Discordant patterns of bacterial translocation markers and implications for innate immune imbalances in schizophrenia
Open accessAbstract
The origin of inflammation in psychiatric disorders is not well understood. The translocation of commensal microbiota across the gastrointestinal barrier can result in a persistent state of low-grade immune activation and/or inflammation. We measured serological surrogate markers of bacterial translocation (soluble CD14 (sCD14) and lipopolysaccharide binding protein (LBP)) in two psychiatric cohorts and compared these levels to C-reactive protein (CRP), body mass index (BMI), and food-related and autoimmune antibodies. The two cohorts were composed of the following: (1) n=141 schizophrenia, n=75 bipolar disorder, n=78 controls; (2) n=78 antipsychotic-naïve first-episode schizophrenia, n=38 medicated first-episode schizophrenia. sCD14 seropositivity conferred a 3.1-fold increased odds of association with schizophrenia (multivariate regressions, OR=3.09, p<0.0001) compared to controls. Case-control differences in sCD14 were not matched by LBP. Quantitative levels of LBP, but not sCD14, correlated with BMI in schizophrenia (R(2)=0.21, p<0.0001). sCD14 and LBP also exhibited some congruency in schizophrenia with both significantly correlated with CRP (R(2)=0.26-0.27, p<0.0001) and elevated in females compared to males (p<0.01). Antipsychotic treatment generally did not impact sCD14 or LBP levels except for significant correlations, especially sCD14, with gluten antibodies in antipsychotic-naïve schizophrenia (R(2)=0.27, p<0.0001). In bipolar disorder, sCD14 levels were significantly correlated with anti-tissue transglutaminase IgG (R(2)=0.37, p<0.001). In conclusion, these bacterial translocation markers produced discordant and complex patterns of activity, a finding that may reflect an imbalanced, activated innate immune state. Whereas both markers may upregulate following systemic exposure to Gram-negative bacteria, non-lipopolysaccharide-based monocyte activation, autoimmunity and metabolic dysfunction may also contribute to the observed marker profiles.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Researchers at Johns Hopkins University School of Medicine found evidence of increased gut bacterial translocation in schizophrenic patients, unrelated to antipsychotic treatment.
“Researchers at Johns Hopkins University School of Medicine found evidence of increased gut bacterial translocation in schizophrenic patients, unrelated to antipsychotic treatment.”
From The Gut Microbiome and the Brain (2014) · cites this paper as [42]
Gut bacterial components other than LPS may be stimulating monocyte activation and inflammation in schizophrenics.
“suggesting that gut bacterial components other than LPS may be stimulating monocyte activation and inflammation in schizophrenics.42”
From The Gut Microbiome and the Brain (2014) · cites this paper as [42]
Presence of the translocation marker soluble CD14 tripled the risk of schizophrenia and was positively associated with C-reactive protein but not with LPS-binding protein.
“Presence of the translocation marker soluble CD14 tripled the risk of schizophrenia and was positively associated with C-reactive protein (CRP) but not with LPS-binding protein (LBP)”
From The Gut Microbiome and the Brain (2014) · cites this paper as [42]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199 · see citing works
Diagnostic and Statistical Manual of Mental Disorders (DSM-IV)
Hu, R. J. (2003) · Elsevier eBooks · doi:10.1016/b0-12-226870-9/01070-4 · Cited by 9,167 · see citing works
Inflammation, Atherosclerosis, and Coronary Artery Disease
Hansson, G. K. (2005) · New England Journal of Medicine · doi:10.1056/nejmra043430 · Cited by 8,773 · see citing works
Inflammatory Mechanisms in Obesity
Gregor, M. F., & Hotamisligil, G. S. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101322 · Cited by 3,754 · see citing works
Microbial translocation is a cause of systemic immune activation in chronic HIV infection
Brenchley, J. M., Price, D. A., Schacker, T. W., Asher, T. E., Silvestri, G., Rao, S., Kazzaz, Z., Bornstein, E., Lambotte, O., Altmann, D., et al. (2006) · Nature Medicine · doi:10.1038/nm1511 · Cited by 3,559 · see citing works
Yatham, L. N., & Malhi, G. S. (2011) · Oxford University Press eBooks · doi:10.1093/med/9780199562305.001.0001 · Cited by 3,515 · see citing works
Adipose Tissue, Inflammation, and Cardiovascular Disease
Berg, A. H., & Scherer, P. E. (2005) · Circulation Research · doi:10.1161/01.res.0000163635.62927.34 · Cited by 2,113 · see citing works
Saha, S., Chant, D., & McGrath, J. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.10.1123 · Cited by 2,065 · see citing works
Meta-Analysis of Cytokine Alterations in Schizophrenia: Clinical Status and Antipsychotic Effects
Miller, B. J., Buckley, P., Seabolt, W., Mellor, A., & Kirkpatrick, B. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.04.013 · Cited by 1,742 · see citing works
Schizophrenia and increased risks of cardiovascular disease
Hennekens, C. H., Hennekens, A. R., Hollar, D., & Casey, D. E. (2005) · American Heart Journal · doi:10.1016/j.ahj.2005.02.007 · Cited by 1,070 · see citing works
Comorbidities and mortality in persons with schizophrenia: a Swedish national cohort study
Crump, C., Winkleby, M. A., Sundquist, K., & Sundquist, J. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2012.12050599 · Cited by 619 · see citing works
Fillman, S. G., Cloonan, N., Catts, V. S., Miller, L. C., Wong, J., McCrossin, T., Cairns, M., & Weickert, C. S. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.110 · Cited by 609 · see citing works
Maes, M. H. J., Kubera, M., & Leunis, J. (2008) · PubMed · Cited by 607 · see citing works
