue, F., Zajonc, D. M., Hühne, K., Hoja, U., Ekici, A. B., Greiner, E., Klein, H., Hofmann, J., Bessoule, J., Sperling, P., et al. (1998) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1998.2520477.x · Cited by 73
Gawrisch, K., Soubias, O., & Mihailescu, M. (2008) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2008.09.002 · Cited by 72
Gawrisch, K., & Soubias, O. (2008) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2008.02.016 · Cited by 71
Poulos, A., Sharp, P. C., Johnson, D., & Easton, C. J. (1988) · Biochemical Journal · doi:10.1042/bj2530645 · Cited by 68
Poulos, A., Sharp, P. C., Fellenberg, A. J., & Johnson, D. W. (1988) · European Journal of Pediatrics · doi:10.1007/bf00442211 · Cited by 68
Genetics and molecular pathology of Stargardt-like macular degeneration
Vasireddy, V., WONG, P. W. K., & Ayyagari, R. (2010) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2010.01.001 · Cited by 68
DHA-Rich phospholipids optimize G-Protein–coupled signaling
Mitchell, D. C., Niu, S., & Litman, B. J. (2003) · The Journal of Pediatrics · doi:10.1067/s0022-3476(03)00405-0 · Cited by 67
McMahon, A., Jackson, S. N., Woods, A. S., & Kędzierski, W. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.10.050 · Cited by 66
Karan, G., Yang, Z., Howes, K. A., Zhao, Y., Chen, Y., Cameron, D. J., Lin, Y., Pearson, E., & Zhang, K. (2005) · PubMed · Cited by 65
Poulos, A., Sharp, P. C., Singh, H., Johnson, D., Fellenberg, A. J., & Pollard, A. C. (1986) · Biochemical Journal · doi:10.1042/bj2350607 · Cited by 64
Probing Specific Lipid−Protein Interaction by Saturation Transfer Difference NMR Spectroscopy
Soubias, O., & Gawrisch, K. (2005) · Journal of the American Chemical Society · doi:10.1021/ja0538942 · Cited by 63
Jakobsson, A., Jörgensen, J. A., & Jacobsson, A. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00045.2005 · Cited by 63
Bazán, H. E. P., Careaga, M. M., Sprecher, H. W., & Bazan, N. G. (1982) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(82)90093-5 · Cited by 62
Harvey, D. J., Tiffany, J. M., DUERDEN, J. M., Pandher, K. S., & Mengher, L. S. (1987) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/0378-4347(87)80051-8 · Cited by 62
Řezanka, T., Nedbalová, L., Sigler, K., & Cepák, V. (2007) · Phytochemistry · doi:10.1016/j.phytochem.2007.06.025 · Cited by 62
Elovl4 5-bp–Deletion Knock-in Mice Develop Progressive Photoreceptor Degeneration
Vasireddy, V., Jablonski, M. M., Mandal, M. N. A., Raz-Prag, D., Wang, X. F., Nizol, L., Iannaccone, A., Musch, D. C., Bush, R. A., Salem, N., et al. (2006) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.06-0353 · Cited by 61
Vasireddy, V., Vijayasarathy, C., Huang, J., Wang, X. F., Jablonski, M. M., Petty, H. R., Sieving, P. A., & Ayyagari, R. (2005) · PubMed · Cited by 59
n-3 fatty acid deficiency alters recovery of the rod photoresponse in rhesus monkeys.
Jeffrey, B. G., Mitchell, D. C., Gibson, R. A., & Neuringer, M. (2002) · PubMed · Cited by 58
Sharp, P. C., Johnson, D., & Poulos, A. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb02558.x · Cited by 58
Christensen, E., Woldseth, B., Hagve, T., Poll‐The, B. T., Wanders, R. J. A., Sprecher, H. W., Stokke, O., & Christophersen, B. O. (1993) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365519309090698 · Cited by 58
Robinson, B. S., Johnson, D. W., & Poulos, A. (1990) · Biochemical Journal · doi:10.1042/bj2650763 · Cited by 57
Bazan, N. G. (2007) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-74904-4_3 · Cited by 56
Zhang, K., Kniazeva, M., Hutchinson, A. A., Han, M., Dean, M. C., & Allikmets, R. L. (1999) · Genomics · doi:10.1006/geno.1999.5896 · Cited by 55
Edwards, A. O., Miedziak, A. I., Vrabec, T. R., Verhoeven, J., Acott, T. S., Weleber, R. G., & Donoso, L. A. (1999) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(98)00331-6 · Cited by 54
Bazan, N. G., & Allan, G. (1997) · Survey of Ophthalmology · doi:10.1016/s0039-6257(97)80004-5 · Cited by 54
Ambasudhan, R., Wang, X., Jablonski, M. M., Thompson, D. A., Lagali, P. S., WONG, P. W. K., Sieving, P. A., & Ayyagari, R. (2003) · Genomics · doi:10.1016/j.ygeno.2003.10.004 · Cited by 54
