Cited by 60Birth, Development, and HealthPregnancy and preeclampsia studiesPrenatal Substance Exposure Effects

Fetal Growth Restriction and Postnatal Development

ELEFTHERIADES, MAKARIOS, CREATSAS, GEORGE, NICOLAIDES, KYPROS·2006·Annals of the New York Academy of Sciences

Abstract

Abstract: The interaction between genetic constitution and in utero environment determines fetal growth and development and influences the susceptibility to certain disorders in adulthood. Data from both animal and human studies indicate that prenatal and early postnatal malnutrition can program the hypothalamus‐pituitary‐adrenal axis (HPA axis), altering neuroendocrine response to stressors throughout lifetime. Impaired uteroplacental perfusion results in fetal growth restriction (FGR). In FGR there is evidence of chronic hypoxemia and alterations in metabolic, endocrine, and hematological parameters, compatible with starvation. Furthermore, FGR is associated with increased perinatal mortality and in the survivors there is increased susceptibility to diabetes and cardiovascular disease in adulthood. There is evidence that early postnatal growth acceleration, which would normally be considered desirable, may exacerbate metabolic dysfunction in later life.

Integrity signals

Registry

Crossref · 10.1196/annals.1365.047

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66 of 66 references verified0 citation errors · 0 not checkable

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  • Preterm birth and FGR are clinically observable sentinel phenotypes that may reflect several adverse maternal-placental-fetal pathways and are themselves associated with long-term cardiometabolic risk.

    “Preterm birth and FGR are clinically observable sentinel phenotypes that may reflect several adverse maternal–placental–fetal pathways and are themselves associated with long-term cardiometabolic risk [97,98,99,100,101].”

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Authors
ELEFTHERIADES, M., CREATSAS, G., & NICOLAIDES, K.
Affiliations
  • University of London (GB)
  • National and Kapodistrian University of Athens (GR)
Corresponding author
ELEFTHERIADES, MAKARIOS
Venue
Annals of the New York Academy of Sciences
Publisher
Wiley
Published
2006-12
Volume
1092
Issue
1
Pages
319-330
ISSN
  • 0077-8923 (ISSN-L)
  • 1749-6632
OpenAlex
W2092250698
Cited by
60
References
66
Citations by year
2026: 1 · 2025: 1 · 2023: 3 · 2022: 8 · 2021: 2 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 4 · 2015: 5 · 2014: 4 · 2012: 2
FWCI
0.50
Type
journal article
Language
en
Open access
closed
Locations
  • Annals of the New York Academy of Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
Keywords
fetal growth restriction, postnatal development, fetal programming, hypothalamic-pituitary-adrenal axis, neuroendocrine stress response, uteroplacental blood flow, fetal hypoxemia, perinatal mortality, diabetes susceptibility, cardiovascular disease susceptibility, metabolic dysfunction
MeSH terms
Animals, Female, Fetal Growth Retardation, Humans, Hypothalamo-Hypophyseal System, Pituitary-Adrenal System, Pregnancy, Models, Animal

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