Lammers, K. M., Lu, R., Brownley, J., Lu, B., Gerard, C. J., Thomas, K., Rallabhandi, P., Shea‐Donohue, T., Tamiz, A. P., Alkan, Ş. Ş., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.03.023 · Cited by 545 · see citing works
Association of Schizophrenia and Autoimmune Diseases: Linkage of Danish National Registers
Eaton, W. W., Byrne, M., Ewald, H., Mors, O., Chen, C.-Y., Agerbo, E., & Mortensen, P. B. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.3.521 · Cited by 527 · see citing works
Life expectancy and cardiovascular mortality in persons with schizophrenia
Laursen, T. M., Munk-Olsen, T., & Vestergaard, M. (2012) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e32835035ca · Cited by 518 · see citing works
Microbial translocation in HIV infection: causes, consequences and treatment opportunities
Utay, N. S., & Douek, D. C. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2848 · Cited by 473 · see citing works
Maes, M., Kubera, M., Leunis, J.-C., & Berk, M. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.02.023 · Cited by 446 · see citing works
Clemente, M. G. (2003) · Gut · doi:10.1136/gut.52.2.218 · Cited by 415 · see citing works
Initial responses to endotoxins and Gram-negative bacteria
Heumann, D., & Roger, T. (2002) · Clinica Chimica Acta · doi:10.1016/s0009-8981(02)00180-8 · Cited by 359 · see citing works
Beumer, W., Gibney, S. M., Drexhage, R. C., Pont-Lezica, L., Doorduin, J., Klein, H. C., Steiner, J., Connor, T. J., Harkin, A., Versnel, M. A., et al. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.0212100 · Cited by 347 · see citing works
Innate recognition of lipopolysaccharide by Toll-like receptor 4–MD-2
Miyake, K. (2004) · Trends in Microbiology · doi:10.1016/j.tim.2004.02.009 · Cited by 333 · see citing works
Sun, L. D., Yu, Z., Ye, X., Zou, S., Li, H., Yu, D., Wu, H., Chen, Y., Dore, J. M., Clément, K., et al. (2010) · Diabetes Care · doi:10.2337/dc10-0340 · Cited by 277 · see citing works
Modulatory effects of sCD14 and LBP on LPS-host cell interactions
Kitchens, R. L., & Thompson, P. A. (2005) · Journal of Endotoxin Research · doi:10.1179/096805105x46565 · Cited by 268 · see citing works
Whiteley, P., Haracopos, D., Knivsberg, A.-M., Reichelt, K. L., Parlar, S., Jacobsen, J., Seim, A., Pedersen, L., Schondel, M., & Shattock, P. (2010) · Nutritional Neuroscience · doi:10.1179/147683010x12611460763922 · Cited by 266 · see citing works
Drexhage, R. C., Knijff, E. M., Padmos, R. C., Heul-Nieuwenhuijzen, L. V. D., Beumer, W., Versnel, M. A., & Drexhage, H. A. (2010) · Expert Review of Neurotherapeutics · doi:10.1586/ern.09.144 · Cited by 263 · see citing works
Autoimmune diseases, bipolar disorder, and non-affective psychosis
Eaton, W. W., Pedersen, M. G., Nielsen, P. R., & Mortensen, P. B. (2010) · Bipolar Disorders · doi:10.1111/j.1399-5618.2010.00853.x · Cited by 262 · see citing works
Evidence for a Dysregulated Immune System in the Etiology of Psychiatric Disorders
Gibney, S. M., & Drexhage, H. A. (2013) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-013-9462-8 · Cited by 237 · see citing works
Thomas, K. E., Sapone, A., Fasano, A., & Vogel, S. N. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.4.2512 · Cited by 231 · see citing works
Modulatory effects of sCD14 and LBP on LPS-host cell interactions
Kitchens, R. L., & Thompson, P. A. (2005) · Journal of Endotoxin Research · doi:10.1177/09680519050110040701 · Cited by 231 · see citing works
Antibodies to infectious agents in individuals with recent onset schizophrenia
Leweke, F. M., Gerth, C. W., Koethe, D., Klosterk�tter, J., Ruslanova, I., Krivogorsky, B., Torrey, E. F., & Yolken, R. H. (2004) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-004-0481-6 · Cited by 228 · see citing works
Self-citationGastrointestinal inflammation and associated immune activation in schizophrenia
Severance, E. G., Alaedini, A., Yang, S., Halling, M., Gressitt, K. L., Stallings, C. R., Origoni, A. E., Vaughan, C., Khushalani, S., Leweke, F. M., et al. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.02.025 · Cited by 226 · see citing works
Self-citationGonzález‐Quintela, A., Alonso‐Sampedro, M., Franco, J. C., Vizcaíno, L., Loidi, L., & Gudé, F. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054600 · Cited by 217 · see citing works
Maes, M. H. J., Kubera, M., Leunis, J., Berk, M., Geffard, M., & Bosmans, E. (2012) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2012.01908.x · Cited by 209 · see citing works
Neurologic and Psychiatric Manifestations of Celiac Disease and Gluten Sensitivity
Jackson, J. R., Eaton, W. W., Cascella, N. G., Fasano, A., & Kelly, D. L. (2011) · Psychiatric Quarterly · doi:10.1007/s11126-011-9186-y · Cited by 207 · see citing works
Kilbourne, A. M., Morden, N. E., Austin, K., Ilgen, M. A., McCarthy, J. F., Dalack, G. W., & Blow, F. C. (2009) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2009.07.008 · Cited by 181 · see citing works
Cascella, N. G., Kryszak, D., Bhatti, B. N., Gregory, P., Kelly, D. L., Evoy, J. P. M., Fasano, A., & Eaton, W. W. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp055 · Cited by 171 · see citing works
WARTIME CHANGES IN HOSPITAL ADMISSIONS FOR SCHIZOPHRENIA
Dohan, F. C. (1966) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1966.tb01912.x · Cited by 164 · see citing works
Beumer, W., Drexhage, R. C., de Wit, H., Versnel, M. A., Drexhage, H. A., & Cohen, D. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.04.001 · Cited by 161 · see citing works
Dickerson, F., Stallings, C. R., Origoni, A. E., Vaughan, C., Khushalani, S., Leister, F. J., Yang, S., Krivogorsky, B., Alaedini, A., & Yolken, R. H. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.03.021 · Cited by 138 · see citing works
Self-citationThe metabolic syndrome in schizophrenia: is inflammation a contributing cause?
