Cited by 144Multiple Sclerosis Research StudiesImmunotherapy and Immune ResponsesT-cell and B-cell Immunology

The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.

Antigen Presentation in the CNS by Myeloid Dendritic Cells Drives Progression of Relapsing Experimental Autoimmune Encephalomyelitis

MILLER, STEPHEN D., McMAHON, EILEEN J., SCHREINER, BETTINA, BAILEY, SAMANTHA L.·2007·Annals of the New York Academy of Sciences

DOI 10.1196/annals.1394.023

Open this paper in CoChat — free account

Abstract

Abstract: Chronic progression of relapsing experimental autoimmune encephalomyelitis (R‐EAE), a mouse model of multiple sclerosis (MS), is dependent on the activation of T cells to endogenous myelin epitopes, that is, epitope spreading. This review focuses on the cellular and molecular mechanisms underlying the process of epitope spreading. Surprisingly, activation of naïve T cells to endogenous myelin epitopes in SJL mice undergoing R‐EAE occurs directly in the central nervous system (CNS), a site generally perceived to be immunologically privileged. Determination of the antigen presentation capacity of antigen‐presenting cell (APC) populations purified from the CNS of mice with established R‐EAE shows that peripherally derived CD11b+CD11c+CD45 hi myeloid dendritic cells (mDCs) most efficiently present endogenous myelin antigens to activate both preactivated effector myelin‐specific T cells and naïve T cells. The mDCs, which drive epitope spreading, preferentially polarize pathogenic Th17 responses correlating with their enhanced expression of TGF‐β1, IL‐6, and IL‐23. Both B220+CD11c+ plasmacytoid (pDCs) and CD8α+CD11c+ (CD8 DCs) were superior to CD11b+CD11c–CD45 hi macrophages, but less efficient than mDCs at presenting endogenous peptide to induce Th17 cells. In contrast, CNS‐resident CD11b+CD11c–CD45 low microglia purified from the inflamed CNS were found to be largely incapable of activating either naïve or effector T cells.

Integrity signals

Registry

Crossref · 10.1196/annals.1394.023

Cites

59 of 59 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
Park, H., Li, Z., Yang, X. O., Chang, S. H., Nurieva, R., Wang, Y.-H., Wang, Y., Hood, L., Zhu, Z., Tian, Q., et al. (2005) · Nature Immunology · doi:10.1038/ni1261 · Cited by 4,265
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
Langrish, C. L., Chen, Y., Blumenschein, W. M., Mattson, J., Basham, B., Sedgwick, J. D., McClanahan, T., Kastelein, R. A., & Cua, D. J. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041257 · Cited by 4,099
TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells
Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M., & Stockinger, B. (2006) · Immunity · doi:10.1016/j.immuni.2006.01.001 · Cited by 3,605
Transforming growth factor-β induces development of the TH17 lineage
Mangan, P. R., Harrington, L. E., O'Quinn, D. B., Helms, W. S., Bullard, D. C., Elson, C. O., Hatton, R. D., Wahl, S. M., Schoeb, T. R., & Weaver, C. T. (2006) · Nature · doi:10.1038/nature04754 · Cited by 3,087
IL-23 is essential for T cell–mediated colitis and promotes inflammation via IL-17 and IL-6
Yen, D., Cheung, J., Scheerens, H., Poulet, F. M., McClanahan, T. K., McKenzie, B. S., Kleinschek, M. A., Owyang, A. M., Mattson, J. D., Blumenschein, W. M., et al. (2006) · Journal of Clinical Investigation · doi:10.1172/jci21404 · Cited by 1,567
Suppression of Immune Induction of Collagen-Induced Arthritis in IL-17-Deficient Mice
Nakae, S., Nambu, A., Sudo, K., & Iwakura, Y. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.11.6173 · Cited by 1,272
Plasmacytoid predendritic cells initiate psoriasis through interferon-α production
Nestle, F. O., Conrad, C., Tun-Kyi, A., Homey, B., Gombert, M., Boyman, O., Burg, G., Liu, Y.-J., & Gilliet, M. F. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050500 · Cited by 1,126
Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes
Kaufman, D. L., Clare-Salzler, M. J., Tian, J., Forsthuber, T. G., Ting, G. S. P., Robinson, P. J., Atkinson, M. A., Sercarz, E. E., Tobin, A. J., & Lehmann, P. (1993) · Nature · doi:10.1038/366069a0 · Cited by 1,057
Antigen-Specific T Cell Sensitization Is Impaired in IL-17-Deficient Mice, Causing Suppression of Allergic Cellular and Humoral Responses
Nakae, S., Komiyama, Y., Nambu, A., Sudo, K., Iwase, M., Homma, I., Sekikawa, K., Asano, M., & Iwakura, Y. (2002) · Immunity · doi:10.1016/s1074-7613(02)00391-6 · Cited by 1,053

