The DOI matches its Crossref record; 144 of the 144 references it cites were found in a registry or an index.
Unraveling the complexities of the HDL lipidome
Open accessAbstract
Plasma high density lipoproteins (HDL) are small, dense, protein-rich particles compared with other lipoprotein classes; roughly half of total HDL mass is accounted for by lipid components. Phospholipids predominate in the HDL lipidome, accounting for 40-60% of total lipid, with lesser proportions of cholesteryl esters (30-40%), triglycerides (5-12%), and free cholesterol (5-10%). Lipidomic approaches have provided initial insights into the HDL lipidome with identification of over 200 individual molecular lipids species in normolipidemic HDL. Plasma HDL particles, however, reveal high levels of structural, compositional, and functional heterogeneity. Establishing direct relationships between HDL structure, composition, and atheroprotective functions bears the potential to identify clinically relevant HDL subpopulations. Furthermore, development of HDL-based therapies designed to target beneficial subspecies within the circulating HDL pool can be facilitated using this approach. HDL lipidomics can equally contribute to the identification of biomarkers of both normal and deficient HDL functionality, which may prove useful as biomarkers of cardiovascular risk. However, numerous technical issues remain to be addressed in order to make such developments possible. With all technical questions resolved, quantitative analysis of the molecular components of the HDL lipidome will contribute to expand our knowledge of cardiovascular and metabolic diseases.
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Cites
Role of Oxidative Modifications in Atherosclerosis
Stocker, R., & Keaney, J. F. (2004) · Physiological Reviews · doi:10.1152/physrev.00047.2003 · Cited by 2,624
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Lipidomics reveals a remarkable diversity of lipids in human plasma
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HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3
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Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M
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Cited by
HDL-targeted therapies: progress, failures and future
Kingwell, B. A., Chapman, M. J., Kontush, A., & Miller, N. E. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4279 · Cited by 354
Self-citationiPS-cell-derived microglia promote brain organoid maturation via cholesterol transfer
Park, D. S., Kozaki, T., Tiwari, S. K., Moreira, M., Khalilnezhad, A., Torta, F., Olivié, N., Thiam, C. H., Liani, O., Silvin, A., et al. (2023) · Nature · doi:10.1038/s41586-023-06713-1 · Cited by 239
From Lipids to Inflammation: New Approaches to Reducing Atherosclerotic Risk
Shapiro, M. D., & Fazio, S. (2016) · Circulation Research · doi:10.1161/circresaha.115.306471 · Cited by 217
Mechanisms of lysophosphatidylcholine‐induced demyelination: A primary lipid disrupting myelinopathy
Plemel, J. R., Michaels, N. J., Weishaupt, N., Caprariello, A. V., Keough, M. B., Rogers, J. A., Yukseloglu, A., Lim, J., Patel, V. V., Rawji, K. S., et al. (2018) · Glia · doi:10.1002/glia.23245 · Cited by 220
Obesity-Related Changes in High-Density Lipoprotein Metabolism and Function
Stadler, J. T., & Marsche, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21238985 · Cited by 200
Metadata
- Authors
- Kontush, A., Lhomme, M., & Chapman, M. J.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 54
- Issue
- 11
- Pages
- 2950-2963
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W2129214913
- Cited by
- 396
- References
- 144
- FWCI
- 24.85
- Type
- journal article
- Language
- en
- Open access
- hybrid
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