Leonard, B. E., Schwarz, M., & Myint, A.-M. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881111431622 · Cited by 134 · see citing works
Stehle, J. R., Leng, X., Kitzman, D. W., Nicklas, B. J., Kritchevsky, S. B., & High, K. P. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls178 · Cited by 133 · see citing works
Soares, F. L. P., Matoso, R. D. O., Teixeira, L. G., Garcia, Z. M., Pereira, S. S., Alves, A. C., Batista, N. V., Faria, A. M. C., Cara, D. C., Ferreira, A. V. M., et al. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.08.009 · Cited by 120 · see citing works
C-reactive protein is elevated in schizophrenia
Dickerson, F., Stallings, C. R., Origoni, A. E., Vaughan, C., Khushalani, S., Yang, S., & Yolken, R. H. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.10.041 · Cited by 120 · see citing works
Self-citationGluten- and casein-free dietary intervention for autism spectrum conditions
Whiteley, P., Shattock, P., Knivsberg, A., Seim, A. R., Reichelt, K. L., Todd, L., Carr, K., & Hooper, M. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2012.00344 · Cited by 119 · see citing works
Gliadin Peptides Activate Blood Monocytes from Patients with Celiac Disease
Cinová, J., Palová-Jelínková, L., Smythies, L. E., Černá, M., Pecharová, B., Dvořák, M., Frühauf, P., Tlaskalová‐Hogenová, H., Smith, P. D., & Tučková, L. (2007) · Journal of Clinical Immunology · doi:10.1007/s10875-006-9061-z · Cited by 113 · see citing works
Novel immune response to gluten in individuals with schizophrenia
Samaroo, D., Dickerson, F., Kasarda, D. D., Green, P. H. R., Briani, C., Yolken, R. H., & Alaedini, A. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2009.08.009 · Cited by 110 · see citing works
Self-citationJelinkova, L. P., Tučková, L., Cinová, J., Flegelová, Z., & Tlaskalová-Hogenová, H. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.06.057 · Cited by 99 · see citing works
Impaired monocyte activation in schizophrenia
Müller, N., Wagner, J. K., Krause, D., Weidinger, E., Wildenauer, A., Obermeier, M., Dehning, S., Gruber, R., & Schwarz, M. (2012) · Psychiatry Research · doi:10.1016/j.psychres.2011.12.049 · Cited by 97 · see citing works
Müller, N., Myint, A.-M., & Schwarz, M. (2012) · Advances in protein chemistry and structural biology · doi:10.1016/b978-0-12-398314-5.00003-9 · Cited by 84 · see citing works
On intrapair differences in male twins with special reference on dominance-submissiveness.
Tienari, P. (1966) · Acta Psychiatrica Scandinavica · Cited by 84 · see citing works
Involvement of Innate Immunity in the Development of Inflammatory and Autoimmune Diseases
Tlaskalová‐Hogenová, H., Tučková, L., Štëpánková, R., Hudcovic, T., Palová-Jelínková, L., Kozáková, H., Rossmann, P., Sánchez, D., Cinová, J., Hrnčíř, T., et al. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1361.122 · Cited by 80 · see citing works
Immune system and glucose metabolism interaction in schizophrenia: A chicken–egg dilemma
Steiner, J. H., Bernstein, H., Schiltz, K., Müller, U., Westphal, S., Drexhage, H. A., & Bogerts, B. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.09.016 · Cited by 79 · see citing works
CŒLIAC DISEASE AND SCHIZOPHRENIA
Dohan, F. C. (1970) · The Lancet · doi:10.1016/s0140-6736(70)91729-0 · Cited by 76 · see citing works
Immune and Neuroimmune Alterations in Mood Disorders and Schizophrenia
Drexhage, R. C., Weigelt, K., van Beveren, N., Cohen, D., Versnel, M. A., Nolen, W. A., & Drexhage, H. A. (2011) · International Review of Neurobiology · doi:10.1016/b978-0-12-387718-5.00007-9 · Cited by 71 · see citing works
Markers of gluten sensitivity and celiac disease in bipolar disorder
Dickerson, F., Stallings, C. R., Origoni, A. E., Vaughan, C., Khushalani, S., Alaedini, A., & Yolken, R. H. (2011) · Bipolar Disorders · doi:10.1111/j.1399-5618.2011.00894.x · Cited by 71 · see citing works
Self-citationMortality and Its Determinants in People With Psychotic Disorder
Suvisaari, J., Partti, K., Perälä, J., Viertiö, S., Saarni, S. E., Lönnqvist, J. K., Saarni, S. I., & Härkänen, T. (2012) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31827ad512 · Cited by 63 · see citing works
Jackson, J. R., Eaton, W. W., Cascella, N. G., Fasano, A., Warfel, D. T., Feldman, S. M., Richardson, C., Vyas, G. R., Linthicum, J., Santora, D., et al. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.06.011 · Cited by 61 · see citing works
Miller, B. J., Mellor, A. L., & Buckley, P. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.08.016 · Cited by 59 · see citing works
Anti-Gluten Immune Response following Toxoplasma gondii Infection in Mice
Severance, E. G., Kannan, G., Gressitt, K. L., Xiao, J., Alaedini, A., Pletnikov, M. V., & Yolken, R. H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050991 · Cited by 56 · see citing works
Self-citationThe Possibility and probability of a Gut-to-Brain Connection in Autism
Reichelt, K. L., & Knivsberg, A. M. (2009) · Annals of Clinical Psychiatry · doi:10.1177/104012370902100403 · Cited by 56 · see citing works