Show all 59 references

Sorted by citations

From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395
Immunotherapy of Diffuse Gliomas: Biological Background, Current Status and Future Developments
Grauer, O. M., Wesseling, P., & Adema, G. J. (2009) · Brain Pathology · doi:10.1111/j.1750-3639.2009.00315.x · Cited by 4,023
Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS)
Constantinescu, C. S., Farooqi, N., O'Brien, K., & Gran, B. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01302.x · Cited by 1,523
The Mystery and Magic of Glia: A Perspective on Their Roles in Health and Disease
Barres, B. A. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.013 · Cited by 1,352
Innate immunity in the central nervous system
Ransohoff, R. M., & Brown, M. A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci58644 · Cited by 1,034
The anatomical and cellular basis of immune surveillance in the central nervous system
Ransohoff, R. M., & Engelhardt, B. (2012) · Nature reviews. Immunology · doi:10.1038/nri3265 · Cited by 1,029
The Blood-Brain Barrier in Brain Homeostasis and Neurological Diseases
Weiss, N., Miller, F., Cazaubon, S., & Couraud, P.-O. (2009) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2008.10.022 · Cited by 731
Infiltration of Th1 and Th17 cells and activation of microglia in the CNS during the course of experimental autoimmune encephalomyelitis
Murphy, Á. C., Lalor, S. J., Lynch, M. A., & Mills, K. H. G. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.01.014 · Cited by 482
Circulating Ly-6C+ myeloid precursors migrate to the CNS and play a pathogenic role during autoimmune demyelinating disease
King, I. L., Dickendesher, T. L., & Segal, B. M. (2009) · Blood · doi:10.1182/blood-2008-07-168575 · Cited by 444
NLRP3 Plays a Critical Role in the Development of Experimental Autoimmune Encephalomyelitis by Mediating Th1 and Th17 Responses
Gris, D., Ye, Z., Iocca, H. A., Wen, H., Craven, R. R., Gris, P., Huang, M., Schneider, M., Miller, S. D., & Ting, J. P.-Y. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0904145 · Cited by 429
Self-citation
Distinct and Nonredundant In Vivo Functions of IFNAR on Myeloid Cells Limit Autoimmunity in the Central Nervous System
Prinz, M., Schmidt, H., Mildner, A., Knobeloch, K., Hanisch, U., Raasch, J., Merkler, D., Detje, C. N., Gutcher, I., Mages, J., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.03.011 · Cited by 387
Role of the innate immune system in the pathogenesis of multiple sclerosis
Gandhi, R., Laroni, A., & Weiner, H. L. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.10.015 · Cited by 330
The role of regulatory T cells in multiple sclerosis
Zozulya, A. L., & Wiendl, H. (2008) · Nature Clinical Practice Neurology · doi:10.1038/ncpneuro0832 · Cited by 242
Balancing between immunity and tolerance: an interplay between dendritic cells, regulatory T cells, and effector T cells
Cools, N., Ponsaerts, P., Tendeloo, V. F. V., & Berneman, Z. N. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0307166 · Cited by 238
Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function
Spiteri, A. G., Wishart, C. L., Pamphlett, R., Locatelli, G., & King, N. J. C. (2022) · Acta Neuropathologica · doi:10.1007/s00401-021-02384-2 · Cited by 216
“Furthermore, myeloidderived DC are critical for the activation and differentiation of TH17 cells [189, 231].”
Background
Mechanisms of Blood Brain Barrier Disruption by Different Types of Bacteria, and Bacterial–Host Interactions Facilitate the Bacterial Pathogen Invading the Brain
Al‐Obaidi, M. M. J., & Desa, M. N. M. (2018) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-018-0609-2 · Cited by 195
Immune cell compartmentalization for brain surveillance and protection
Croese, T., Castellani, G., & Schwartz, M. (2021) · Nature Immunology · doi:10.1038/s41590-021-00994-2 · Cited by 197
The innate immune system in demyelinating disease
Mayo, L., Quintana, F. J., & Weiner, H. L. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01135.x · Cited by 192
Increased Osteopontin Expression in Dendritic Cells Amplifies IL-17 Production by CD4+ T Cells in Experimental Autoimmune Encephalomyelitis and in Multiple Sclerosis
