Dissociable Contributions of the Orbitofrontal and Infralimbic Cortex to Pavlovian Autoshaping and Discrimination Reversal Learning: Further Evidence for the Functional Heterogeneity of the Rodent Frontal Cortex
Open accessAbstract
To examine possible heterogeneity of function within the ventral regions of the rodent frontal cortex, the present study compared the effects of excitotoxic lesions of the orbitofrontal cortex (OFC) and the infralimbic cortex (ILC) on pavlovian autoshaping and discrimination reversal learning. During the pavlovian autoshaping task, in which rats learn to approach a stimulus predictive of reward [conditional stimulus (CS+)], only the OFC group failed to acquire discriminated approach but was unimpaired when preoperatively trained. In the visual discrimination learning and reversal task, rats were initially required to discriminate a stimulus positively associated with reward. There was no effect of either OFC or ILC lesions on discrimination learning. When the stimulus-reward contingencies were reversed, both groups of animals committed more errors, but only the OFC-lesioned animals were unable to suppress the previously rewarded stimulus-reward association, committing more "stimulus perseverative" errors. In contrast, the ILC group showed a pattern of errors that was more attributable to "learning" than perseveration. These findings suggest two types of dissociation between the effects of OFC and ILC lesions: (1) OFC lesions impaired the learning processes implicated in pavlovian autoshaping but not instrumental simultaneous discrimination learning, whereas ILC lesions were unimpaired at autoshaping and their reversal learning deficit did not reflect perseveration, and (2) OFC lesions induced perseverative responding in reversal learning but did not disinhibit responses to pavlovian CS-. In contrast, the ILC lesion had no effect on response inhibitory control in either of these settings. The findings are discussed in the context of dissociable executive functions in ventral sectors of the rat prefrontal cortex.
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The lateral and medial orbitofrontal cortex have been linked to associative learning, decision making, and reversal learning.
“Consistent with the idea that the OFC unites internal and external sensory information, the lateral OFC and the medial OFC have been linked to associative learning (Rolls et al. 1994; 1996) decision making (e.g., Bechara et al. 1996; 2000; Koenigs et al. 2007) and reversal learning, in which the reward values associated with choice options are reversed and animals must learn the current reward”
From The brain basis of emotion: a meta-analytic review (2012) · cites this paper as Chudasama & Robbins 2003
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- Authors
- Chudasama, Y., & Robbins, T. W.
- Affiliations
- University of Cambridge (GB)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2003-09-24
- Volume
- 23
- Issue
- 25
- Pages
- 8771-8780
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6740430
- OpenAlex
- W2116813115
- Cited by
- 543
- References
- 8
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 13 · 2023: 12 · 2022: 23 · 2021: 22 · 2020: 24 · 2019: 28 · 2018: 20 · 2017: 21 · 2016: 23 · 2015: 34 · 2014: 21 · 2013: 32 · 2012: 26
- FWCI
- 9.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Medical Research Council
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- orbitofrontal cortex, infralimbic cortex, discrimination reversal learning, perseverative responding, response inhibition, excitotoxic lesions, ventral prefrontal cortex, functional heterogeneity, stimulus-reward associations
- MeSH terms
- Animals, Behavior, Animal, Cerebral Cortex, Conditioning, Classical, Discrimination Learning, Frontal Lobe, Inhibition, Psychological, Limbic System, Male, Neurotoxins, Photic Stimulation, Rats, Inbred Strains, Reaction Time, Retention, Psychology, Reversal Learning, Reward, Sensitivity and Specificity, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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