Genetic and Environmental Influences on Pro-Inflammatory Monocytes in Bipolar Disorder
Padmos, R. C., van Baal, G. C. M., Vonk, R., Wijkhuijs, A. J. M., Kahn, R. S., Nolen, W. A., & Drexhage, H. A. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.116 · Cited by 55 · see citing works
Complement C1q formation of immune complexes with milk caseins and wheat glutens in schizophrenia
Severance, E. G., Gressitt, K. L., Halling, M., Stallings, C. R., Origoni, A. E., Vaughan, C., Khushalani, S., Alaedini, A., Dupont, D., Dickerson, F., et al. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.07.005 · Cited by 53 · see citing works
Self-citationRomero-Sánchez, M. C., González‐Serna, A., Pacheco, Y. M., Ferrando‐Martínez, S., Machmach, K., García-García, M., Álvarez‐Ríos, A. I., Vidal, F., Leal, M., & Ruíz-Mateos, E. (2012) · Journal of Infection · doi:10.1016/j.jinf.2012.06.008 · Cited by 49 · see citing works
Celiac syndrome in the case histories of five schizophrenics
Graff, H., & Handford, A. (1961) · Psychiatric Quarterly · doi:10.1007/bf01566581 · Cited by 48 · see citing works
Severance, E. G., Dickerson, F., Halling, M., Krivogorsky, B., Haile, L., Yang, S., Stallings, C. R., Origoni, A. E., Bossis, I., Xiao, J., et al. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2009.12.030 · Cited by 47 · see citing works
Self-citationBIOMARKERS OF NEUROLOGICAL AND PSYCHIATRIC DISEASE
Drexhage, R. C., Weigelt, K., van Beveren, N. J. M., Cohen, D., Versnel, M. A., Nolen, W. A., & Drexhage, H. A. (2011) · Cited by 47 · see citing works
Markers of gluten sensitivity in acute mania: A longitudinal study
Dickerson, F., Stallings, C. R., Origoni, A. E., Vaughan, C., Khushalani, S., & Yolken, R. H. (2012) · Psychiatry Research · doi:10.1016/j.psychres.2011.11.007 · Cited by 46 · see citing works
Self-citationDohan, F. C. (1980) · New England Journal of Medicine · doi:10.1056/nejm198005293022216 · Cited by 40 · see citing works
Association between bovine casein antibody and new onset schizophrenia among US military personnel
Niebuhr, D. W., Li, Y., Cowan, D. N., Weber, N. S., Fisher, J. A., Ford, G. M., & Yolken, R. H. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.02.005 · Cited by 37 · see citing works
Self-citationImmune activation by casein dietary antigens in bipolar disorder
Severance, E. G., Dupont, D., Dickerson, F., Stallings, C. R., Origoni, A. E., Krivogorsky, B., Yang, S., Haasnoot, W., & Yolken, R. H. (2010) · Bipolar Disorders · doi:10.1111/j.1399-5618.2010.00879.x · Cited by 34 · see citing works
Self-citationCeliac Disease and Schizophrenia
(1980) · New England Journal of Medicine · doi:10.1056/nejm198005293022214 · Cited by 14 · see citing works
García‐Manzanares, Á. (2011) · World Journal of Gastrointestinal Pathophysiology · doi:10.4291/wjgp.v2.i3.49 · Cited by 11 · see citing works
Lazz (1994) · Cited by 11 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- First MB Spitzer RL Gibbon M Williams JBW Structured Clinical Interview for DSM-IV Axis I Disorders - Non-patient Edition (SCID I/NP) 1998 Biometrics Research, New York State Psychiatric Institute New York
Cited by
Sorted by citations
The central nervous system and the gut microbiome
Sharon, G., Sampson, T. R., Geschwind, D. H., & Mazmanian, S. K. (2016) · Cell · doi:10.1016/j.cell.2016.10.027 · Cited by 1,513 · see citing works
From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways
Rogers, G. B., Keating, D. J., Young, R. L., Wong, M.-L., Licinio, J., & Wesselingh, S. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.50 · Cited by 969 · see citing works
The role of microbiome in central nervous system disorders
Wang, Y., & Kasper, L. H. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.12.015 · Cited by 803 · see citing works
Human Intestinal Barrier Function in Health and Disease
König, J., Wells, J. M., Cani, P. D., García‐Ródenas, C. L., MacDonald, T. T., Mercenier, A., Whyte, J., Troost, F. J., & Brummer, R. J. (2016) · Clinical and Translational Gastroenterology · doi:10.1038/ctg.2016.54 · Cited by 787 · see citing works
Liang, S., Wang, T., Hu, X., Luo, J., Li, W., Wu, X., Duan, Y., & Jin, F. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.09.033 · Cited by 651 · see citing works
The Gut Microbiome and the Brain
Galland, L. (2014) · Journal of Medicinal Food · doi:10.1089/jmf.2014.7000 · Cited by 648 · see citing works
Metagenome-wide association of gut microbiome features for schizophrenia
Zhu, F., Ju, Y., Wang, W., Wang, Q., Guo, R., Ma, Q., Sun, Q., Fan, Y., Xie, Y., Yang, Z., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15457-9 · Cited by 409 · see citing works
The dormant blood microbiome in chronic, inflammatory diseases
Potgieter, M., Bester, J., Kell, D. B., & Pretorius, E. (2015) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuv013 · Cited by 377 · see citing works
The HPA axis dysregulation in severe mental illness: Can we shift the blame to gut microbiota?