Murugaiyan, G., Mittal, A., & Weiner, H. L. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.11.7480 · Cited by 186
Myeloid cells — targets of medication in multiple sclerosis
Mishra, M. K., & Yong, V. W. (2016) · Nature Reviews Neurology · doi:10.1038/nrneurol.2016.110 · Cited by 190
Lymphatics in Neurological Disorders: A Neuro-Lympho-Vascular Component of Multiple Sclerosis and Alzheimer’s Disease?
Louveau, A., Mesquita, S. D., & Kipnis, J. (2016) · Neuron · doi:10.1016/j.neuron.2016.08.027 · Cited by 177
Mechanisms regulating regional localization of inflammation during CNS autoimmunity
Pierson, E. R., Simmons, S. B., Castelli, L., & Goverman, J. M. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01126.x · Cited by 188
Brain dendritic cells: biology and pathology
D’Agostino, P. M., Gottfried‐Blackmore, A., Anandasabapathy, N., & Bulloch, K. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-1018-0 · Cited by 176
Pericytes regulate vascular immune homeostasis in the CNS
Török, O., Schreiner, B., Schaffenrath, J., Tsai, H.-C., Maheshwari, U., Stifter, S. A., Welsh, C., Amorim, A., Sridhar, S., Utz, S. G., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2016587118 · Cited by 166
Self-citation
When encephalitogenic T cells collaborate with microglia in multiple sclerosis
Dong, Y., & Yong, V. W. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-019-0253-6 · Cited by 169
Immunotherapeutic Approaches for Glioma
Okada, H., Kohanbash, G., Zhu, X., Kastenhuber, E. R., Hoji, A., Ueda, R., & Fujita, M. (2009) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.v29.i1.10 · Cited by 157
Signaling via the RIP2 Adaptor Protein in Central Nervous System-Infiltrating Dendritic Cells Promotes Inflammation and Autoimmunity
Shaw, P. J., Barr, M., Lukens, J. R., McGargill, M. A., Chi, H., Mak, T. W., & Kanneganti, T. (2011) · Immunity · doi:10.1016/j.immuni.2010.12.015 · Cited by 144
Myeloid Cells in Glioblastoma Microenvironment
Leo, A. D., Ugolini, A., & Veglia, F. (2020) · Cells · doi:10.3390/cells10010018 · Cited by 150
Swift Entry of Myelin-Specific T Lymphocytes into the Central Nervous System in Spontaneous Autoimmune Encephalomyelitis
Furtado, G. C., Marcondes, M. C. G., Latkowski, J.-A. M., Tsai, J., Wensky, A. K., & Lafaille, J. J. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.7.4648 · Cited by 140
Neutrophils Amplify Autoimmune Central Nervous System Infiltrates by Maturing Local APCs
Steinbach, K., Piédavent, M., Bauer, S., Neumann, F., & Friese, M. A. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202613 · Cited by 137
A Close Encounter of the Third Kind
Mildner, A., Yona, S., & Jung, S. (2013) · Advances in immunology · doi:10.1016/b978-0-12-417028-5.00003-x · Cited by 136
Dendritic cell CNS recruitment correlates with disease severity in EAE via CCL2 chemotaxis at the blood–brain barrier through paracellular transmigration and ERK activation
Sagar, D., Lamontagne, A., Foss, C. A., Khan, Z. K., Pomper, M. G., & Jain, P. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-245 · Cited by 106
Central histamine H 3 receptor signaling negatively regulates susceptibility to autoimmune inflammatory disease of the CNS
Teuscher, C., Subramanian, M., Noubade, R., Gao, J. F., Offner, H., Zachary, J. F., & Blankenhorn, E. P. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702291104 · Cited by 104
CNS-resident classical DCs play a critical role in CNS autoimmune disease
Giles, D. A., Duncker, P. C., Wilkinson, N. M., Washnock-Schmid, J. M., & Segal, B. M. (2018) · Journal of Clinical Investigation · doi:10.1172/jci123708 · Cited by 99
Tolerogenic dendritic cell vaccines to treat autoimmune diseases: Can the unattainable dream turn into reality?
Brussel, I. V., Lee, W. P., Rombouts, M., Nuyts, A. H., Heylen, M., Winter, B. Y. D., Cools, N., & Schrijvers, D. M. (2013) · Autoimmunity Reviews · doi:10.1016/j.autrev.2013.09.008 · Cited by 97
The Role of Dendritic Cells in Tissue-Specific Autoimmunity
Mbongue, J. C., Nicholas, D., Firek, A. F., & Langridge, W. H. R. (2014) · Journal of Immunology Research · doi:10.1155/2014/857143 · Cited by 96