Bridges, R. B., & Coniglio, J. G. (1970) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63420-9 · Cited by 53
The meibomian lipids of the rabbit. I. Overall composition
Tiffany, J. M. (1979) · Experimental Eye Research · doi:10.1016/0014-4835(79)90084-8 · Cited by 53
The lipid composition of maturing rat testis the effect of α-tocopherol
Carpenter, M. P. (1971) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(71)90255-4 · Cited by 53
Effects of aging on the composition and metabolism of docosahexaenoate‐containing lipids of retina
Rotstein, N. P., de Boschero, M. G. I., Giusto, N. M., & Aveldaño, M. I. (1987) · Lipids · doi:10.1007/bf02533988 · Cited by 52
Autosomal Dominant Stargardt-Like Macular Dystrophy
Donoso, L. A., Edwards, A. O., Frost, A. T., Vrabec, T. R., Stone, E. M., Hageman, G. S., & Perski, T. (2001) · Survey of Ophthalmology · doi:10.1016/s0039-6257(01)00251-x · Cited by 50
Harvey, D. J., & Tiffany, J. M. (1984) · Journal of Chromatography A · doi:10.1016/s0021-9673(01)89187-1 · Cited by 50
Fatty Acids and Other Lipids of Marine Sponges
Rodkina, S. A. (2005) · Russian Journal of Marine Biology · doi:10.1007/s11179-006-0015-3 · Cited by 49
Metabolism of linolenic acid and docosahexaenoic acid in rat retinas and rod outer segments
Wetzel, M. G., Li, J., Alvarez, R., Anderson, R. E., & O’Brien, P. J. (1991) · Experimental Eye Research · doi:10.1016/0014-4835(91)90161-7 · Cited by 49
Bloomston, M., Durkin, A. J., Yang, I. V., Rojiani, M. V., Rosemurgy, A. S., Enkmann, S., Yeatman, T. J., & Zervos, E. E. (2004) · Annals of Surgical Oncology · doi:10.1245/aso.2004.03.077 · Cited by 48
Zanetti, S. R., Maldonado, E. N., & Aveldaño, M. I. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0376 · Cited by 48
Autosomal dominant macular atrophy at 6q14 excludes CORD7 and MCDR1/PBCRA loci.
Griesinger, I. B., Sieving, P. A., & Ayyagari, R. (2000) · PubMed · Cited by 47
Aveldaño, M. I., Robinson, B. S., Johnson, D. W., & Poulos, A. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50251-4 · Cited by 47
Infante, J. P., Tschanz, C. L., Shaw, N., Michaud, A. L., Lawrence, P., & Brenna, J. T. (2002) · Molecular Genetics and Metabolism · doi:10.1006/mgme.2001.3279 · Cited by 47
Vasireddy, V., Jablonski, M. M., Khan, N. W., Wang, X., Sahu, P., Sparrow, J. R., & Ayyagari, R. (2009) · Experimental Eye Research · doi:10.1016/j.exer.2009.07.021 · Cited by 47
Raz-Prag, D., Ayyagari, R., Fariss, R. N., Mandal, M. N. A., Vasireddy, V., Majchrzak, S. F., Webber, A. L., Bush, R. A., Salem, N., Petrukhin, K. E., et al. (2006) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.05-1527 · Cited by 46
Suh, M., & Clandinin, M. T. (2005) · Current Eye Research · doi:10.1080/02713680500246957 · Cited by 46
Evolutionarily Conserved ELOVL4 Gene Expression in the Vertebrate Retina
Lagali, P. S., Liu, J., Ambasudhan, R., Kakuk, L. E., Bernstein, S. L., Seigel, G. M., WONG, P. W. K., & Ayyagari, R. (2003) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.02-0991 · Cited by 43
Polyunsaturated very-long-chain C28-C36 fatty acids and retinal physiology
McMahon, A., & Kędzierski, W. (2009) · British Journal of Ophthalmology · doi:10.1136/bjo.2008.149286 · Cited by 43
Takeuchi, A., Takeuchi, M., Oikawa, K., Sonoda, K., Usui, Y., Okunuki, Y., Takeda, A., Oshima, Y., Yoshida, K., Usui, M., et al. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-2299 · Cited by 42
Zhang, X.-M., Yang, Z., Karan, G., Hashimoto, T., Baehr, W., Yang, X.-J., & Zhang, K. (2003) · PubMed · Cited by 41
Metabolism of arachidonate in rat testis: Characterization of 26–30 carbon polyenoic acids
Grogan, W. M. (1984) · Lipids · doi:10.1007/bf02534785 · Cited by 40
Řezanka, T., Nedbalová, L., & Sigler, K. (2008) · Phytochemistry · doi:10.1016/j.phytochem.2008.08.021 · Cited by 40
Karan, G., Yang, Z., & Zhang, K. (2004) · PubMed · Cited by 39
Sharp, P. C., Poulos, A., Fellenberg, A. J., & Johnson, D. (1987) · Biochemical Journal · doi:10.1042/bj2480061 · Cited by 38
DHA does not protect ELOVL4 transgenic mice from retinal degeneration.