Misiak, B., Łoniewski, I., Marlicz, W., Frydecka, D., Szulc, A., Rudzki, L., & Samochowiec, J. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109951 · Cited by 343 · see citing works
The gut-brain axis: the missing link in depression
Evrensel, A., & Ceylan, M. E. (2015) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2015.13.3.239 · Cited by 338 · see citing works
Schwarz, E., Maukonen, J., Hyytiäinen, T., Kieseppä, T., Orešič, M., Sabunciyan, S., Mantere, O., Saarela, M., Yolken, R., & Suvisaari, J. (2018) · Schizophrenia Research · doi:10.1016/j.schres.2017.04.017 · Cited by 333 · see citing works
Self-citationAutism spectrum disorders and intestinal microbiota
De Angelis, M., Francavilla, R., Piccolo, M., De Giacomo, A., & Gobbetti, M. (2015) · Gut Microbes · doi:10.1080/19490976.2015.1035855 · Cited by 311 · see citing works
Shen, Y., Xu, J., Li, Z., Huang, Y., Yuan, Y., Wang, J., Zhang, M., Hu, S., & Liang, Y. (2018) · Schizophrenia Research · doi:10.1016/j.schres.2018.01.002 · Cited by 316 · see citing works
The gut microbiome composition associates with bipolar disorder and illness severity
Evans, S. J., Bassis, C. M., Hein, R., Assari, S., Flowers, S. A., Kelly, M., Young, V. B., Ellingrod, V. E., & McInnis, M. G. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.12.007 · Cited by 308 · see citing works
Yarandi, S., Peterson, D. A., Treisman, G. J., Moran, T. H., & Pasricha, P. J. (2016) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm15146 · Cited by 294 · see citing works
The microbiome, immunity, and schizophrenia and bipolar disorder.
Dickerson, F., Severance, E., & Yolken, R. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.12.010 · Cited by 268 · see citing works
Self-citationCross talk: the microbiota and neurodevelopmental disorders
Kelly, J. R., Minuto, C., Cryan, J. F., Clarke, G., & Dinan, T. G. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00490 · Cited by 271 · see citing works
Kim, Y., & Shin, C. (2018) · Current Neuropharmacology · doi:10.2174/1570159x15666170915141036 · Cited by 273 · see citing works
Castro‐Nallar, E., Bendall, M. L., Pérez‐Losada, M., Sabunciyan, S., Severance, E. G., Dickerson, F., Schroeder, J. R., Yolken, R. H., & Crandall, K. A. (2015) · PeerJ · doi:10.7717/peerj.1140 · Cited by 269 · see citing works
Self-citationNguyen, T. T., Kosciolek, T., Maldonado, Y., Daly, R. E., Martin, A. S., McDonald, D., Knight, R., & Jeste, D. V. (2019) · Schizophrenia Research · doi:10.1016/j.schres.2018.09.014 · Cited by 260 · see citing works
Severance, E. G., Yolken, R. H., & Eaton, W. W. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.06.027 · Cited by 256 · see citing works
Self-citationMitrea, L., Nemeș, S. A., Szabo, K., Teleky, B., & Vodnar, D. C. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.813204 · Cited by 242 · see citing works
The “psychomicrobiotic”: targeting microbiota in major psychiatric disorders: a systematic review
Fond, G., Boukouaci, W., Chevalier, G., Regnault, A., Eberl, G., Hamdani, N., Dickerson, F., Macgregor, A., Boyer, L., Dargel, A., et al. (2015) · Pathologie Biologie · doi:10.1016/j.patbio.2014.10.003 · Cited by 219 · see citing works
Self-citationGut Microbiota: The Conductor in the Orchestra of Immune–Neuroendocrine Communication
El Aidy, S., Dinan, T. G., & Cryan, J. F. (2015) · Clinical Therapeutics · doi:10.1016/j.clinthera.2015.03.002 · Cited by 215 · see citing works
Overview and systematic review of studies of microbiome in schizophrenia and bipolar disorder
Nguyen, T. T., Kościółek, T., Eyler, L. T., Knight, R. D., & Jeste, D. V. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.01.013 · Cited by 210 · see citing works
Altered gut microbiota and mucosal immunity in patients with schizophrenia
Xu, R., Wu, B., Liang, J., He, F., Gu, W., Li, K., Luo, Y., Chen, J., Gao, Y., Wu, Z., et al. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.06.039 · Cited by 198 · see citing works
Gastroenterology Issues in Schizophrenia: Why the Gut Matters
Severance, E. G., Prandovszky, E., Castiglione, J., & Yolken, R. H. (2015) · Current Psychiatry Reports · doi:10.1007/s11920-015-0574-0 · Cited by 196 · see citing works
Self-citationImmune System Abnormalities in Schizophrenia: An Integrative View and Translational Perspectives
Ermakov, E. A., Melamud, M. M., Buneva, V. N., & Ivanova, S. А. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.880568 · Cited by 184 · see citing works
Gómez-Eguílaz, M., Ramón-Trapero, J. L., Pérez-Martínez, L., & Blanco, J. R. (2018) · Beneficial Microbes · doi:10.3920/bm2018.0018 · Cited by 177 · see citing works
The Role of Gut Dysbiosis in the Pathophysiology of Neuropsychiatric Disorders
Anand, N., Gorantla, V. R., & Chidambaram, S. B. (2022) · Cells · doi:10.3390/cells12010054 · Cited by 185 · see citing works
Severance, E. G., Gressitt, K. L., Stallings, C. R., Katsafanas, E., Schweinfurth, L. A. B., Savage, C. L. G., Adamos, M. B., Sweeney, K., Origoni, A. E., Khushalani, S., et al. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.11.019 · Cited by 178 · see citing works
Self-citationThe Gut Microbiome and Schizophrenia: The Current State of the Field and Clinical Applications
Szeligowski, T., Yun, A. L., Lennox, B., & Burnet, P. W. J. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00156 · Cited by 157 · see citing works
Innate immune receptor Toll-like receptor 4 signalling in neuropsychiatric diseases
García‐Bueno, B., Caso, J. R., Madrigal, J. L. M., & Leza, J. C. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.02.013 · Cited by 149 · see citing works