α4β1 Integrin Mediates the Recruitment of Immature Dendritic Cells across the Blood-Brain Barrier during Experimental Autoimmune Encephalomyelitis
Jain, P., Coisne, C., Enzmann, G. U., Rottapel, R. K., & Engelhardt, B. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0901404 · Cited by 85
Dendritic cells in brain diseases
Ludewig, P., Gallizioli, M., Urra, X., Behr, S., Brait, V. H., Gelderblom, M., Magnus, T. U., & Planas, A. M. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.11.003 · Cited by 86
The role of dendritic cells in CNS autoimmunity
Zozulya, A. L., Clarkson, B. D. S., Ortler, S., Fábry, Z., & Wiendl, H. (2010) · Journal of Molecular Medicine · doi:10.1007/s00109-010-0607-4 · Cited by 81
Follicular dendritic cells, conduits, lymphatic vessels, and high endothelial venules in tertiary lymphoid organs: Parallels with lymph node stroma
Stranford, S. A., & Ruddle, N. H. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00350 · Cited by 83
The Therapeutic Potential of HDAC Inhibitors in the Treatment of Multiple Sclerosis
Faraco, G., Cavone, L., & Chiarugi, A. (2011) · Molecular Medicine · doi:10.2119/molmed.2011.00077 · Cited by 80
Cutting Edge: Mast Cells Regulate Disease Severity in a Relapsing–Remitting Model of Multiple Sclerosis
Sayed, B. A., Walker, M. E., & Brown, M. A. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003574 · Cited by 79
IL-10 Modulates Th17 Pathogenicity during Autoimmune Diseases
Guo, B. (2016) · Journal of Clinical & Cellular Immunology · doi:10.4172/2155-9899.1000400 · Cited by 80
Redox Signaling, Neuroinflammation, and Neurodegeneration
Aguilera, G., Colín-González, A. L., Rangel‐López, E., Chavarría, A., & Santamaría, A. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7099 · Cited by 81
CC chemokine receptor 4 is required for experimental autoimmune encephalomyelitis by regulating GM-CSF and IL-23 production in dendritic cells
Poppensieker, K., Otte, D.-M., Schürmann, B., Limmer, A., Dresing, P., Drews, E., Schumak, B., Klotz, L., Raasch, J., Mildner, A., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1114153109 · Cited by 75
Plasticity of Ly-6Chi Myeloid Cells in T Cell Regulation
Zhu, B., Kennedy, J. K., Wang, Y., Sandoval-Garcia, C., Cao, L., Xiao, S., Wu, C., Elyaman, W., & Khoury, S. J. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100403 · Cited by 72
CD4+CD25+FoxP3+PD1— regulatory T cells in acute and stable relapsing‐remitting multiple sclerosis and their modulation by therapy
Saresella, M., Marventano, I., Longhi, R., Lissoni, F., Trabattoni, D., Mendozzi, L., Caputo, D., & Clerici, M. (2008) · The FASEB Journal · doi:10.1096/fj.08-110650 · Cited by 72
IFN-β Inhibits Dendritic Cell Migration through STAT-1–Mediated Transcriptional Suppression of CCR7 and Matrix Metalloproteinase 9
Yen, J.-H. J., Kong, W., & Ganea, D. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902542 · Cited by 71
Recent insights into the mechanism of action of glatiramer acetate
Kala, M., Miravalle, A. A., & Vollmer, T. L. (2011) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2011.01.009 · Cited by 68
Intracerebral Dendritic Cells Critically Modulate Encephalitogenic versus Regulatory Immune Responses in the CNS
Zozulya, A. L., Ortler, S., Lee, J., Weidenfeller, C., Sándor, M., Wiendl, H., & Fábry, Z. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2199-08.2009 · Cited by 69
Constitutive activity of NF-kappa B in myeloid cells drives pathogenicity of monocytes and macrophages during autoimmune neuroinflammation
Ellrichmann, G., Thöne, J., Lee, D.-H., Rupec, R., Gold, R., & Linker, R. A. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-15 · Cited by 70
Analysis of Behavior and Trafficking of Dendritic Cells within the Brain during Toxoplasmic Encephalitis
John, B., Ricart, B. G., Wojno, E. D. T., Harris, T. H., Randall, L. M., Christian, D. A., Gregg, B., de Almeida, D. M., Weninger, W., Hammer, D. A., et al. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002246 · Cited by 67
Do not judge a cell by its cover—diversity of CNS resident, adjoining and infiltrating myeloid cells in inflammation
Brendecke, S. M., & Prinz, M. (2015) · Seminars in Immunopathology · doi:10.1007/s00281-015-0520-6 · Cited by 68
