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Cited by 45Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchSubstance Abuse Treatment and Outcomes

Role of Alcohol Consumption in Escalation to Violence

MICZEK, KLAUS A., FISH, ERIC W., De ALMEIDA, ROSA M. M., FACCIDOMO, SARA, DEBOLD, JOSEPH F.·2004·Annals of the New York Academy of Sciences
DOI 10.1196/annals.1330.018
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Abstract

A bstract:No other drug has been associated with aggressive and violent behavior more than alcohol has. A major characteristic of the link between alcohol and social interactions is the very large variation in who becomes more aggressive while drinking and who does not. Tracing the origins of these individual differences has led to a focus on predispositions, such as the antisocial behavior of Type 2 alcoholics. Successful development of an experimental procedure to model heightened aggressive behavior after voluntary consumption of alcohol has facilitated the neurobiologic analysis of the link between alcohol and aggression. From a pharmacologic perspective, consumption of low to moderate doses of alcohol engenders heightened aggressive behavior in a significant minority of individuals before the circulation of appreciable amounts of the aldehyde metabolite. Ionophoric receptors such as NMDA, 5‐HT 3 and GABA A have been identified in the brain as major sites of action for alcohol in the dose range that is relevant for engendering heightened aggression. Actions at the GABA A receptor complex that depend on particular GABA A subunits appear to be necessary for alcohol‐heightened aggression. Genes that encode the synthesis of these alpha and gamma subunits are potentially significant markers for those individuals that are prone to engage in heightened aggressive behavior after the consumption of alcohol. Of particular importance are the reciprocal interactions between GABA and serotonin. Activating specific serotonin receptor subtypes such as 5‐HT 1B receptors reduces alcohol‐heightened aggressive behavior. How these GABAergic and serotonergic corticolimbic mechanisms for alcohol‐heightened aggression develop during the adolescent period remains an area of urgent study.

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Crossref · 10.1196/annals.1330.018

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72 of 72 references verified0 citation errors · 0 not checkable

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  • Prolonged exposure to alcohol increases the proportion of laboratory animals that exhibit alcohol-heightened aggression and extends the dose range over which alcohol increases aggression.

    “Evidence from rodent models suggests that prolonged exposure to alcohol increases the proportion of laboratory animals that exhibit alcohol-heightened aggression and extends the dose range over which alcohol increases aggression.”

    From Decoding the bidirectional links between alcohol misuse and aggression: toward a unified translational framework (2026) · cites this paper as Miczek et al. 2004

  • Operant self-administration protocols extend the dose range that increases aggression from 0.3 to 1.0 g/kg for acute gavage administration to 0.5-1.7 g/kg.

    “operant self-administration protocols (which require extensive training and therefore chronic alcohol exposure) extend the dose range that increases aggression (from 0.3 to 1.0 g/kg for acute gavage administration) to 0.5–1.7 g/kg (Miczek et al. 2004).”

    From Decoding the bidirectional links between alcohol misuse and aggression: toward a unified translational framework (2026) · cites this paper as Miczek et al. 2004

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Authors
MICZEK, K. A., FISH, E. W., De ALMEIDA, R. M. M., FACCIDOMO, S., & DEBOLD, J. F.
Affiliations
Tufts University (US)
Corresponding author
MICZEK, KLAUS A.
ORCID
Venue
Annals of the New York Academy of Sciences
Publisher
Wiley
Published
2004-12
Volume
1036
Issue
1
Pages
278-289
ISSN
  • 0077-8923 (ISSN-L)
  • 1749-6632
DOI
10.1196/annals.1330.018
OpenAlex
W2166133248
Cited by
45
References
72
Citations by year
2025: 3 · 2024: 1 · 2021: 1 · 2020: 6 · 2019: 1 · 2017: 1 · 2016: 1 · 2015: 3 · 2014: 5 · 2013: 3 · 2012: 2
FWCI
0.94
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 407 d)
Locations
  • Annals of the New York Academy of Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords
alcohol consumption, alcohol-related aggression, violence, GABAA receptor subunits, serotonin receptors, 5-HT3 receptor, NMDA receptor, adolescent development, alcohol pharmacology
MeSH terms
Aggression, Alcohol Drinking, Ethanol, Female, Humans, Male, Piperidines, Pregnanolone, Pyridines, Receptors, Serotonin, Tryptamines, Violence, Receptors, GABA, Analgesics, Non-Narcotic, Oxazolidinones

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