Cited by 225Atherosclerosis and Cardiovascular DiseasesImmune Response and InflammationCholesterol and Lipid Metabolism

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Emerging role of Toll-like receptors in atherosclerosis

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Curtiss, Linda K., Tobias, Peter S.·2009·Journal of Lipid Research

DOI 10.1194/jlr.r800056-jlr200PMC PMC2674724

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Abstract

Atherosclerosis is inflammation of the vessel wall of the arterial tree. This inflammation arises at specific areas that experience disturbed blood flow such as bifurcations and the lesser curvature of the aortic arch. Although all endothelial cells are exposed to comparable levels of circulating plasma cholesterol, only endothelial cells overlaying lesions display an inflamed phenotype. This occurs even in the absence of any additional exacerbating disease factors because blood flow controls the expression of Toll-like receptors (TLR), which are initiators of cellular activation and inflammation. TLR2- and 4-expression exert an overall proatherogenic effect in hyperlipidemic mice. TLR activation of the endothelium promotes lipid accumulation and leukocyte accumulation within lesions.

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Authors: Curtiss, L. K., & Tobias, P. S.
Affiliations: Scripps Research Institute (US)
Venue: Journal of Lipid Research
Publisher: Elsevier BV
Published: 2009-04
Volume: 50
Pages: S340-S345
ISSN: 0022-2275 (ISSN-L)
DOI: 10.1194/jlr.r800056-jlr200
PMC: PMC2674724
OpenAlex: W2003013587
Cited by: 225
References: 72
Citations by year: 2026: 2 · 2025: 3 · 2024: 9 · 2023: 10 · 2022: 5 · 2021: 14 · 2020: 11 · 2019: 21 · 2018: 12 · 2017: 14 · 2016: 25 · 2015: 16 · 2014: 10 · 2013: 14 · 2012: 18
FWCI: 1.01
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 4185 d)
Locations: Journal of Lipid Research (publishedVersion, cc-by)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Keywords: Toll-like receptors, atherosclerosis, endothelial inflammation, TLR2, TLR4, blood flow, hyperlipidemia, lipid accumulation, leukocyte accumulation, arterial lesions, vascular inflammation
MeSH terms: Animals, Humans, Inflammation, Time Factors, Atherosclerosis, Toll-Like Receptors

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