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Can Posttraumatic Stress Disorder Be Prevented with Glucocorticoids?
Abstract
A bstract: Patients with critical illness who are treated in an intensive care unit (ICU) often report traumatic memories from ICU treatment, receive exogenously administered glucocorticoids for medical reasons, and have a relatively high incidence of chronic stress symptoms and posttraumatic stress disorder (PTSD) during follow‐up. ICU therapy could therefore represent a useful model for investigating glucocorticoid effects on traumatic memories and PTSD development. Studies in long‐term survivors of ICU treatment demonstrated a clear and vivid recall of different categories of traumatic memory such as nightmares, anxiety, respiratory distress, or pain. The incidence and intensity of PTSD symptoms increased with the number of categories of traumatic memory present. The prolonged administration of glucocorticoids (stress doses of hydrocortisone) to critically ill patients resulted in a significant reduction of PTSD symptoms measured after recovery without influencing the number of categories of traumatic memory. This protective effect of cortisol can possibly be explained by a cortisol‐induced temporary impairment in traumatic memory retrieval which has previously been demonstrated in both rats and humans. Therefore, stress doses of hydrocortisone could be useful for prophylaxis and treatment of PTSD.
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“Data on human PTSD support a protective role for adequate glucocorticoid levels at time of trauma.”
From Neurobiological and Systemic Effects of Chronic Stress (2017) · cites this paper as [35]
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“Data on human PTSD support a protective role for adequate glucocorticoid levels at time of trauma.(34,35) Yet, repeated high dose glucocorticoids treatment mimics chronic stress and induces dendritic lengthening in BlA.”
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Metadata
- Authors
- SCHELLING, G., ROOZENDAAL, B., & de QUERVAIN, D. J. ‐.
- Affiliations
- Ludwig-Maximilians-Universität München (DE)
- Corresponding author
- SCHELLING, GUSTAV
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2004-12
- Volume
- 1032
- Issue
- 1
- Pages
- 158-166
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2131975102
- Cited by
- 130
- References
- 43
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 2 · 2022: 7 · 2021: 2 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 6 · 2016: 9 · 2015: 11 · 2014: 5 · 2013: 5 · 2012: 7
- FWCI
- 12.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
- Keywords
- post-traumatic stress disorder, glucocorticoids, cortisol, intensive care unit, critical illness, traumatic memory, PTSD prevention, memory retrieval
- MeSH terms
- Critical Care, Emotions, Glucocorticoids, Humans, Hydrocortisone, Memory, Stress Disorders, Post-Traumatic, Critical Illness, Survivors
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