Antigen-presenting cell diversity for T cell reactivation in central nervous system autoimmunity
Waisman, A., & Johann, L. (2018) · Journal of Molecular Medicine · doi:10.1007/s00109-018-1709-7 · Cited by 68
CCR2-Dependent Dendritic Cell Accumulation in the Central Nervous System during Early Effector Experimental Autoimmune Encephalomyelitis Is Essential for Effector T Cell Restimulation In Situ and Disease Progression
Clarkson, B. D. S., Walker, A. J., Harris, M. G., Rayasam, A., Sándor, M., & Fábry, Z. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1401320 · Cited by 68
The Interdependent, Overlapping, and Differential Roles of Type I and II IFNs in the Pathogenesis of Experimental Autoimmune Encephalomyelitis
Naves, R. F., Singh, S. P., Cashman, K. S., Rowse, A. L., Axtell, R. C., Steinman, L., Mountz, J. D., Steele, C. H., Sarno, P. D., & Raman, C. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300419 · Cited by 65
Clinical, Pathological, and Immunologic Aspects of the Multiple Sclerosis Model in Common Marmosets (Callithrix jacchus)
Hart, B. A. ‘., & Massacesi, L. (2009) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31819f1d24 · Cited by 65
Differential roles of resident microglia and infiltrating monocytes in murine CNS autoimmunity
Shemer, A., & Jung, S. (2015) · Seminars in Immunopathology · doi:10.1007/s00281-015-0519-z · Cited by 66
Interferon β induces mature dendritic cell apoptosis through caspase-11/caspase-3 activation
Yen, J.-H. J., & Ganea, D. (2009) · Blood · doi:10.1182/blood-2008-12-196592 · Cited by 64
Friends with Benefits: Chemokines, Glioblastoma-Associated Microglia/Macrophages, and Tumor Microenvironment
Codrici, E., Popescu, I. D., Tănase, C., & Enciu, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052509 · Cited by 62
Negative regulation of autoimmune demyelination by the inhibitory receptor CLM-1
Xi, H., Katschke, K. J., Helmy, K. Y., Wark, P. A., Kljavin, N. M., Clark, H. F., Eastham‐Anderson, J., Shek, T., Roose‐Girma, M., Ghilardi, N., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20091508 · Cited by 54
Oestrogen receptor β ligand acts on CD11c+ cells to mediate protection in experimental autoimmune encephalomyelitis
Kim, R. Y., Mangu, D., Hoffman, A., Kavosh, R., Jung, E., Itoh, N., & Voskuhl, R. R. (2017) · Brain · doi:10.1093/brain/awx315 · Cited by 54
TNFR1-Dependent Regulation of Myeloid Cell Function in Experimental Autoimmune Uveoretinitis
Raveney, B. J. E., Copland, D. A., Dick, A. D., & Nicholson, L. B. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901340 · Cited by 53
A natural flavonoid glucoside icariin inhibits Th1 and Th17 cell differentiation and ameliorates experimental autoimmune encephalomyelitis
Shen, R., Deng, W., Li, C., & Zeng, G. (2014) · International Immunopharmacology · doi:10.1016/j.intimp.2014.12.015 · Cited by 51
Dendritic Cell Differentiation Signals Induce Anti-Inflammatory Properties in Human Adult Microglia
Lambert, C., Desbarats, J., Arbour, N., Hall, J. A., Olivier, A., Bar-Or, A., & Antel, J. P. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.12.8288 · Cited by 50
Wnt/TLR Dialog in Neuroinflammation, Relevance in Alzheimer’s Disease
Zolezzi, J. M., & Inestrosa, N. C. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00187 · Cited by 50
Suppression of ongoing experimental autoimmune myasthenia gravis by transfer of RelB-silenced bone marrow dentritic cells is associated with a change from a T helper Th17/Th1 to a Th2 and FoxP3+ regulatory T-cell profile
Yang, H., Zhang, Y., Wu, M., Li, J., Zhou, W., Li, G., Li, X., Xiao, B., & Christadoss, P. (2009) · Inflammation Research · doi:10.1007/s00011-009-0087-6 · Cited by 48
To the Brain and Back: Migratory Paths of Dendritic Cells in Multiple Sclerosis
Laere, M. D., Berneman, Z. N., & Cools, N. (2018) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlx114 · Cited by 47
Targeting the B7 Family of Co-Stimulatory Molecules
Podojil, J. R., & Miller, S. D. (2012) · BioDrugs · doi:10.1007/s40259-012-0001-6 · Cited by 48
Self-citation
Chemokine CCL17 is expressed by dendritic cells in the CNS during experimental autoimmune encephalomyelitis and promotes pathogenesis of disease
