Keynote address: revaluing the orbital prefrontal cortex
Open accessAbstract
The importance of orbitofrontal cortex (OFC) in human behavioral regulation is no longer a matter of dispute, though its precise role remains a matter of ongoing investigation. It is ironic that this revaluation of OFC required a major departure from a historical nadir, during which it was viewed as redundant or "silent cortex," a situation that prevailed even up to the latter half of the 20th century. The increasing wealth of data from diverse fields within neuroscience now provides an unambiguous testament to the importance of this cortical region in behavioral regulation and cognition in general.
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Within the vPFC, the lateral portion is involved in attention control and related processes and the medial portion is implicated in controlling flexible and adaptive motivational responses, such as acquisition of fearful responding, fear extinction, as well as approach and reward-driven behaviors.
“Within the vPFC, the lateral portion is involved in attention control and related processes and the medial portion is implicated in controlling flexible and adaptive motivational responses, such as acquisition of fearful responding, fear extinction, as well as approach and reward-driven behaviors (Dolan, 2007, Murray et al., 2007).”
From Gaining insight into adolescent vulnerability for social anxiety from developmental cognitive neuroscience (2014) · cites this paper as Dolan, 2007
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- Authors
- DOLAN, R. J.
- Affiliations
- Wellcome Centre for Human Neuroimaging (GB)
- Corresponding author
- DOLAN, R. J.
- ORCID
- DOLAN, R. J.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2007-12
- Volume
- 1121
- Issue
- 1
- Pages
- 1-9
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- PMC
- PMC2864434
- OpenAlex
- W2065548190
- Cited by
- 16
- References
- 24
- Citations by year
- 2017: 1 · 2015: 1 · 2013: 2
- FWCI
- 1.33
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Max Planck Digital Library (submittedVersion, other-oa)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- Funders
- Wellcome Trust (078865)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
- Keywords
- orbitofrontal cortex, behavioral regulation, cognition, history of neuroscience, prefrontal cortex function
- MeSH terms
- Humans, Models, Neurological, Neurosciences, Psychiatry, Biomarkers, Prefrontal Cortex
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