Li, F., Marchette, L. D., Brush, R. S., Elliott, M. H., Le, Y.-Z., Henry, K., Anderson, A. G., Zhao, C., Sun, X., Zhang, K., et al. (2009) · PubMed Central · Cited by 37
Active synthesis of C24:5, n-3 fatty acid in retina
Rotstein, N. P., Pennacchiotti, G. L., Sprecher, H. W., & Aveldaño, M. I. (1996) · Biochemical Journal · doi:10.1042/bj3160859 · Cited by 37
The production of long chain polyunsaturated fatty acids in transgenic plants by reverse-engineering
Napier, J. A., Beaudoin, F., Michaelson, L. V., & Sayanova, O. (2004) · Biochimie · doi:10.1016/j.biochi.2004.09.020 · Cited by 36
Visual development: neural basis and new assessment methods
Neuringer, M., & Jeffrey, B. G. (2003) · The Journal of Pediatrics · doi:10.1067/s0022-3476(03)00406-2 · Cited by 36
Synthesis of very long chain (up to 36 carbon) tetra, penta and hexaenoic fatty acids in retina
Rotstein, N. P., & Aveldaño, M. I. (1988) · Biochemical Journal · doi:10.1042/bj2490191 · Cited by 36
Essential fatty acid deficiency and renewal of rod outer segments in the albino rat.
Anderson, R. E., Landis, D. J., & Dudley, P. A. (1976) · PubMed · Cited by 35
Flagged first, then by citations
14 of the 254 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
- Butovich, 2009, Human tear film and meibum. Very long chain wax esters and (O-acyl)-omega-hydroxy fatty acids of meibum, J. Lipid Res., 50, 2471, 10.1194/jlr.M900252-JLR200 · DOI
- Mitchell, 2007, Effects of ROS disk membrane phospholipids with extremely long polyunsaturated acyl chains on visual signalling, Invest. Ophthalmol. Vis. Sci., 48, 2928
- Liu, 2009, Enhanced methods for analysis of very long chain polyunsaturated fatty acids from retina and RPE, Invest. Ophthalmol. Vis. Sci., 50, 3410
Cited by
Sorted by citations
Dyall, S. C., Balas, L., Bazan, N. G., Brenna, J. T., Chiang, N., Souza, F. D. C., Dalli, J., Durand, T., Galano, J., Lein, P. J., et al. (2022) · Progress in Lipid Research · doi:10.1016/j.plipres.2022.101165 · Cited by 707
“In photoreceptor cells, VLC-PUFAs are in phosphatidylcholines (PC) of the outer segment membranes, tightly bound to rhodopsin [183].”
BackgroundMetabolism and functional effects of plant-derived omega-3 fatty acids in humans
Baker, E. J., Miles, E. A., Burdge, G. C., Yaqoob, P., & Calder, P. C. (2016) · Progress in Lipid Research · doi:10.1016/j.plipres.2016.07.002 · Cited by 500
Castro, L. F. C., Tocher, D. R., & Monroig, Ó. (2016) · Progress in Lipid Research · doi:10.1016/j.plipres.2016.01.001 · Cited by 461
Very long-chain fatty acids: elongation, physiology and related disorders
Kihara, A. (2012) · The Journal of Biochemistry · doi:10.1093/jb/mvs105 · Cited by 453
“to six double bonds at the sn 1 position (13, 34).”
BackgroundInfluentialMetabolism of Very Long-Chain Fatty Acids: Genes and Pathophysiology
Sassa, T., & Kihara, A. (2014) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2014.017 · Cited by 302
“ULC-PUFAs are found in the testis, brain, and retina (Agbaga et al., 2010).”
Metadata
- Authors
- Agbaga, M.-P., Mandal, M. N. A., & Anderson, R. E.
- Affiliations
- Dean McGee Eye Institute (US)
- Corresponding author
- Anderson, Robert E.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 51
- Issue
- 7
- Pages
- 1624-1642
- ISSN
- 0022-2275 (ISSN-L)
- PMC
- PMC2882734
- OpenAlex
- W2137994863
- Cited by
- 167
- References
- 254
- Citations by year
- 2026: 2 · 2025: 11 · 2024: 8 · 2023: 12 · 2022: 11 · 2021: 19 · 2020: 13 · 2019: 12 · 2018: 15 · 2017: 12 · 2016: 10 · 2015: 6 · 2014: 9 · 2013: 7 · 2012: 7
- FWCI
- 0.97
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Lipid Research (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Eye Institute (P30EY012190, EY-12190, EY04149, R01EY000871, R01EY004149, EY 00871)
- National Center for Research Resources (RR 17703, P20RR017703)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- very long chain polyunsaturated fatty acids, ELOVL4, fatty acid elongation, retinal lipids, Stargardt disease, photoreceptors, retinal development, fatty acid synthesis, essential fatty acids
- MeSH terms
- Fatty Acid Elongases, Acetyltransferases, Animals, Cell Membrane, DNA Mutational Analysis, Eye Proteins, Fatty Acids, Unsaturated, Humans, Membrane Proteins, Retina, Retinaldehyde, Substrate Specificity, Tissue Distribution, Molecular Structure
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review