Ruland, C., Renken, H., Kuzmanov, I., Mehr, A. F., Schwarte, K., Cerina, M., Herrmann, A. M., Otte, D.-M., Zimmer, A., Schwab, N., et al. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.06.010 · Cited by 45
Signal Transduction Inhibition of APCs Diminishes Th17 and Th1 Responses in Experimental Autoimmune Encephalomyelitis
Škarica, M., Wang, T., McCadden, E., Kardian, D., Calabresi, P. A., Small, D., & Whartenby, K. A. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803631 · Cited by 44
Focal transient CNS vessel leak provides a tissue niche for sequential immune cell accumulation during the asymptomatic phase of EAE induction
Barkauskas, D. S., Dorand, R. D., Myers, J., Evans, T. A., Barkauskas, K. J., Askew, D., Purgert, R., & Huang, A. Y.-C. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.02.018 · Cited by 44
CD8+ T cells directed against a viral peptide contribute to loss of motor function by disrupting axonal transport in a viral model of fulminant demyelination.
Howe, C., Ure, D., Adelson, J. D., Lafrance-Corey, R., Johnson, A. J., & Rodriguez, M. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2007.04.005 · Cited by 47
Personalizing Oncolytic Virotherapy for Glioblastoma: In Search of Biomarkers for Response
Stavrakaki, Ε., Dirven, C. M. F., & Lamfers, M. L. M. (2021) · Cancers · doi:10.3390/cancers13040614 · Cited by 42
Antibody blockade of CLEC12A delays EAE onset and attenuates disease severity by impairing myeloid cell CNS infiltration and restoring positive immunity
Sagar, D., Singh, N. P., Ginwala, R., Huang, X., Philip, R., Nagarkatti, M., Nagarkatti, P. S., Neumann, K., Ruland, J., Andrews, A. M., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-03027-x · Cited by 39
Cutting Edge: CD99 Is a Novel Therapeutic Target for Control of T Cell–Mediated Central Nervous System Autoimmune Disease
Winger, R. C., Harp, C. T., Chiang, M., Sullivan, D. P., Watson, R. L., Weber, E. W., Podojil, J. R., Miller, S. D., & Müller, W. A. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501634 · Cited by 35
Self-citation
Role of Dendritic Cells in Viral Brain Infections
Constant, O., Maarifi, G., Blanchet, F. P., Van de Perre, P., Simonin, Y., & Salinas, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.862053 · Cited by 35
Innate-Adaptive Crosstalk: How Dendritic Cells Shape Immune Responses in the CNS
Clarkson, B. D. S., Héninger, E., Harris, M. G., Lee, J., Sándor, M., & Fábry, Z. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-0106-3_18 · Cited by 32
Dendritic Cells and Multiple Sclerosis: Disease, Tolerance and Therapy
Mohammad, M. G., Hassanpour, M., Tsai, V. W.-W., Li, H., Ruitenberg, M. J., Booth, D. R., Serrats, J., Hart, P. H., Symonds, G., Sawchenko, P. E., et al. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms14010547 · Cited by 34
The 3.0 Cell Communication: New Insights in the Usefulness of Tunneling Nanotubes for Glioblastoma Treatment
Taiarol, L., Formicola, B., Fagioli, S., Sierri, G., D’Aloia, A., Kravicz, M., Renda, A., Viale, F., Magro, R. D., Ceriani, M., et al. (2021) · Cancers · doi:10.3390/cancers13164001 · Cited by 31
Male rats develop more severe experimental autoimmune encephalomyelitis than female rats: Sexual dimorphism and diergism at the spinal cord level
Nacka-Aleksić, M., Djikić, J., Pilipović, I., Stojić-Vukanić, Z., Kosec, D. J., Bufan, B., Arsenović-Ranin, N., Dimitrijević, M., & Leposavić, G. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.04.017 · Cited by 32
Peripheral dendritic cells are essential for both the innate and adaptive antiviral immune responses in the central nervous system
Steel, C., Hahto, S. M., & Ciavarra, R. P. (2009) · Virology · doi:10.1016/j.virol.2009.01.032 · Cited by 30
Modulating dendritic cells (DC) from immunogenic to tolerogenic responses: A novel mechanism of AZA/6-MP
Aldinucci, A., Biagioli, T., Manuelli, C., Repice, A. M., Massacesi, L., & Ballerini, C. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.11.001 · Cited by 30
Targeting poly(ADP-ribose) polymerase-1 as a promising approach for immunomodulation in multiple sclerosis?
Cavone, L., & Chiarugi, A. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2011.10.002 · Cited by 29