Revisiting inflammation in bipolar disorder
Fries, G. R., Walss-Bass, C., Bauer, M. E., & Teixeira, A. L. (2019) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2018.12.006 · Cited by 147 · see citing works
Leaky brain in neurological and psychiatric disorders: Drivers and consequences
Morris, G., Fernandes, B. S., Puri, B. K., Walker, A. J., Carvalho, A. F., & Berk, M. (2018) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867418796955 · Cited by 144 · see citing works
Role of the gut microbiome in three major psychiatric disorders
Borkent, J., Ioannou, M., Laman, J. D., Haarman, B. C. M., & Sommer, I. E. (2022) · Psychological Medicine · doi:10.1017/s0033291722000897 · Cited by 132 · see citing works
Schizophrenia and the gut–brain axis
Nemani, K., Hosseini Ghomi, R., McCormick, B., & Fan, X. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.08.018 · Cited by 151 · see citing works
Th17 Pathway-Mediated Immunopathogenesis of Schizophrenia: Mechanisms and Implications
Debnath, M., & Berk, M. (2014) · Schizophrenia Bulletin · doi:10.1093/schbul/sbu049 · Cited by 129 · see citing works
Ortega, M. A., Álvarez-Mon, M. Á., Montero, C. G., Fraile‐Μartinez, O., Monserrat, J., Martinez-Rozas, L., Rodríguez–Jiménez, R., Álvarez‐Mon, M., & Lahera, G. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-01964-w · Cited by 129 · see citing works
Inflammation‐driven brain and gut barrier dysfunction in stress and mood disorders
Doney, E., Cadoret, A., Dion‐Albert, L., Lebel, M., & Ménard, C. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15239 · Cited by 130 · see citing works
Severance, E. G., Gressitt, K. L., Stallings, C. R., Katsafanas, E., Schweinfurth, L. A. B., Savage, C. L. G., Adamos, M. B., Sweeney, K., Origoni, A. E., Khushalani, S., et al. (2016) · Schizophrenia · doi:10.1038/npjschz.2016.18 · Cited by 127 · see citing works
Self-citationGut microbes in neurocognitive and mental health disorders
Halverson, T., & Alagiakrishnan, K. (2020) · Annals of Medicine · doi:10.1080/07853890.2020.1808239 · Cited by 125 · see citing works
Safadi, J. M., Quinton, A. M. G., Lennox, B., Burnet, P. W. J., & Minichino, A. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01032-1 · Cited by 127 · see citing works
Mongan, D., Ramesar, M., Föcking, M., Cannon, M., & Cotter, D. (2020) · Early Intervention in Psychiatry · doi:10.1111/eip.12859 · Cited by 123 · see citing works
Cattane, N., Richetto, J., & Cattaneo, A. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.07.001 · Cited by 118 · see citing works
Ly, V., Bottelier, M. A., Hoekstra, P. J., Vásquez, A. A., Buitelaar, J. K., & Rommelse, N. N. J. (2017) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-017-0959-1 · Cited by 114 · see citing works
The role of the gut microbiome in the development of schizophrenia
Kelly, J. R., Minuto, C., Cryan, J. F., Clarke, G. A., & Dinan, T. G. (2020) · Schizophrenia Research · doi:10.1016/j.schres.2020.02.010 · Cited by 119 · see citing works
Proteomics analysis of the gut–brain axis in a gut microbiota-dysbiosis model of depression
Liu, Y., Wang, H., Gui, S., Zeng, B., Pu, J., Zheng, P., Zeng, L., Luo, Y., Wu, Y., Zhou, C., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01689-w · Cited by 104 · see citing works
Munawar, N., Ahsan, K., Muhammad, K., Ahmad, A., Anwar, M. A., Shah, I., Ameri, A. A., & Mughairbi, F. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147671 · Cited by 105 · see citing works
Monocyte and microglial activation in patients with mood-stabilized bipolar disorder
Jakobsson, J., Bjerke, M., Sahebi, S., Isgren, A., Ekman, C. J., Sellgren, C. M., Olsson, B., Zetterberg, H., Blennow, K., Pålsson, E., et al. (2015) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.140183 · Cited by 99 · see citing works
Joseph, J., Depp, C. A., Shih, P.-A. B., Cadenhead, K. S., & Schmid‐Schönbein, G. W. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00155 · Cited by 95 · see citing works
The connection between microbiome and schizophrenia
Golofast, B., & Vales, K. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.12.011 · Cited by 92 · see citing works
C-Reactive Protein as a Peripheral Biomarker in Schizophrenia. An Updated Systematic Review
Fond, G. B., Lançon, C., Auquier, P., & Boyer, L. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00392 · Cited by 95 · see citing works
Gut microbiota, kynurenine pathway and mental disorders – Review
Więdłocha, M., Marcinowicz, P., Janoska-Jaździk, M., & Szulc, A. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110145 · Cited by 87 · see citing works
García‐Bueno, B., Gassó, P., MacDowell, K. S., Callado, L. F., Mas, S., Bernardo, M., Lafuente, A., Meana, J. J., & Leza, J. C. (2016) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.150195 · Cited by 87 · see citing works
Nguyen, T. T., Kościółek, T., Daly, R. E., Vázquez‐Baeza, Y., Swafford, A. D.-E., Knight, R. D., & Jeste, D. V. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.10.003 · Cited by 87 · see citing works
Morris, G., Puri, B. K., Bortolasci, C. C., Carvalho, A., Berk, M., Walder, K., Moreira, E. G., & Maes, M. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.02.037 · Cited by 84 · see citing works
Fetal programming of schizophrenia: Select mechanisms
Debnath, M., Venkatasubramanian, G., & Berk, M. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.12.003 · Cited by 84 · see citing works
Rudzki, L., & Szulc, A. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00205 · Cited by 79 · see citing works
