The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Can Posttraumatic Stress Disorder Be Prevented with Glucocorticoids?
Abstract
A bstract: Patients with critical illness who are treated in an intensive care unit (ICU) often report traumatic memories from ICU treatment, receive exogenously administered glucocorticoids for medical reasons, and have a relatively high incidence of chronic stress symptoms and posttraumatic stress disorder (PTSD) during follow‐up. ICU therapy could therefore represent a useful model for investigating glucocorticoid effects on traumatic memories and PTSD development. Studies in long‐term survivors of ICU treatment demonstrated a clear and vivid recall of different categories of traumatic memory such as nightmares, anxiety, respiratory distress, or pain. The incidence and intensity of PTSD symptoms increased with the number of categories of traumatic memory present. The prolonged administration of glucocorticoids (stress doses of hydrocortisone) to critically ill patients resulted in a significant reduction of PTSD symptoms measured after recovery without influencing the number of categories of traumatic memory. This protective effect of cortisol can possibly be explained by a cortisol‐induced temporary impairment in traumatic memory retrieval which has previously been demonstrated in both rats and humans. Therefore, stress doses of hydrocortisone could be useful for prophylaxis and treatment of PTSD.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Data on human PTSD support a protective role for adequate glucocorticoid levels at time of trauma.”
From Neurobiological and Systemic Effects of Chronic Stress (2017) · cites this paper as [35]
Citations
Cites
Stress and glucocorticoids impair retrieval of long-term spatial memory
de Quervain, D. J.-F., Roozendaal, B., & McGaugh, J. L. (1998) · Nature · doi:10.1038/29542 · Cited by 1,182
Self-citationPost-Traumatic Stress Disorder
Yehuda, R. (2002) · New England Journal of Medicine · doi:10.1056/nejmra012941 · Cited by 1,134
Corticosteroid insufficiency in acutely ill patients
Cooper, M. S., & Stewart, P. M. (2003) · New England Journal of Medicine · doi:10.1056/nejmra020529 · Cited by 1,033
Stress doses of hydrocortisone reverse hyperdynamic septic shock
Briegel, J., Forst, H., Haller, M., Schelling, G., Kilger, E., Kuprat, G., Hemmer, B., Hummel, T., Lenhart, A., Heyduck, M., et al. (1999) · Critical Care Medicine · doi:10.1097/00003246-199904000-00025 · Cited by 876
Self-citationStress and memory: opposing effects of glucocorticoids on memory consolidation and memory retrieval
Roozendaal, B. (2002) · Neurobiology of Learning and Memory · doi:10.1006/nlme.2002.4080 · Cited by 838
Self-citationAcute cortisone administration impairs retrieval of long-term declarative memory in humans
de Quervain, D. J.-F., Roozendaal, B., Nitsch, R. M., McGaugh, J. L., & Hock, C. (2000) · Nature Neuroscience · doi:10.1038/73873 · Cited by 745
Self-citationAspirin and Mortality from Coronary Bypass Surgery
Mangano, D. T. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa020798 · Cited by 674
Schelling, G., Stoll, C., Haller, M., Briegel, J., Manert, W., Hummel, T., Lenhart, A., Heyduck, M., Polasek, J., Meier, M., et al. (1998) · Critical Care Medicine · doi:10.1097/00003246-199804000-00011 · Cited by 606
Self-citationLow Urinary Cortisol Excretion in Patients with Posttraumatic Stress Disorder
Yehuda, R., Southwick, S. M., Nussbaum, G., Wahby, V. S., Giller, E. L., & Mason, J. W. (1990) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-199006000-00004 · Cited by 528
Current status of cortisol findings in post-traumatic stress disorder
Yehuda, R. (2002) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(02)00002-3 · Cited by 511
Research works printed but not linked: 1
- 10.1037/0735-7044.115.5.1002 · DOI
Cited by
Sorted by citations
Items 101–129 of 129
Posttraumatic Stress Disorder: Overview
Yehuda, R. (2009) · Elsevier eBooks · doi:10.1016/b978-008045046-9.00095-4 · Cited by 3
Post-traumatic stress disorder in the critically ill patients
Kishen, R. (2006) · Indian Journal of Critical Care Medicine · doi:10.4103/0972-5229.27856 · Cited by 2
Fornari, R. V., Aerni, A., de Quervain, D. J. ‐., & Roozendaal, B. (2019) · Springer eBooks · doi:10.1007/978-3-030-16996-1_7 · Cited by 2
Self-citationGlucocorticoid Effects on Memory: the Positive and the Negative
Wolf, O. T. (2007) · Elsevier eBooks · doi:10.1016/b978-012373947-6.00647-4 · Cited by 2