Metabolic regulation and function of T helper cells in neuroinflammation
Spiljar, M., & Kuchroo, V. K. (2022) · Seminars in Immunopathology · doi:10.1007/s00281-022-00959-z · Cited by 29
Neuroinflammation in Autoimmune Disease and Primary Brain Tumors: The Quest for Striking the Right Balance
Mitchell, D. K., Shireman, J. M., Potchanant, E. A. S., Lara-Velazquez, M. A., & Dey, M. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.716947 · Cited by 27
Defining a new biomarker for the autoimmune component of Multiple Sclerosis: Th40 cells
Waid, D., Schreiner, T., Vaitaitis, G. M., Carter, J. R., Corboy, J. R., & Wagner, D. H. (2014) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.03.009 · Cited by 27
Neuroantigen-Specific Autoregulatory CD8+ T Cells Inhibit Autoimmune Demyelination through Modulation of Dendritic Cell Function
Kashi, V. P., Ortega, S. B., & Karandikar, N. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105763 · Cited by 28
Inhibition of Interferon Regulatory Factor 4 Suppresses Th1 and Th17 Cell Differentiation and Ameliorates Experimental Autoimmune Encephalomyelitis
Yang, C., He, D., Yin, C. C., & Tan, J. Y. (2015) · Scandinavian Journal of Immunology · doi:10.1111/sji.12334 · Cited by 26
Lymphocyte transmigration in the brain: a new way of thinking
Lee, B. P.-L., & Imhof, B. A. (2008) · Nature Immunology · doi:10.1038/ni0208-117 · Cited by 26
Dendritic cells as therapeutic targets in neuroinflammation
Lüssi, F., Zipp, F., & Witsch, E. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2170-9 · Cited by 26
Diazepam treatment reduces inflammatory cells and mediators in the central nervous system of rats with experimental autoimmune encephalomyelitis
Hurst, N. F., Zanetti, S. R., Baez, N. S., Bibolini, M. J., Bouzat, C., & Roth, G. A. (2017) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2017.09.012 · Cited by 26
Route of Uptake of Palmitoylated Encephalitogenic Peptides of Myelin Proteolipid Protein by Antigen-Presenting Cells: Importance of the Type of Bond between Lipid Chain and Peptide and Relevance to Autoimmunity
Nadège, P., Grosch, S., Roussel, G., Koch, M., Trifilieff, É., & Greer, J. M. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.3.1398 · Cited by 26
CNS Resident Innate Immune Cells: Guardians of CNS Homeostasis
Muzio, L., & Perego, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25094865 · Cited by 27
Autoimmunity in multiple sclerosis: role of sphingolipids, invariant NKT cells and other immune elements in control of inflammation and neurodegeneration
Podbielska, M., O’Keeffe, J., & Hogan, E. L. (2017) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2017.12.022 · Cited by 26
Reduction in CD11c+ microglia correlates with clinical progression in chronic experimental autoimmune demyelination
Mayrhofer, F., Dariychuk, Z., Zhen, A., Daugherty, D. J., Bannerman, P. G. C., Hanson, A. M., Pleasure, D., Soulika, A. M., Deng, W., & Chechneva, O. V. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105556 · Cited by 25
Glatiramer acetate biases dendritic cells towards an anti-inflammatory phenotype by modulating OPN, IL-17, and RORγt responses and by increasing IL-10 production in experimental allergic encephalomyelitis
Begum-Haque, S., Christy, M., Wang, Y., Kasper, E. J., Ochoa‐Repáraz, J., Smith, J. Y., Haque, A., & Kasper, L. H. (2012) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2012.10.003 · Cited by 24
Experimental Autoimmune Encephalomyelitis (EAE) Induced by Antigen Pulsed Dendritic Cells in the C57BL/6 Mouse: Influence of Injection Route
Aghdami, N., Gharibdoost, F., & Moazzeni, S. M. (2008) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.57.45 · Cited by 23
Effective effectors: How T cells access and infiltrate the central nervous system
Congdon, K. L., Sanchez-Perez, L. A., & Sampson, J. H. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.12.007 · Cited by 22
Early influx of macrophages determines susceptibility to experimental allergic encephalomyelitis in Dark Agouti (DA) rats
Mensah‐Brown, E. P. K., Shahin, A., Al‐Shamisi, M., & Lukić, M. L. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.10.010 · Cited by 22

