Cited by 193Lipid metabolism and disordersParaoxonase enzyme and polymorphismsLipoproteins and Cardiovascular Health

Hepatic lipase and dyslipidemia: interactions among genetic variants, obesity, gender and diet.

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Deeb, Samir S., Zambon, Alberto, Carr, Molly C., Ayyobi, Amir F., Brunzell, John D.·2003·Journal of Lipid Research

Abstract

Hepatic lipase (HL) plays a central role in LDL and HDL remodeling. High HL activity is associated with small, dense LDL particles and with reduced HDL2 cholesterol levels. HL activity is determined by an HL gene promoter polymorphism, by gender (lower in premenopausal women), and by visceral obesity with insulin resistance. The activity is affected by dietary fat intake and selected medications. There is evidence for an interaction of the HL promoter polymorphism with visceral obesity, dietary fat intake, and with lipid-lowering medications in determining the level of HL activity. The dyslipidemia with high HL activity is a potentially proatherogenic lipoprotein profile in the metabolic syndrome, in Type 2 diabetes, and in familial combined hyperlipidemia.

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Crossref · 10.1194/jlr.r200017-jlr200

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  • Small HDL in hypertriglyceridemia is associated with hypercatabolism of apolipoprotein A-I and seems related to elevated hepatic lipase activity in central obesity and insulin resistance.

    “Small HDL in hypertriglyceridemia is associated with hypercatabolism of apolipoprotein A-I (47, 48), and it seems to be related to elevated hepatic lipase activity in central obesity and insulin resistance (49).”

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Authors
Deeb, S. S., Zambon, A., Carr, M. C., Ayyobi, A. F., & Brunzell, J. D.
Affiliations
University of Washington (US)
Corresponding author
Deeb, Samir S.
Venue
Journal of Lipid Research
Publisher
Elsevier BV
Published
2003-07
Volume
44
Issue
7
Pages
1279-1286
ISSN
0022-2275 (ISSN-L)
OpenAlex
W2128832145
Cited by
193
References
80
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2023: 8 · 2022: 6 · 2021: 5 · 2020: 4 · 2019: 5 · 2018: 12 · 2017: 4 · 2016: 6 · 2015: 9 · 2014: 9 · 2013: 7 · 2012: 8
FWCI
2.51
Type
journal article
Language
en
Open access
Locations
  • Journal of Lipid Research (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Heart, Lung, and Blood Institute (P01HL030086, HL3-0086, HL 64322, R01HL064322)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Keywords
hepatic lipase, dyslipidemia, visceral obesity, insulin resistance, dietary fat intake, gender differences, HDL cholesterol, small dense LDL, lipid-lowering drugs, metabolic syndrome, type 2 diabetes, familial combined hyperlipidemia, atherogenic lipoprotein profile
MeSH terms
Diabetes Mellitus, Type 2, Diet, Female, Haplotypes, Humans, Hyperlipidemias, Hyperlipidemia, Familial Combined, Lipase, Lipoproteins, LDL, Liver, Male, Models, Biological, Obesity, Polymorphism, Genetic, Promoter Regions, Genetic, Sex Factors, Genetic Variation

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