The microbiome-gut-brain axis: implications for schizophrenia and antipsychotic induced weight gain
Kanji, S., Fonseka, T. M., Marshe, V. S., Sriretnakumar, V., Hahn, M. K., & Müller, D. J. (2018) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-017-0820-z · Cited by 79 · see citing works
Ribera, C., Sánchez‐Ortí, J. V., Clarke, G. A., Marx, W., Mörkl, S., & Balanzá‐Martínez, V. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105561 · Cited by 85 · see citing works
Xiu, M. H., Yang, G. G., Tan, Y., Chen, D. C., Tan, S., Wang, Z. R., Yang, F. D., Okusaga, O. O., Soares, J. C., & Zhang, X. Y. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.03.024 · Cited by 79 · see citing works
Severance, E. G., Gressitt, K. L., Yang, S., Stallings, C. R., Origoni, A. E., Vaughan, C., Khushalani, S., Alaedini, A., Dickerson, F., & Yolken, R. H. (2013) · Bipolar Disorders · doi:10.1111/bdi.12159 · Cited by 79 · see citing works
Self-citationInfection and inflammation in schizophrenia and bipolar disorder
Tanaka, T., Matsuda, T., Hayes, L. N., Yang, S., Rodriguez, K. M., Severance, E. G., Yolken, R. H., Sawa, A., & Eaton, W. W. (2016) · Neuroscience Research · doi:10.1016/j.neures.2016.11.002 · Cited by 78 · see citing works
Self-citationGut microbiome in serious mental illnesses: A systematic review and critical evaluation
Nguyen, T. T., Hathaway, H., Kościółek, T., Knight, R. D., & Jeste, D. V. (2019) · Schizophrenia Research · doi:10.1016/j.schres.2019.08.026 · Cited by 78 · see citing works
The gut microbiota in neuropsychiatric disorders
Grochowska, M., Wojnar, M., & Radkowski, M. (2018) · Acta Neurobiologiae Experimentalis · doi:10.21307/ane-2018-008 · Cited by 73 · see citing works
“WHAT'S BUGGING THE GUT IN OCD?” A REVIEW OF THE GUT MICROBIOME IN OBSESSIVE-COMPULSIVE DISORDER
Turna, J., Kaplan, K. G., Anglin, R., & Ameringen, M. V. (2015) · Depression and Anxiety · doi:10.1002/da.22454 · Cited by 74 · see citing works
The gut microbiota promotes the pathogenesis of schizophrenia via multiple pathways
Yuan, X., Kang, Y., Zhuo, C., Huang, X., & Song, X. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.02.152 · Cited by 73 · see citing works
Investigating Gut Permeability in Animal Models of Disease
González-González, M., Díaz-Zepeda, C., Eyzaguirre‐Velásquez, J., González‐Arancibia, C., Bravo, J. A., & Julio‐Pieper, M. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2018.01962 · Cited by 71 · see citing works
Evaluating the Hypothesis That Schizophrenia Is an Inflammatory Disorder
Miller, B. J., & Goldsmith, D. R. (2020) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.20200015 · Cited by 71 · see citing works
First-Episode Psychosis: An Inflammatory State?
Zajkowska, Z., & Mondelli, V. (2014) · NeuroImmunoModulation · doi:10.1159/000356536 · Cited by 67 · see citing works
Detection of Microbial 16S rRNA Gene in the Blood of Patients With Parkinson’s Disease
Qian, Y., Yang, X., Xu, S., Wu, C., Qin, N., Chen, S., & Xiao, Q. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00156 · Cited by 68 · see citing works
Ames, N. J., Barb, J. J., Schuebel, K. E., Mudra, S. E., Meeks, B., Tuason, R. T. S., Brooks, A. T., Kazmi, N., Yang, S. B., Ratteree, K., et al. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1758010 · Cited by 67 · see citing works
Gut microbial changes of patients with psychotic and affective disorders: A systematic review
Vindegaard, N., Speyer, H., Nordentoft, M., Rasmussen, S., & Benros, M. E. (2021) · Schizophrenia Research · doi:10.1016/j.schres.2019.12.014 · Cited by 66 · see citing works
Gondalia, S. V., Parkinson, L., Stough, C. K. K., & Scholey, A. B. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05248-6 · Cited by 66 · see citing works
Alzheimer's disease and symbiotic microbiota: an evolutionary medicine perspective
Fox, M. M., Knorr, D. A., & Haptonstall, K. P. (2019) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14129 · Cited by 65 · see citing works
Microbiota-Orientated Treatments for Major Depression and Schizophrenia
Fond, G. B., Lagier, J., Honoré, S., Lançon, C., Korchia, T., de Verville, P. L. S., Llorca, P., Auquier, P., Guedj, É., & Boyer, L. (2020) · Nutrients · doi:10.3390/nu12041024 · Cited by 63 · see citing works
Jiang, N. M., Tofail, F., Ma, J. Z., Haque, R., Kirkpatrick, B. D., Nelson, C. A., & Petri, W. A. (2017) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.17-0083 · Cited by 61 · see citing works
The microbiome and disorders of the central nervous system
Felice, V. D., & O'Mahony, S. M. (2017) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.06.016 · Cited by 60 · see citing works
Severance, E. G., Gressitt, K. L., Alaedini, A., Rohleder, C., Enning, F., Bumb, J. M., Müller, J. K., Schwarz, E., Yolken, R. H., & Leweke, F. M. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.09.009 · Cited by 59 · see citing works
Self-citationPrestwood, T. R., Asgariroozbehani, R., Wu, S., Agarwal, S. M., Logan, R. W., Ballon, J. S., Hahn, M., & Freyberg, Z. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.113101 · Cited by 58 · see citing works
Bridging the Gap between Genes and Language Deficits in Schizophrenia: An Oscillopathic Approach
Murphy, E., & Benítez‐Burraco, A. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00422 · Cited by 52 · see citing works
Autoimmune phenotypes in schizophrenia reveal novel treatment targets
Severance, E. G., Dickerson, F., & Yolken, R. H. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.05.005 · Cited by 52 · see citing works