Authors: MILLER, S. D., McMAHON, E. J., SCHREINER, B., & BAILEY, S. L.
Affiliations: Northwestern University (US)
Westmont College (US)
Corresponding author: MILLER, STEPHEN D.
ORCID: MILLER, STEPHEN D.
SCHREINER, BETTINA
Venue: Annals of the New York Academy of Sciences
Publisher: Wiley
Published: 2007-04
Volume: 1103
Issue: 1
Pages: 179-191
ISSN: 0077-8923 (ISSN-L)
1749-6632
DOI: 10.1196/annals.1394.023
OpenAlex: W2099046115
Cited by: 144
References: 59
Citations by year: 2026: 1 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 5 · 2021: 8 · 2020: 1 · 2019: 1 · 2018: 9 · 2017: 8 · 2016: 7 · 2015: 14 · 2014: 7 · 2013: 7 · 2012: 16
FWCI: 10.37
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 40 d)
Locations: Annals of the New York Academy of Sciences (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: multiple sclerosis, antigen presentation, myeloid dendritic cells, epitope spreading, Th17 polarization, plasmacytoid dendritic cells, CD8α+ dendritic cells, microglia, macrophages, T cell activation, TGF-β1, IL-23, interleukin-6, SJL mice
MeSH terms: Animals, Epitopes, Central Nervous System, Chronic Disease, Dendritic Cells, Disease Models, Animal, Encephalomyelitis, Autoimmune, Experimental, Mice, Inbred Strains, Multiple Sclerosis, Recurrence, Models, Immunological, Disease Progression, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Antigen Presentation in the CNS by Myeloid Dendritic Cells Drives Progression of Relapsing Experimental Autoimmune Encephalomyelitis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks