The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.
Emerging role of Toll-like receptors in atherosclerosis
Open accessAbstract
Atherosclerosis is inflammation of the vessel wall of the arterial tree. This inflammation arises at specific areas that experience disturbed blood flow such as bifurcations and the lesser curvature of the aortic arch. Although all endothelial cells are exposed to comparable levels of circulating plasma cholesterol, only endothelial cells overlaying lesions display an inflamed phenotype. This occurs even in the absence of any additional exacerbating disease factors because blood flow controls the expression of Toll-like receptors (TLR), which are initiators of cellular activation and inflammation. TLR2- and 4-expression exert an overall proatherogenic effect in hyperlipidemic mice. TLR activation of the endothelium promotes lipid accumulation and leukocyte accumulation within lesions.
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“Inactivation of the lipopolysaccharide pathway by deletion of Toll-like receptor 4 or the downstream cytosolic adaptor myeloid differentiation factor-88 or the prevention of its transport by inhibiting lipopolysaccharide-binding protein reduces aortic lesions in Apoe -/-and low-density lipoprotein receptor-deficient (Ldlr -/-) mice.”
From Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe −/− Mice (2016) · cites this paper as [47]
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Metadata
- Authors
- Curtiss, L. K., & Tobias, P. S.
- Affiliations
- Scripps Research Institute (US)
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2009-04
- Volume
- 50
- Pages
- S340-S345
- ISSN
- 0022-2275 (ISSN-L)
- PMC
- PMC2674724
- OpenAlex
- W2003013587
- Cited by
- 225
- References
- 72
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 9 · 2023: 10 · 2022: 5 · 2021: 14 · 2020: 11 · 2019: 21 · 2018: 12 · 2017: 14 · 2016: 25 · 2015: 16 · 2014: 10 · 2013: 14 · 2012: 18
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Lipid Research (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Keywords
- Toll-like receptors, atherosclerosis, endothelial inflammation, TLR2, TLR4, blood flow, hyperlipidemia, lipid accumulation, leukocyte accumulation, arterial lesions, vascular inflammation
- MeSH terms
- Animals, Humans, Inflammation, Time Factors, Atherosclerosis, Toll-Like Receptors
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