Difficulty Overcoming Learned Non‐reward during Reversal Learning in Rats with Ibotenic Acid Lesions of Orbital Prefrontal Cortex
Abstract
Abstract: Behavioral flexibility is a concept often invoked when describing the function of the prefrontal cortex. However, the psychological substrate of behavioral flexibility is complex. Its key components are allocation of attention, goal‐directedness, planning, working memory, and response selection. Furthermore, there is evidence that different regions of the prefrontal cortex might be implicated in these different components. In rule‐switching tasks, a distinction is made between errors that are perseverative (difficulty switching from a previously rewarded strategy) and errors due to learned‐irrelevance (difficulty switching to a strategy previously uncorrelated with reward). A similar distinction might be made for reversal learning, which involves inhibition of a previously rewarded response and activation of a previously unrewarded response. Damage to the orbital prefrontal cortex (OPFC) results in a deficit in reversal learning. The present study was designed to examine whether one or both of either perseveration or learned non‐reward might account for the deficit. Rats with bilateral ibotenic acid‐induced lesions of the OPFC were not impaired in acquisition of discriminations. They were impaired, relative to controls, only when they had to overcome learned non‐reward. They did not show enhanced perseveration. We conclude that an inability to overcome learned non‐reward significantly contributes to OPFC lesion‐induced deficits in behavioral flexibility.
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This is consistent with intact acquisition of Pavlovian responses but impaired reversal learning in OFC-lesioned animals.
“This is consistent with the reported intact acquisition of Pavlovian responses, but impaired reversal learning in OFC‐lesioned animals.”
From Behavioral flexibility in a mouse model for obsessive‐compulsive disorder: Impaired Pavlovian reversal learning in SAPAP3 mutants (2019) · cites this paper as [67]
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- Authors
- TAIT, D. S., & BROWN, V. J.
- Affiliations
- University of St Andrews (GB)
- Corresponding author
- BROWN, VERITY J.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2007-12
- Volume
- 1121
- Issue
- 1
- Pages
- 407-420
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W1970346321
- Cited by
- 75
- References
- 19
- Citations by year
- 2026: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 7 · 2018: 3 · 2017: 3 · 2016: 6 · 2015: 4 · 2014: 2 · 2013: 8 · 2012: 5
- FWCI
- 3.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- reversal learning, orbitofrontal cortex, behavioral flexibility, perseveration, ibotenic acid lesions, rats, rule switching, response inhibition, prefrontal cortex function
- MeSH terms
- Animals, Frontal Lobe, Ibotenic Acid, Male, Memory, Reversal Learning, Reward, Rats
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