Orbital prefrontal cortex mediates reversal learning and not attentional set shifting in the rat

McAlonan, Kerry; Brown, Verity J.

doi:10.1016/j.bbr.2003.09.019

Cited by 618Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorMemory and Neural Mechanisms

Orbital prefrontal cortex mediates reversal learning and not attentional set shifting in the rat

McAlonan, Kerry, Brown, Verity J.·2003·Behavioural Brain Research

DOI 10.1016/j.bbr.2003.09.019

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Abstract

It has been demonstrated previously that lesions to medial prefrontal cortex in rats impair the shifting of attentional set between perceptual features of complex stimuli [J. Neurosci. 20 (2000) 4320], a result that mirrors the deficit found in humans and monkeys [Nature 380 (1996) 69; Behav. Neurosci. 110 (1996) 872; J. Neurosci. 17 (1997) 9285; Neuropsychologia 29 (1991) 993]. These data imply functional homology between rat medial prefrontal cortex and primate prefrontal cortex.In marmoset monkeys, there is a double dissociation between the effects of lesions of lateral prefrontal cortex, which impair shifting of attentional set, and lesions of orbital prefrontal cortex, which result in impairments of reversal of stimulus-reward contingencies, leaving attentional set-shifting capacities intact [Nature 380 (1996) 69; Behav. Neurosci. 110 (1996) 872; J. Neurosci. 17 (1997) 9285]. The present investigation examined whether lesions to rat orbital prefrontal cortex would produce deficits in reversal learning in the absence of deficits in shifting attentional set, as seen in monkeys. Rats were trained to perform an attentional set-shifting task that is formally the same as that used in monkeys and humans. In a single session, rats performed a series of discriminations, including acquisitions and reversals. Damage to orbital prefrontal cortex in the rats did not disrupt the ability to acquire, maintain or shift attentional set. We report here the same selective impairment in reversal learning in rats as seen in primates with orbital prefrontal cortex lesions.

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Orbitofrontal cortex damage impairs ability to refrain from responding to formerly rewarding cues no longer reinforced.
“damage to the OFC impairs the ability to refrain from responding to formerly rewarding cues that are no longer reinforced (Dias et al., 1996; McAlonan and Brown, 2003; Mishkin, 1964; Ostlund and Balleine, 2007; Rahman et al., 1999; Rolls et al., 1994; Schoenbaum and Roesch, 2005; Schoenbaum et al., 2007; Tait and Brown, 2007).”
From Impulsivity, frontal lobes and risk for addiction (2009) · cites this paper as McAlonan and Brown, 2003
Spatial reversal learning is not exclusively associated with hippocampal function but also with the prefrontal cortex, namely the prelimbic and infralimbic, and orbitalfrontal regions.
“This particular cognitive task is not exclusively associated with hippocampal function but also the prefrontal cortex,42 namely the prelimbic and infralimbic, and orbitalfrontal regions;43”
From Adult hippocampal neuroplasticity triggers susceptibility to recurrent depression (2017) · cites this paper as [43]
OFC lesions consistently result in impaired reversal learning.
“as OFC lesions consistently result in impaired reversal learning.60, 61, 62, 63, 64, 65, 66, 67”
From Behavioral flexibility in a mouse model for obsessive‐compulsive disorder: Impaired Pavlovian reversal learning in SAPAP3 mutants (2019) · cites this paper as [61]
Previous studies indicate crucial involvement of the prefrontal cortex (PFC) in reversal learning.
“Previous studies indicate crucial involvement of the prefrontal cortex (PFC) in reversal learning.”
From Behavioral flexibility in a mouse model for obsessive‐compulsive disorder: Impaired Pavlovian reversal learning in SAPAP3 mutants (2019) · cites this paper as [61]

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Authors: McAlonan, K., & Brown, V. J.
Affiliations: University of St Andrews (GB)
Corresponding author: Brown, Verity J.
ORCID: Brown, Verity J.
Venue: Behavioural Brain Research
Publisher: Elsevier BV
Published: 2003-11
Volume: 146
Issue: 1-2
Pages: 97-103
ISSN: 0166-4328 (ISSN-L)
DOI: 10.1016/j.bbr.2003.09.019
OpenAlex: W2098736996
Cited by: 618
References: 31
Citations by year: 2026: 11 · 2025: 10 · 2024: 21 · 2023: 13 · 2022: 19 · 2021: 27 · 2020: 22 · 2019: 36 · 2018: 28 · 2017: 35 · 2016: 32 · 2015: 51 · 2014: 26 · 2013: 35 · 2012: 33
FWCI: 7.24
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Behavioural Brain Research (publishedVersion)
PubMed (publishedVersion)
Funders: Biotechnology and Biological Sciences Research Council
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: orbitofrontal cortex, reversal learning, set-shifting, medial prefrontal cortex, lesion studies, rats, functional homology, double dissociation, lateral prefrontal cortex
MeSH terms: Analysis of Variance, Animals, Attention, Behavior, Animal, Discrimination Learning, Male, Reaction Time, Reversal Learning, Set, Psychology, Prefrontal Cortex, Rats

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Orbital prefrontal cortex mediates reversal learning and not attentional set shifting in the rat

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