van Gelder, T. G., Lalmohamed, A., Zaal, I. J., Egberts, T. C. G., & Slooter, A. J. C. (2022) · Intensive Care Medicine · doi:10.1007/s00134-022-06725-x · Cited by 1
Prophylaxe und Therapie der posttraumatischen Belastungsstörung mit Propranolol
Kuehlmeyer, K., & Jox, R. J. (2013) · Der Nervenarzt · doi:10.1007/s00115-013-3735-6 · Cited by 1
Kreutzer, C. P. (2013) · Journal of International Crisis and Risk Communication Research · Cited by 1
Les modèles animaux du traumatisme et du trouble de stress post-traumatique
Benchenane, K. (2023) · Biologie Aujourd hui · doi:10.1051/jbio/2023022 · Cited by 1
Responding to Stress: Genomic and Nongenomic Actions of Corticosteroid Receptors in the Brain
Haque, S. N., Mifsud, K. R., Price, E. M., & Reul, J. M. H. M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-813156-5.00020-0 · Cited by 1
Fornari, R. V., Aerni, A., Roozendaal, B., & de Quervain, D. J. ‐. (2011) · Springer eBooks · doi:10.1007/978-3-642-22272-6_5 · Cited by 1
Self-citationOptimizing care for patients surgically treated for severe peritonitis
Boer, K. R. (2007) · UvA-DARE (University of Amsterdam) · Cited by 1
Neuroendocrinology and Neurotransmitters
Gray, J. D., & McEwen, B. S. (2014) · Wiley eBooks · doi:10.1002/9781118775349.ch16 · Cited by 1
Stress and Glucocorticoid Effects on Memory
de Quervain, D. J. ‐. (2011) · Wiley eBooks · doi:10.1002/9781118083222.ch21 · Cited by 1
Bertoli, E. (2005) · UKnowledge (University of Kentucky)
Putman, P. (2006) · Utrecht University Repository (Utrecht University)
Der Einfluss von Stress auf abrufinduziertes Vergessen
Sektion, M.-N., & Psychologie, F. (2010)
Post traumatic stress disorder: Insights from cat hair and catfish
Nalloor, R. (2012)
Acute Optic Neuropathy and Development of Posttraumatic Stress Disorder
Fabian, I. D., Abudy, A., Kinori, M., Moisseiev, J., Liashets-Peer, A., Zohar, J., & Huna-Baron, R. (2016) · Seminars in Ophthalmology · doi:10.3109/08820538.2015.1115086
“These preventive effects were proven in the settings of intensive care units, in which the administration of glucocorticoids to critically ill patients resulted in a significant reduction of PTSD symptoms.(26,27) In the present study, 34% of the AON subjects, as opposed to none of the RRD subjects, received steroid th…”
ResultLong-term Outcomes After Acute Lung Injury/Acute Respiratory Distress Syndrome
Siddiqi, F., & Needham, D. M. (2008)
Langzeitfolgen nach Intensivtherapie
Börner, U. (2008) · Springer eBooks · doi:10.1007/978-3-540-72296-0_14
Advances in the pathogenesis and pharmacotherapy of acute stress disorder
Wang, X., Tian, W., & Fu, F. (2022) · International Journal of Science and Research Archive · doi:10.30574/ijsra.2022.5.1.0031
Basu, A. (2012) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.717959963.793463117
Emotional Hormones and Memory Modulation☆
McGaugh, J. L., & Roozendaal, B. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.02216-1
Self-citation(2014) · Society for Neuroscience eBooks · doi:10.1523/hon.008005
Enhancing Resilience: Early Intervention Strategies for Post-Traumatic Stress Disorder (PTSD)
-, I. B. (2023) · International Journal For Multidisciplinary Research · doi:10.36948/ijfmr.2023.v05i06.11213
Li, X., Woodard, G. E., Chen, J., Zhang, L., Hu, X., Li, C. H., Xing, E., Su, Y. A., & Li, H. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111394
Fonctionnement de la mémoire autobiographique dans un contexte de traumatisme psychique
Gachons, S. B. P. D. (2016) · theses.fr (ABES) · doi:10.70675/5654df1dzd71cz4f4fzb92azf1eebc0eb5f2
Metadata
- Authors
- SCHELLING, G., ROOZENDAAL, B., & de QUERVAIN, D. J. ‐.
- Affiliations
- Ludwig-Maximilians-Universität München (DE)
- Corresponding author
- SCHELLING, GUSTAV
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2004-12
- Volume
- 1032
- Issue
- 1
- Pages
- 158-166
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2131975102
- Cited by
- 130
- References
- 43
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 2 · 2022: 7 · 2021: 2 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 6 · 2016: 9 · 2015: 11 · 2014: 5 · 2013: 5 · 2012: 7
- FWCI
- 12.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
- Keywords
- post-traumatic stress disorder, glucocorticoids, cortisol, intensive care unit, critical illness, traumatic memory, PTSD prevention, memory retrieval
- MeSH terms
- Critical Care, Emotions, Glucocorticoids, Humans, Hydrocortisone, Memory, Stress Disorders, Post-Traumatic, Critical Illness, Survivors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
