Cited by 90Immune Response and Inflammationinterferon and immune responsesImmunotherapy and Immune Responses

Toll like receptors and viruses

Finberg, Robert W., Wang, Jennifer P., Kurt‐Jones, Evelyn A.·2007·Reviews in Medical Virology

Abstract

Toll like receptors (TLRs) are ‘pattern recognition proteins’ that discriminate between self and non‐self. They interact with products of infectious agents to activate cells of the innate immune system and also stimulate the adaptive immune system. Intracellular and extracellular TLRs recognise a wide range of viruses leading to the production of different cytokines. In this paper, we summarise the types of TLRs that recognise viruses, the cytokines produced, the specific cell types involved and the activation pathways that have been characterised. We also provide an overview of the viruses demonstrated to interact with TLRs. A greater understanding of relationships between viruses or viral products and TLRs should improve understanding of pathogenesis and lead to the development of new anti‐viral therapies. Copyright © 2006 John Wiley & Sons, Ltd.

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Crossref · 10.1002/rmv.525

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Authors
Finberg, R. W., Wang, J. P., & Kurt‐Jones, E. A.
Affiliations
University of Massachusetts Chan Medical School (US)
Corresponding author
Finberg, Robert W.
Venue
Reviews in Medical Virology
Publisher
Wiley
Published
2006-12-05
Volume
17
Issue
1
Pages
35-43
ISSN
  • 1052-9276 (ISSN-L)
  • 1099-1654
OpenAlex
W2067982460
Cited by
90
References
49
Citations by year
2025: 1 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 5 · 2016: 1 · 2015: 4 · 2014: 5 · 2013: 11 · 2012: 6
FWCI
0.60
Type
journal article
Language
en
Open access
closed
Locations
  • Reviews in Medical Virology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Institute of Allergy and Infectious Diseases (R01AI064349, P01AI057784, AI051405, AI053542, AI064349, AI057784, R01AI051405, R01AI049309, AI049309, K08AI053542)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords
Toll-like receptors, viral recognition, innate immunity, pattern recognition receptors, cytokine production, adaptive immune activation, antiviral therapy, viral pathogenesis
MeSH terms
Animals, Humans, Receptors, Virus, Species Specificity, Virulence, Virus Diseases, Viruses, Cytokines, Toll-Like Receptors

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