Self-citationThe gut microbiome in psychiatry: A primer for clinicians
Ameringen, M. V., Turna, J., Patterson, B. A., Pipe, A., Mao, R. Q., Anglin, R., & Surette, M. G. (2019) · Depression and Anxiety · doi:10.1002/da.22936 · Cited by 51 · see citing works
Inflammatory biomarkers in psychosis and clinical high risk populations
Delaney, S., Fallon, B. A., Alaedini, A., Yolken, R. H., Indart, A. C., Feng, T., Wang, Y., & Javitt, D. C. (2018) · Schizophrenia Research · doi:10.1016/j.schres.2018.10.017 · Cited by 50 · see citing works
Self-citationThe Gut Microbiome in Bipolar Disorder and Pharmacotherapy Management
Flowers, S. A., Ward, K. M., & Clark, C. T. (2019) · Neuropsychobiology · doi:10.1159/000504496 · Cited by 50 · see citing works
Inflammatory Pathways in Psychiatric Disorders: the Case of Schizophrenia and Depression
Feng, T., Tripathi, A., & Pillai, A. (2020) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-020-00207-4 · Cited by 50 · see citing works
Toxoplasma gondii—A Gastrointestinal Pathogen Associated with Human Brain Diseases
Severance, E. G., Xiao, J., Jones‐Brando, L. V., Sabunciyan, S., Li, Y., Pletnikov, M. V., Prandovszky, E., & Yolken, R. H. (2016) · International review of neurobiology · doi:10.1016/bs.irn.2016.08.008 · Cited by 48 · see citing works
Self-citationDysregulation of the gut–brain axis in schizophrenia and bipolar disorder
Genedi, M., Janmaat, I. E., Haarman, B. C. M., & Sommer, I. E. (2019) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000499 · Cited by 48 · see citing works
Petruso, F., Giff, A., Milano, B. A., Rossi, M. M. D., & Saccaro, L. F. (2023) · Neuronal Signaling · doi:10.1042/ns20220077 · Cited by 51 · see citing works
Anderson, G., & Maes, M. H. J. (2015) · Advances in Integrative Medicine · doi:10.1016/j.aimed.2014.12.007 · Cited by 46 · see citing works
MacDowell, K. S., Caso, J. R., Martín‐Hernández, D., Madrigal, J. L. M., Leza, J. C., & García‐Bueno, B. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu070 · Cited by 45 · see citing works
Pan, J.-X., Deng, F.-L., Zeng, B., Zheng, P., Liang, W., Yin, B., Wu, J., Dong, M.-X., Luo, Y., Wang, H., et al. (2019) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2019.03.027 · Cited by 44 · see citing works
Ling, Z., Jin, G., Yan, X., Cheng, Y., Shao, L., Song, Q., Liu, X., & Zhao, N. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.886872 · Cited by 45 · see citing works
Gut microbiome in schizophrenia and antipsychotic-induced metabolic alterations: a scoping review
Singh, R., Stogios, N., Smith, E., Lee, J., Maksyutynska, K., Au, E., Wright, D. C., Palma, G. D., Graff‐Guerrero, A., Gerretsen, P., et al. (2022) · Therapeutic Advances in Psychopharmacology · doi:10.1177/20451253221096525 · Cited by 43 · see citing works
Gut Microbiome: A Brief Review on Its Role in Schizophrenia and First Episode of Psychosis
Tsamakis, K., Galinaki, S., Alevyzakis, E., Hortis, I., Tsiptsios, D., Kollintza, E., Kympouropoulos, S. P., Τriantafyllou, Κ., Smyrnis, N., & Rizos, E. N. (2022) · Microorganisms · doi:10.3390/microorganisms10061121 · Cited by 45 · see citing works
Dickerson, F., Adamos, M., Katsafanas, E., Khushalani, S., Origoni, A., Savage, C., Schweinfurth, L., Stallings, C., Sweeney, K., Alaedini, A., et al. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.05.005 · Cited by 41 · see citing works
Self-citationGut microbiota, metabolism and psychopathology: A critical review and novel perspectives
Groen, R. N., de Clercq, N. C., Nieuwdorp, M., Hoenders, R. H. J., & Groen, A. K. (2018) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2018.1463507 · Cited by 41 · see citing works
Inflammation in Mental Disorders: Is the Microbiota the Missing Link?
Marin, S., Hé, Y., Butler, K., & Tsuang, M. T. (2020) · Neuroscience Bulletin · doi:10.1007/s12264-020-00535-1 · Cited by 41 · see citing works
From Infection to the Microbiome: An Evolving Role of Microbes in Schizophrenia
Severance, E. G., & Yolken, R. H. (2019) · Current topics in behavioral neurosciences · doi:10.1007/7854_2018_84 · Cited by 40 · see citing works
Self-citation
- Authors
- Severance, E. G., Gressitt, K. L., Stallings, C. R., Origoni, A. E., Khushalani, S., Leweke, F. M., Dickerson, F. B., & Yolken, R. H.
- Affiliations
- Johns Hopkins University (US)
- Sheppard and Enoch Pratt Hospital (US)
- University of Cologne (DE)
- Corresponding author
- Severance, Emily G.
- ORCID
- Venue
- Schizophrenia Research
- Publisher
- Elsevier BV
- Published
- 2013-08
- Volume
- 148
- Issue
- 1-3
- Pages
- 130-137
- ISSN
- 0920-9964 (ISSN-L)
- PMC
- PMC3732507
- OpenAlex
- W2106172174
- Cited by
- 243
- References
- 74
- Citations by year
- 2026: 7 · 2025: 16 · 2024: 18 · 2023: 22 · 2022: 13 · 2021: 23 · 2020: 23 · 2019: 23 · 2018: 22 · 2017: 17 · 2016: 24 · 2015: 19 · 2014: 13 · 2013: 3
- FWCI
- 6.65
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Schizophrenia Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (MH‑94268, P50MH094268)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K08HD073315)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- bacterial translocation, soluble CD14
- MeSH terms
- Lipopolysaccharide-Binding Protein, Acute-Phase Proteins, Adult, Analysis of Variance, Autoantibodies, Bipolar Disorder, C-Reactive Protein, Carrier Proteins, Female, Humans, Male, Membrane Glycoproteins, Regression Analysis, Schizophrenia, Cohort Studies, Body Mass Index, Lipopolysaccharide Receptors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
